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Contribution to physico-chemical studies of squalenoylated nanomedicines for cancer treatment

Abstract : Previous research in Pr. Patrick Couvreur’s team (Institut Galien Paris-Sud) has designed a therapeutic nanomedicine made of doxorubicin chlorhydrate conjugated to squalene, a natural and biocompatible lipid. Compared to free doxorubicin, this nanomedicine presented an increased anticancer activity, a prolonged plasmatic circulation time and a strongly reduced cardiac toxicity, one of the most important limitations of doxorubicin use in clinical studies. These improvements have been attributed to the particular “loop-train” elongated structure of these nanoparticles which, by increasing the plasmatic half-life of Dox, may avoid massive uptake by liver and spleen macrophages to accumulate in tumor.But the mechanism allowing the formation of these elongated structures remained completely unknown, and this has been extensively investigated in the current thesis by using physico-chemical techniques (cryo-TEM, X-ray scattering, etc) as well as molecular modelling.
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Submitted on : Tuesday, June 30, 2020 - 2:49:29 PM
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Julie Mougin. Contribution to physico-chemical studies of squalenoylated nanomedicines for cancer treatment. Theoretical and/or physical chemistry. Université Paris-Saclay, 2020. English. ⟨NNT : 2020UPASS038⟩. ⟨tel-02885220⟩

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