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Synthèse orthogonale de polymères à séquences contrôlées, optimisés pour la lecture de données digitales

Abstract : Information-containing sequenced-controlled polymers were synthesized by an « AB+CD » supported iterative strategy, involving two orthogonal reactions. This approach allowed the protecting-group-free synthesis of monodisperse sequence-controlled poly(alkoxyamine amide)s and poly(alkoxyamine triazole)s. The poly(alkoxyamine amide)s were synthesized on different supports - solid, soluble, and fluorinated – and also by a convergent strategy. Besides, the synthesis of the poly(alkoxyamine triazole)s allowed studying the SpAAC, involving a cyclooctyne and an azide for a copper-free formation of a triazole. The structure of the obtained polymers also allowed an MS/MS sequencing of the binary code implemented along the chains through functional groups coding for 0 or 1, thanks to the presence of weak linkages. Furthermore, the poly(alkoxyamine amide)s were optimized for data encoding, by synthesizing molecular barcodes to increase storage capacity, and by an induced polydispersity to decode the polymers without fragmentation.
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Chloé Laure. Synthèse orthogonale de polymères à séquences contrôlées, optimisés pour la lecture de données digitales. Polymères. Université de Strasbourg, 2017. Français. ⟨NNT : 2017STRAF080⟩. ⟨tel-02917987⟩

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