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Pathologie inflammatoire : étude de la contribution des PAMP et DAMP

Abstract : Inflammation is the basic mechanism of the immune system. In the case of inflammatory pathologies this inflammation persists and becomes deleterious to the organism. Many reasons can explain this persistance. One of these causes is the presence of inflammatory-inducing molecules. They may have exogenous origin such as PAMP (Pathogen Associated Molecular Pattern). They are derived from pathogens (LPS, peptidoglycans, CpG DNA ...), and are able to activate the immune system. These molecules can also have endogenous origin such as the DAMP (Damage Associated Molecular Pattern). They are released by stress cells (HMGB1, HSP60, S100 ...) to prevent and activate the immune system. The presence of receptors (TLR2, TLR4, RAGE ...) capable of recognizing these PAMPs and DAMPs is also necessary in order to elicit inflammation.My work explores the contribution of PAMPs and DAMPs to inflammatory diseases at molecular and cellular levels. To this end, my study focuses on recognition and induction of inflammation by PAMPs and DAMPs.We have thus demonstrated cellular and molecular mechanisms in the inflammatory response related to DAMP and PAMP. We were also interested in the receptors involved in these mechanisms and even showed a new potential receptor. We hypothesize that CD93 may have a role in inflammatory pathologies by his ability to bind DAMPs and PAMPs. Thus CD93, HMGB1, HSP60 and LPS could be potential therapeutic targets concerning inflammatory diseases.
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  • HAL Id : tel-02900689, version 1

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Brice Nativel. Pathologie inflammatoire : étude de la contribution des PAMP et DAMP. Biochimie, Biologie Moléculaire. Université de la Réunion, 2017. Français. ⟨NNT : 2017LARE0065⟩. ⟨tel-02900689⟩

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