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De la décellularisation de cartilage de porc à la chondrogenèse auriculaire

Abstract : Ear reconstruction is a real challenge for the surgeon. Several techniques exist, each having significant drawbacks.Development of tissue engineering over the past 20 years has opened up the possibility for new therapies.Cartilage engineering is no exception to the rule and is undergoing a serious evolution, concerning articular cartilage but also other types of cartilage including ear cartilage.Applied to ear reconstruction, these techniques provide cartilage tissue while reducing side effects: scar removal, immune response, graft rejection, etc.In this work, we detail the making and characterize the composition of a pro-chondrogenic biomaterial made from a decellularized xenogenic tissue from pig ear. We then study the inflammatory reaction generated and the pro-chondrogenic power in vivo and in vitro in rabbits.Finally, a review of the literature makes it possible to develop current knowledge on cartilaginous engineering from decellularized cartilage and in particular its advances in humans.
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https://tel.archives-ouvertes.fr/tel-02901765
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Submitted on : Friday, July 17, 2020 - 3:03:12 PM
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  • HAL Id : tel-02901765, version 1

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Alexis Veyssiere. De la décellularisation de cartilage de porc à la chondrogenèse auriculaire. Médecine humaine et pathologie. Normandie Université, 2020. Français. ⟨NNT : 2020NORMC408⟩. ⟨tel-02901765⟩

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