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Modélisation TLM du transfert biothermique lors des soins cliniques

Abstract : Therapeutic thermoablation and cryoablation are clinical care procedures increasingly used in hospitals for the treatment of various diseases and for the removal of unhealthy biological tissue. They are often used in oncology, ophthalmology, cosmetic surgery, etc. The numerical model of transmission lines TLM is developed in this thesis to effectively solve the equation of bioheat transfer during thermo and cryoablative treatments. This model, which illustrates the coupling of the tissue denaturation process with blood perfusion, also incorporates the phase change during solidification and takes into account the variable thermophysical properties with the different phases of the material. The model uses a fixed spatial mesh of 1D and 2D with a variable time-step to make the mobile front of solidification correspond to the fixed nodes of the system. It also takes into consideration the thermal relaxation of biological materials which increases during low temperatures. The results obtained show a quasi-linear dependence on blood perfusion with moderate temperature gradients. This perfusion begins to lose its thermoregulatory role during intense thermal gradients, especially in biological tissues near energy applicators (laser probe and cryoprobe). The release of latent heat during solidification is also affected by the intensity of the temperature gradients. In general, the results confirm that the role of the technical conditions of the thermoablative treatment (energy power, duration of treatment, etc.) is decisive and dominant, unlike that of the thermophysical and physiological properties of living biological matter. The results of the simulations are validated by numerical and experimental studies on organic and biological materials.
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Contributor : Melouka Bellil <>
Submitted on : Friday, July 10, 2020 - 3:01:08 PM
Last modification on : Friday, July 10, 2020 - 3:07:48 PM


thèse de doctorat.pdf
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  • HAL Id : tel-02896418, version 1


Melouka Bellil. Modélisation TLM du transfert biothermique lors des soins cliniques. Physique Médicale []. Ecole Normale Polytechnique Oran (Algérie), 2015. Français. ⟨tel-02896418⟩



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