Epidémiologie de l'artériopathie des membres inférieurs, La Presse Médicale, vol.47, pp.38-46, 2018. ,
, Alginate in Wound Dressings. Pharmaceutics, vol.10, issue.2, p.42, 2018.
Soins des plaies, pp.74-80, 1997. ,
Diabetic foot ulcers, Journal of the American Academy of Dermatology, vol.70, 2014. ,
Management of Diabetic Foot Ulcers, Diabetes Therapy, vol.3, p.4, 2012. ,
Emerging Innovative Wound Dressings, Annals of Biomedical Engineering, vol.47, pp.659-675, 2019. ,
,
, Diagnosis and Classification of Diabetes Mellitus, Diabetes Care, vol.37, pp.81-90, 2014.
Synthesis of highly porous crosslinked elastin hydrogels and their interaction with fibroblasts in vitro, Biomaterials, vol.30, pp.4550-4557, 2009. ,
Surface modification of porous anodic alumina for medical and biological applications, Nanomedicine, pp.438-466, 2014. ,
Functional Characterization of Chitin and Chitosan, Current Chemical Biology, vol.3, pp.203-230, 2009. ,
Management of Acute and Chronic Open Wounds: The Importance of Moist Environment in Optimal Wound Healing, Current Pharmaceutical Biotechnology, vol.3, pp.179-195, 2002. ,
Synthesis of chitosan-caffeic acid derivatives and evaluation of their antioxidant activities, Journal of Bioscience and Bioengineering, vol.111, pp.212-216, 2011. ,
Fabrication of porous anodic aluminum oxide layers on paper for humidity sensors, Sensors and Actuators B: Chemical, vol.220, pp.829-839, 2015. ,
Epidémiologie des escarres en France. Revue francophone de cicatrisation, vol.3, pp.10-14, 2017. ,
Collagenase Production by Human Skin Fibroblasts, Biochemical and Biophysical Research Communications, vol.64, pp.232-240, 1975. ,
Prévention et traitement des escarres, Actualités pharmaceutiques, vol.57, issue.578, pp.55-58, 2018. ,
Collagen structure: new tricks from a very old dog, Biochemical Journal, vol.473, pp.1001-1025, 2016. ,
Disposable MMP-9 sensor based on the degradation of peptide cross-linked Hydrogel films using electrochemical impedance spectroscopy, Biosensors and Bioelectronics, vol.68, pp.660-667, 2015. ,
Wound Healing Dressings and Drug Delivery Systems: A Review, Journal of Pharmaceutical Sciences, vol.97, pp.2892-2923, 2008. ,
Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the "metzincins, Federation of European Biochemical Societies Letters, vol.331, pp.134-140, 1993. ,
Global economic burden of diabetes in adults: projections from, Diabetes Care, vol.41, pp.963-970, 2015. ,
The global burden of diabetic foot disease, The Lancet, vol.336, pp.1719-1724, 2005. ,
A Review of Collagen and Collagen-based Wound Dressings. Wounds, vol.20, pp.347-356, 2008. ,
The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity, Biochimica et Biophysica Acta, vol.1803, pp.55-71, 2010. ,
Wearable Technology for Chronic Wound Monitoring: Current Dressings, Advancements, and Future Prospects, Frontiers in Bioengineering and Biotechnology, vol.6, p.47, 2018. ,
Acute and Chronic Wounds: Current Management Concepts, p.46, 2016. ,
Metalloproteinases and Wound Healing, Advances in Wound Care, vol.4, pp.225-234, 2015. ,
Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat, Annual Review of Immunology, vol.8, pp.647-679, 1990. ,
Identification of Gram Negative Bacteria Using Nanoscale Silicon Microcavities, Journal of the American Chemical Society, vol.123, pp.11797-11798, 2001. ,
Les métalloprotéases matricielles et leurs inhibiteurs synthétiques dans la progression tumorale, Medecine Sciences, vol.18, pp.565-575, 2002. ,
Functions of Hyaluronan in Wound Repair, Wound Repair and Regeneration, vol.7, pp.79-89, 2002. ,
Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications, Marine Drugs, vol.13, pp.5156-5186, 2015. ,
Biomechanical Properties of Dermis, The Journal of Investigative Dermatology, vol.79, pp.17-20, 1982. ,
Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads, Current Diabetes Reports, vol.18, issue.2, 2018. ,
The risk of pressure sores: a conceptual scheme, Journal of Clinical Nursing, vol.8, pp.206-216, 1999. ,
A Sensor Gauze with Multi-Channel Moisture and pH Monitoring for CW Care, IEEE Access, vol.7, pp.29185-29192, 2019. ,
Single-domain antibody fragments with high conformational ability, Protein Science, vol.11, pp.500-515, 2002. ,
Diabetic Foot Ulcers: Practical Treatment Recommendations, Drugs, vol.66, pp.913-929, 2006. ,
Elevated uric acid correlates with wound severity, International Wound Journal, vol.9, pp.139-149, 2012. ,
Modern Collagen Wound Dressings: Function and Purpose, Journal of the American College of Certified Wound Specialists, vol.2, pp.50-54, 2010. ,
Comparison of global estimates of prevalence and risk for peripheral artery disease in 2000 and 2010: a systematic review and analysis, The Lancet, vol.382, pp.1329-1340, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00925590
Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking, Cellular and Molecular Life Sciences, vol.71, pp.1191-1210, 2014. ,
Purification and characterization of rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components, Biochemical Journal, vol.209, pp.741-752, 1983. ,
La green fluorescent protein: application à la dynamique intracellulaire des récepteurs stéroïdiens. médecine/sciences, vol.15, pp.45-55, 1999. ,
Monitoring of pH and temperature of neuropathic diabetic and non-diabetic foot ulcers for 12-weeks: an observational study, Wound Repair and Regeneration, vol.26, pp.251-256, 2018. ,
The significance of surface pH in chronic wounds, Wounds UK, vol.3, pp.52-56, 2007. ,
Smart Wound Dressings for Diabetic Chronic Wounds, Bioengineering, vol.5, p.51, 2018. ,
Metalloproteinases and Their Inhibitors: Regulators of Wound Healing, The International Journal of Biochemistry & Cell Biology, vol.40, pp.1334-1347, 2008. ,
Growth Factors and Chronic Wound Healing: Past, Present, and Future, Advances in Skin & Wound Care, vol.17, pp.24-35, 2004. ,
Wound healing -A literature review, Anais Brasileiros de Dermatologia, vol.91, pp.614-620, 2016. ,
Dual Beneficial Effect of Interloop Disulfide Bond for Single Domain Antibody Fragments, Journal of Biological Chemistry, vol.287, pp.1970-1979, 2011. ,
Venous and arterial leg ulcers, British Medical Journal, vol.332, pp.347-350, 2006. ,
Collagenolytic Activity in Amphibian Tissues: A Tissue Culture Assay, Proceedings of the National Academy of Sciences, vol.48, pp.1014-1022, 1962. ,
,
Structure and function of the skin: overview of the epidermis and dermis, The Biology of the skin, pp.19-45, 2001. ,
Chronic Wound Healing: A Review of Current Management and Treatment, Advanced Therapy, vol.34, pp.599-610, 2017. ,
, Multifunctional Skin-Like Electronics for Quantitative, vol.3, pp.1597-1607, 2014.
Shivashankara, Prediction of peak plantar pressure for diabetic foot: The regressional model. The foot, vol.40, pp.87-91, 2019. ,
The Role of Hypoxia-Inducible Factor in Wound Healing, Advances in Wound Care, vol.3, pp.390-399, 2014. ,
A clinically practical way to estimate surgical blood loss, Dermatology Online Journal, vol.13, issue.4, p.17, 2007. ,
Protein immobilization to alumina supports: I. characterization of alumina-organophosphate ligand interactions and use in the attachment of papain, Biotechnology and Bioengineering, vol.40, pp.1319-1327, 1992. ,
, International Diabetes Federation
Chitosan and Its Use as a Pharmaceutical Excipient, Pharmaceutical Research, vol.15, pp.1326-1331, 1998. ,
Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review, Systematic Reviews, vol.5, p.152, 2016. ,
Diabetic foot ulcers, The Lancet, vol.361, pp.1545-1551, 2003. ,
Management of Chronic Wounds, Journal of the American Medical Association, vol.320, pp.1481-1482, 2018. ,
Insulin Action, Diabetogenes, and the Cause of Type II Diabetes, Diabetes, vol.43, pp.1066-1084, 1994. ,
Anatomy, histology and immunohistochemistry of the normal human skin, European Journal of dermatology, vol.12, pp.390-399, 2002. ,
Smart bandage with wireless connectivity for optical monitoring of pH, Sensors and Actuators B: Chemical, vol.246, pp.455-460, 2017. ,
Smart bandage with wireless connectivity for uric acid biosensing as an indicator of wound status, Electrochemistry Communications, vol.56, pp.6-10, 2015. ,
The Utility of Silkelastin Hydrogel as a New Material for Wound Healing, Plastic and Reconstructive Surgery -Global Open, 2018. ,
Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders, Biomolecules and Therapeutics, vol.20, pp.133-143, 2012. ,
The Constitution and Fundamental Properties of Solids and Liquids II, Journal of the American Chemical Society, vol.39, pp.1848-1906, 1917. ,
The Evaporation, Condensation and Reflection of Molecules and the Mechanism of Adsorption, Physical Review, vol.8, pp.149-176, 1916. ,
Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence, Journal of Wound Care, vol.25, pp.277-287, 2016. ,
On the Weight of the Skin, The Journal of Investigative Dermatology, vol.12, pp.187-191, 1949. ,
Expression and Influence of Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-I and Vascular Endothelial Growth Factor in Diabetic Foot Ulcers, The International Journal of Lower Extremity Wounds, vol.16, pp.6-13, 2017. ,
Current conjugation methods for immunosensors, Nanomaterials, vol.8, p.278, 2018. ,
Metastatic potential correlates with enzymatic degradation of basement membrane collagen, Nature, vol.284, pp.67-68, 1980. ,
A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing, Royal Society of Chemistry, vol.8, pp.7533-7549, 2018. ,
Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers, Diabetes Care, vol.32, pp.117-119, 2009. ,
Biological role of matrix metalloproteinases: a critical balance, European Respiratory Journal, vol.38, pp.191-208, 2010. ,
Treatment of War Wounds, Clinical Orthopaedics and Related Research, vol.467, pp.2168-2191, 2009. ,
Flow-through-type DNA array based on ideally ordered anodic porous alumina substrate, Advanced Materials, vol.16, pp.23-24, 2004. ,
Skin temperature monitoring by a wireless sensor, IECON 2011-37th Annual Conference of the IEEE Industrial Electronics Society, pp.3533-3535, 2011. ,
Phage antibodies: filamentous phage displaying antibody variable domains, Nature, vol.348, pp.552-554, 1990. ,
Molecular Wiring in Smart Dressings: Opening a New Route to Monitoring Wound pH, Healthcare, vol.3, pp.466-477, 2015. ,
Nanoporous anodic aluminium oxide: advances in surface engineering and emerging applications, Progress in Materials Science, vol.58, pp.636-704, 2013. ,
Inflammation 2010: New Adventures of an Old Flame, Cell, vol.140, pp.771-776, 2010. ,
Development of Wearable Sensors for Tailored Patient Wound Care, Proceedings of the 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.618-621, 2014. ,
A wearable wound moisture sensor as an indicator for wound dressing change: an observational study of wound moisture and status, International Wound Journal, vol.13, pp.1309-1314, 2016. ,
Wound healing and treating wounds, Journal of the American Academy of Dermatology, vol.74, pp.589-605, 2016. ,
Wireless flexible smart bandage for continuous monitoring of wound oxygenation, IEEE Transactions on Biomedical Circuits and Systems, vol.9, pp.670-677, 2015. ,
Mechanisms for pro matrix metalloproteinase activation, APMIS, vol.107, pp.38-44, 1999. ,
Tissue inhibitors of metalloproteinases, Genome Biology, vol.12, p.233, 2011. ,
Structure and function of matrix metalloproteinases and TIMPs, Cardiovascular Research, vol.69, pp.565-573, 2006. ,
High-dose hook effect, Journal of Dr. NTR University of Health Sciences, vol.3, pp.5-7, 2014. ,
Matrix Metalloproteinases: Biologic Activity and Clinical Implications, Journal of Clinical Oncology, vol.18, pp.1135-1149, 2000. ,
Chitosan in Medical Dressings. Fibres & Textiles in Eastern Europe, vol.13, pp.16-18, 2005. ,
Measurement of Epidermis, Dermis, and Total Skin Thicknesses from Six Different Body Regions with a new Ethical Histometric Technique, Turkish Journal of Plastic Surgery, vol.26, pp.56-61, 2018. ,
Les ulcères veineux : bilan diagnostique et options thérapeutiques. Revue Francophone de cicatrisation, vol.4, pp.28-33, 2017. ,
Adsorption Behaviors of L-Histidine and DL-Tryptophan on Cholesterol, Silica, Alumina and Graphite, Journal of Colloid and Interface Science, vol.239, pp.20-26, 2001. ,
Characteristics of barrier anodized coatings on 6061 aluminum alloy, Thin Solid Films, vol.95, pp.113-118, 1982. ,
Diabetic foot infections: a comprehensive overview, European Review for Medical and Pharmacological Sciences, vol.23, pp.26-37, 2019. ,
Surface modification of nanoporous alumina surfaces with poly(ethylene glycol), Langmuir, vol.20, pp.8035-8041, 2004. ,
The Role of Hyaluronic Acid in Wound Healing, American Journal of clinical dermatology, vol.6, pp.393-402, 2005. ,
A dressing history, International Wound Journal, vol.1, pp.59-77, 2004. ,
A label-free optical biosensor based on nanoporous anodic alumina for tumour necrotic factor-alpha detection in chronic wounds, Sensors and Actuators B: Chemical, vol.257, pp.116-123, 2018. ,
Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer, British Journal of Dermatology, vol.158, pp.951-961, 2008. ,
L'inhibiteur de type 1 des activateurs du plasminogène : physiologie et rôle en physiopathologie rénale, Néphrologie, vol.22, pp.5-13, 2001. ,
Temperature-and pH-sensitive wearable materials for monitoring foot ulcers, International Journal of Nanomedicine, vol.12, pp.949-954, 2017. ,
Nanoporous anodic aluminum oxide for chemical sensing and biosensors, Trends in Analytical Chemistry, vol.44, pp.25-38, 2013. ,
Interactions between extracellular matrix and growth factors in wound healing, Wound Repair and Regeneration, vol.17, pp.153-162, 2009. ,
Human Wounds and its Burden: An Updated Compendium of Estimates, Advances in wound care, vol.8, pp.39-48, 2019. ,
The History of Wound Care, Journal of the American College of Certified Wound Specialists, vol.3, pp.65-66, 2011. ,
Development of a functional wound dressing composed of hyaluronic acid spongy sheet containing bioactive components: evaluation of wound healing potential in animal tests, Journal of Biomaterials Science, vol.25, pp.1278-1291, 2014. ,
Structure of the Chromophore of Aequorea Green Fluorescent Protein, FEBS Letters, vol.104, pp.220-222, 1979. ,
Hydrogel matrices based on elastin and alginate for tissue engineering applications, Biological Macromolecules, vol.114, pp.614-625, 2018. ,
Management of venous leg ulcers, British Medical Journal, vol.328, pp.1358-1362, 2004. ,
Preventing Foot Ulcers in Patients with Diabetes, Journal of the American Medical Association, vol.293, pp.217-228, 2005. ,
Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface, Science, vol.228, pp.1315-1316, 1985. ,
Matrix Metalloproteinases: Fold and function of their catalytic domains, Biochimica et Biophysica Acta -Molecular Cell Research, vol.1803, pp.20-28, 2010. ,
Flexible pH-Sensing Hydrogel Fibers for Epidermal Applications, Advanced Healthcare Materials, vol.5, pp.711-719, 2016. ,
Les pansements de traitement par pression négative, Soins, vol.61, pp.45-47, 2015. ,
Prototype Development of the Intelligent Hydrogel Wound Dressing and Its Efficacy in the Detection of Model Pathogenic Wound Biofilms, Applied Materials & Interfaces, vol.8, pp.14909-14919, 2016. ,
Porous anodic alumina: fabrication, characterization and applications, Thin Solid Films, vol.297, pp.192-201, 1997. ,
The pH changes of pressure ulcers related to the healing process of wounds, Wounds, vol.4, pp.16-20, 1992. ,
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance, The New England Journal of Medicine, vol.344, pp.1343-1350, 2001. ,
Comparison of physical chemical properties of llama VHH antibody fragments and mouse monoclonal antibodies, Biochimica et Biophysica Acta, vol.1431, pp.37-46, 1999. ,
Immobilization of antibodies on 3-aminopropyltriethoxysilane-functionalized bioanalytical platforms for biosensors and diagnostics, Chemical Reviews, vol.114, pp.11083-11130, 2014. ,
Inhibitor of Human Collagenase from Cultures of Human Tendon, The Journal of Biological Chemistry, vol.254, pp.3045-3053, 1978. ,
Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in the Other Family Members, The Journal of Biological Chemistry, vol.274, pp.4570-4576, 1999. ,
, Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function and Biochemistry, vol.92, pp.827-839, 2003.
Levels of Tumor Necrosis Factor-? (TNF-?) and Soluble TNF-? Receptors in Chronic Venous Leg Ulcers -Correlations to Healing Status, The Journal of Investigative Dermatology, vol.110, pp.292-296, 1998. ,
Angiogenesis Induced by Degradation Products of Hyaluronic Acid, Science, vol.228, pp.1324-1326, 1985. ,
Smart bandages diagnose wound infection, Drug Discovery Today, vol.7, pp.9-10, 2002. ,
Structure and function of the epidermal barrier, American Journal of Infection Control, vol.34, pp.98-110, 2006. ,
The pH of varicose ulcer surfaces and its relationship to healing, European Journal of Vascular Medicine, 1979. ,
The proteolytic environment of chronic wounds, Wound Repair and Regeneration, vol.7, pp.433-441, 1999. ,
Inflammation un Chronic Wounds, International Journal of Molecular Sciences, vol.17, pp.1-14, 2016. ,
Ces plaies possèdent de nombreux facteurs participant à ce phénomène de pérennisation, dont les métalloprotéases matricielles ou MMP, endopeptidases à zinc aux rôles variés. Ces travaux de thèse s'intéressent à l'élaboration d'un dispositif de pansement connecté pour le suivi de l'évolution des plaies du pied diabétique. Ce suivi se fait par mesure de la concentration d'une enzyme clé dans les phénomènes d'inflammation de ce type de plaie, la métalloprotéase matricielle 9 (MMP9), également appelée Gelatinase B. Ce système se base sur l, il a été estimé que 425 millions de personnes souffraient de diabète. Les raisons de ce boom, liées au contexte socio-économique actuel, représentent une dépense globale de 1.3 milliard de dollars par an avec des estimations atteignant jusqu'à 2.1 milliards de dollars en 2030, p.9, 2005. ,
, Dans un premier temps, une recherche d'ERB possédant une affinité pour la cible est étudiée. Cette recherche se base sur un screening de banques d'anticorps de camélidé (VHH) et de banques peptidiques par la méthode de phage display
, La suite du projet se focalise sur l'élaboration de deux prototypes de biocapteurs capacitifs, l'un avec l'étude de la fonctionnalisation d'un anticorps conventionnel anti-MMP9, l'autre avec l'utilisation d'un VHH tiers possédant une affinité pour la GFP. Ces deux preuves de concept seront utiles