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Effets de la lumière bleue et du champ magnétique sur la synthèse des ROS par le cryptochrome

Abstract : Cryptochromes are photoreceptors that absorb blue light, they are found in animals and plants and have multiple signaling roles. In plants they can regulate growth, development, circadian rhythms or stress; in animals they also regulate circadian rhythms and stress responses. Their activation in the presence of blue light is reflected biochemically by the photoreduction of the flavin which is associated with these proteins, this cofactor then triggers a conformational change of the C-terminus domain that will allow the binding of cryptochromes to multiple partners responsible for signaling. Today, research on the functioning of cryptochromes is based on new fields of study, among them are their link with the ROS and their sensitivity to magnetic fields. In our work we show for the first time that animal cryptochromes can also directly synthesize some ROS after activation in blue light, and that this synthesis which is also observed in plants has a signaling role. Finally, we have linked their magnetoreception property with their ROS synthesis in animal cell models.
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  • HAL Id : tel-02885958, version 1

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Louis-David Arthaut. Effets de la lumière bleue et du champ magnétique sur la synthèse des ROS par le cryptochrome. Biologie moléculaire. Sorbonne Université, 2018. Français. ⟨NNT : 2018SORUS400⟩. ⟨tel-02885958⟩

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