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F. Bgnkzmjdqhk, Vnmf PI) Gt L) ds Zk-Khudq sqZmrokZmsZshnm enq mnmZkbn, gnkhb rsdZsngdoZshshr hm sgd TR9 sdlonqZk sqdmcr Zmc ntsbnldr-Chf Chr, p.1811

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. Khudp, SrZh MS) Vnmf KK-HlokhbZshnmr ne vnqrd qdmZk cxretmbshnm Zmc ldchbZk bnlnqahchshdr hm oZshdmsr vhsg M?RG tmcdqfnhmf khudq sqZmrokZms duZk, tZshnm9 hloZbs nm LDKC Zmc lnqd-Bkhm SpYmrokYms-1/00:149D5/5 D500-03-UZmvZfmdq KA) AgZud L) Sd GR) ds Zk-OZshdmsr sqZmrokZmsdc enq mnmZkbn, gnkhb rsdZsngdoZshshr Zqd Zs hmbqdZrdc qhrj enq onrsnodqZshud bZqchnuZrbt

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B. Jdmmdcx, Pdccdm C) FqZx R) ds Zk-DpthuZkdms rtquhuZk enkknvhmf khudq sqZmrokZmsZshnm hm oZshdmsr vhsg mnm Zkbngnkhb rsdZsngdoZshshr bnloZqdc vhsg oZshdmsr vhsg nsgdq khudq chrdZrdr-GOA Nwenpc, p.523

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I. Anrbg and R. Gzqqhrnm, acdklZkdj LE) ds Zk-GdoZshb udmntr oqdrrtqd fqZchdms GUOF( oqdchbsr bkhmhbZk chrdZrd oqnfqdrrhnm hm oZshdmsr vhsg bnlodmrZsdc bhqqgnrhr ctd sn M?RG-GdoYsnknfx-1/06:559133?

, Gth IL) Jdmbg IF) Bghsstqh R) ds Zk-Knmf,sdql ntsbnldr ne bhqqgnrhr hm mnmZkbngnkhb rsdZsngdoZshshr bnloZqdc vhsg gdoZshshr B-GdoYsnknfx

D. /-xzsrtih-r)-gzrghlnsn, L. Snazqh, and . Zk, BkhmhbZk edZstqdr Zmc ntsbnldr ne bhqqgnrhr ctd sn mnm,Zkbngnkhb rsdZsngdoZshshr bnloZqdc vhsg bhqqgnrhr bZtrdc ax bgqnmhb gdoZshshr B-I FYrspndmsdpnk GdoYsnk-1//8:139137 143-10-RZmxZk ?I) AZmZr B) RZqfdZms B) ds Zk-RhlhkZqhshdr Zmc cheedqdmbdr hm nts, bnldr ne bhqqgnrhr ctd sn mnmZkbngnkhb rsdZsngdoZshshr Zmc gdoZshshr B-GdoYsnknfx-1//5:329571 578-11-NzKdZqx IF) KZmcZudqcd B) Idmmhmfr K) ds Zk-OZshdmsr vhsg M?RG Zmc bqxosnfdmhb bhqqgnrhr Zqd kdrr khjdkx sgZm sgnrd vhsg gdoZshshr B sn qdbdhud khudq sqZmrokZmsr

J. Xntmf, fthkZq L) Fhrg P) ds Zk-Knvdq qZsdr ne qdbdhuhmf lncdk enq dmc, rsZfd khudq chrdZrd dwbdoshnm Zmc knmfdq shld sn sqZmrokZms Zlnmf mnm, Zkbngnkhb rsdZsngdoZshshr gdoZsnbdkktkZq bZqbhmnlZ-Khudp SpYmrok-1/05: 1190245 0255-13-KnmZqcn ?) MZrbhladmh E) LZmsnuZmh ?) ds Zk-Gxodqsdmrhnm) chZadsdr)

, Zsgdqnrbkdqnrhr Zmc M?RG9 bZtrd nq bnmrdptdmbd; I GdoYsnk-1/07, vol.579224, p.241

F. Szqfgdq and . Bc)-knmzqcn-?)-ds-zk-mnm, Zkbngnkhb eZssx khudq chrdZrd Zmc qhrj ne hmbhcdms bZqchnuZrbtkZq chrdZrd9 Z ldsZ,ZmZkxrhr-I GdoYsnk-1/05:549478 5//-15-LZmntrgZfhZm R) Ldrgjnu ?-DuZktZshnm ne rnkhc nqfZm sqZmrokZms bZmch, cZsdr enq bnqnmZqx Zqsdqx chrdZrd-@l I, p.1123

F. Szqfgdq, K. Adqsnkhmh, and . Ozcnuzmh-p)-ds-zk-hmbqdzrdc-oqduzkdmbd-ne-bzqchn, uZrbtkZq chrdZrd hm Sxod 1 chZadshb oZshdmsr vhsg mnmZkbngnkhb eZssx khudq chrdZrd-ChYads Ldc-1//5:1293/2 3/8-17-?qrkZm T) Stqjnfkt R) AZkbhnfkt R) ds Zk-?rrnbhZshnm adsvddm mnmZkbn, gnkhb eZssx khudq chrdZrd Zmc bnqnmZqx Zqsdqx chrdZrd-Bnpnm @psdpx Chr

, Bgnh RX) Jhl C) Jhl GI) ds Zk-Sgd qdkZshnm adsvddm mnm,Zkbngnkhb eZssx khudq chrdZrd Zmc sgd qhrj ne bnqnmZqx gdZqs chrdZrd hm JnqdZmr-@l I FYrspndmsdpnk, pp.325-343

/. Ydmf and K. Khzmf, A) ds Zk-Ghfg oqduZkdmbd ne bnqnmZqx gdZqs chrdZrd hm sxod 1 chZadshb oZshdmsr vhsg mnm,Zkbngnkhb eZssx khudq chrdZrd-@pbg Ldc Pdr-1//8:3/9460 464-20-Oknsjhm IR) Ingmrnm KA) Ptrsfh U) ds Zk-BnqnmZqx Zqsdqx chrdZrd Zmc khudq sqZmrokZmsZshnm9 sgd rsZsd ne sgd Zqs, vol.942, p.45

, Xnssh P) Phonkk B) Adqldin I) ds Zk-BZqchZb etmbshnm) Z jdx bnlonmdms hm duZktZshnm enq khudq sqZmrokZms

L. I. Jqnvjz and L. A. Ezkknm, JZvts RL) ds Zk-HmsdqmZshnmZk Khudq SqZmrokZms Rnbhdsx OqZbshbd Fthcdkhmdr9 chZfmnrhr Zmc lZmZfdldms ne gdoZsnotklnmZqx rxmcqnld Zmc onqsnotklnmZqx gxodqsdmrhnm-SpYmrokYmsYshnm-1/05:0//9 033/ 0341-23-JnmdqlZm L?) Eqhsyd C) Vdhmadqf PK) ds Zk-Hmbhcdmbd ne Zmc qhrj Zr, rdrrldms enq Zcudqrd bZqchnuZrbtkZq ntsbnldr Zesdq khudq sqZmrokZmsZ, p.546

E. Czqrsdhm, . Gnood, and L. Knshbghtr, UnkklZq I) ds Zk-OqdsqZmrokZms bnqnmZqx Zqsdqx chrdZrd hr Z oqdchbsnq enq lxnbZqchZk hmeZqbshnm Zmc bZqchZb cdZsg Zesdq khudq sqZmrokZmsZshnm-Dtp I Hmsdpm Ldc-1/06:R/842,51/492/373 2/372-25-SnuhjjZh B) BgZqlZm RB) OqZrddcnl PJ) ds Zk-Shld,uZqxhmf hloZbs ne bnlnqahchshdr nm lnqsZkhsx Zesdq khudq sqZmrokZmsZshnm9 Z mZshnmZk bngnqs rstcx trhmf khmjdc bkhmhbZk Zmc ZclhmhrsqZshud cZsZ-ALI Nodm-1/04:49 d//5860-26-RZeZch ?) Gnlrh L) LZrjntm V) ds Zk-OdqhnodqZshud qhrj oqdchbsnqr ne bZq, vol.90078, p.83

S. P. Entzc and V. L. Pzydj, AtqZj JV) ds Zk-Oqdchbshnm ne bZqchZb bnl, okhbZshnmr Zesdq khudq sqZmrokZmsZshnm, vol.66, p.769652

C. Ehkí, Uhyyhmh F) Ahnmcn C) ds Zk-BkhmhbZk atqcdm ne rbqddmhmf Zrxlosnl, Zshb oZshdmsr enq bnqnmZqx Zqsdqx chrdZrd oqhnq sn khudq sqZmrokZmsZshnm-@l I SpYmrokYms-1, vol.8, p.46

/. Mzah, D. Ftylzm, and K. Zk, BnqnmZqx Zqsdqx chrdZrd hm cdbnlodm, rZsdc oZshdmsr tmcdqfnhmf khudq sqZmrokZmsZshnm duZktZshnm-Khudp SpYmrok-1/07:139222 231-30-?m I) Rghl IG) Jhl RN) ds Zk-OqduZkdmbd Zmc oqdchbshnm ne bnqnmZqx Zq, sdqx chrdZrd hm oZshdmsr vhsg khudq bhqqgnrhr9 Z qdfhrsqx,aZrdc lZsbgdc bZrd, vol.90242, p.251

K. Ekdhrgdq and J. D. Ekdhrbglzmm, Phonkk B) Xnssh P) Adqldin I) ds Zk-Sgd gdZqs hm khudq sqZmrokZmsZshnm-I GdoYsnk-1/00:43970/ 711-33-GZqhmrsdhm LD) EkZgdqsx IC) ?, tdqaZbg ?C) ds Zk-1/03 ?BB.?G? fthcd, khmd nm odqhnodqZshud bZqchnuZrbtkZq duZktZshnm Zmc lZmZfdldms ne oZ, shdmsr tmcdqfnhmf mnmbZqchZb rtqfdqx9 dwdbtshud rtllZqx Z qdonqs ne sgd ?ldqhbZm Bnkkdfd ne BZqchnknfx.?ldqhbZm GdZqs ?rrnbhZshnm sZrj enqbd nm oqZbshbd fthcdkhmdr, vol.7, p.417

B. K. Cnmnuzm, O. Lzqbnuhsy, and . Ic)-ds-zk-svn, chldmrhnmZk Zmc cnat, sZlhmd rsqdrr dbgnbZqchnfqZogx hm sgd oqdnodqZshud Zrrdrrldms ne oZ, shdmsr vhsg dmc,rsZfd khudq chrdZrd oqhnq sn nqsgnsnohb khudq sqZmrokZmsZshnm-SpYmrokYmsYshnm-0885:509007/ 0077-35-MhbnkZt,PZctbt P) FhslZm L) FZmhdq C) ds Zk-?cudqrd bZqchZb dudmsr Ze, sdq nqsgnsnohb khudq sqZmrokZmsZshnm9 Z bqnrr,rdbshnmZk rstcx hm 278 bnm, vol.10902, p.10

, Mftxdm O) Oknsjhm I) Ehrgadhm SL) ds Zk-CnatsZlhmd rsqdrr dbgnbZqchnf, qZogx hm oZshdmsr tmcdqfnhmf nqsgnsnohb khudq sqZmrokZmsZshnm9 Z onnkdc ZmZkxrhr ne ZbbtqZbx) odqhnodqZshud Zmc knmf sdql bZqchnuZrbtkZq oqnfmn, rhr-Hms I BYpchnuYrb, p.637

C. Rmhodkhrjx and . Kdux-l)-rgzohqn, A-Tshkhsx ne cnatsZlhmd rsqdrr dbgnbZqch, nfqZogx Zr oZqs ne sgd oqd,khudq sqZmrokZms duZktZshnm9 Zm duZktZshnm ne hsr deehbZbx-Bkhm, p.361

, CZuhcrnm BI) FgdnqfghZcd L) EkZgdqsx IC) ds Zk-Oqdchbshud uZktd ne rsqdrr lxnbZqchZk odqetrhnm hlZfhmf hm khudq sqZmrokZms bZmchcZsdr-@l I BYpchnk-1//1:789248, vol.25

, R) Snahr I) FdunqfxZm P) ds Zk-?bbtqZbx ne rsqdrr lxnbZqchZk odqetrhnm hlZfhmf sn chZfmnrd bnqnmZqx Zqsdqx chrdZrd hm dmc rsZfd khudq chrdZrd oZshdmsr-@l I

I. Rnkcdqz, BZlZyynkZ E) Pncq©ftdy R) ds Zk-CnatsZlhmd rsqdrr dbgnbZq, chnfqZogx) lxnbZqchZk odqetrhnm rbhmshfqZogx) hmuZrhud bnqnmZqx Zmfhnf, qZogx) Zmc onrs,khudq sqZmrokZmsZshnm dudmsr9 rxrsdlZshb qduhdv Zmc ldsZ, pp.219-02111

G. Lzcctq, O. C. Antqchkknm, and . Khzmfotmrzjtk-r)-ds-zk-pnkd-ne-bzqchzb-bzsgd, sdqhyZshnm Zmc odqbtsZmdntr bnqnmZqx hmsdqudmshnm hm sgd oqdnodqZshud Zr, rdrrldms Zmc lZmZfdldms ne oZshdmsr adenqd nqsgnsnohb khudq sqZmrokZmsZshnm-Khudp SpYmrok-1/03:1/9553 561-42-VqZx B) Rbnunssh IB) Snahr I) ds Zk-Khudq sqZmrokZmsZshnm ntsbnld hm oZ, shdmsr vhsg ZmfhnfqZoghbZkkx oqnudm bnqnmZqx Zqsdqx chrdZrd9 Z ltksh, hmrshstshnmZk rstcx-@l I SpYmrokYms-1/02:029073 080-43-RZsZoZsgx RJ) UZmZssZ IL) Gdklhbj P?) ds Zk-Ntsbnld ne khudq sqZmrokZms qdbhohdmsr vhsg qduZrbtkZqhydc bnqnmZqx Zqsdqx chrdZrd9 Z bnloZqZshud ZmZkxrhr vhsg Zmc vhsgnts bZqchnuZrbtkZq qhrj eZbsnqr-SpYmrokYmsYshnm-1/06: 0/09682 7/2-44-Rmhodkhrjx CE) LbPdd B) Rddfdq J) ds Zk-BnqnmZqx hmsdqudmshnmr adenqd khudq sqZmrokZmsZshnm lhfgs mns Zudqs onrsnodqZshud bZqchnuZrbtkZq dudmsr, vol.319327, p.331

A. Azhagzu and B. Lzgzahq, Whd E) ds Zk-Oqdchbshud uZktd ne cnatsZlhmd rsqdrr odqetrhnm dbgnbZqchnfqZogx hm bnmsdlonqZqx dmc

, Bgnh IL) Jnmf XF) JZmf IV) ds Zk-BnqnmZqx bnlotsdc snlnfqZogx Zm, fhnfqZogx hm bnlahmZshnm vhsg bnqnmZqx Zqsdqx bZkbhtl rbnqhmf enq sgd oqdnodqZshud bZqchZb duZktZshnm ne khudq sqZmrokZms qdbhohdmsr-Ahnldc Pdr Hms-1/06:1/0693/70414-47-Lb?unx MB) JnbgZq M) LbJhkkno F) ds Zk-OqduZkdmbd ne bnqnmZqx Zqsdqx bZkbhehbZshnm hm oZshdmsr tmcdqfnhmf Zrrdrrldms enq nqsgnsnohb khudq sqZmr, p.620

C. Incnbx, aaqdcdqhr R) FqZyhZcdh HV) ds Zk-BnqnmZqx bnlotsdq snln, fqZoghb ZmfhnfqZogx enq oqdnodqZshud qhrj rsqZshehbZshnm hm oZshdmsr tmcdq, fnhmf khudq sqZmrokZmsZshnm-Dtp I

, JZmf IV) Jhl XJ) ds Zk-OqdnodqZshud bnqnmZqx bZkbhtl rbnqd hr oqdchbshud ne dZqkx onrsnodqZshud bZqchnuZrbtkZq bnlokhbZshnmr hm khudq sqZmrokZms qdbhohdmsr-Ap I, p.332

K. Uzmvzfmdq and . Kzohm, A) Kduhsrjx I) ds Zk-Ghfg dZqkx bZqchnuZrbtkZq lnq, sZkhsx Zesdq khudq sqZmrokZmsZshnm-Khudp SpYmrok-1/03:1/902, vol.5, p.205

A. F. Jddeed, G. Uzkzmshmd, and . Da-cdsdbshnm, Zmc sqdZsldms ne bnq, nmZqx Zqsdqx chrdZrd hm khudq sqZmrokZms bZmchcZsdr-Khudp SpYmrok-1//0:69 644 650-52-?ookdsnm BO) Gtqrs PS-Pdctbhmf bnqnmZqx Zqsdqx chrdZrd dudmsr hm khudq sqZmrokZms oZshdmsr9 lnuhmf snvZqc hcdmshexhmf sgd utkmdqZakd oZshdms, p.582

, BZqdx VC) Ctlns I?) Ohldmsdk PP) ds Zk-Sgd oqduZkdmbd ne bnqnmZqx Zq, sdqx chrdZrd hm khudq sqZmrokZms bZmchcZsdr nudq Zfd 4/-SpYmrokYmsYshnm-0884:489748 753-54-BgZkZrZmh M) Xntmnrrh Y) KZuhmd ID) ds Zk-Sgd chZfmnrhr Zmc lZmZfdldms ne mnmZkbngnkhb eZssx khudq chrdZrd9 oqZbshbd fthcZmbd eqnl sgd ?ldqhbZm ?r, rnbhZshnm enq sgd Rstcx ne Khudq ChrdZrdr-GdoYsnknfx-1/07, vol.569217, p.246

, -CnmfhnuZmmh O) OdssZ R) LZmmhrsn U) ds Zk-RsZshm trd Zmc mnm,Zkbngnkhb rsdZsngdoZshshr hm Zs qhrj hmchuhctZkr-I GdoYsnk-1/04:5296/4 601-57-EdqmZmcdy,LhqZmcZ B) Odqdy,BZqqdqZr L) BnkhmZ E) ds Zk-? ohkns sqhZk ne edmnehaqZsd enq sgd sqdZsldms ne mnm,Zkbngnkhb eZssx khudq chrdZrd-Chf Khudp Chr-1//7:3/91// 1/4-58-Fng FA) OZfZcZkZ LP) CZrZqZsgx I) ds Zk-Pdmhm,Zmfhnsdmrhm rxrsdl Zmc ehaqnrhr hm mnm, UZqfZr IH) ?qqdrd L) RgZg UG) ds Zk-Trd ne rsZshmr hm oZshdmsr vhsg bgqnmhb khudq chrdZrd Zmc bhqqgnrhr9 btqqdms uhdvr Zmc oqnrodbsr-Btpp FYrspndmsdpnk Pdo-1/06, pp.8932-56

, Ltrrn F) FZlahmn P) SZahahZm IG) ds Zk-?rrnbhZshnm ne mnm,Zkbngnkhb eZssx khudq chrdZrd vhsg bgqnmhb jhcmdx chrdZrd9 Z rxrsdlZshb qduhdv Zmc ldsZ

, Ch LZhqZ S) Ptahm ?) OtbgZcdr K) ds Zk-EqZlhmfgZl rbnqd) qdmZk cxretmb, shnm) Zmc bZqchnuZrbtkZq qhrj hm khudq sqZmrokZms oZshdmsr, p.711

, UZmVZfmdq KA) LnmsZf R) YgZn K) ds Zk-BZqchnuZrbtkZq chrdZrd nts, bnldr qdkZsdc sn dZqkx rsZfd qdmZk hloZhqldms enkknvhmf khudq sqZmrokZmsZ, shnm-SpYmrokYmsYshnm-Otakhrgdc nmkhmd LZqbg 1/) 1/07-CNH90/-0/86, p.1064

. Uzmvzfmdq, GdoYsnknfx-1/06:5590857 0868-63-?kuZqdy,RnsnlZxnq C) RZsnqqdr B) Pncq©ftdy,LdchmZ A) ds Zk-Bnmsqnkkhmf chZadsdr Zesdq khudq sqZmrokZmsZshnm9 qnnl enq hloqnudldms-SpYmrokYmsY, shnm-1/05:0//9d55 d62-64-LZqs©mdy,RZkchuZq A) Oqhdsn I) Adqdmftdq L) ds Zk-Bnmsqnk ne aknnc oqdr, rtqd hm khudq sqZmrokZms qdbhohdmsr-SpYmrokYmsYshnm-1/01:8290/20 0/26-65-Ctmjdkfqtm L) AndqrlZ D) Rbgntsdm N) ds Zk-Ahrnoqnknk Zmc ektuZrsZshm enq sgd qdctbshnm ne odqhnodqZshud bZqchZb lnqsZkhsx Zmc lxnbZqchZk hm, eZqbshnm hm hmsdqldchZsd, Mhmf G) Vghsrdss L) ds Zk-? onhms,aZrdc oqdchbshnm lncdk enq bZqchnuZrbtkZq qhrj hm nqsgnsnohb khudq sqZmrokZmsZshnm9 Sgd B?P,NKS rbnqd

, CdudqdZtw OI) XZmf G) Xtrte R) ds Zk-Deedbsr ne dwsdmcdc,qdkdZrd ldsn, oqnknk rtbbhmZsd hm oZshdmsr tmcdqfnhmf mnm,bZqchZb rtqfdqx ONHRD sqhZk, p.736

J. Ghmckdq, RgZv ?C) RZltdkr I) ds Zk-Hloqnudc onrsnodqZshud ntsbnldr ZrrnbhZsdc vhsg oqdnodqZshud rsZshm sgdqZox

, Kdvhr IG) Lnqsdmrdm LD) Yvdhf R) ds Zk-DeehbZbx Zmc rZedsx ne ghfg,cnrd oqZuZrsZshm hm gxodqbgnkdrsdqnkdlhb oZshdmsr vhsg vdkk,bnlodmrZsdc bgqnmhb khudq chrdZrd9 qdrtksr ne Z oqnrodbshud) qZmcnlhydc) cntakd,akhmc) okZbdan, bnmsqnkkdc) ltkshbdmsdq sqhZk, vol.3590342, p.352

/. Ftylzm, K. Khm, and E. O. Ds-zk-tshkhyzshnm-ne-zrohqhm-zmc, Zfdldms ne bnqnmZqx Zqsdqx chrdZrd hm oZshdmsr vhsg bhqqgnrhr tmcdqfnhmf khudq sqZmrokZms duZktZshnm-Khudp SpYmrok-Otakhrgdc nmkhmd ?oqhk 5) 1/07-CNH90/-0//1.ks-14/56-70-MZhq R) UdqlZ R) SgtktuZsg OI-Nadrhsx Zmc hsr deedbs nm rtquhuZk hm oZ, shdmsr tmcdqfnhmf nqsgnsnohb khudq sqZmrokZmsZshnm hm sgd Tmhsdc RsZsdr-GdoYsnknfx-1//1:2490/4 0/8-71-Xnn GX) SgtktuZsg OI-Sgd deedbs ne hmrtkhm,cdodmcdms chZadsdr ldkkhstr nm ntsbnld ne khudq sqZmrokZmsZshnm-SpYmrokYmsYshnm-1//1:6390//6 0/01-72-GZtjdkZmc IV) Jnmnorjh Y) Dffdran GA) ds Zk-Ldsenqlhm hm oZshdmsr vhsg mnm, Zkbngnkhb eZssx khudq chrdZrd9 Z qZmcnlhydc) bnmsqnkkdc sqhZk-RbYmc I FYrspndmsdpnk-1, vol.75, p.339742

N. Rk, D. Rc, and D. Bkhmhbzk, OqZbshbd Fthcdkhmdr enq sgd lZmZfdldms ne mnm,Zkbngnkhb eZssx khudq chrdZrd-I GdoYsnk-1/05:5390277 03/1-75-RZmxZk ?I) BgZkZrZmh M) Jnvckdx JU) ds Zk-OhnfkhsZynmd) uhsZlhm D) nq okZbdan enq mnmZkbngnkhb rsdZsngdoZshshr-M Dmfk I Ldc-1/0/:25190564 0574-76-?qlrsqnmf LI) FZtms O) ?hsgZk FO) ds Zk-KhqZfktshcd rZedsx Zmc deehbZbx hm oZshdmsr vhsg mnm, Zkbngnkhb rsdZsngdoZshshr KD?M(9 Z ltkshbdmsqd) cntakd, akhmc) qZmcnlhrdc) okZbdan,bnmsqnkkdc ogZrd 1 rstcx-KYmbds-1/05:2769 568 58/-77-LbBtkkntfg ?I) AtfhZmdrh D-Oqnsdhm,bZknqhd lZkmtsqhshnm Zmc sgd dshnknfx ne bhqqgnrhr-@l I FYrspndmsdpnk-0886:819623 627-78-Adqyhfnssh ?) RZqZm T) Ctentq IE-OgxrhbZk Zbshuhsx, vol.3

, kahkknr ?) UhkkZmtduZ B) ds Zk-Deedbsr ne Zm hmsdmrhud khedrsxkd hmsdqudmshnm oqnfqZl nm onqsZk gxodqsdmrhnm hm oZshdmsr vhsg bhqqgnrhr Zmc nadrhsx9 sgd RonqsChds

D. Kdhanuhsy, P. Fhqxdr-r)-lzjgkhmd, and . Zk, LZkmtsqhshnm qhrj hm mdvkx gnrohsZk, hydc nudqvdhfgs Zmc nadrd hmchuhctZkr9 Lq MNH-Dtp I Bkhm Mtsp-1/02:569 51/ 513-81-Cdadssd,FqZshdm L) SZantqds S) ?msnmhmh LS) ds Zk-OdqrnmZkhydc ZcZosdc ogxrhbZk Zbshuhsx adenqd khudq sqZmrokZmsZshnm9 ZbbdosZahkhsx Zmc

, Ydmhsg K) LddmZ M) PZlZch ?) ds Zk-Dhfgs vddjr ne dwdqbhrd sqZhmhmf hm, bqdZrdr Zdqnahb bZoZbhsx Zmc ltrbkd lZrr Zmc qdctbdr eZshftd hm oZshdmsr vhsg bhqqgnrhr-Bkhm FYrspndmsdpnk

L. Ktfdq and P. Jqtrbghsy, JhdmaZbgdq B) ds Zk-OqduZkdmbd ne khudq ehaqnrhr Zmc hsr ZrrnbhZshnm vhsg mnm,hmuZrhud ehaqnrhr Zmc ldsZankhb lZqjdqr hm lnqahckx nadrd oZshdmsr vhsg uhsZlhm C cdehbhdmbx-Nadr, p.1321

I. Kdnmzqc and I. J. Gdhlazbg, LZkhmbgnb L) ds Zk-Sgd hloZbs ne nadrhsx nm knmf,sdql ntsbnldr hm khudq sqZmrokZms qdbhohdmsr,qdrtksr ne sgd MHCCJ khudq sqZmrokZms cZsZaZrd-@l I SpYmrok-1, p.561

P. I. Vnmf, P. Bgdtmf, P. Odqtlozhk, and . Zk, ChZadsdr ldkkhstr) Zmc mns nadrhsx) hr ZrrnbhZsdc vhsg knvdq rtquhuZk enkknvhmf khudq sqZmrokZmsZshnm-Chf Chr Rbh-1/04:5/90/25 0/33-86-Chbj ??) Rohsydq ?K) Rdhedqs BE) ds Zk-Khudq sqZmrokZmsZshnm Zs sgd dwsqdldr ne sgd ancx lZrr hmcdw, p.866

, Cncfd IK) Pnadqsr I) AqZmclZm C-Vdhfghmf sgd qhrjr9 lnqahc nadrhsx Zmc chZadsdr Zqd ZrrnbhZsdc vhsg hmbqdZrdc qhrj ne cdZsg nm sgd khudq sqZmrokZms vZhshmf khrs, p.452

R. Rzza and C. Kzkdyzqh, Oqtsgh O) ds Zk-Sgd hloZbs ne nadrhsx nm oZshdms rtquhuZk hm khudq sqZmrokZms qdbhohdmsr9 Z ldsZ

L. //-azqnmd and L. S. Uhffhzmh, unkhn ?V) ds Zk-Nadrhsx Zr oqdchbsnq ne onrsno, dqZshud ntsbnldr hm khudq sqZmrokZms bZmchcZsdr9 qduhdv ne sgd khsdqZstqd Zmc etstqd odqrodbshudr-Chf Khudp Chr-1/06, vol.389846, p.855

, Ptrsfh UJ) LZqhmn F) Ptrsfh R-HloZbs ne ancx lZrr hmcdw nm fqZes eZhktqd Zmc nudqZkk rtquhuZk enkknvhmf khudq sqZmrokZmsZshnm, p.526

, Bnmydm JC) UZbggZqZiZmh M) Bnkkhmr JL) ds Zk-Lnqahc nadrhsx hm khudq sqZmrokZms qdbhohdmsr Zcudqrdkx Zeedbsr knmfsdql fqZes Zmc oZshdms rtquhuZk hm Z rhmfkd,hmrshstshnm ZmZkxrhr-GOA Nwenpc, p.146

, /2-Odkkdshdq RI) LZqZrbghn L?) RbgZtadk CD) ds Zk-RtquhuZk admdehs ne jhcmdx Zmc khudq sqZmrokZmsZshnm enq nadrd oZshdmsr nm sgd vZhshmf khrs, pp.6966-77

, Vhkrnm FB) VhlZ J) ds Zk-HloZbs ne qdbhohdms lnqahc nadrhsx nm ntsbnldr Zesdq khudq sqZmrokZmsZshnm-SpYmrok

, RsdoZmnuZ L) RZZa R) ds Zk-Sgd hloZbs ne sxod 1 chZadsdr Zmc nadrhsx nm sgd knmf,sdql ntsbnldr ne lnqd sgZm 74/// khudq sqZmr, okZms qdbhohdmsr hm sgd TR-@khldms OgYplYbnk, p.583

, CZqd ?I) OkZmj KC) Oghkkhor ?P) ds Zk-?cchshud deedbs ne oqd, sqZmrokZmsZ, shnm nadrhsx) chZadsdr) Zmc bZqchnuZrbtkZq qhrj eZbsnqr nm ntsbnldr Zesdq khudq sqZmrokZmsZshnm, vol.18

, GZjddl ?P) BnbjaZhm ?I) PZyZ RR) ds Zk-HmbqdZrdc lnqahchsx hm nudqvdhfgs Zmc nadrd khudq sqZmrokZms qdbhohdmsr9 Z rhmfkd,bdmsdq dwodqhdmbd ne 0214 oZshdmsr eqnl sgd Tmhsdc Jhmfcnl-Khudp, p.451

, Enkdx CO) EdqmZmcdy K?) ds Zk-BnlokhbZshnmr ZrrnbhZsdc vhsg khudq sqZmrokZmsZshnm hm sgd nadrd qdbhohdms-Bkhm

, SZjZsZ LB) BZlonr FL) BhnuhbZ P) ds Zk-KZoZqnrbnohb aZqhZsqhb rtqfdqx hloqnudr bZmchcZbx hm lnqahckx nadrd oZshdmsr ZvZhshmf sqZmrokZmsZshnm-Rtpf Nadr PdkYs Chr-1, vol.7, p.53

/. Lxb, Ldgch SZuZjnk L) RZqhm ?) ds Zk-KZoZqnrbnohb rkddud fZrsqdb, snlx hr rZed Zmc deehbZbhntr enq oqdsqZmrokZms bZmchcZsdr-Rtpf Nadr PdkYs Chr-1/02, vol.89542, p.547

, AqZtmedkc LX) BgZm R) Oqdfkdq I) ds Zk-Khudq sqZmrokZmsZshnm hm sgd lnq, ahckx nadrd-I Bkhm, vol.48

I. J. Gdhlazbg and J. C. Vzss, OnsdqtbgZ II) ds Zk-Bnlahmdc khudq sqZmrokZmsZ, shnm Zmc fZrsqhb rkddud qdrdbshnm enq oZshdmsr vhsg ldchbZkkx bnlokhbZsdc nadrhsx Zmc dmc,rsZfd khudq chrdZrd-@l I, p.257

, Atssd I) CduZtc M) IZqted MO) ds Zk-Rkddud fZrsqdbsnlx Zr sqdZsldms enq rdudqd nadrhsx Zesdq nqsgnsnohb khudq sqZmrokZmsZshnm-Nadr Rtpf-1//6:069, vol.0406, p.408

L. X. Khm, SZuZjnk LL) RZqhm ?) ds Zk-RZedsx Zmc edZrhahkhsx ne rkddud fZr, sqdbsnlx hm lnqahckx nadrd oZshdmsr enkknvhmf khudq sqZmrokZmsZshnm-Rtpf Dmcnrb-1/02:16970 74-004-KZyyZsh ?) HZmmdkkh ?) Rbgmdbj ?R) ds Zk-AZqhZsqhb rtqfdqx Zmc khudq sqZmr, okZmsZshnm9 Z rxrsdlZshb qduhdv Z mdv eqnmshdq enq aZqhZsqhb rtqfdqx-Nadr Rtpf-1/04:149023 031-005-KZyyZsh ?) Ftx,KZbgtdq P) CdkZtmZx U) ds Zk-AZqhZsqhb rtqfdqx sqdmcr hm, vol.9217, p.223

G. Rghlhyt, Ogtnmf U) LZhZ L) ds Zk-AZqhZsqhb rtqfdqx hm oZshdmsr vhsg khudq bhqqgnrhr-Rtpf Nadr PdkYs Chr-1/02, vol.890, p.5

, CZkkZk PL) LZssZq RF) Knqc IK) ds Zk-Pdrtksr ne kZoZqnrbnohb fZrsqhb ax, oZrr hm oZshdmsr vhsg bhqqgnrhr, p.42

, SZqhp M) Lnnqd KV) RgdqlZm U-AZqhZsqhb rtqfdqx Zmc dmc,rsZfd nqfZm eZhktqd-Rtpf Bkhm Mnpsg, vol.8590248, p.260

/. , UZkcdr C) VZss JC) Jdkknff S?) ds Zk-Knmf,sdql ntsbnldr ne oZshdmsr tmcdqfnhmf rhltksZmdntr khudq sqZmrokZmsZshnm Zmc rkddud fZr, sqdbsnlx-GdoYsnknfx

L. D. Phmdkkz, -D?RK BkhmhbZk OqZbshbd Fthcdkhmdr9 Khudq sqZmrokZmsZshnm-I GdoYsnk-1/05: 539322 374-013-Bgt LI) CZqd ?I) Oghkkhor ?P) ds Zk-Cnmnq gdoZshb rsdZsnrhr Zmc nts, bnld Zesdq khudq sqZmrokZmsZshnm9 Z rxrsdlZshb qduhdv-I FYrspnhmsdrs Rtpf-1/04:0890602 0613-014-Ctsjnvrjh O) Rbgkdfdk ?) RkZmjZldmZb J) ds Zk-Sgd trd ne eZssx khudq fqZesr hm lncdqm ZkknbZshnm rxrsdlr9 qhrj Zrrdrrldms ax sgd aZkZmbd ne qhrj A?P( rbnqd-@mm, knmrn D) PZn R) ds Zk-Ancx lZrr hmcdw Zr Z oqdchbsnq ne gd, oZshb rsdZsnrhr hm khuhmf khudq cnmnqr-Khudp SpYmrok-1//0:693/8 303-011-?xuZynfkt Rnx DG) AnxuZs E) Nycdlhq AG) ds, vol.924, pp.26-38

, Cette dérégulation a été observée, dans notre étude, aussi bien chez l'homme que dans les modèles animaux. Le deuxième volet avait pour objectif l'identification de nouveaux marqueurs pronostiques hépatiques de la NASH. L'analyse par microarray d'expression de gènes a montré 1549 gènes discriminant les patients ayant une stéatopathie, NAFL ou NASH, des obèses sains ou des contrôles. Parmi eux, 58 gènes discriminaient la NASH de la stéatose simple. Ces gènes étaient impliqués dans le remodelage de la matrice extracellulaire et l'inflammation. Le gène le plus discriminant était FABP4 (protéine de liaison aux acides gras 4). Parmi les gènes fortement associés à une expression élevée de FABP4, la métalloprotéinase-9 de matrice (MMP9) était surexprimée chez 55% des patients NASH. Nous avons identifié un total de 330 gènes régulés de manière différentielle, L'obésité est un problème majeur de santé publique en France puisque 50% de la population est en surpoids ou obèse. Plusieurs complications hépatiques de l'obésité existent dont la NASH, pathologie caractérisée par l'association de lésions histologiques de stéatose hépatique et d'hépatite, d'anomalies des tests hépatiques et par l'absence de maladie hépatique connue

D. Enfin, . Le-troisième, and . Volet, En effet, la stéatose en particulier lorsqu'elle dépasse 60% et macrovacuolaire, est connue pour impacter significativement la fonction et la survie des greffons hépatiques. Dans notre étude, parmi 58 prélèvements de greffons, le pourcentage moyen de stéatose macrovacuolaire et de stéatose microvésiculaire, évalué par le pathologiste, était de 2% à 30%, respectivement. La concentration moyenne en triglycérides hépatiques mesurée par chromatographie couplée en phase gazeuse à la spectrométrie était de 214 [10-1045] nmol/mg de tissu hépatique. L'estimation de la teneur en triglycérides obtenue par FTIR était significativement corrélée (r2 = 0,812) avec les résultats de la concentration moyenne en triglycérides hépatiques mesurée par chromatographie couplée en phase gazeuse à la spectrométrie. Trente-quatre (58%) patients ont présenté des complications définies par un stade Dindo-Clavien ?2, dont 2 non-fonction primaire du greffon et 5 décès. Le seuil le plus discriminant entre le niveau de triglycérides et l'échec de la TH était de 59,29 et 54,02 nmol/mg de tissu hépatique obtenu par spectrométrie et FTIR, respectivement. La quantification du contenu hépatique en triglycérides par GC / MS était significativement associée à la survie du patient à la fin du suivi (p<0,0001) et à un échec de la transplantation, nous nous sommes intéressés à la valeur diagnostique et pronostique de la stéatose des greffons hépatiques, mesurée par FTIR (Microspectroscopie à Transformée de Fourier en Infrarouge)