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Theses

Plateforme modulable pour le développement de glycolipides à potentiel immunoadjuvant

Abstract : The constant evolution of vaccines led research teams to focus on the injection of smaller antigenic patterns. Immunoadjuvants are added to formulations in order to have better and longer lasting immune response. Glycolipids are compounds having immunoadjuvant properties since they can act as vehicle for therapeutic agents and/or interact with the immune system cells. Archaea’ lipids are known for their great stability and their capacity to form archaeosome that activate immune responses. Carbohydrates, like mannopyranosides and galactofuranosides can target and interact with receptors on dendritic cells (mannose receptor, DC-SIGN). These receptors are multivalent so glycolipids having several carbohydrate patterns possess a greater affinity compared to monovalent ones. This thesis goal was to synthetize molecules that can be easily modified combining properties of the archaeolipids, the carbohydrates and the multivalency. Three final compounds were synthetized and are tested for their biological properties. In the same time, we had the opportunity to study the influence of fluorine atom on the regioselectivity of glycosylation reactions.
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Submitted on : Thursday, July 9, 2020 - 1:56:27 PM
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Jeane Vaugenot. Plateforme modulable pour le développement de glycolipides à potentiel immunoadjuvant. Autre. Université Rennes 1, 2019. Français. ⟨NNT : 2019REN1S098⟩. ⟨tel-02895005⟩

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