Skip to Main content Skip to Navigation
Theses

Analyse du rôle du facteur de transcription Ikaros dans le développement des lymphocytes TH17

Abstract : TH17 cells are characterized by the expression of the cytokine IL-17A, as well as the transcription factor RORɣt. They are known to play key role in the pathogenesis of the multiple sclerosis. These cells exist in two forms: the regulating cells, immunomodulatory, and the pathogenic cells which are critical for the inflammation. Thus it is important to understand the mechanism which underlies the differentiation of naïve CD4+ T cells in these two cellular types. I found that the transcription factor Ikaros is an indirect repressor of the transcription of pathogenic genes (Il3, Csf2, Ifng, Stat4…) in naïve CD4+ T cells, cultured to induce a polarization toward regulatory TH17 cells. Moreover, in absence of Ikaros and in regulatory condition of culture, adding IL-6 alone increases the expression of GM-CSF, key factor to induce auto-immune diseases, suggesting a role of Ikaros in this pathway. In conclusion, our results suggest that Ikaros is necessary to polarize correctly naïve CD4+ T cells in TH17 cells.
Complete list of metadatas

Cited literature [209 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02918040
Contributor : Abes Star :  Contact
Submitted on : Thursday, August 20, 2020 - 10:11:03 AM
Last modification on : Friday, October 23, 2020 - 4:45:54 PM

File

MAURER_Gaetan_2017_ED414.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02918040, version 1

Collections

Citation

Gaëtan Maurer. Analyse du rôle du facteur de transcription Ikaros dans le développement des lymphocytes TH17. Génomique, Transcriptomique et Protéomique [q-bio.GN]. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAJ115⟩. ⟨tel-02918040⟩

Share

Metrics

Record views

22

Files downloads

18