Skip to Main content Skip to Navigation
Theses

Contribution to the study of uremic toxins in the context of chronic kidney disease

Abstract : Chronic kidney disease (CKD) is a condition characterized by progressive loss of kidney function. CKD is associated with the accumulation of various uremic toxins. Uremic toxins or uremic retention solutes are compounds that accumulate in patients with CKD due to impaired renal clearance and exert deleterious biological effects. Protein-bound uremic toxins (PBUT) is poorly removed by hemodialysis because of its binding to plasma proteins, particularly human serum albumin. As a result, protein-bound uremic toxins accumulate in patients with CKD and their concentration can hardly be reduced in patients with end-stage renal disease (ESRD). My work focuses mainly on uremic toxins, particularly protein-bound uremic toxins such as indoxyl-sulfate (IS), phenylacetic acid (PAA) and p-cresyl-glucuronide (p-CG); and zinc-alpha2-glycoprotein (ZAG) which is a "middle molecule". We investigated the role of IS in the development of insulin resistance and other metabolic disorders associated with CKD, as well as its effects on inflammation and oxidative stress. We have investigated the binding properties of PAA and p-CG to serum albumin, which is the most abundant protein in human plasma. Finally, we tried to develop a new strategy to eliminate PBUTs, using chemical displacers / competitors.
Document type :
Theses
Complete list of metadatas

Cited literature [155 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02917972
Contributor : Abes Star :  Contact
Submitted on : Thursday, August 20, 2020 - 9:52:19 AM
Last modification on : Tuesday, August 25, 2020 - 4:53:19 PM

File

these.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02917972, version 1

Citation

Dan Yi. Contribution to the study of uremic toxins in the context of chronic kidney disease. Agricultural sciences. Université de Lyon, 2018. English. ⟨NNT : 2018LYSEI054⟩. ⟨tel-02917972⟩

Share

Metrics

Record views

21

Files downloads

8