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, Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia, Clin Hemorheol Microcirc, vol.52, pp.15-26

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, Publications, communications, prix et bourses Publications dans des revues scientifiques internationales

A. *. Merlet, B. Chatel, C. Hourdé, M. Ravelojaona, D. Bendahan et al., How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life, Med Sci Sports Exerc, 2018.

B. Gellen, L. *. Messonnier, F. Galactéros, E. Audureau, A. N. Merlet et al., Moderate-intensity endurance-exercise training in sickle cell disease patients without severe chronic complications: an open-label randomized controlled trial, The Lancet Haematology, 2018.

A. N. Merlet, L. Messonnier, B. Gellen, P. Bartolucci, and L. Féasson, Beneficial effects of a moderateintensity endurance-exercise training on skeletal muscle microvasculature in sickle cell disease patients, Haematologica

A. N. Merlet, L. Messonnier, P. Bartolucci, C. Hourde, B. Gellen et al., Muscle structural and energetic benefits of endurance exercise training in sickle cell disease patients

L. Januel, A. N. Merlet, Z. He, B. Gellen, P. Bartolucci et al., Could moderate-intensity endurance-exercise modulate the muscle regeneration potential in sickle cell disease patients?

A. Merlet, L. Messonnier, P. Bartolucci, C. Hourde, R. Lacroix et al., Beneficial effects of endurance training on skeletal muscle microvasculature in patients with sickle cell disease, European College of Sport Science, 2018.

A. Merlet, L. Messonnier, P. Bartolucci, C. Hourde, R. Lacroix et al., Beneficial effects of endurance training on skeletal muscle microvasculature in patients with sickle cell disease. 13ème congrès international sur la drépanocytose, 2018.

A. Merlet, L. Messonnier, P. Bartolucci, B. Gellen, C. Hourde et al., Evaluation d'un programme d'entrainement pour des patients drépanocytaires homozygotes : bénéfices sur l'aptitude physique et le tissu musculaire squelettique. Congrès International de l'Association des, Chercheurs en Activité Physique et Sportive. Octobre, 2017.

, Communications dans des congrès nati onaux

A. Merlet, L. Messonnier, P. Bartolucci, B. Gellen, C. Hourde et al., L'exercice physique chez le patient drépanocytaire : plus redouté que redoutable ! Journée de la recherche de l'école doctorale, 2018.

A. Merlet, L. Messonnier, C. Hourde, P. Bartolucci, B. Gellen et al., Muscle structural and energetic benefits of 8 weeks of moderate endurance training in sickle cell disease patients. Exercise, locomotion and musculoskeletal system, 2018.

A. Merlet, L. Messonnier, P. Bartolucci, B. Gellen, C. Hourde et al., L'activité physique adaptée pour le muscle du patient drépanocytaire ? Même très peu, c'est déjà très bien, 2017.

A. Merlet, L. Messonnier, P. Bartolucci, R. Lacroix, B. Gellen et al., Endurance training program to improve physical fitness and skeletal muscle characteristics in sickle cell anemia, 2016.

A. Merlet, L. Messonnier, P. Bartolucci, R. Lacroix, B. Gellen et al., Evaluation d'un programme d'entrainement pour des patients drépanocytaires homozygotes : bénéfices sur l'aptitude physique et le tissu musculaire squelettique, 2016.

, Communication de vulgarisation scientifique

A. Merlet, Le sport : le meilleur ennemi du drépanocytaire. Ma thèse en 180 secondes, finale nationale belge. Mars et Mai, 2017.

, Lauréate pour les meilleures communications orales, Juin, 2018.

, Journée Exercise, locomotion and musculoskeletal system. Mai, 2018.

, Lauréate pour le concours Ma Thèse en 180 secondes. Participation à la finale nationale belge. Mars et mai, 2017.

A. *. Merlet, T. Cattagni, C. Cornu, and M. Jubeau, Effect of knee angle on neuromuscular assessment of plantar flexor muscles: A reliability study, PLoS ONE, vol.13, issue.3, p.195220, 2018.

T. Cattagni, A. N. Merlet, C. Cornu, and M. Jubeau, H-reflex and M-wave recordings: effect of pressure application to the stimulation electrode on the assessment of evoked potentials and subject's discomfort, Clin Physiol Funct Imaging, vol.38, issue.3, pp.416-424, 2018.

A. Merlet, T. Cattagni, C. Cornu, and M. Jubeau, Reproductibilité intra-et intersession des mesures neuromusculaires des fléchisseurs plantaires selon l'angle du genou, 2015.

, Faire sécher les lames 1 heure 2. Délimiter avec le stylo hydrophobe « Dakopen » le contour des coupes 3

, 05 M pendant 2 x 5 min 6. Passage dans le TSAB pendant 5 min 7. Hybridation avec l'anticorps secondaire pendant 1 heure à température ambiante

, Passage dans le TSAB pendant 5 min 10. Hybridation avec l'anticorps tertiaire pendant 1 heure à température ambiante

, 05 M pendant 2 x 5 min 12. Passage dans le TSAB pendant 5 min 1. 10 µg de protéines ont été combinés avec le tampon Laemmli puis chauffés pendant 5 minutes à 95°C (sauf pour oxphos, chauffés pendant 3 minutes à 55°C)

, Les protéines ont été séparées par SDS-PAGE (gels de 12% pour les oxphos et 10% pour les autres protéines) pendant 2 heures à une intensité constante de 40 mA. Ces protéines ont ensuite été transférées sur des membranes à pendant 2h30 à une intensité de 80 V

, Découper les membranes en fonctions des protéines à analyser

, Bloquer les membranes pendant 1h dans une solution de lait

, Incuber les membranes à 4°C pendant la nuit avec l'un des anticorps suivants dilué dans du lait (5% de regilait dilué dans du TBST) a. complexe oxphos total (ab110413, Abcam, 1 : 1000) i. complexe I : sous-unité NDUFB8 ii. complexe II : sous-unité SDHB iii. complexe III : sous-unité UQCRC2 iv. complexe IV : sous-unité MTCO1 v. complexe V : sous-unité ATP5A

, Thermo Fisher Scientific, vol.1, p.1000

. Caii-(anhydrase-carbonique, . Ii, . Birborb10230, and . Vwr, , p.250

, CAIII (anhydrase carbonique III, BSBTPA1439, VWR, 1 : 1000) e. MCT1 (transporteur monocarboxylate 1, AB3538P, Merck Millipore, 1 : 1000) f. MCT4 (transporteur monocarboxylate 4, AB3316P, Merck Millipore, vol.1, p.1000

, Laver 3 fois les membranes pendant 10 minutes dans du TBST

, Incuber les membranes pendant 1 heure à température ambiante avec un anticorps secondaire anti-rabbit (A6154 ; Sigma-Aldrich) ou anti-mouse (610-1319

, Laver 3 fois les membranes pendant 10 minutes dans du TBST

, Révélation à l'ECL avec le kit Western blot ECL-Plus (Advansta

, Faire les photos avec la GBox (Syngene, Cambridge, Royaume-Uni) à l'aide du logiciel GeneSnap

I. Le-logiciel, ) a été utilisé pour les quantifications, National Institutes of Health