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Le récepteur opioïde Mu et les interactions entre systèmes opioïde et cannabinoïde dans les effets nociceptifs et addictogènes de la morphine

Abstract : The opioid system controls pain and reward, and the Mu opioid receptor plays a central role in these effects. In the first part of the thesis, we showed that Mu receptor is also involved in the development of hyperalgesia induced by chronic opiate exposure. In the second part of the thesis, we studied the impact of opioid and cannabinoid interactions on effects associated to chronic morphine administration. We explored the effects of a pretreatment with a CB1 cannabinoid receptor selective agonist, arachidonyl-2-chloroethylamide (ACEA), on morphine-associated nociceptive, withdrawal, reward and naturalistic behaviors. To complete this behavioral study, we performed transcriptional and functional analyses to identify the neuroadaptative processes involved. Our study demonstrates that dual activation of CB1 and Mu receptors has a beneficial effect on behavioral parameters related to addiction, pointing to potential usefulness of combining both medications for therapeutic interventions.
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https://tel.archives-ouvertes.fr/tel-02917931
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Submitted on : Thursday, August 20, 2020 - 9:42:36 AM
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  • HAL Id : tel-02917931, version 1

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Laurie-Anne Roeckel. Le récepteur opioïde Mu et les interactions entre systèmes opioïde et cannabinoïde dans les effets nociceptifs et addictogènes de la morphine. Neurosciences [q-bio.NC]. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAJ012⟩. ⟨tel-02917931⟩

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