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Characterization of the Signaling Pathways Involved in Cellular Cannibalism Elicited by Ionizing Radiation

Abstract : Many types of anticancer therapies are available to kill tumor cells. The tumoral cell death modalities may be different upon the treatment, the cell type and inter-individual sensitivity. Besides the typical cell death processes apoptosis and necrosis, cellular cannibalism has also been reported in patients’ tumoral biopsies. This cellular process is defined as the engulfment of one live cell by another live cell followed by the degradation of the inner cell. The mechanisms beyond cellular cannibalism are still partially understoof but it appears to be of clinical relevance. Indeed, we have shown that these events could be modulated by anticancer treatments and there are evidences of their utility as a potent prognostic biomarker in some cancers. This thesis presents the in vitro experiments which led to the identification of the signaling pathways involved in cellular cannibalism induced by ionizing radiation.
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Dorine de Jong. Characterization of the Signaling Pathways Involved in Cellular Cannibalism Elicited by Ionizing Radiation. Cancer. Université Paris Saclay (COmUE), 2018. English. ⟨NNT : 2018SACLS101⟩. ⟨tel-02891567v2⟩

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