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EFFETS D’UN ENTRAINEMENT EN ENDURANCE SUR LES CARACTERISTIQUES MUSCULAIRES DES PATIENTS DREPANOCYTAIRES HOMOZYGOTES

Abstract : Sickle cell disease is a genetic hemoglobinopathy resulting in chronic and severe hemolytic anemia and iterative vaso-occlusive crisis. This pathology is also accompanied by exercise intolerance and alterations in muscle function and tissue. Recently, we demonstrated, through a randomized controlled study, the safety and functional benefits of a moderate-intensity endurance exercise training program in sickle cell disease patients. The objective of this doctoral work was to evaluate the effects of this training program on the muscle characteristics of forty homozygous sickle cell disease patients. The analysis of muscle biopsies reported tissue adaptations in trained patients, illustrated by an increase in the surface area of myocytes, an improvement in their oxidative capacity, an increase in the number of microvessels without modification of their tortuosity, suggesting a better muscle oxygenation. The excellent tolerance of this training mode seems to be based on a lower mobilization of the anaerobic pathways, as shown by the stability of the enzymatic activities associated with lactic glycolysis and the lack of any modification of the muscle protein content involved in pH regulation. Moreover, this training did not result in any significant tissue degradation. Thus, this training provided functional benefits, but also reduced muscle tissue dysfunctions. This exercise therapy can therefore be considered a promising adjuvant strategy for sickle cell disease patients.
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Submitted on : Thursday, August 20, 2020 - 10:00:05 AM
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Angèle Merlet. EFFETS D’UN ENTRAINEMENT EN ENDURANCE SUR LES CARACTERISTIQUES MUSCULAIRES DES PATIENTS DREPANOCYTAIRES HOMOZYGOTES. Médecine humaine et pathologie. Université de Lyon; Université catholique de Louvain (1970-..), 2018. Français. ⟨NNT : 2018LYSES036⟩. ⟨tel-02917995⟩

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