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, Left, oxygenase (heme) domain of human eNOS. The PDB structure 4D1O (chain A, cyan, clipped surface) was aligned with 5VVD (chain A, showing chains A and B of the crystal, purple).The Lysine residues are shown in orange (4D1O) at right (spheres) and the counterparts in 5VVD (chain B) are shown at left ( sticks?), 3D-visualization of the oxygenase and reductase domains of eNOS, and putative location of ONEmodifiable Lys-residues

, Right, reductase domains neuronal (Rat), endothelial (Human) and inducible (Human) NOS

, Combination of 3 aligned structures: Human eNOS (ModBase model 7e09b, Chain A: brown

, Rat nNOS (PDB entry 1TLL, chain A: cyan, chain B: light-blue behind)

, On the upper part of the picture, the domain 595-640 of eNOS(AI element) is depicted in purple. The ligands (FAD, FMN and NADPH with molecular surface, p.1

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S. Le, mais les données actuelles se limitent à quelques petites études seulement. Bien que, théoriquement, le GSNO soit un donneur de NO sélectif pour les tissus, les données limitées dont on dispose à ce jour ont montré qu'il cible non seulement le dysfonctionnement endothélial de la pré-éclampsie, mais aussi qu'il réduit l'agrégation et l'activation plaquettaire, tout en améliorant la perfusion utéroplacentaire. Il est probable que le GSNO puisse reconstituer les niveaux réduits de glutathion observés chez les femmes en PE, avec peu d'effets secondaires. D'autres recherches sont nécessaires pour déterminer l, 1995.

, Le sildenafil apparaissait comme une option intéressante avec un effet hypotenseur efficace, mais le seul essai randomisé utilisant le sildenafil chez des femmes enceintes (STRIDER trial) a été stoppé pour des effets indésirables sévères chez le foetus de mères traitées, Simon-Tillaux, 2012.

, La supplémentation alimentaire en l-arginine a été étudiée dans la prévention et le traitement de la PE, avec certains effets qui semblent prometteurs sur de petites séries, Toutefois, les rares essais randomisés ne retrouvent pas de bénéfice dans le traitement du RCIU, 2009.

, Les données actuelles sont trop limitées pour recommander ces thérapeutiques en prévention ou traitement de la PE, 2010.

, Des molécules associant un donneur de NO et l'aspirine ont été développées (NCX-4016, NCX-4040), et leur utilisation permettrait de diminuer la pression artérielle dans certains modèles d'hypertension, ainsi que l

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