C. Luo, J. Sun, B. Sun, and Z. He, Prodrug-Based Nanoparticulate Drug Delivery Strategies for Cancer Therapy, Trends in Pharmacological Sciences, issue.11, pp.556-566, 2014.

W. Ma, A. G. Cheetham, and H. Cui, Building Nanostructures with Drugs, Nano Today, vol.11, issue.1, pp.13-30, 2016.

F. Baldelli-bombelli, D. Berti, U. Keiderling, and P. Baglioni, Giant Polymerlike Micelles Formed by Nucleoside-Functionalized Lipids, The Journal of Physical Chemistry B, issue.44, pp.11613-11621, 2002.

A. Maksimenko, F. Dosio, J. Mougin, A. Ferrero, S. Wack et al., A Unique Squalenoylated and Nonpegylated Doxorubicin Nanomedicine with Systemic Long-Circulating Properties and Anticancer Activity, Proceedings of the National Academy of Sciences, vol.111, issue.2, pp.217-226, 2014.

H. Su, P. Zhang, A. G. Cheetham, J. M. Koo, R. Lin et al., Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells, Theranostics, vol.2016, issue.7, pp.1065-1074

T. Xiong, X. Li, Y. Zhou, Q. Song, R. Zhang et al., Glycosylation-Enhanced Biocompatibility of the Supramolecular Hydrogel of an Anti-Inflammatory Drug for Topical Suppression of Inflammation, Acta Biomaterialia, vol.73, pp.275-284, 2018.

Y. Zhou, L. Lei, Z. Zhang, R. Zhang, Q. Song et al., Cation Instructed Steroidal Prodrug Supramolecular Hydrogel, Journal of Colloid and Interface Science, vol.528, pp.10-17, 2018.

P. Couvreur, B. Stella, L. H. Reddy, H. Hillaireau, C. Dubernet et al., Cattel, L. Squalenoyl Nanomedicines as Potential Therapeutics, vol.6, pp.2544-2548, 2006.

L. Kotelevets, E. Chastre, J. Caron, J. Mougin, G. Bastian et al., A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer, Cancer Research, vol.77, issue.11, pp.2964-2975, 2017.

, Chapitre 1 : Revue bibliographique 67

D. Sobot, S. Mura, S. O. Yesylevskyy, L. Dalbin, F. Cayre et al., Conjugation of Squalene to Gemcitabine as Unique Approach Exploiting Endogenous Lipoproteins for Drug Delivery, Nature Communications, vol.8, p.15678, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01666114

A. Gaudin, M. Yemisci, H. Eroglu, S. Lepetre-mouelhi, O. F. Turkoglu et al., Squalenoyl Adenosine Nanoparticles Provide Neuroprotection after Stroke and Spinal Cord Injury, Nature Nanotechnology, vol.9, issue.12, pp.1054-1062, 2014.

J. Feng, S. Lepetre-mouelhi, A. Gautier, S. Mura, C. Cailleau et al., A New Painkiller Nanomedicine to Bypass the Blood-Brain Barrier and the Use of Morphine, Sci. Adv, vol.2019, issue.2, p.5148
URL : https://hal.archives-ouvertes.fr/tel-02463466

Y. Wang, A. G. Cheetham, G. Angacian, H. Su, L. Xie et al., Peptide-Drug Conjugates as Effective Prodrug Strategies for Targeted Delivery, Advanced Drug Delivery Reviews, pp.112-126, 2017.

M. Kang, P. Zhang, H. Cui, and S. M. Loverde, ?-? Stacking Mediated Chirality in Functional Supramolecular Filaments, Macromolecules, vol.49, issue.3, pp.994-1001, 2016.

A. G. Cheetham, Y. Ou, P. Zhang, and H. Cui, Linker-Determined Drug Release Mechanism of Free Camptothecin from Self-Assembling Drug Amphiphiles, Chem. Commun, vol.50, issue.45, pp.6039-6042, 2014.

M. J. Webber, J. B. Matson, V. K. Tamboli, and S. I. Stupp, Controlled Release of Dexamethasone from Peptide Nanofiber Gels to Modulate Inflammatory Response, Biomaterials, vol.2012, issue.28, pp.6823-6832

S. Das, H. Horo, U. Goswami, and L. M. Kundu, Synthesis of a Peptide Conjugated 5-Fluorouracil Gelator Prodrug for Photo-Controlled Release of the Antitumor Agent, ChemistrySelect, vol.2019, issue.22, pp.6778-6783

, Chapitre 1 : Revue bibliographique 68

J. Li, Y. Gao, Y. Kuang, J. Shi, X. Du et al., Dephosphorylation of D-Peptide Derivatives to Form Biofunctional

, Nanofibers/Hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy, vol.135, pp.9907-9914, 2013.

R. W. Chakroun, F. Wang, R. Lin, Y. Wang, H. Su et al., Fine-Tuning the Linear Release Rate of Paclitaxel-Bearing Supramolecular Filament Hydrogels through Molecular Engineering, ACS Nano, 2019.

W. A. Henne, D. D. Doorneweerd, A. R. Hilgenbrink, S. A. Kularatne, and P. S. Low, Synthesis and Activity of a Folate Peptide Camptothecin Prodrug, Bioorganic & Medicinal Chemistry Letters, vol.16, issue.20, pp.5350-5355, 2006.

S. Qin, M. Peng, L. Rong, B. Li, S. Wang et al., Self-Defensive Nano-Assemblies from Camptothecin-Based Antitumor Drugs, Regen Biomater, vol.2, issue.3, pp.159-166, 2015.

V. Bala, S. Rao, B. J. Boyd, and C. A. Prestidge, Prodrug and Nanomedicine Approaches for the Delivery of the Camptothecin Analogue SN38, Journal of Controlled Release, vol.172, issue.1, pp.48-61, 2013.

H. Zhao, C. Lee, P. Sai, Y. H. Choe, M. Boro et al., 20-O -Acylcamptothecin Derivatives: Evidence for Lactone Stabilization, J. Org. Chem, issue.15, pp.4601-4606, 2000.

H. Lerchen, J. Baumgarten, K. Bruch, T. E. Lehmann, M. Sperzel et al., Design and Optimization of 20-O-Linked Camptothecin Glycoconjugates as Anticancer Agents, J. Med. Chem, issue.24, pp.4186-4195, 2001.

Y. Li, X. Hu, X. Zheng, Y. Liu, S. Liu et al., Self-Assembled Organic Nanorods for Dual Chemo-Photodynamic Therapies, RSC Adv, vol.8, issue.10, pp.5493-5499, 2018.

E. A. Lefrak, J. Pi?ha, S. Rosenheim, and J. A. Gottlieb, A Clinicopathologic Analysis of Adriamycin Cardiotoxicity, Cancer, vol.32, issue.2, pp.302-314, 1973.

Y. Geng, P. Dalhaimer, S. Cai, R. Tsai, M. Tewari et al., Shape Effects of Filaments versus Spherical Particles in Flow and Drug Delivery, Nature Nanotechnology, vol.2, issue.4, pp.249-255, 2007.

D. A. Christian, S. Cai, O. B. Garbuzenko, T. Harada, A. L. Zajac et al.,

E. , Flexible Filaments for in Vivo Imaging and Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage, Molecular Pharmaceutics, vol.6, issue.5, pp.1343-1352, 2009.

Y. Li, Y. Lian, L. T. Zhang, S. M. Aldousari, H. S. Hedia et al., Cell and Nanoparticle Transport in Tumour Microvasculature: The Role of Size, Shape and Surface Functionality of Nanoparticles, Interface Focus, vol.6, issue.1, 2016.

J. A. Champion and S. Mitragotri, Shape Induced Inhibition of Phagocytosis of Polymer Particles, Pharmaceutical Research, vol.26, issue.1, pp.244-249, 2009.

J. Sun, L. Zhang, J. Wang, Q. Feng, D. Liu et al., Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake, Advanced Materials, vol.27, issue.8, pp.1402-1407, 2015.

K. Jelonek, S. Li, X. Wu, J. Kasperczyk, and A. Marcinkowski, Self-Assembled Filomicelles Prepared from Polylactide/Poly(Ethylene Glycol) Block Copolymers for Anticancer Drug Delivery, International Journal of Pharmaceutics, vol.485, issue.1-2, pp.357-364, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01684507

X. Wan, Y. Min, H. Bludau, A. Keith, S. S. Sheiko et al., Drug Combination Synergy in Worm-like Polymeric Micelles Improves Treatment Outcome for Small Cell and Non-Small Cell Lung Cancer, ACS, vol.12, issue.3, pp.2426-2439, 2018.

P. R. Nair, S. Karthick, K. R. Spinler, M. R. Vakili, A. Lavasanifar et al., Filomicelles from Aromatic Diblock Copolymers Increase Paclitaxel-Induced Tumor Cell Death and Aneuploidy Compared with Aliphatic Copolymers, Nanomedicine, vol.2016, issue.12, pp.1551-1569

A. Round, F. Felisaz, L. Fodinger, A. Gobbo, J. Huet et al., BioSAXS Sample Changer: A Robotic Sample Changer for Rapid and Reliable High-Throughput X-Ray Solution Scattering Experiments, Acta Crystallographica Section D Biological Crystallography, vol.71, issue.1, pp.67-75, 2015.

P. Pernot, A. Round, R. Barrett, A. De-maria-antolinos, A. Gobbo et al.,

, Beamline for SAXS on Macromolecules in Solution, Journal of Synchrotron Radiation, vol.20, issue.4, pp.660-664, 2013.

M. E. Brennich, J. Kieffer, G. Bonamis, A. De-maria-antolinos, S. Hutin et al., Online Data Analysis at the ESRF BioSAXS Beamline, BM29, Journal of Applied Crystallography, vol.49, issue.1, pp.203-212, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01283860

I. Breßler, J. Kohlbrecher, and A. F. Thünemann, SASfit : A Tool for Small-Angle Scattering Data Analysis Using a Library of Analytical Expressions, Journal of Applied Crystallography, vol.48, issue.5, pp.1587-1598, 2015.

S. O. Yesylevskyy, C. Ramseyer, M. Savenko, S. Mura, and P. Couvreur, Low-Density Lipoproteins and Human Serum Albumin as Carriers of Squalenoylated Drugs: Insights from Molecular Simulations, Molecular Pharmaceutics, vol.15, issue.2, pp.585-591, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01684377

, Langmuir, vol.2013, issue.48, pp.14795-14803

A. L. Kholodenko, Analytical Calculation of the Scattering Function for Polymers of Arbitrary Flexibility Using the Dirac Propagator, Macromolecules, vol.26, issue.16, pp.4179-4183, 1993.

J. S. Pedersen and P. Schurtenberger, Scattering Functions of Semiflexible Polymers with and without Excluded Volume Effects, Macromolecules, vol.29, issue.23, pp.7602-7612, 1996.

I. Bori?ev, J. Mr?anovic, D. Petrovic, M. Seke, D. Jovi? et al., Nanoformulations of Doxorubicin: How Far Have We Come and Where Do We Go from Here?, Nanotechnology, vol.2018, issue.33, p.332002

F. B. Bombelli, D. Berti, M. Almgren, G. Karlsson, and P. Baglioni, Light Scattering and Cryo-Transmission Electron Microscopy Investigation of the Self-Assembling Behavior of, p.12

, P-Nucleosides in Solution. The Journal of Physical Chemistry B, issue.35, pp.17627-17637, 2006.

A. Gissot, M. Camplo, M. W. Grinstaff, P. Barthélémy, and . Nucleoside, Nucleotide and Oligonucleotide Based Amphiphiles: A Successful Marriage of Nucleic Acids with Lipids
URL : https://hal.archives-ouvertes.fr/hal-02484364

, Organic & Biomolecular Chemistry, vol.6, issue.8, p.1324, 2008.

D. Berti, C. Montis, and P. Baglioni, Self-Assembly of Designer Biosurfactants, Soft Matter, vol.7, issue.16, pp.7150-7158, 2011.

J. Lei, Y. Chen, X. Feng, J. Jin, and J. Gu, Electrostatic Potentials of Camptothecin and Its Analogues, Theoretical Chemistry Accounts, issue.10, p.133, 2014.

G. Zhang, L. Zhang, D. Yang, N. Zhang, L. He et al., Salt Screening and Characterization of Ciprofloxacin, Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, vol.72, issue.1, pp.20-28, 2016.

Z. Zhao, A. Ukidve, V. Krishnan, and S. Mitragotri, Effect of Physicochemical and Surface Properties on in Vivo Fate of Drug Nanocarriers, Advanced Drug Delivery Reviews, vol.143, pp.3-21, 2019.

, Synthesis of squalenoyl-doxorubicin. Squalenoyl-doxorubicin hydrochloride (SQ-Dox) was synthesized as previously described 2 with some slight modifications

, 83 mmol) was added to a solution of daunorubicin hydrochloride

, mmol) dissolved in methanol/1,4-dioxane (v/v = 1:2, 12 mL). The reaction mixture was then stirred at room temperature for 20 min

, mL) and the solid residue was filtered and washed with ether (50 mL x 3). The solid was recrystallized from acetone/ether (v/v = 1:1, 10 mL), filtered off, washed with ether, and dried over P2O5 to give 14-bromo-daunorubicin (4, 0.19 g, 84 %) as a red solid (m.p. 176-177 °C). 14-Bromodaunorubicin (415.6 mg, 0.625 mmol) and 1,1?,2-tris-norsqualenoic acid (320 mg, 0.80 mmol) were dissolved in acetone (150 mL) under inert Argon atmosphere, mmol) solution. After stirring for 40 min at 30 °C, the resulting solution was poured into dry ether

, CH2Cl2-MeOH) to give a red powder (Scheme S1, 365.5 mg, 63 %). The target compound dissolved in anhydrous THF (325 mg in 22 mL) was then converted to hydrochloride salt by adding a anhydrous, titrated 1.64 M solution of HCl in dioxane (1.2 eq, 0.185 ml) and stirring at 20 °C for 2 h. The solvents were then removed and the red solid product was further purified by washing with diisopropylether, The solvent was evaporated and the crude product was purified by silica gel flash column chromatography, vol.95, p.303

, H-2), 5.46 (s, 1H, H-10), 5.3-5.25 (m, 2H, H-14a, H-14b) and 5.20 (s, 5H, C(sq-H)), 5.19 (s, 1H, The purity of SQ-Dox was checked by SiO2 TLC eluted CH2Cl2:MeOH:HCOOH:H2O (88:15:2:1, Rf 0,5) and by HPLC-MS. 1H NMR (methanol-d4): 8.02 (d, 1H, H-3), 7.87 (d, 1H, H-1), 7.70 (t, 1H

, HPLC: Waters XTerra RP-18 column eluted with water, methanol, (starting 50:50, and then after 7 min gradient up to 100 % methanol, 15 min) plus formic acid 0.05 %, elution time 28, p.95

, Chapitre 2 : Article de recherche

, The elution was monitored at 234 and 480 nm using a Waters 2996 Photodiode Array detector

. Esi-ms, Waters micromass) m/z calculated for

, Cl, 3.68; N, 1.46; found C 67, p.42

, Scheme S1. SQ-Dox synthesis Spectroscopic characterization of Dox and SQ-Dox. Dox and SQ-Dox solutions were prepared at a concentration of 104 µM in water and loaded into a quartz cell. Absorbance profiles were obtained using a LS25 Spectrophotometer (Perkin Elmer). Fluorescence profiles were obtained using a LS-50B luminescence spectrometer, p.61

, The compression properties of a SQ-Dox monolayer were characterized at a constant temperature of 293K using a computer-controlled KSV-Nima Langmuir-Blodgett balance coupled to a Wilhelmy plate Device (Biolin Scientific). 100 ?L of a 1 mg mL -1 SQ-Dox solution in CHCl3:MeOH (9:1 v:v) was spread onto pure water

P. Changenet-barret, T. Gustavsson, D. Markovitsi, I. Manet, and S. Monti, Unravelling Molecular Mechanisms in the Fluorescence Spectra of Doxorubicin in Aqueous Solution by Femtosecond Fluorescence Spectroscopy, Physical Chemistry Chemical Physics, vol.15, issue.8, pp.2937-2944, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00807306

S. Kumar, J. M. Rosenberg, D. Bouzida, R. H. Swendsen, and P. A. Kollman, THE Weighted Histogram Analysis Method for Free-Energy Calculations on Biomolecules. I. The Method, Journal of Computational Chemistry, vol.13, issue.8, pp.1011-1021, 1992.

M. J. Abraham, T. Murtola, R. Schulz, S. Páll, J. C. Smith et al., High Performance Molecular Simulations through Multi-Level Parallelism from Laptops to Supercomputers, 2015.

D. Van-der-spoel, E. Lindahl, B. Hess, G. Groenhof, A. E. Mark et al., GROMACS: Fast, Flexible, and Free, Journal of Computational Chemistry, vol.26, issue.16, pp.1701-1718, 2005.

S. O. Yesylevskyy, T. Rivel, and C. Ramseyer, The Influence of Curvature on the Properties of the Plasma Membrane. Insights from Atomistic Molecular Dynamics Simulations, Scientific Reports, vol.7, issue.1, p.16078, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01666113

S. O. Yesylevskyy, Pteros: Fast and Easy to Use Open-Source C++ Library for Molecular Analysis, Journal of Computational Chemistry, vol.2012, issue.19, pp.1632-1636

S. O. Yesylevskyy, Pteros 2.0: Evolution of the Fast Parallel Molecular Analysis Library for C++ and Python, Journal of Computational Chemistry, vol.36, issue.19, pp.1480-1488, 2015.

W. Humphrey, A. Dalke, and K. Schulten, VMD: Visual Molecular Dynamics, Journal of Molecular Graphics, vol.14, issue.1, pp.33-38, 1996.

. Vi and . References,

P. Couvreur, B. Stella, L. H. Reddy, H. Hillaireau, C. Dubernet et al.,

S. Mouelhi, F. Rocco, N. Dereuddre-bosquet, P. Clayette, V. Rosilio et al., Squalenoyl Nanomedicines as Potential Therapeutics, Nano Letters, vol.6, issue.11, pp.2544-2548, 2006.

L. Kotelevets, E. Chastre, J. Caron, J. Mougin, G. Bastian et al., A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer, Cancer Research, vol.77, issue.11, pp.2964-2975, 2017.

Y. Geng, P. Dalhaimer, S. Cai, R. Tsai, M. Tewari et al., Shape Effects of Filaments versus Spherical Particles in Flow and Drug Delivery, Nature Nanotechnology, vol.2, issue.4, pp.249-255, 2007.

J. A. Champion and S. Mitragotri, Role of Target Geometry in Phagocytosis, Proceedings of the National Academy of Sciences, pp.4930-4934, 2006.

J. A. Champion and S. Mitragotri, Shape Induced Inhibition of Phagocytosis of Polymer Particles, Pharmaceutical Research, vol.26, issue.1, pp.244-249, 2009.

J. Israelachvili and I. Ladyzhinski, The Physico-Chemical Basis of Self-Assembling Structures, Forces, vol.160, pp.1-28, 2005.

A. Ben-shaul and S. May, Molecular Packing in Cylindrical Micelles, Giant Micelles, pp.41-79, 2007.

M. Menozzi, L. Valentini, E. Vannini, and F. Arcamone, Self-Association of Doxorubicin and Related Compounds in Aqueous Solution, Journal of Pharmaceutical Sciences, issue.6, pp.766-770, 1984.

P. Agrawal, S. K. Barthwal, and R. Barthwal, Studies on Self-Aggregation of Anthracycline Drugs by Restrained Molecular Dynamics Approach Using Nuclear Magnetic Resonance Spectroscopy Supported by Absorption, Fluorescence, Diffusion Ordered Spectroscopy and Mass Spectrometry, European Journal of Medicinal Chemistry, vol.44, issue.4, pp.1437-1451, 2009.

M. Zhao, Y. Zhang, C. Zou, C. Dai, M. Gao et al., Can More Nanoparticles Induce Larger Viscosities of Nanoparticle-Enhanced Wormlike Micellar System (NEWMS)? Materials, vol.10, p.1096, 2017.

R. Nagarajan, K. M. Shah, and S. Hammond, Viscometric Detection of Sphere to Cylinder Transition and Polydispersity in Aqueous Micellar Solutions, Colloids and Surfaces, vol.4, issue.2, pp.147-162, 1982.

G. Porte and J. Appell, Growth and Size Distributions of Cetylpyridinium Bromide Micelles in High Ionic Strength Aqueous Solutions, The Journal of Physical Chemistry, vol.85, issue.17, pp.2511-2519, 1981.

L. C. Salay and S. Schreier, Effect of a Kosmotropic Ion on Doxorubicin Self-Assembly and Interaction with Biomimetic Systems, Surface and Colloid Science, pp.156-158, 2004.

C. Yang, D. Wu, W. Zhao, W. Ye, Z. Xu et al., Anion-Induced Self-Assembly of Positively Charged Polycyclic Aromatic Hydrocarbons towards Nanostructures with Controllable Two-Dimensional Morphologies, CrystEngComm, vol.2016, issue.6, pp.877-880

J. Caron, A. Maksimenko, S. Wack, E. Lepeltier, C. Bourgaux et al., Improving the Antitumor Activity of Squalenoyl-Paclitaxel Conjugate Nanoassemblies by Manipulating the Linker between Paclitaxel and Squalene

, Advanced Healthcare Materials, vol.2013, issue.1, pp.172-185

D. Berti, F. Baldelli-bombelli, M. Fortini, and P. Baglioni, Amphiphilic Self-Assemblies Decorated by Nucleobases, The Journal of Physical Chemistry B, issue.40, pp.11734-11744, 2007.

F. Baldelli-bombelli, D. Berti, S. Milani, M. Lagi, P. Barbaro et al., Collective Headgroup Conformational Transition in Twisted Micellar Superstructures, Soft Matter, issue.5, p.4, 2008.

J. ?-mougin, S. O. Yesylevskyy, C. Bourgaux, D. Chapron, J. Michel et al., Stacking as a Key Property for Creating Nanoparticles with Tunable Shape: The Case of Squalenoyl-Doxorubicin, ACS Nano, vol.127, issue.11, pp.12870-12879, 2019.

D. Vinciguerra, M. Jacobs, S. Denis, J. Mougin, Y. Guillaneuf et al.,

S. Mura, P. Couvreur, and J. Nicolas, Heterotelechelic Polymer Prodrug Nanoparticles: Adaptability to Different Drug Combinations and Influence of the Dual Functionalization on the Cytotoxicity, Journal of Controlled Release, vol.295, pp.223-236, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02093429

M. ?-rouquette, S. Lepetre-mouelhi, O. Dufrançais, X. Yang, J. Mougin et al.,

S. Garcia-argote, A. P. Ijzerman, P. Couvreur, D. Vinciguerra, A. Degrassi et al., Squalene-Adenosine Nanoparticles: Ligands or Prodrug?, Journal of Pharmacology and Experimental Therapeutics, vol.2019, issue.1, pp.144-151

Y. Bao and E. Guégain, Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for in Vivo Imaging and Cancer Cell Targeting, vol.2019, pp.2464-2476, 2018.

, Paclitaxel Polymer Prodrug Nanoparticles for Cancer Therapy, Polymer Chemistry, vol.9, issue.6, pp.687-698, 2018.

D. Vinciguerra, S. Denis, J. Mougin, M. Jacobs, Y. Guillaneuf et al.,

J. Nicolas, D. Sobot, S. Mura, S. O. Yesylevskyy, L. Dalbin et al., A Facile Route to Heterotelechelic Polymer Prodrug Nanoparticles for Imaging, Drug Delivery and Combination Therapy, Journal of Controlled Release, vol.286, pp.425-438, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02093423

D. Desmaële, S. Lepetre-mouelhi, G. Pieters, B. Andreiuk, A. S. Klymchenko et al., Conjugation of Squalene to Gemcitabine as Unique Approach Exploiting Endogenous Lipoproteins for Drug Delivery, Nature Communications, vol.8, issue.11, pp.2964-2975, 2016.

B. Stella, D. Desmaële, P. Couvreur, A. Gaudin, S. Lepetre-mouelhi et al., Vitro Investigation of Multidrug Nanoparticles for Combined Therapy with Gemcitabine and a Tyrosine Kinase Inhibitor: Together Is Not Better, vol.130, pp.4-13, 2015.

O. Loreau, J. Goncalves, H. Chacun, Y. Courbebaisse, P. Clayette et al.,

, Adenosine Nanoparticles in Mice Using Dual Radio-Labeling and Radio-HPLC Analysis, Journal of Controlled Release, vol.212, pp.50-58, 2015.

N. ?-abed, F. Saïd-hassane, F. Zouhiri, J. Mougin, V. Nicolas et al.,

P. Couvreur, A. Gaudin, O. Tagit, D. Sobot, S. Lepetre-mouelhi et al., An Efficient System for Intracellular Delivery of Beta-Lactam Antibiotics to Overcome Bacterial Resistance, Scientific Reports, vol.5, issue.1, p.13500, 2015.

K. Braeckmans, V. Nicolas, D. Desmaële, S. C. De-smedt, N. Hildebrandt et al.,

K. , Transport Mechanisms of Squalenoyl-Adenosine Nanoparticles Across the Blood-Brain Barrier, Chemistry of Materials, vol.27, pp.3636-3647, 2015.

A. Maksimenko, J. Caron, J. Mougin, D. Desmaële, and P. Couvreur, Gemcitabine-Based Therapy for Pancreatic Cancer Using the Squalenoyl Nucleoside Monophosphate Nanoassemblies, International Journal of Pharmaceutics, vol.482, issue.1-2, pp.38-46, 2015.

E. Buchy, S. Valetti, S. Mura, J. Mougin, C. Troufflard et al., Synthesis and Cytotoxic Activity of Self-Assembling Squalene Conjugates of 3-[(Pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one Anticancer Agents: Self-Assembling Squalene Conjugates of Anticancer Agents, European Journal of Organic Chemistry, issue.1, pp.202-212, 2014.

B. Caban, S. Sargon, M. F. Garcia-argote, S. Pieters, G. Loreau et al., Squalenoyl Adenosine Nanoparticles Provide Neuroprotection After Stroke and Spinal Cord Injury, Nature Nanotechnology, vol.2014, issue.12, pp.1054-1062

N. Mackiewicz, J. Nicolas, N. Handké, M. Noiray, J. Mougin et al.,

R. Bazile, D. Couvreur, and P. , Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging, Chemistry of Materials, vol.26, issue.5, pp.1834-1847, 2014.

A. Maksimenko, M. Alami, F. Zouhiri, J. Brion, A. Pruvost et al., Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy, ACS Nano, vol.8, issue.3, pp.2018-2032, 2014.

J. Caron, A. Maksimenko, J. Mougin, P. Couvreur, and D. Desmaële, Combined Antitumoral Therapy with Nanoassemblies of Bolaform Polyisoprenoyl Paclitaxel/Gemcitabine Prodrugs, Polymer Chemistry, vol.5, issue.5, pp.1662-1673, 2014.

A. Maksimenko, F. Dosio, J. Mougin, A. Ferrero, S. Wack et al.,

E. Lepeltier, C. Bourgaux, B. Stella, L. Cattel, P. Couvreur et al., A Unique Squalenoylated and Nonpegylated Doxorubicin Nanomedicine with Systemic Long-Circulating Properties and Anticancer Activity, Proceedings of the National Academy of Sciences, vol.111, issue.2, pp.217-226, 2013.

J. Caron, E. Sliwinski, A. Lepape, D. Desmaële, and P. Couvreur, Novel Isoprenoyl Nanoassembled Prodrug for Paclitaxel Delivery, Bioconjugate Chemistry, vol.24, issue.11, pp.1840-1849, 2013.

A. Maksimenko, J. Mougin, S. Mura, E. Sliwinski, E. Lepeltier et al., Polyisoprenoyl Gemcitabine Conjugates Self Assemble as Nanoparticles, Useful for Cancer Therapy, Cancer Letters, vol.334, issue.2, pp.346-353, 2013.

S. ?-harrisson, J. Nicolas, A. Maksimenko, D. T. Bui, J. Mougin et al.,

, Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization, vol.52, pp.1678-1682, 2013.