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Le rôle des noyaux reuniens et rhomboïde de la ligne médiane du thalamus ventral dans la consolidation d’un souvenir spatial chez le rat : approches comportementales et moléculaires

Abstract : Memorization relies on a dialogue between the hippocampus and the medial prefrontal cortex (mPFC). This dialog takes place progressively after the encoding of an event. Given their connectivity, the thalamic nuclei named reuniens and rhomboid (ReRh) may modulate the functional loop between these two structures. Indeed, a lesion of these nuclei impairs the persistence of a spatial memory. The mechanisms underlying this process are still unknown. Therefore, we analyzed the molecular mechanisms underlying spatial memory consolidation within the hippocampus and the mPFC, and the consequences of a lesion of the ReRh nuclei. After a stereotaxic lesion of the ReRh nuclei, rats were subjected to three days of a spatial training in the Morris water maze. We then performed a RNA sequencing of the dorsal and ventral hippocampus (CA1 regions), RT-qPCR analysis of the mPCF, and a quantification of the expression of c-fos in these two structures. Results show that ReRh nuclei lesion impairs the transcriptional and translational mechanisms within the hippocampus and the mPFC as soon as after three days of a spatial learning. These alterations could lead to the retrieval deficit observed after a long post-acquisition delay.
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Amélie Gressier. Le rôle des noyaux reuniens et rhomboïde de la ligne médiane du thalamus ventral dans la consolidation d’un souvenir spatial chez le rat : approches comportementales et moléculaires. Neurobiologie. Université de Strasbourg, 2018. Français. ⟨NNT : 2018STRAJ010⟩. ⟨tel-02917929⟩

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