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, Under preparation Oral communications: Treatment of rats with the omega fatty acid 3 formulation EPA:DHA 6:1 decreases the leukocyte microparticles-induced endothelial pro-inflammatory responses and senescence
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, Toti. International meeting on ischemia reperfusion injury in transplantation (IMIRT), 2018.
, Leukocyte-derived microparticles exaggerate endothelial senescence and vascular dysfunction induced by high glucose
, Poster communications: Intake of the omega 3 PUFAs formulation EPA:DHA 6:1 by aged rats reduced shedding of microvesicles from spleen-derived cultured leukocytes and their ability to promote senescence in endothelial cells, Printemps de la Cardiologie Recherche Fondamentale & Clinique, pp.4-6, 2018.
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, European Society of Cardiology (ESC), 2019.
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, Qureshi Abdul Wahid Les microvésicules splénocytaires effecteurs de la sénescence endothéliale : Impact de l'âge et protection par apport nutritionnel d'une formule optimisée d'acides gras polyinsaturés eicosapentaénoïque et docosahexaénoïque, EPA:DHA, vol.6, p.1
, Seules les SMVs de MA et O induisent une sénescence des ECs prématurée avec une activité Senescence-Associated-?-galactosidase et un stress oxydant augmentés, la surexpression des marqueurs p53, p21, p16, un phénotype pro-inflammatoire et proarthérogène et une sous-expression de la eNOS, Résumé L'âge conduit à une senescence progressive des cellules endothéliales (ECs) favorisant une dysfonction endothéliale et vasculaire, souvent associée aux maladies cardiovasculaires, vol.6
, Omega-3 EPA:DHA, vol.6, issue.1
, Oxidative stress accumulates in spleen tissue and SMVs shedding increases with age. SMVs from MA, O but not Y rats induced premature endothelial senescence, with increased Senescence-Associated-?-galactosidase activity and up-regulated p53, p21, p16. SMVs shifted ECs towards a pro-inflammatory and pro-atherothrombotic phenotype with increased endothelial oxidative stress and down-regulated eNOS. Short-term intake of omega-3 EPA:DHA 6:1 but not EPA:DHA 1:1 reduced age-related oxidative stress and SMVs shedding in MA and O spleen tissues, and abolished SMVs-induced premature endothelial senescence in MA, Ageing is associated with progressive endothelial senescence favoring endothelial and vascular dysfunction, often associated with cardiovascular diseases. We investigated in young, middle-aged and old rats