, , 2013.
, Agence nationale de recherches sur le sida et les hépatites virales, Ministère des affaires sociales et de la Santé, 2013.
Anti-HIV Drug Development: Structural Features and Limitations of Present Day Drugs and Future Challenges in the Successful HIV/AIDS Treatment, Curr. Pharm. Design, vol.19, pp.1767-1783, 2013. ,
Pill burden in HIV infection: 20 years of experience, Antivir. Ther, vol.17, pp.833-840, 2012. ,
Reasons for modification and discontinuation of antiretrovirals: results from a single treatment centre, Aids, vol.15, pp.185-194, 2001. ,
, for The International AIDS Society Scientific Working Group on HIV Cure, Towards an HIV cure: a global scientific strategy, vol.12, pp.607-614, 2012.
5 '-amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter, Pharm. Res, vol.15, pp.1154-1159, 1998. ,
Tipranavir -A ritonavir-boosted protease inhibitor, Drugs, vol.65, pp.1669-1677, 2005. ,
Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailaibility, Nanomedicine, vol.5, pp.11-23, 2010. ,
Novel approaches for designing 5 '-O-ester prodrugs of 3'-azido-2 ',3 '-dideoxythymidine (AZT), Curr. Med. Chem, vol.7, pp.995-1039, 2000. ,
Synthesis and Anti-Hiv Activity of Prodrugs of Azidothymidine, Antivir. Chem. Chemother, vol.4, pp.93-96, 1993. ,
Adamantane as a Brain-Directed Drug Carrier for Poorly Absorbed Drug .2. Azt Derivatives Conjugated with the 1-Adamantane Moiety, J. Pharm. Sci, vol.83, pp.481-484, 1994. ,
Ester Prodrugs of Zidovudine, J. Pharm. Sci, vol.79, pp.531-533, 1990. ,
Differential Patterns of Intracellular Metabolism of 2',3'-Didehydro-2',3'-Dideoxythymidine and 3'-Azido-2',3'-Dideoxythymidine, 2 Potent Anti-Human Immunodeficiency Virus Compounds, J. Biol. Chem, vol.264, pp.6127-6133, 1989. ,
Cellular phosphorylation of Anti-HIV nucleosides -Role of nucleoside diphosphate kinase, J. Biol. Chem, vol.271, pp.7887-7890, 1996. ,
Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine, J. Med. Chem, vol.39, pp.3418-3422, 1996. ,
Decomposition Pathways of the Mono-(Pivaloyl-Oxymethyl) and Bis(Pivaloyl-Oxymethyl) Esters of Azidothymidine 5'-Monophosphate in Cell Extract and in Tissue-Culture Medium -an Application of the Online Isrp-Cleaning Hplc Technique, Antivir. Chem. Chemother, vol.5, pp.91-98, 1994. ,
Synthesis and Anti-Hiv Activity of Some Haloalkyl Phosphoramidate Derivatives of 3'-Azido-3'-Deoxythymidine (Azt) -Potent Activity of the Trichloroethyl Methoxyalaninyl Compound, Antiviral Res, vol.15, pp.255-263, 1991. ,
Pharmacokinetics and Bioavailability of Zidovudine in Humans, Am. J. Med, vol.85, pp.189-194, 1988. ,
Stavudine -A review of its pharmacodynamic and pharmacokinetic properties and clinical potential in HIV infection, Drugs, vol.51, pp.846-864, 1996. ,
Pharmacokinetics of 2',3'-Dideoxycytidine in Patients with Aids and Related Disorders, J. Clin. Pharmacol, vol.28, pp.837-842, 1988. ,
Regiospecific Intestinal-Absorption of the Hiv Protease Inhibitor L-735,524 in Beagle Dogs, Pharm. Res, vol.12, pp.884-888, 1995. ,
Better maintained adherence on switching from twice-daily to once-daily therapy for HIV: a 24-week randomized trial of treatment simplification using stavudine prolonged-release capsules, HIV Med, vol.6, pp.185-190, 2005. ,
Stavudine extended release (oncedaily, Bristol-Myers Squibb) for the treatment of HIV/AIDS, Expert Opin. Pharmacother, vol.14, pp.1055-1064, 2013. ,
Formulation and in vitro, in vivo evaluation of extended-release matrix tablet of zidovudine: Influence of combination of hydrophilic and hydrophobic matrix formers, Aaps Pharmscitech, p.7, 2006. ,
New sustained release of Zidovudine Matrix tablets -cytotoxicity toward Caco-2 cells, Drug Dev. Ind. Pharm, vol.39, pp.1154-1166, 2013. ,
Efficacy and safety of nevirapine extended-release once daily versus nevirapine immediaterelease twice-daily in treatment-naive HIV-1-infected patients, Antivir. Ther, vol.16, pp.759-769, 2011. ,
Synthesis and in vitro chemical and enzymatic stability of glycosyl 3 '-azido-3 '-deoxythymidine derivatives as potential anti-HIV agents, Eur. J. Pharm. Sci, vol.16, pp.167-174, 2002. ,
A Novel Anti-HIV Dextrin-Zidovudine Conjugate Improving the Pharmacokinetics of Zidovudine in Rats, Aaps Pharmscitech, vol.9, pp.840-850, 2008. ,
Formulation and Characterization of Drug Loaded Nonionic Surfactant Vesicles (Niosomes) for Oral Bioavailability Enhancement, Sci. World J, 2014. ,
Investigation on the stability of saquinavir loaded liposomes: Implication on stealth, release characteristics and cytotoxicity, Int. J. Pharm, vol.431, pp.120-129, 2012. ,
Lipid-drug association enhanced HIV-1 protease inhibitor indinavir localization in lymphoid tissues and viral load reduction: A proof of concept study in HIV-2(287)-infected macaques, Jaids, vol.34, pp.387-397, 2003. ,
Feasibility of weekly HIV drug delivery to enhance drug localization in lymphoid tissues based on pharmacokinetic models of lipid-associated indinavir, Pharm. Res, vol.23, pp.1750-1755, 2006. ,
The Critical Need for Alternative Antiretroviral Formulations, and Obstacles to Their Development, J. Infect. Dis, vol.204, pp.669-674, 2011. ,
Development of an implantable infusion pump for sustained anti-HIV drug administration, Int. J. Pharm, vol.355, pp.38-44, 2008. ,
In situ forming implant for controlled delivery of an anti-HIV fusion inhibitor, Int. J. Pharm, vol.426, pp.132-143, 2012. ,
The challenge of viral reservoirs in HIV-1 infection, Annu. Rev. Med, vol.53, pp.557-593, 2002. ,
Reservoirs, sanctuaries, and residual disease: The hiding spots of HIV-1, HIV Clin. Trials, vol.4, pp.137-143, 2003. ,
Macrophages and residual HIV infection, Curr. Opin. HIV AIDS, vol.1, pp.129-133, 2006. ,
, Targeting of Antiviral Drugs to Lymphocytes-T4 -Anti-Hiv Activity of Neoglycoprotein Aztmp Conjugates Invitro, vol.40, pp.2603-2610, 1990.
Reduced hematopoietic toxicity, enhanced cellular uptake and altered pharmacokinetics of azidothymidine loaded galactosylated liposomes, J. Drug Target, vol.14, pp.1-11, 2006. ,
Enhanced delivery of AZT to macrophages via acetylated LDL, J. Control. Release, vol.69, pp.327-335, 2000. ,
Novel hydrophilic chitosanpolyethylene oxide nanoparticles as protein carriers, J Appl Polym Sci, vol.63, pp.125-132, 1997. ,
Chitosan-based drug nanocarriers: where do we stand?, J Control Release, vol.161, pp.496-504, 2012. ,
Biocompatibility of Chitosan Carriers with Application in Drug Delivery, J Funct Biomater, vol.3, pp.615-641, 2012. ,
Monodisperse chitosan nanoparticles for mucosal drug delivery, Biomacromolecules, vol.5, pp.2461-2469, 2004. ,
Influence of anions on the formation and properties of chitosan-DNA nanoparticles, J Nanosci Nanotechnol, vol.5, pp.713-720, 2005. ,
Development and characterisation of chitosan nanoparticles for siRNA delivery, J Control Release, vol.115, pp.216-241, 2006. ,
Drug-Induced Nanocarrier Assembly as a Strategy for the Cellular Delivery of Nucleotides and Nucleotide Analogues, Biomacromolecules, vol.14, pp.737-742, 2013. ,
Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior, J Colloid Interface Sci, vol.283, pp.344-51, 2005. ,
ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in vivo, Atherosclerosis, vol.188, pp.323-330, 2006. ,
Necrotic cell death in atherosclerosis, Basic Research in Cardiology, vol.106, pp.749-760, 2011. ,
Molecular targeting of atherosclerotic plaques by a stabilin-2-specific peptide ligand, J. Control. Release, vol.155, pp.211-217, 2011. ,
Preparation of coated nanoparticles for a new mucosal vaccine delivery system, Int J Pharm, vol.299, pp.155-166, 2005. ,
Chitosan/TPP and chitosan/TPP-hyaluronic acid nanoparticles: systematic optimisation of the preparative process and preliminary biological evaluation, Pharm Res, vol.26, pp.1918-1948, 2009. ,
Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints, J Control Release, vol.144, pp.242-50, 2010. ,
Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads, Polymer, vol.44, pp.6521-6530, 2003. ,
Stability of a biological tissue fixed with a naturally occurring crosslinking agent (genipin), J. Biomed. Mater. Res, vol.55, pp.538-546, 2001. ,
A magnetic study of an Fe-chitosan complex and its relevance to other biomolecules, Biomacromolecules, vol.1, pp.413-420, 2000. ,
Spray-dried chitosan-metal microparticles for ciprofloxacin adsorption: Kinetic and equilibrium studies, Soft Matter, vol.7, pp.7304-7312, 2011. ,
Interaction of orthophosphate with iron(III) and aluminum hydroxides, Environ Sci Technol, vol.14, pp.537-541, 1980. ,
Characterization and extracorporeal application of a new phosphate-binding agent, Eur J Clin Chem Clin Biochem, vol.32, pp.733-742, 1994. ,
Determination of Iron with o-Phenanthroline: A Spectrophotometric Study, Ind Eng Chem Anal Ed, vol.10, pp.60-64, 1938. ,
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, vol.65, pp.55-63, 1983. ,
Iron oxyhydroxide nanoparticles formed by forced hydrolysis: dependence of phase composition on solution concentration, Phys Chem Chem Phys, vol.13, pp.18523-18529, 2011. ,
Polyplex Nanogel formulations for drug delivery of cytotoxic nucleoside analogs, J Control Release, vol.107, pp.143-157, 2005. ,
Turbidity spectroscopy for characterization of submicroscopic drug carriers, such as nanoparticles and lipid vesicles: size determination, Pharm Res, vol.28, pp.2204-2226, 2011. ,
A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum, J Control Release, vol.126, pp.67-76, 2008. ,
Intimal vascularisation and atherosclerosis, The Journal of Pathology and Bacteriology, vol.63, pp.201-211, 1951. ,
, Hypoxia Is Present in Murine Atherosclerotic Plaques and Has Multiple Adverse Effects on Macrophage Lipid Metabolism, vol.109, pp.1141-1152, 2011.
Overcoming pharmacologic sanctuaries, Curr. Opin. HIV AIDS, issue.8, pp.190-195, 2013. ,
HIV interactions with monocytes and dendritic cells: viral latency and reservoirs, Retrovirology, p.6, 2009. ,
Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART, Antiviral Res, vol.87, pp.269-271, 2010. ,
Antiretroviral Tissue Kinetics: In Vivo Imaging Using Positron Emission Tomography, Antimicrob. Agents Chemother, vol.53, pp.4086-4095, 2009. ,
Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS, J Virol, vol.84, pp.2913-2935, 2010. ,
Differential Patterns of Intracellular Metabolism of 2',3'-Didehydro-2',3'-Dideoxythymidine and 3'-Azido-2',3'-Dideoxythymidine, 2 Potent Anti-Human Immunodeficiency Virus Compounds, J. Biol. Chem, vol.264, pp.6127-6133, 1989. ,
Cellular phosphorylation of Anti-HIV nucleosides -Role of nucleoside diphosphate kinase, J. Biol. Chem, vol.271, pp.7887-7890, 1996. ,
Body distribution of azidothymidine bound to nanoparticles after oral administration, Eur. J. Pharm. Biopharm, vol.44, pp.127-132, 1997. ,
Body distribution of azidothymidine bound to hexyl-cyanoacrylate nanoparticles after i.v. injection to rats, J. Control. Release, vol.50, pp.21-30, 1998. ,
Reduced hematopoietic toxicity, enhanced cellular uptake and altered pharmacokinetics of azidothymidine loaded galactosylated liposomes, J. Drug Target, vol.14, pp.1-11, 2006. ,
Antiviral Efficacy, Intracellular Uptake and Pharmacokinetics of Free and Liposome-Encapsulated 2',3'-Dideoxyinosine, Aids, vol.8, pp.1545-1553, 1994. ,
Lymphoid-Tissues Targeting of Liposome-Encapsulated 2',3'-Dideoxyinosine, Aids, vol.9, pp.701-707, 1995. ,
Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies, Biomaterials, vol.34, pp.4831-4838, 2013. ,
Cross-linked polymeric nanogel formulations of 5 '-triphosphates of nucleoside analogues: Role of the cellular membrane in drug release, Mol. Pharm, vol.2, pp.449-461, 2005. ,
Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages, J. Control. Release, vol.116, pp.346-352, 2006. ,
Towards an Improved anti-HIV Activity of NRTI via Metal-Organic Frameworks Nanoparticles, Adv. Health. Mater, issue.2, pp.1630-1637, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00935744
Targeting Antiretroviral Nucleoside Analogs in Phosphorylated Form to Macrophages -Invitro and Invivo Studies, Proc. Natl. Acad. Sci. U. S. A, vol.89, pp.6477-6481, 1992. ,
Liposomes as carriers of the antiretroviral agent dideoxycytidine-5'-triphosphate, Int J Pharm, vol.180, pp.261-270, 1999. ,
Porcine interleukin-2 gene encapsulated in chitosan nanoparticles enhances immune response of mice to piglet paratyphoid vaccine, Comp. Immunol. Microbiol. Infect. Dis, vol.30, pp.19-32, 2007. ,
Blood protein adsorption onto chitosan, Biomaterials, vol.23, pp.2561-2568, 2002. ,
Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover, J. Virol, vol.76, pp.10692-10701, 2002. ,
Stabilization and cellular delivery of chitosan-polyphosphate nanoparticles by incorporation of iron, J Control Release, vol.194, pp.211-219, 2014. ,
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, vol.65, pp.55-63, 1983. ,
In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20), J. Antimicrob. Chemother, vol.64, pp.1192-1195, 2009. ,
Programmed Cell Death, General Principles for Studying Cell Death, Pt A, vol.442, pp.51-82, 2008. ,
Expression of CD4 controls the susceptibility of THP-1 cells to infection by R5 and X4 HIV type 1 isolates, Aids Res. Hum. Retrovir, vol.18, pp.123-131, 2002. ,
Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?, Nat. Rev. Microbiol, vol.4, pp.312-317, 2006. ,
Macrophages and their relevance in Human Immunodeficiency Virus Type I infection, Retrovirology, p.9, 2012. ,
IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation, J. Exp. Med, vol.210, pp.517-534, 2013. ,
Hock immunization: A humane alternative to mouse footpad injections, J. Immunol. Methods, vol.328, pp.204-214, 2007. ,
Nanocarriers for intravenous injection -The long hard road to the market, Int. J. Pharm, vol.457, pp.50-62, 2013. ,
, , 1990.
PLGA in situ implants formed by phase inversion: Critical physicochemical parameters to modulate drug release, J. Control. Release, vol.172, pp.292-304, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01273194
Phase inversion dynamics of PLGA solutions related to drug delivery, J. Control. Release, vol.58, pp.233-245, 1999. ,
Biodegradation and biocompatibility of PLA and PLGA microspheres, Adv. Drug Deliv. Rev, vol.28, pp.5-24, 1997. ,
, Toxicity of N-Methyl-2
Teratogenic, Subchronic, and 2-Year Inhalation Studies, Fundam. Appl. Toxicol, vol.9, pp.222-235, 1987. ,
Controlled delivery of aspirin: Effect of aspirin on polymer degradation and in vitro release from PLGA based phase sensitive systems, Int. J. Pharm, vol.357, pp.119-125, 2008. ,
Development of an in-Situ Forming Biodegradable Poly-Lactide-Co-Glycolide System for the Controlled-Release of Proteins, J. Control. Release, vol.33, pp.189-195, 1995. ,
Sustained release of human growth hormone from PLGA solution depots, Pharm. Res, vol.16, pp.1825-1829, 1999. ,
Eligard: Leuprolide acetate in a novel sustained-release delivery system, Urology, vol.61, pp.25-31, 2003. ,
Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model, Int. J. Hyperthermia, vol.25, pp.229-239, 2009. ,
Rheological and syringeability properties of highly concentrated human polyclonal immunoglobulin solutions, Eur. J. Pharm. Biopharm, vol.76, pp.351-356, 2010. ,
The role of polymer membrane formation in sustained release drug delivery systems, J. Control. Release, vol.109, pp.211-221, 2005. ,
Challenges in the Development of Pre-filled Syringes for Biologics from a Formulation Scientist's Point of View, Am. Pharm. Rev, vol.15, 2012. ,
Phase inversion dynamics of PLGA solutions related to drug delivery -Part II. The role of solution thermodynamics and bath-side mass transfer, J. Control. Release, vol.62, pp.333-344, 1999. ,
Biocompatibility of a biodegradable in situ forming implant system in rhesus monkeys, J. Biomed. Mater. Res, vol.45, pp.231-239, 1999. ,
In situ forming implants -an attractive formulation principle for parenteral depot formulations, J. Control. Release, vol.161, pp.668-679, 2012. ,
Novel hydrophilic chitosanpolyethylene oxide nanoparticles as protein carriers, J Appl Polym Sci, vol.63, pp.125-132, 1997. ,
Monodisperse chitosan nanoparticles for mucosal drug delivery, Biomacromolecules, vol.5, pp.2461-2469, 2004. ,
Influence of anions on the formation and properties of chitosan-DNA nanoparticles, J Nanosci Nanotechnol, vol.5, pp.713-720, 2005. ,
Development and characterisation of chitosan nanoparticles for siRNA delivery, J Control Release, vol.115, pp.216-241, 2006. ,
Cross-linked polymeric nanogel formulations of 5 '-triphosphates of nucleoside analogues: Role of the cellular membrane in drug release, Mol. Pharm, vol.2, pp.449-461, 2005. ,
Formulations of biodegradable Nanogel carriers with 5'-triphosphates of nucleoside analogs that display a reduced cytotoxicity and enhanced drug activity, J Control Release, vol.121, pp.19-27, 2007. ,
Macrophages and their relevance in Human Immunodeficiency Virus Type I infection, Retrovirology, p.9, 2012. ,
Physicochemical characterization of chitosan nanoparticles: electrokinetic and stability behavior, J Colloid Interface Sci, vol.283, pp.344-51, 2005. ,
A magnetic study of an Fe-chitosan complex and its relevance to other biomolecules, Biomacromolecules, vol.1, pp.413-420, 2000. ,
Spray-dried chitosan-metal microparticles for ciprofloxacin adsorption: Kinetic and equilibrium studies, Soft Matter, vol.7, pp.7304-7312, 2011. ,
Interaction of orthophosphate with iron(III) and aluminum hydroxides, Environ Sci Technol, vol.14, pp.537-541, 1980. ,
Characterization and extracorporeal application of a new phosphate-binding agent, Eur J Clin Chem Clin Biochem, vol.32, pp.733-742, 1994. ,
A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum, J Control Release, vol.126, pp.67-76, 2008. ,
Biodegradable PLGA Based Nanoparticles for Sustained Regional Lymphatic Drug Delivery, J. Pharm. Sci, vol.99, 2009. ,
Hock immunization: A humane alternative to mouse footpad injections, J. Immunol. Methods, vol.328, pp.204-214, 2007. ,
In situ forming parenteral drug delivery systems: an overview, Eur. J. Pharm. Biopharm, vol.58, pp.445-455, 2004. ,
, , 2013.
Histone deacetylase inhibitors and HIV latency, Curr. Opin. HIV AIDS, vol.6, pp.25-29, 2011. ,
, Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast Agents, vol.51, pp.9119-9122, 2012.