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Intégration de l'évolution pour contribuer à l'étude de la relation séquence, structure, fonction des protéines

Abstract : Evolution can help to provide valuable information to understand protein sequence, structure and function relationship. In a first project, I used molecular phylogeny to show the coevolution of “Testis expressed 19” (Tex19) and “Secreted and Transmembrane 1” (Sectm1) genes. Although Tex19 and Sectm1 are involved in different biological pathways, i.e. transposon regulation and immunity respectively, coevolution supports a strong functional relationship between both genes.Since Tex19 is expressed only in adult healthy testis and cancer cells, this result may be useful for cancer immunotherapy. In a second project, I used molecular modelling and sequence evolution analysis to question the validity of the glucocorticoïd receptor ɑ (GR ɑ ) ligand binding domain (LBD) homodimeric assembly [Bledsoe R.K. et al, 2002]. First, this complex is likely a crystallization artefact. Second, I have identified an alternative assembly that presents the molecular characteristics of a biological interface.
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Laurent Bianchetti. Intégration de l'évolution pour contribuer à l'étude de la relation séquence, structure, fonction des protéines. Bio-Informatique, Biologie Systémique [q-bio.QM]. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAJ060⟩. ⟨tel-02899941⟩

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