L. J. Jin, I. B. Lamster, J. S. Greenspan, N. B. Pitts, C. Scully et al., Global burden of oral diseases: Emerging concepts, management and interplay with systemic health, Oral Dis, vol.22, pp.609-619, 2016.

M. S. Tonetti, S. Jepsen, L. Jin, and J. Otomo-corgel, Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action, J. Clin. Periodontol, vol.44, pp.456-462, 2017.

D. D. Bosshardt, The periodontal pocket: Pathogenesis, histopathology and consequences. Periodontology, vol.76, pp.43-50, 2018.

M. E. Nunn, J. Fan, X. Su, R. A. Levine, H. Lee et al., Development of prognostic indicators using classification and regression trees for survival, vol.58, pp.134-142, 2012.

D. F. Kinane, P. G. Stathopoulou, and P. N. Papapanou, Periodontal diseases, Nat. Rev. Dis. Primer, vol.3, 2017.

I. Olsen, J. D. Lambris, and G. Hajishengallis, Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function, J. Oral Microbiol, vol.9, 2017.

M. Feres, L. C. Figueiredo, G. M. Soares, and M. Faveri, Systemic antibiotics in the treatment of periodontitis, Periodontology, vol.67, pp.131-186, 2015.

R. Martin-cabezas, J. Davideau, H. Tenenbaum, and O. Huck, Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: A systematic review and meta-analysis, J. Clin. Periodontol, vol.43, pp.520-530, 2016.

L. J. Heitz-mayfield and N. P. Lang, Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts, Periodontology, vol.62, pp.218-231, 2013.

S. Ivanovski, C. Vaquette, S. Gronthos, D. W. Hutmacher, and P. M. Bartold, Multiphasic scaffolds for periodontal tissue engineering, J. Dent. Res, vol.93, pp.1212-1221, 2014.

D. D. Bosshardt and A. Sculean, Does periodontal tissue regeneration really work? Periodontology, vol.51, pp.208-219, 2009.

P. Cortellini, J. Buti, G. Pini-prato, and M. S. Tonetti, Periodontal regeneration compared with access flap surgery in human intra-bony defects 20-year follow-up of a randomized clinical trial: Tooth retention, periodontitis recurrence and costs, J. Clin. Periodontol, vol.44, pp.58-66, 2017.

S. Ravi, S. Malaiappan, S. Varghese, N. D. Jayakumar, and G. Prakasam, Additive Effect of Plasma Rich in Growth Factors with Guided Tissue Regeneration in Treatment of Intrabony Defects in Patients with Chronic Periodontitis: A Split-Mouth Randomized Controlled Clinical Trial, J. Periodontol, vol.88, pp.839-845, 2017.

N. Jenabian, S. Haghanifar, H. Ehsani, E. Zahedi, and M. Haghpanah, Guided tissue regeneration and platelet rich growth factor for the treatment of Grade II furcation defects: A randomized double-blinded clinical trial-A pilot study, Dent. Res. J, vol.14, pp.363-369, 2017.

M. C. Bottino and V. Thomas, Membranes for Periodontal Regeneration-A Materials Perspective, Front. Oral Biol, vol.17, pp.90-100, 2015.

L. C. Parrish, T. Miyamoto, N. Fong, J. S. Mattson, and D. R. Cerutis, Non-bioabsorbable vs. bioabsorbable membrane: Assessment of their clinical efficacy in guided tissue regeneration technique. A systematic review, J. Oral Sci, vol.51, pp.383-400, 2009.

N. Yoshinari, T. Tohya, A. Mori, M. Koide, H. Kawase et al., Inflammatory cell population and bacterial contamination of membranes used for guided tissue regenerative procedures, J. Periodontol, vol.69, pp.460-469, 1998.

M. Ranjbar-mohammadi, M. Zamani, M. P. Prabhakaran, S. H. Bahrami, and S. Ramakrishna, Electrospinning of PLGA/gum tragacanth nanofibers containing tetracycline hydrochloride for periodontal regeneration, Mater. Sci. Eng. C Mater. Biol. Appl, vol.58, pp.521-531, 2016.

S. Yamano, K. Haku, T. Yamanaka, J. Dai, T. Takayama et al., The effect of a bioactive collagen membrane releasing PDGF or GDF-5 on bone regeneration, Biomaterials, vol.35, pp.2446-2453, 2014.

M. Yar, A. Farooq, L. Shahzadi, A. S. Khan, N. Mahmood et al., Novel meloxicam releasing electrospun polymer/ceramic reinforced biodegradable membranes for periodontal regeneration applications, Mater. Sci. Eng. C Mater. Biol. Appl, vol.64, pp.148-156, 2016.

D. N. Morand, J. Davideau, F. Clauss, N. Jessel, H. Tenenbaum et al., Cytokines during periodontal wound healing: Potential application for new therapeutic approach, Oral Dis, vol.23, pp.300-311, 2017.

A. Cekici, A. Kantarci, H. Hasturk, and T. E. Van-dyke, Inflammatory and immune pathways in the pathogenesis of periodontal disease, Periodontology, vol.64, pp.57-80, 2014.

U. Brägger, T. Mühle, I. Fourmousis, N. P. Lang, and A. Mombelli, Effect of the NSAID flurbiprofen on remodelling after periodontal surgery, J. Periodontal Res, vol.32, pp.575-582, 1997.

K. Agossa, D. Morand, H. Tenenbaum, J. Davideau, and O. Huck, Systemic Application of Anti-inflammatory Agents in Periodontal Treatment, Clin. Anti-Inflamm. Anti-Allergy Drugs, vol.2, p.30, 2015.

C. X. Lam, M. M. Savalani, S. Teoh, and D. W. Hutmacher, Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: Accelerated versus simulated physiological conditions, Biomed. Mater, vol.3, p.34108, 2008.

D. Liang, B. S. Hsiao, and B. Chu, Functional electrospun nanofibrous scaffolds for biomedical applications, Adv. Drug Deliv. Rev, vol.59, pp.1392-1412, 2007.

G. E. Salvi and N. P. Lang, The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases, Curr. Pharm. Des, vol.11, pp.1757-1769, 2005.

S. B. Bozkurt, S. S. Hakki, E. E. Hakki, Y. Durak, and A. Kantarci, Porphyromonas gingivalis Lipopolysaccharide Induces a Pro-inflammatory Human Gingival Fibroblast Phenotype, vol.40, pp.144-153, 2017.

T. Ara, K. Kurata, K. Hirai, T. Uchihashi, T. Uematsu et al., Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease, J. Periodontal Res, vol.44, pp.21-27, 2009.

P. Hu, P. Huang, and M. W. Chen, Curcumin attenuates cyclooxygenase-2 expression via inhibition of the NF-?B pathway in lipopolysaccharide-stimulated human gingival fibroblasts, Cell Biol. Int, vol.37, pp.443-448, 2013.

R. Mcclure and P. Massari, TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens, Front. Immunol, vol.5, 2014.

S. W. Spiekstra, M. Breetveld, T. Rustemeyer, R. J. Scheper, and S. Gibbs, Wound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes. Wound Repair Regen, vol.15, pp.708-717, 2007.

L. Kocgozlu, R. Elkaim, H. Tenenbaum, and S. Werner, Variable cell responses to P. gingivalis lipopolysaccharide, J. Dent. Res, vol.88, pp.741-745, 2009.

P. Wang and K. Ohura, Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors, Crit. Rev. Oral Biol. Med. Off. Publ. Am. Assoc. Oral Biol, vol.13, pp.132-142, 2002.

I. Cantón, R. Mckean, M. Charnley, K. A. Blackwood, C. Fiorica et al., Development of an Ibuprofen-releasing biodegradable PLA/PGA electrospun scaffold for tissue regeneration, Biotechnol. Bioeng, vol.105, pp.396-408, 2010.

A. Kasaj, C. Reichert, H. Götz, B. Röhrig, R. Smeets et al., In vitro evaluation of various bioabsorbable and nonresorbable barrier membranes for guided tissue regeneration, Head Face Med, 2008.

H. Larjava, L. Koivisto, L. Häkkinen, and J. Heino, Epithelial integrins with special reference to oral epithelia, J. Dent. Res, vol.90, pp.1367-1376, 2011.

H. G. Gräber, G. Conrads, J. Wilharm, and F. Lampert, Role of interactions between integrins and extracellular matrix components in healthy epithelial tissue and establishment of a long junctional epithelium during periodontal wound healing: A review, J. Periodontol, vol.70, pp.1511-1522, 1999.

C. Preeja, P. Janam, and B. R. Nayar, Fibrin clot adhesion to root surface treated with tetracycline hydrochloride and ethylenediaminetetraacetic acid: A scanning electron microscopic study, Dent. Res. J, vol.10, pp.382-388, 2013.

M. Fairweather, Y. I. Heit, J. Buie, L. M. Rosenberg, A. Briggs et al., Celecoxib inhibits early cutaneous wound healing, J. Surg. Res, vol.194, pp.717-724, 2015.

C. H. Kim, M. S. Khil, H. Y. Kim, H. U. Lee, and K. Y. Jahng, An improved hydrophilicity via electrospinning for enhanced cell attachment and proliferation, J. Biomed. Mater. Res. B Appl. Biomater, vol.78, pp.283-290, 2006.

P. Fabbri, F. Bondioli, M. Messori, C. Bartoli, D. Dinucci et al., Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering, J. Mater. Sci. Mater. Med, vol.21, pp.343-351, 2010.

J. Chen and Y. Chang, Preparation and characterization of composite nanofibers of polycaprolactone and nanohydroxyapatite for osteogenic differentiation of mesenchymal stem cells, Colloids Surf. B Biointerfaces, vol.86, pp.169-175, 2011.

M. I. Hassan and N. Sultana, Characterization, drug loading and antibacterial activity of nanohydroxyapatite/ polycaprolactone (nHA/PCL) electrospun membrane, vol.7, 2017.

M. F. Groppo, P. H. Caria, A. R. Freire, S. R. Figueroba, W. A. Ribeiro-neto et al., The effect of a hydroxyapatite impregnated PCL membrane in rat subcritical calvarial bone defects, Arch. Oral Biol, vol.82, pp.209-215, 2017.

S. Park, T. Kim, Y. Ku, C. Chung, S. Han et al., Effect of hydroxyapatite-coated nanofibrous membrane on the responses of human periodontal ligament fibroblast, J. Ceram. Soc. Jpn, vol.116, pp.31-35, 2008.

P. Bonilla, C. E. Trujillo, S. Demirdögen, B. Perilla, J. E. Murat-elcin et al., New porous polycaprolactone-silica composites for bone regeneration, Mater. Sci. Eng. C, vol.40, pp.418-426, 2014.

O. Petrauskaite, P. D. Gomes, M. H. Fernandes, G. Juodzbalys, A. Stumbras et al., Biomimetic mineralization on a macroporous cellulose-based matrix for bone regeneration, BioMed. Res. Int, 2013.

K. Saadi-thiers, O. Huck, P. Simonis, P. Tilly, J. Fabre et al., Periodontal and systemic responses in various mice models of experimental periodontitis: Respective roles of inflammation duration and Porphyromonas gingivalis infection, J. Periodontol, vol.84, pp.396-406, 2013.

R. S. De-molon, V. I. Mascarenhas, E. D. De-avila, L. S. Finoti, G. B. Toffoli et al., Long-term evaluation of oral gavage with periodontopathogens or ligature induction of experimental periodontal disease in mice, Clin. Oral Investig, vol.20, pp.1203-1216, 2016.

N. Y. Karimbux, N. S. Ramamurthy, L. M. Golub, and I. Nishimura, The expression of collagen I and XII mRNAs in Porphyromonas gingivalis-induced periodontitis in rats: The effect of doxycycline and chemically modified tetracycline, J. Periodontol, vol.69, pp.34-40, 1998.

T. Abe and G. Hajishengallis, Optimization of the ligature-induced periodontitis model in mice, J. Immunol. Methods, vol.394, pp.49-54, 2013.

S. Kimura, A. Nagai, T. Onitsuka, T. Koga, T. Fujiwara et al., Induction of experimental periodontitis in mice with Porphyromonas gingivalis-adhered ligatures, J. Periodontol, vol.71, pp.1167-1173, 2000.

M. Noordijk, J. Davideau, S. Eap, O. Huck, F. Fioretti et al., Bone defects and future regenerative nanomedicine approach using stem cells in the mutant Tabby mouse model, Biomed. Mater. Eng, vol.25, pp.111-119, 2015.

M. Cicciù, Real Opportunity for the Present and a Forward Step for the Future of Bone Tissue Engineering, J. Craniofac. Surg, vol.28, pp.592-593, 2017.

I. M. Bugueno, F. Batool, L. Korah, N. Benkirane-jessel, and O. Huck, Porphyromonas gingivalis differentially modulates apoptosome APAF-1 in epithelial cells and fibroblasts, Am. J. Pathol, 2017.

D. F. Kinane, P. G. Stathopoulou, and P. N. Papapanou, Periodontal diseases, Nature Reviews Disease Primers, vol.3, p.17038, 2017.

A. Cekici, A. Kantarci, H. Hasturk, and T. E. Van-dyke, Inflammatory and immune pathways in the pathogenesis of periodontal disease, Periodontology, vol.64, issue.1, pp.57-80, 2000.

I. Olsen, J. D. Lambris, and G. Hajishengallis, Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function, Journal of Oral Microbiology, vol.9, issue.1, p.1340085, 2017.

C. M. Cobb, Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing, Journal of Clinical Periodontology, vol.29, issue.2, pp.22-32, 2002.

K. Agossa, D. N. Morand, H. Tenenbaum, J. L. Davideau, and O. Huck, Systemic application of anti-inflammatory agents in periodontal treatment, Clinical Anti-Inflammatory & Anti-Allergy Drugs, vol.2, issue.1, pp.3-13, 2016.

Z. Akram, T. Abduljabbar, S. V. Kellesarian, M. I. Hassan, F. Javed et al., Efficacy of bisphosphonate as an adjunct to nonsurgical periodontal therapy in the management of periodontal disease: a systematic review, British Journal of Clinical Pharmacology, vol.83, issue.3, pp.444-454, 2017.

A. Alshammari, J. Patel, and J. Hashemi, Kava-241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis, Journal of Clinical Periodontology, vol.44, issue.11, pp.1123-1132, 2017.

S. R. Gokhale and A. M. Padhye, Future prospects of systemic host modulatory agents in periodontal therapy, British Dental Journal, vol.214, issue.9, pp.467-471, 2013.

R. Martin-cabezas, J. L. Davideau, H. Tenenbaum, and O. Huck, Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: a systematic review and meta-analysis, Journal of Clinical Periodontology, vol.43, issue.6, pp.520-530, 2016.

I. M. Estanislau, I. R. Terceiro, and M. R. Lisboa, Pleiotropic effects of statins on the treatment of chronic periodontitis -a systematic review, British Journal of Clinical Pharmacology, vol.79, issue.6, pp.877-885, 2015.

E. Martin-ruiz, A. Olry-de-labry-lima, R. Ocaña-riola, and D. Epstein, Systematic review of the effect of adherence to statin treatment on critical cardiovascular events and mortality in primary prevention, Journal of Cardiovascular Pharmacology and Therapeutics, vol.23, issue.3, pp.200-215, 2018.

L. Pasin, G. Landoni, and M. L. Castro, The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials, PLoS One, vol.8, issue.12, p.82775, 2013.

C. W. Fong, Statins in therapy: understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic stability based on electrostatic molecular orbital studies, European Journal of Medicinal Chemistry, vol.85, pp.661-674, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01344986

M. Margaritis, F. Sanna, and C. Antoniades, Statins and oxidative stress in the cardiovascular system, Current Pharmaceutical Design, vol.23, issue.46, pp.7040-7047, 2017.

K. Sakoda, M. Yamamoto, Y. Negishi, J. K. Liao, K. Node et al., Simvastatin decreases IL-6 and IL-8 production in epithelial cells, Journal of Dental Research, vol.85, issue.6, pp.520-523, 2006.

E. J. Whitaker and A. Alshammari, Bacteriostatic effect of simvastatin on selected oral streptococci in vitro, Contemporary Clinical Dentistry, vol.8, pp.59-63, 2017.

R. Zeiser, Immune modulatory effects of statins, Immunology, vol.154, issue.1, pp.69-75, 2018.

H. Zhou, Y. Xie, Z. Baloch, Q. Shi, Q. Huo et al., The effect of atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (HMG-CoA), on the prevention of osteoporosis in ovariectomized rabbits, Journal of Bone and Mineral Metabolism, vol.35, issue.3, pp.245-254, 2017.

V. Cicek-ari, Y. D. Ilarslan, and B. Erman, Statins and IL-1?, IL-10, and MPO levels in gingival crevicular fluid: preliminary results, Inflammation, vol.39, issue.4, pp.1547-1557, 2016.

A. R. Pradeep, V. Garg, D. Kanoriya, and S. Singhal, 1.2% rosuvastatin versus 1.2% atorvastatin gel local drug delivery and redelivery in treatment of intrabony defects in chronic periodontitis: a randomized placebo-controlled clinical trial, Journal of Periodontology, vol.87, issue.7, pp.756-762, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02388970

G. Vemanaradhya, S. Emani, D. S. Mehta, and S. Bhandari, Effect of 1.2% of simvastatin gel as a local drug delivery system on gingival crevicular fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic periodontitis patients, Archives of Oral Biology, vol.82, pp.55-61, 2017.

A. I. Özdo?an, Y. D. ?larslan, and K. Kösemehmeto?lu, In vivo evaluation of chitosan based local delivery systems for atorvastatin in treatment of periodontitis, International Journal of Pharmaceutics, vol.550, issue.1-2, pp.470-476, 2018.

D. Pankaj, I. Sahu, I. G. Kurian, and A. R. Pradeep, Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial, Journal of Periodontology, vol.89, issue.11, pp.1318-1325, 2018.

D. T. Graves, J. Li, and D. L. Cochran, Inflammation and uncoupling as mechanisms of periodontal bone loss, Journal of Dental Research, vol.90, issue.2, pp.143-153, 2011.

F. Y. K?rz?o?lu, M. Bulut, and B. Do?an, Anti-inflammatory effect of rosuvastatin decreases alveolar bone loss in experimental periodontitis, Journal of Oral Science, vol.59, issue.2, pp.247-255, 2017.

L. H. Sousa, E. V. Linhares, and J. T. , Effects of atorvastatin on periodontitis of rats subjected to glucocorticoid-induced osteoporosis, Journal of Periodontology, vol.87, issue.10, pp.1206-1216, 2016.

K. Pahan, Lipid-lowering drugs, Cellular and Molecular Life Sciences, vol.63, issue.10, pp.1165-1178, 2006.

P. E. Lazzerini, C. Capperucci, and A. Spreafico, Rosuvastatin inhibits spontaneous and IL-1?-induced interleukin-6 production from human cultured osteoblastic cells, Joint, Bone, Spine, vol.80, issue.2, pp.195-200, 2013.

M. Arora, L. Chen, and M. Paglia, Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells, Proceedings of the National Academy of Sciences of the United States of America, vol.103, pp.7777-7782, 2006.

E. Mira, B. Leon, and D. F. Barber, Statins induce regulatory T cell recruitment via a CCL1 dependent pathway, The Journal of Immunology, vol.181, issue.5, pp.3524-3534, 2008.

R. Fernandes-de-araújo, T. Oliveira, L. Souza, and . Moreno-de-moura, Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis, PLoS One, vol.8, issue.10, p.75322, 2013.

J. Jin, E. R. Machado, and H. Yu, Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome, Journal of Dental Research, vol.93, issue.3, pp.294-299, 2014.

J. Jin, X. Zhang, and Z. Lu, Simvastatin inhibits lipopolysaccharide-induced osteoclastogenesis and reduces alveolar bone loss in experimental periodontal disease, Journal of Periodontal Research, vol.49, issue.4, pp.518-526, 2014.

W. M. Machado, A. P. Prestes, and T. P. Costa, The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis, Journal of Periodontal Research, vol.49, issue.5, pp.634-641, 2014.

P. O. Nassar, C. A. Nassar, and M. R. Guimarães, Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats, Journal of Periodontal Research, vol.44, issue.4, pp.479-488, 2009.

D. Morand, J. L. Davideau, F. Clauss, N. Jessel, H. Tenenbaum et al., Cytokines during periodontal wound healing: potential application for new therapeutic approach, Oral Diseases, vol.23, issue.3, pp.300-311, 2017.

T. E. Van-dyke, H. Hasturk, and A. Kantarci, Proresolving nanomedicines activate bone regeneration in periodontitis, Journal of Dental Research, vol.94, issue.1, pp.148-156, 2015.

H. Hasturk, A. Kantarci, and T. Ohira, RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis, The FASEB Journal, vol.20, issue.2, pp.401-403, 2006.

M. Spite and C. N. Serhan, Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins, Circulation Research, vol.107, issue.10, pp.1170-1184, 2010.

P. Goes, I. M. Melo, and L. M. Silva, Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats, Journal of Periodontal Research, vol.49, issue.1, pp.45-54, 2014.

S. Kagami, T. Owada, and H. Kanari, Protein geranylgeranylation regulates the balance between T h 17 cells and Foxp3 + regulatory T cells, International Immunology, vol.21, issue.6, pp.679-689, 2009.

K. Mausner-fainberg, G. Luboshits, and A. Mor, The effect of HMG-CoA reductase inhibitors on naturally occurring CD4 + CD25 + T cells, vol.197, pp.829-839, 2008.

G. Hajishengallis, Toll gates to periodontal host modulation and vaccine therapy, Periodontology, vol.51, issue.1, pp.181-207, 2000.

S. ,

J. Lee, H. Qin, and E. ,

N. Benveniste, The IFN-?induced transcriptional program of the CIITA gene is inhibited by statins, European Journal of Immunology, vol.38, issue.8, pp.2325-2336, 2008.

G. Hajishengallis and S. E. Sahingur, Novel inflammatory pathways in periodontitis, Advances in Dental Research, vol.26, issue.1, pp.23-29, 2014.

F. Montecucco, F. Burger, and G. Pelli, Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes, Rheumatology, vol.48, issue.3, pp.233-242, 2009.

G. Weitz-schmidt, K. Welzenbach, and V. Brinkmann, Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site, Nature Medicine, vol.7, issue.6, pp.687-692, 2001.

Y. Korkmaz, W. Bloch, S. Behrends, H. Schroder, K. Addicks et al., NO-cGMP signaling molecules in the rat epithelial rests of Malassez, European Journal of Oral Sciences, vol.112, issue.1, pp.55-60, 2004.

L. Tóthová and P. Celec, Oxidative stress and antioxidants in the diagnosis and therapy of periodontitis, Frontiers in Physiology, vol.8, p.1055, 2017.

A. C. Batista, T. A. Silva, J. H. Chun, and V. S. Lara, Nitric oxide synthesis and severity of human periodontal disease, Oral Diseases, vol.8, issue.5, pp.254-260, 2002.

Y. Kim, S. H. Pi, Y. M. Lee, S. I. Lee, and E. C. Kim, The anti-inflammatory role of heme oxygenase-1 in lipopolysaccharide and cytokine-stimulated inducible nitric oxide synthase and nitric oxide production in human periodontal ligament cells, Journal of Periodontology, vol.80, issue.12, pp.2045-2055, 2009.

V. L. Popkov, I. A. Fil'chukova, N. V. Lapina, V. P. Galenko-yaroshevskii, and A. S. Dukhanin, Activity of nitric oxide synthase and concentration of nitric oxide end metabolites in the gingiva under experimental pathological conditions, Bulletin of Experimental Biology and Medicine, vol.140, issue.4, pp.391-393, 2005.

B. S. Herrera, R. Martins-porto, and A. Maia-dantas, iNOS-derived nitric oxide stimulates osteoclast activity and alveolar bone loss in ligature-induced periodontitis in rats, Journal of Periodontology, vol.82, issue.11, pp.1608-1615, 2011.

F. Y. K?rz?o?lu, Ö. Özmen, B. Do?an, M. T. Bulut, Ö. Fento?lu et al., Effects of rosuvastatin on inducible nitric oxide synthase in rats with hyperlipidaemia and periodontitis, Journal of Periodontal Research, vol.53, issue.2, pp.258-266, 2018.

C. Franco, H. Patricia, S. Timo, B. Claudia, and H. Marcela, Matrix metalloproteinases as regulators of periodontal inflammation, International Journal of Molecular Sciences, vol.18, issue.2, p.440, 2017.

C. J. Poston, T. C. Pierce, and Y. Li, Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis, Oral Diseases, vol.22, issue.5, pp.438-444, 2016.

U. Balli, G. C. Keles, B. O. Cetinkaya, U. Mercan, B. Ayas et al., Assessment of vascular endothelial growth factor and matrix metalloproteinase-9 in the periodontium of rats treated with atorvastatin, Journal of Periodontology, vol.85, issue.1, pp.178-187, 2014.

R. Dalcico, A. M. De-menezes, and O. B. Deocleciano, Protective mechanisms of simvastatin in experimental periodontal disease, Journal of Periodontology, vol.84, issue.8, pp.1145-1157, 2013.

B. F. Santos, E. Q. Souza, M. R. Brigagão, D. C. Lima, and L. A. Fernandes, Local application of statins in the treatment of experimental periodontal disease in rats, Journal of Applied Oral Science, vol.25, issue.2, pp.168-176, 2017.

Y. Zhang, A. D. Bradley, D. Wang, and R. A. Reinhardt, Statins, bone metabolism and treatment of bone catabolic diseases, Pharmacological Research, vol.88, pp.53-61, 2014.

P. Chen, J. Sun, Y. Tsuang, M. Chen, P. Weng et al., Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway, Nutrition Research, vol.30, issue.3, pp.191-199, 2010.

M. Yamashita, F. Otsuka, and T. Mukai, Simvastatin antagonizes tumor necrosis factor-? inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway, Journal of Endocrinology, vol.196, issue.3, pp.601-613, 2008.

I. S. Kim, B. C. Jeong, and O. S. Kim, Lactone form 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) stimulate the osteoblastic differentiation of mouse periodontal ligament cells via the ERK pathway, Journal of Periodontal Research, vol.46, issue.2, pp.204-213, 2011.

T. Maeda, A. Matsunuma, I. Kurahashi, T. Yanagawa, H. Yoshida et al., Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells, Journal of Cellular Biochemistry, vol.92, issue.3, pp.458-471, 2004.

K. Hu and B. R. Olsen, Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair, Journal of Clinical Investigation, vol.126, issue.2, pp.509-526, 2016.

R. Reyes, J. A. Rodríguez, J. Orbe, M. R. Arnau, C. Évora et al., Combined sustained release of BMP2 and MMP10 accelerates bone formation and mineralization of calvaria critical size defect in mice, Drug Delivery, vol.25, issue.1, pp.750-756, 2018.

D. Stein, Y. Lee, and M. J. Schmid, Local simvastatin effects on mandibular bone growth and inflammation, Journal of Periodontology, vol.76, issue.11, pp.1861-1870, 2005.

Z. Wang, Y. Li, F. Zhou, Z. Piao, and J. Hao, Effects of statins on bone mineral density and fracture risk: a PRISMA-compliant systematic review and meta-analysis, Medicine, vol.95, issue.22, p.3042, 2016.

T. Maeda, T. Kawane, and N. Horiuchi, Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation, Endocrinology, vol.144, issue.2, pp.681-692, 2003.

K. H. Baek, W. Y. Lee, and K. W. Oh, The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells, Journal of Korean Medical Science, vol.20, issue.3, pp.438-444, 2005.

Y. Liu, M. E. Ou, and H. Liu, The effect of simvastatin on chemotactic capability of SDF-1? and the promotion of bone regeneration, Biomaterials, vol.35, issue.15, pp.4489-4498, 2014.

E. De-monès, S. Schlaubitz, S. Catros, and J. C. Fricain, Statins and alveolar bone resorption: a narrative review of preclinical and clinical studies," Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol.119, pp.65-73, 2015.

P. Chang, A. S. Dovban, L. P. Lim, L. Y. Chong, M. Y. Kuo et al., Dual delivery of PDGF and simvastatin to accelerate periodontal regeneration in vivo, Biomaterials, vol.34, issue.38, pp.9990-9997, 2013.

L. Lin, S. K. Lin, and Y. L. Chao, Simvastatin suppresses osteoblastic expression of Cyr61 and progression of apical periodontitis through enhancement of the transcription factor Forkhead/winged helix box protein O3a, Mediators of Inflammation, vol.39, issue.5, pp.619-625, 2013.

H. Kaji, J. Naito, Y. Inoue, H. Sowa, T. Sugimoto et al., Statin suppresses apoptosis in osteoblastic cells: role of transforming growth factor-?-Smad3 pathway, Hormone and Metabolic Research, vol.40, issue.11, pp.746-751, 2008.

N. K. Pokhrel, Y. G. Kim, J. Y. Kim, H. H. Kim, and Y. Lee, Fluvastatin inhibits osteoclast differentiation and Porphyromonas gingivalis lipopolysaccharide-induced alveolar bone erosion in mice, Journal of Periodontology, vol.88, issue.4, pp.390-398, 2017.

K. E. Evans and S. W. Fox, Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus, BMC Cell Biology, vol.8, issue.1, p.4, 2007.

A. Hughes, M. J. Rogers, A. I. Idris, and J. C. Crockett, A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo, Calcified Tissue International, vol.81, issue.5, pp.403-413, 2007.

M. Yamashita, F. Otsuka, and T. Mukai, Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling, Regulatory Peptides, vol.162, issue.1-3, pp.99-108, 2010.

M. Z. Chaudhry, J. H. Wang, S. Blankson, and H. P. Redmond, Statin (cerivastatin) protects mice against sepsis-related death via reduced proinflammatory cytokines and enhanced bacterial clearance, Surgical Infections, vol.9, issue.2, pp.183-194, 2008.

H. H. Ko, R. R. Lareu, B. R. Dix, and J. D. Hughes, In vitro antibacterial effects of statins against bacterial pathogens causing skin infections, European Journal of Clinical Microbiology & Infectious Diseases, vol.37, issue.6, pp.1125-1135, 2018.

S. Emani, G. V. Gunjiganur, and D. S. Mehta, Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: an in vitro study, Contemporary Clinical Dentistry, vol.5, issue.3, pp.377-382, 2014.

P. Bergman, C. Linde, and K. Pütsep, Studies on the antibacterial effects of statins -in vitro and in vivo, PLoS One, vol.6, issue.8, p.24394, 2011.

J. K. Liao and U. Laufs, Pleiotropic effects of statins, Annual Review of Pharmacology and Toxicology, vol.45, issue.1, pp.89-118, 2005.

H. H. Ko, R. R. Lareu, B. R. Dix, and J. D. Hughes, Statins: antimicrobial resistance breakers or makers?, PeerJ, vol.5, p.3952, 2017.

C. D. Russell and J. Schwarze, The role of pro-resolution lipid mediators in infectious disease, Immunology, vol.141, issue.2, pp.166-173, 2014.

C. N. Serhan, A. Jain, and S. Marleau, Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators, The Journal of Immunology, vol.171, issue.12, pp.6856-6865, 2003.

M. Abdel-nour, J. Tsalikis, D. Kleinman, and S. E. Girardin, The emerging role of mTOR signalling in antibacterial immunity, Immunology and Cell Biology, vol.92, issue.4, pp.346-353, 2014.

U. Laufs, H. Kilter, C. Konkol, S. Wassmann, M. Böhm et al., Impact of HMG CoA reductase inhibition on small GTPases in the heart, Cardiovascular Research, vol.53, issue.4, pp.911-920, 2002.

U. Price and H. ,

O. T. Le and S. E. Powell, Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss, Journal of Periodontal Research, vol.48, issue.5, pp.541-548, 2013.

H. Vaziri, R. Naserhojjati-roodsari, and N. Tahsili-fahadan, Effect of simvastatin administration on periodontitis-associated bone loss in ovariectomized rats, Journal of Periodontology, vol.78, issue.8, pp.1561-1567, 2007.

X. Xu, H. Chen, and X. Zhang, Simvastatin prevents alveolar bone loss in an experimental rat model of periodontitis after ovariectomy, Journal of Translational Medicine, vol.12, issue.1, p.284, 2014.

M. R. Messora, G. H. Vieira, and J. M. Vanderlei, Rosuvastatin promotes benefits on induced periodontitis in hypertensive rats, Journal of Periodontal Research, vol.52, issue.4, pp.734-744, 2017.

L. Y. Chong, L. Y. Chien, and M. C. Chung, Controlling the proliferation and differentiation stages to initiate periodontal regeneration, Connective Tissue Research, vol.54, issue.2, pp.101-107, 2013.

A. C. Killeen, P. A. Rakes, and M. J. Schmid, Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects, Journal of Periodontology, vol.83, issue.12, pp.1463-1471, 2012.

N. Maciel-oliveira, V. Bradaschia-correa, and V. E. Arana--chavez, Early alveolar bone regeneration in rats after topical administration of simvastatin, Oral Radiology, and Endodontics, vol.112, issue.2, pp.170-179, 2011.

R. M. Moraes, Effects of simvastatin on prevention and progression of induced periodontitis in rats, Journal of Dental Health, vol.8, issue.1, 2017.

J. Rutledge, M. D. Schieber, and J. M. Chamberlain, Simvastatin application to augment facial jaw bone in a dog model: pilot study, Journal of Periodontology, vol.82, issue.4, pp.597-605, 2011.

M. S. Morris, Y. Lee, and M. T. Lavin, Injectable simvastatin in periodontal defects and alveolar ridges: pilot studies, Journal of Periodontology, vol.79, issue.8, pp.1465-1473, 2008.

S. M. Surve, A. B. Acharya, and S. L. Thakur, Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing, Drug Metabolism and Personalized Therapy, vol.30, issue.4, pp.263-269, 2015.

S. S. Martande, M. Kumari, A. R. Pradeep, S. P. Singh, and D. K. Suke, Comparative evaluation of efficacy of subgingivally delivered 1.2% atorvastatin and 1.2% simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial, Dental Clinics, Dental Prospects, vol.11, issue.1, pp.18-25, 2017.

S. Garg and A. R. Pradeep, 1.2% rosuvastatin and 1.2% atorvastatin gel local drug delivery and redelivery in the treatment of class II furcation defects: a randomized controlled clinical trial, Journal of Periodontology, vol.88, issue.3, pp.259-265, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02383431

H. S. Grover, S. Kapoor, and A. Singh, Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, p.31

, Mediators of Inflammation interleukin-8 and interleukin-10 levels in chronic periodontitis -a clinicobiochemical study, Journal of Oral Biology and Craniofacial Research, vol.6, issue.2, pp.85-92, 2016.

P. Kinra, H. Gupta, S. Khan, and M. S. Ahmad, Evaluation of the relative efficacy of an allograft used alone and that in combination with simvastatin in the treatment of human periodontal Infrabony defects -a clinical and radiological study, Journal of Taibah University Medical Sciences, vol.5, issue.2, pp.75-88, 2010.

S. S. Martande, M. Kumari, A. R. Pradeep, S. P. Singh, D. K. Suke et al., Platelet-rich fibrin combined with 1.2% atorvastatin for treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial, Journal of Periodontology, vol.87, issue.9, pp.1039-1046, 2016.

A. R. Pradeep, V. Garg, D. Kanoriya, and S. Singhal, Platelet-rich fibrin with 1.2% rosuvastatin for treatment of Intrabony defects in chronic periodontitis: a randomized controlled clinical trial, Journal of Periodontology, vol.87, issue.12, pp.1468-1473, 2016.

A. R. Pradeep, S. Karvekar, K. Nagpal, K. Patnaik, A. Raju et al., Rosuvastatin 1.2 mg in situ gel combined with 1:1 mixture of autologous platelet-rich fibrin and porous hydroxyapatite bone graft in surgical treatment of mandibular class II furcation defects: a randomized clinical control trial, Journal of Periodontology, vol.87, issue.1, pp.5-13, 2016.

R. Ranjan, S. R. Patil, and H. R. Veena, Effect of in-situ application of simvastatin gel in surgical management of osseous defects in chronic periodontitis-a randomized clinical trial, Journal of Oral Biology and Craniofacial Research, vol.7, issue.2, pp.113-118, 2017.

J. Cunha-cruz, B. Saver, G. Maupome, and P. P. Hujoel, Statin use and tooth loss in chronic periodontitis patients, Journal of Periodontology, vol.77, issue.6, pp.1061-1066, 2006.

Ö. Fento?lu, T. Sözen, and S. G. Öz, Short-term effects of periodontal therapy as an adjunct to anti-lipemic treatment, Oral Diseases, vol.16, issue.7, pp.648-654, 2010.

P. Meisel, H. K. Kroemer, M. Nauck, B. Holtfreter, and T. Kocher, Tooth loss, periodontitis, and statins in a population-based follow-up study, Journal of Periodontology, vol.85, issue.6, pp.160-168, 2014.

M. E. Fajardo, M. L. Rocha, F. J. Sánchez-marin, and E. J. Espinosa-chávez, Effect of atorvastatin on chronic periodontitis: a randomized pilot study, Journal of Clinical Periodontology, vol.37, issue.11, pp.1016-1022, 2010.

Ö. Fento?lu, F. Y. K?rz?o?lu, M. Özdem, H. Koçak, R. Sütçü et al., Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment, Oral Diseases, vol.18, issue.3, pp.299-306, 2012.

A. Sangwan, S. Tewari, H. Singh, R. K. Sharma, and S. C. Narula, Effect of hyperlipidemia on response to nonsurgical periodontal therapy: statin users versus nonusers, European Journal of Dentistry, vol.10, issue.1, pp.69-76, 2016.

H. S. Grover, S. Luthra, and S. Maroo, Are statins really wonder drugs?, Journal of the Formosan Medical Association, vol.113, issue.12, pp.892-898, 2014.

A. I. Martinez, P. R. Freeman, and D. C. Moga, Statin use and gastrointestinal hemorrhage: a large retrospective cohort study, American Journal of Cardiovascular Drugs, vol.46, pp.107-110, 2018.

H. A. Da-rocha, C. F. Silva, F. L. Santiago, L. G. Martins, P. C. Dias et al., Local drug delivery systems in the treatment of periodontitis: a literature review, Journal of the International Academy of Periodontology, vol.17, issue.3, pp.82-90, 2015.

D. Joshi, T. Garg, A. K. Goyal, and G. Rath, Advanced drug delivery approaches against periodontitis, Drug Delivery, vol.23, issue.2, pp.363-377, 2016.

A. Mombelli and L. P. Samaranayake, Topical and systemic antibiotics in the management of periodontal diseases, International Dental Journal, vol.54, issue.1, pp.3-14, 2004.

J. Park, The use of simvastatin in bone regeneration, Patología Oral y Cirugía Bucal, vol.14, issue.9, pp.485-488, 2009.

P. Schwinté, A. Mariotte, and P. Anand, Anti-inflammatory effect of active nanofibrous polymeric membrane bearing nanocontainers of atorvastatin complexes, Nanomedicine, vol.12, issue.23, pp.2651-2674, 2017.

C. Sima and M. Glogauer, Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone, Periodontology, vol.63, issue.1, pp.80-101, 2000.

M. R. Thylin, J. C. Mcconnell, and M. J. Schmid, Effects of simvastatin gels on murine calvarial bone, Journal of Periodontology, vol.73, issue.10, pp.1141-1148, 2002.

J. W. Wang, S. W. Xu, D. S. Yang, and R. K. Lv, Locally applied simvastatin promotes fracture healing in ovariectomized rat, Osteoporosis International, vol.18, issue.12, pp.1641-1650, 2007.

M. Kumari, S. S. Martande, and A. R. Pradeep, Subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis among smokers: a randomized, controlled clinical trial, Journal of Investigative and Clinical Dentistry, vol.8, issue.2, p.12213, 2017.

A. R. Pradeep, N. Priyanka, N. Kalra, S. B. Naik, S. P. Singh et al., Clinical efficacy of subgingivally delivered 1.2-mg simvastatin in the treatment of individuals with class II furcation defects: a randomized controlled clinical trial, Journal of Periodontology, vol.83, issue.12, pp.1472-1479, 2012.

Z. Akram, F. Vohra, and F. Javed, Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a meta-analysis, Journal of Investigative and Clinical Dentistry, vol.9, issue.2, p.12304, 2018.

J. Meza-mauricio, D. Soto-peñaloza, D. Peñarrocha-oltra, J. M. Montiel-company, and D. C. Peruzzo, Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and metaanalysis, Clinical Oral Investigations, vol.22, issue.7, pp.2413-2430, 2018.

F. W. Muniz, K. Taminski, J. Cavagni, R. K. Celeste, P. Weidlich et al., The effect of statins on periodontal treatment-a systematic review with meta-analyses and meta-regression, Clinical Oral Investigations, vol.22, issue.2, pp.671-687, 2018.

S. Agarwal, K. K. Chaubey, A. Chaubey, V. Agarwal, E. Madan et al., Clinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients, Journal of Indian Society of Periodontology, vol.20, issue.4, pp.409-416, 2016.

K. Sinjab, N. Zimmo, G. H. Lin, M. P. Chung, L. Shaikh et al., The effect of locally delivered statins on treating periodontal intrabony defects: a systematic review and 32 Mediators of Inflammation meta-analysis, Journal of Periodontology, vol.88, issue.4, pp.357-367, 2017.

L. M. Ambrósio, E. S. Rovai, D. I. Sendyk, M. Holzhausen, and C. M. Pannuti, Does the adjunctive use of statins provide additional benefits to nonsurgical periodontal treatment? A systematic review and meta-analysis, Journal of Periodontal Research, vol.53, issue.1, pp.12-21, 2018.

G. J. Linden, A. Lyons, and F. A. Scannapieco, Periodontal systemic associations: review of the evidence, Journal of Periodontology, vol.84, issue.4-s, pp.8-19, 2013.

Q. Zhou, S. E. Leeman, and S. Amar, Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity, Proceedings of the National Academy of Sciences of the United States of America, vol.108, pp.2867-2872, 2011.

V. G. Athyros, A. A. Papageorgiou, D. S. Demitriadis, and A. G. Kontopoulos, Atorvastatin plus pravastatin for the treatment of heterozygous familial hypercholesterolaemia-a pilot study, Current Medical Research and Opinion, vol.17, issue.4, pp.267-272, 2001.

Y. A. Ogai, T. A. Banks, and S. M. Gada, Statin allergy: clinical experience and structural relation as a framework for evaluation, The Journal of Allergy and Clinical Immunology: In Practice, vol.3, issue.6, pp.993-995, 2015.

D. R. Rosenberg, C. X. Andrade, and A. P. Chaparro, Short-term effects of 2% atorvastatin dentifrice as an adjunct to periodontal therapy: a randomized double-masked clinical trial, Journal of Periodontology, vol.86, issue.5, pp.623-630, 2015.

B. Lee, C. C. Lee, and H. P. Lin, A functional chitosan membrane with grafted epigallocatechin-3-gallate and lovastatin enhances periodontal tissue regeneration in dogs, Carbohydrate Polymers, vol.151, pp.790-802, 2016.

A. D. Bradley, Y. Zhang, and Z. Jia, Effect of simvastatin prodrug on experimental periodontitis, Journal of Periodontology, vol.87, issue.5, pp.577-582, 2016.

B. S. Lee, C. C. Lee, and Y. P. Wang, Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs, International Journal of Nanomedicine, vol.11, pp.285-297, 2016.

H. Seto, H. Ohba, K. Tokunaga, H. Hama, M. Horibe et al., Topical administration of simvastatin recovers alveolar bone loss in rats, Journal of Periodontal Research, vol.43, issue.3, pp.261-267, 2008.

A. A. Swerts, B. F. Santos, S. R. Bruzadelli, M. R. Brigagão, and D. C. ,

L. A. Lima and . Fernandes, Treatment of experimental periodontal disease by laser therapy in simvastatin-modified rats, Journal of Applied Oral Science, vol.25, issue.4, pp.387-395, 2017.

X. Wang, Z. Jia, Y. Almoshari, S. M. Lele, R. A. Reinhardt et al., Local application of pyrophosphorylated simvastatin prevents experimental periodontitis, Pharmaceutical Research, vol.35, issue.8, p.164, 2018.

P. Goes, A. P. Lima, I. M. Melo, R. O. Rêgo, and V. Lima, Effect of atorvastatin in radiographic density on alveolar bone loss in Wistar rats, Brazilian Dental Journal, vol.21, issue.3, pp.193-198, 2010.

P. Goes, N. A. Lima, J. A. Rodrigues, N. M. Benevides, G. A. Brito et al., Anti-inflammatory and anti-resorptive effects of atorvastatin on alveolar bone loss in Wistar rats, Brazilian Dental Journal, vol.27, issue.3, pp.267-272, 2016.

J. C. Júnior, C. G. Macedo, and H. B. Abdalla, Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis, Clinical, Cosmetic and Investigational Dentistry, vol.9, pp.33-38, 2017.

C. A. Nassar, G. D. Battistetti, and F. P. Nahsan, Evaluation of the effect of simvastatin on the progression of alveolar bone loss in experimental periodontitis-an animal study, Journal of the International Academy of Periodontology, vol.16, issue.1, pp.2-7, 2014.

M. Kumari, S. S. Martande, A. R. Pradeep, and S. B. Naik, Efficacy of subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus: a randomized controlled clinical trial, Journal of Periodontology, vol.87, issue.11, pp.1278-1285, 2016.

A. R. Pradeep and M. S. Thorat, Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial, Journal of Periodontology, vol.81, issue.2, pp.214-222, 2010.

A. R. Pradeep, M. Kumari, N. S. Rao, S. S. Martande, and S. B. Naik, Clinical efficacy of subgingivally delivered 1.2% atorvastatin in chronic periodontitis: a randomized controlled clinical trial, Journal of Periodontology, vol.84, issue.7, pp.871-879, 2013.

A. R. Pradeep, N. S. Rao, P. Bajaj, and M. Kumari, Efficacy of subgingivally delivered simvastatin in the treatment of patients with type 2 diabetes and chronic periodontitis: a randomized double-masked controlled clinical trial, Journal of Periodontology, vol.84, issue.1, pp.24-31, 2013.

A. R. Pradeep, S. Karvekar, K. Nagpal, K. Patnaik, C. N. Guruprasad et al., Efficacy of locally delivered 1.2% rosuvastatin gel to non-surgical treatment of patients with chronic periodontitis: a randomized, placebo-controlled clinical trial, Journal of Periodontology, vol.86, issue.6, pp.738-745, 2015.

A. R. Pradeep, D. Kanoriya, S. Singhal, V. Garg, B. Manohar et al., Comparative evaluation of subgingivally delivered 1% alendronate versus 1.2% atorvastatin gel in treatment of chronic periodontitis: a randomized placebo-controlled clinical trial, Journal of Investigative and Clinical Dentistry, vol.8, issue.3, p.12215, 2017.

N. Priyanka, A. Abhilash, and S. Saquib, Clinical efficacy of subgingivally delivered 1.2 mg simvastatin in the treatment of patients with aggressive periodontitis: a randomized controlled clinical trial, The International Journal of Periodontics & Restorative Dentistry, vol.37, issue.2, pp.135-141, 2017.

N. S. Rao, A. R. Pradeep, P. Bajaj, M. Kumari, and S. B. Naik, Simvastatin local drug delivery in smokers with chronic periodontitis: a randomized controlled clinical trial, Australian Dental Journal, vol.58, issue.2, pp.156-162, 2013.

A. Rath, J. Mahenra, L. Thomas, M. Sandhu, A. Namasi et al., A clinical, radiological and il-6 evaluation of subgingivally delivered simvastatin in the treatment of chronic periodontitis, International Journal of Drug Delivery, vol.4, pp.70-81, 2012.

P. A. Adriaens, A. , and L. M. , Effects of nonsurgical periodontal therapy on hard and soft tissues, Periodontol, vol.36, pp.121-145, 2000.

K. Agossa, D. Morand, H. Tenenbaum, J. Davideau, and O. Huck, Systemic Application of Anti-inflammatory Agents in Periodontal Treatment, Clin Anti-Infl Anti-All Drugs, vol.2, pp.3-13, 2015.

K. Agossa, M. Lizambard, T. Rongthong, E. Delcourt-debruyne, J. Siepmann et al., Physical key properties of antibiotic-free, PLGA/HPMC-based in-situ forming implants for local periodontitis treatment, Int J Pharm, vol.521, pp.282-293, 2017.

G. C. Aithal, U. Y. Nayak, C. Mehta, R. Narayan, P. Gopalkrishna et al., Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for Periodontitis: Development and Computational Simulations, Molecules, vol.23, 2018.

A. Akcal?, O. Huck, H. Tenenbaum, J. L. Davideau, and N. Buduneli, Periodontal diseases and stress: a brief review, J Oral Rehabil, vol.40, pp.60-68, 2013.

A. Akcal? and N. P. Lang, Dental calculus: the calcified biofilm and its role in disease development, Periodontol, vol.76, pp.109-115, 2000.

A. Akcal?, Z. Akcal?, F. Batool, C. Petit, and O. Huck, Are Sex Steroid Hormones Influencing Periodontal Conditions? A Systematic Review, Curr Oral Health Rep, vol.5, pp.33-38, 2018.

J. M. Albandar and T. E. Rams, Global epidemiology of periodontal diseases: an overview, Periodontol, vol.29, pp.7-10, 2000.

M. Aljateeli, T. Koticha, J. Bashutski, J. V. Sugai, T. M. Braun et al., Surgical periodontal therapy with and without initial scaling and root planing in the management of chronic periodontitis: a randomized clinical trial, J. Clin. Periodontol, vol.41, pp.693-700, 2014.

F. M. Alpiste-illueca, P. Vera, P. De-grado-cabanilles, V. Fuenmayor-fernandez, G. Loscos et al., Periodontal regeneration in clinical practice, Med Oral Patol Oral Cir Bucal, vol.11, pp.382-392, 2006.

E. Alsberg, H. J. Kong, Y. Hirano, M. K. Smith, A. Albeiruti et al., Regulating bone formation via controlled scaffold degradation, J. Dent. Res, vol.82, pp.903-908, 2003.

A. Alshammari, J. Patel, J. Al-hashemi, B. Cai, J. Panek et al., , 2017.

, Kava-241 Reduced Periodontal Destruction in a Collagen Antibody Primed Porphyromonas gingivalis Model of Periodontitis, J Clin Periodontol, vol.44, pp.1123-1132

N. Anton and T. F. Vandamme, The universality of low-energy nano-emulsification, Int J Pharm, vol.377, pp.142-147, 2009.

N. Anton and T. F. Vandamme, Nano-emulsions and micro-emulsions: clarifications of the critical differences, Pharm. Res, vol.28, pp.978-985, 2011.

N. Anton, F. Hallouard, M. F. Attia, and T. F. Vandamme, Nano-emulsions for Drug Delivery and Biomedical Imaging, Intracellular Delivery III, pp.273-300, 2016.

D. A. Apatzidou and D. F. Kinane, Nonsurgical mechanical treatment strategies for periodontal disease, Dent. Clin. North Am, vol.54, pp.1-12, 2010.

R. F. De-araújo, T. O. Souza, L. M. De-moura, K. P. Torres, L. B. De-souza et al., Atorvastatin Decreases Bone Loss, Inflammation and Oxidative Stress in Experimental Periodontitis, PLoS One, vol.8, 2013.

S. Baba, Y. Yamada, A. Komuro, Y. Yotsui, M. Umeda et al., Phase I/II Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis, Stem Cells Int, p.6205910, 2016.

M. G. Balta, B. G. Loos, and E. A. Nicu, Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1, 2017.

M. Barczyk, A. I. Bolstad, and D. Gullberg, Role of integrins in the periodontal ligament: organizers and facilitators, Periodontol, vol.63, pp.29-47, 2000.

S. P. Barros, R. Williams, S. Offenbacher, and T. Morelli, Gingival crevicular fluid as a source of biomarkers for periodontitis, Periodontol, vol.70, pp.53-64, 2000.

P. M. Bartold and T. E. Van-dyke, Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts, Periodontol, vol.62, pp.203-217, 2000.

P. M. Bartold, S. Gronthos, S. Ivanovski, A. Fisher, and D. W. Hutmacher, Tissue engineered periodontal products, J. Periodont. Res, vol.51, pp.1-15, 2016.

S. H. Bassir, W. Wisitrasameewong, J. Raanan, S. Ghaffarigarakani, J. Chung et al., Potential for Stem Cell-Based Periodontal Therapy, J. Cell. Physiol, vol.231, pp.50-61, 2016.

F. Batool, M. Strub, C. Petit, I. M. Bugueno, F. Bornert et al., Periodontal Tissues, Maxillary Jaw Bone, and Tooth Regeneration Approaches: From Animal Models Analyses to Clinical Applications. Nanomaterials 8, p.337, 2018.

M. Benakanakere and D. F. Kinane, Innate cellular responses to the periodontal biofilm, Front Oral Biol, vol.15, pp.41-55, 2012.

K. Bertl, A. Parllaku, N. Pandis, K. Buhlin, B. Klinge et al., The effect of local and systemic statin use as an adjunct to non-surgical and surgical periodontal therapy-A systematic review and meta-analysis, J Dent, vol.67, pp.18-28, 2017.

A. K. Bhavsar, S. Parween, B. V. Karthikeyan, and M. L. Prabhuji, Critical Issues in Periodontal Regeneration -A Review, J Oral Health Dent, vol.2, p.204, 2018.

C. Bode, H. Kranz, F. Siepmann, and J. Siepmann, In-situ forming PLGA implants for intraocular dexamethasone delivery, Int J Pharm, vol.548, pp.337-348, 2018.

D. D. Bosshardt, The periodontal pocket: pathogenesis, histopathology and consequences, Periodontol, vol.76, pp.43-50, 2000.

D. D. Bosshardt and N. P. Lang, The junctional epithelium: from health to disease, J. Dent. Res, vol.84, pp.9-20, 2005.

D. D. Bosshardt and A. Sculean, Does periodontal tissue regeneration really work?, Periodontol, vol.51, pp.208-219, 2000.

N. Bostanci, T. Thurnheer, J. Aduse-opoku, M. A. Curtis, A. S. Zinkernagel et al., Porphyromonas gingivalis regulates TREM-1 in human polymorphonuclear neutrophils via its gingipains, vol.8, p.75784, 2013.

M. C. Bottino, T. , and V. , Membranes for Periodontal Regeneration--A Materials Perspective, Front Oral Biol, vol.17, pp.90-100, 2015.

M. C. Bottino, D. Pankajakshan, and J. E. Nör, Advanced Scaffolds for Dental Pulp and Periodontal Regeneration, Dent Clin North Am, vol.61, pp.689-711, 2017.

D. Bourgeois, P. Bouchard, and C. Mattout, Epidemiology of periodontal status in dentate adults in France, J. Periodont. Res, vol.42, pp.219-227, 2002.

F. Y. Bozkurt, Z. Yetkin-ay, E. Berker, E. Tepe, A. et al., Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: a preliminary report, Cytokine, vol.35, pp.180-185, 2006.

S. B. Bozkurt, S. S. Hakki, E. E. Hakki, Y. Durak, and A. Kantarci, Porphyromonas gingivalis Lipopolysaccharide Induces a Pro-inflammatory Human Gingival Fibroblast Phenotype, Inflammation, vol.40, pp.144-153, 2017.

A. D. Bradley, Y. Zhang, Z. Jia, G. Zhao, X. Wang et al., Effect of Simvastatin Prodrug on Experimental Periodontitis, J. Periodontol, vol.87, pp.577-582, 2016.

S. K. Brancato, A. , and J. E. , Wound macrophages as key regulators of repair: origin, phenotype, and function, Am. J. Pathol, vol.178, pp.19-25, 2011.

M. D. Bresaola, M. A. Matsumoto, A. Zahoui, C. C. Biguetti, and H. Nary-filho, Influence of rapid-and slow-rate resorption collagen membrane in maxillary sinus augmentation, Clin Oral Implants Res, vol.28, pp.320-326, 2017.

I. M. Bugueno, F. Batool, L. Korah, N. Benkirane-jessel, and O. Huck, Porphyromonas gingivalis differentially modulates apoptosome APAF-1 in epithelial cells and fibroblasts, Am. J. Pathol, vol.188, pp.404-416, 2017.

I. M. Bugueno, F. Batool, L. Keller, S. Kuchler-bopp, N. Benkirane-jessel et al., Porphyromonas gingivalis bypasses epithelial barrier and modulates fibroblastic inflammatory response in an in vitro 3D spheroid model, Scientific Reports, vol.8, 2018.

S. J. Byrne, S. G. Dashper, I. B. Darby, G. G. Adams, B. Hoffmann et al., Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque, Oral Microbiol. Immunol, vol.24, pp.469-477, 2009.

I. Cantón, R. Mckean, M. Charnley, K. A. Blackwood, C. Fiorica et al., Development of an Ibuprofen-releasing biodegradable PLA/PGA electrospun scaffold for tissue regeneration, Biotechnol. Bioeng, vol.105, pp.396-408, 2010.

L. Casanova, F. J. Hughes, and P. M. Preshaw, Diabetes and periodontal disease: a twoway relationship, Br Dent J, vol.217, pp.433-437, 2014.

J. G. Caton, G. Armitage, T. Berglundh, I. L. Chapple, S. Jepsen et al., A new classification scheme for periodontal and peri-implant diseases and conditions -Introduction and key changes from the 1999 classification, J. Clin. Periodontol, vol.45, pp.1-8, 2018.

J. Cavagni, F. W. Muniz, C. K. Rösing, J. Cavagni, F. W. Muniz et al., The effect of inflammatory response modulator agents on gingivitis and periodontitis, Revista Gaúcha de Odontologia, vol.64, pp.312-319, 2016.

A. Cekici, A. Kantarci, H. Hasturk, and T. E. Van-dyke, Inflammatory and immune pathways in the pathogenesis of periodontal disease, Periodontol, vol.64, pp.57-80, 2000.

B. Cetinkaya, E. Guzeldemir, E. Ogus, and S. Bulut, Proinflammatory and antiinflammatory cytokines in gingival crevicular fluid and serum of patients with rheumatoid arthritis and patients with chronic periodontitis, J. Periodontol, vol.84, pp.84-93, 2013.

I. L. Chapple and R. Genco, Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases, J. Periodontol, vol.84, pp.106-112, 2013.

I. L. Chapple, B. L. Mealey, T. E. Dyke, P. M. Bartold, H. Dommisch et al., Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions, J Clin Periodontol, vol.45, pp.68-77, 2018.

F. Chen, J. , and Y. , Periodontal tissue engineering and regeneration: current approaches and expanding opportunities, Tissue Eng Part B Rev, vol.16, pp.219-255, 2010.

B. Chen, W. Wu, W. Sun, Q. Zhang, F. Yan et al., RANKL Expression in Periodontal Disease: Where Does RANKL Come from, Biomed Res Int, p.731039, 2014.

F. Chen, J. Zhang, M. Zhang, Y. An, F. Chen et al., A review on endogenous regenerative technology in periodontal regenerative medicine, Biomaterials, vol.31, pp.7892-7927, 2010.

F. Chen, L. Gao, B. Tian, X. Zhang, Y. Zhang et al., Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial, Stem Cell Res Ther, vol.7, p.33, 2016.

K. Chien, Y. Chang, M. Wang, J. Chuang, Y. Yang et al., Promoting Induced Pluripotent Stem Cell-driven Biomineralization and Periodontal Regeneration in Rats with Maxillary-Molar Defects using Injectable BMP-6 Hydrogel, 2018.

M. I. Cho and P. R. Garant, Development and general structure of the periodontium, Periodontol, vol.24, pp.9-27, 2000.

Y. Cho, K. Kim, H. Ryoo, Y. Lee, Y. Ku et al., Recent Advances of Useful Cell Sources in the Periodontal Regeneration, Curr Stem Cell Res Ther, vol.14, pp.3-8, 2019.

J. Choi, U. Jung, C. Kim, T. Eom, E. Kang et al., The effects of newly formed synthetic peptide on bone regeneration in rat calvarial defects, J Periodontal Implant Sci, vol.40, pp.11-18, 2010.

C. M. Cobb, Clinical significance of non-surgical periodontal therapy: an evidencebased perspective of scaling and root planing, J. Clin. Periodontol, vol.29, issue.2, pp.6-16, 2002.

P. Cortellini, J. Buti, G. Pini-prato, and M. S. Tonetti, Periodontal regeneration compared with access flap surgery in human intra-bony defects 20-year follow-up of a randomized clinical trial: tooth retention, periodontitis recurrence and costs, J Clin Periodontol, vol.44, pp.58-66, 2017.

R. P. Darveau, Periodontitis: a polymicrobial disruption of host homeostasis, Nat. Rev. Microbiol, vol.8, pp.481-490, 2010.

D. E. Deas, A. J. Moritz, R. S. Sagun, S. F. Gruwell, and C. A. Powell, Scaling and root planing vs. conservative surgery in the treatment of chronic periodontitis, Periodontol, vol.71, pp.128-139, 2000.

A. J. Delima, T. Oates, R. Assuma, Z. Schwartz, D. Cochran et al., Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis, J. Clin. Periodontol, vol.28, pp.233-240, 2001.

S. Deschamps-lenhardt, R. Martin-cabezas, T. Hannedouche, and O. Huck, Association between periodontitis and chronic kidney disease: Systematic review and meta-analysis, Oral Dis, vol.25, pp.385-402, 2019.

G. Di-turi, C. Riggio, O. Vittorio, S. Marconcini, F. Briguglio et al., Sub-micrometric liposomes as drug delivery systems in the treatment of periodontitis, Int J Immunopathol Pharmacol, vol.25, pp.657-670, 2012.

R. F. Diegelmann and M. C. Evans, Wound healing: an overview of acute, fibrotic and delayed healing, Front. Biosci, vol.9, pp.283-289, 2004.

K. Divaris, K. L. Monda, K. E. North, A. F. Olshan, L. M. Reynolds et al., Exploring the genetic basis of chronic periodontitis: a genome-wide association study, Hum. Mol. Genet, vol.22, pp.2312-2324, 2013.

M. P. Do, C. Neut, E. Delcourt, T. Seixas-certo, J. Siepmann et al., In situ forming implants for periodontitis treatment with improved adhesive properties, Eur J Pharm Biopharm, vol.88, pp.342-350, 2014.

M. P. Do, C. Neut, H. Metz, E. Delcourt, K. Mäder et al., In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance, Int J Pharm, vol.486, pp.38-51, 2015.

M. P. Do, C. Neut, H. Metz, E. Delcourt, J. Siepmann et al., Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for periodontitis treatment, Eur J Pharm Biopharm, vol.94, pp.273-283, 2015.

C. H. Drisko, Nonsurgical periodontal therapy, Periodontol, vol.25, pp.77-88, 2000.

J. Du, Z. Shan, P. Ma, S. Wang, F. et al., Allogeneic bone marrow mesenchymal stem cell transplantation for periodontal regeneration, J. Dent. Res, vol.93, pp.183-188, 2014.

M. Du, X. Duan, Y. , and P. , Induced Pluripotent Stem Cells and Periodontal Regeneration, Curr Oral Health Rep, vol.2, pp.257-265, 2015.

B. A. Dye, Global periodontal disease epidemiology, Periodontology, vol.58, pp.10-25, 2000.

S. Eap, A. Ferrand, C. M. Palomares, A. Hébraud, J. Stoltz et al., Electrospun nanofibrous 3D scaffold for bone tissue engineering, Biomed Mater Eng, vol.22, pp.137-141, 2012.

P. I. Eke, B. A. Dye, L. Wei, G. O. Thornton-evans, R. J. Genco et al., Prevalence of periodontitis in adults in the United States, J. Dent. Res, vol.91, pp.914-920, 2009.

R. Elkaïm, M. Dahan, L. Kocgozlu, S. Werner, D. Kanter et al., Prevalence of periodontal pathogens in subgingival lesions, atherosclerotic plaques and healthy blood vessels: a preliminary study, J. Periodont. Res, vol.43, pp.224-231, 2008.

S. Emani, G. V. Gunjiganur, and D. S. Mehta, Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: An in vitro study, Contemp Clin Dent, vol.5, pp.377-382, 2014.

M. A. Eskan, R. Jotwani, T. Abe, J. Chmelar, J. Lim et al., The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss, Nat. Immunol, vol.13, pp.465-473, 2012.

I. M. Estanislau, I. R. Terceiro, M. R. Lisboa, P. Teles, B. De et al., Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review, Br J Clin Pharmacol, vol.79, pp.877-885, 2015.

A. Farooq, M. Yar, A. S. Khan, L. Shahzadi, S. A. Siddiqi et al., Synthesis of piroxicam loaded novel electrospun biodegradable nanocomposite scaffolds for periodontal regeneration, Mater Sci Eng C Mater Biol Appl, vol.56, pp.104-113, 2015.

O. Fento?lu, F. Y. Kirzio?lu, M. Ozdem, H. Koçak, R. Sütçü et al., Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment, Oral Dis, vol.18, pp.299-306, 2012.

A. Ferrand, S. Eap, L. Richert, S. Lemoine, D. Kalaskar et al., Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan-based nanoreservoirs of growth factors, Macromol Biosci, vol.14, pp.45-55, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00966560

S. Fickl, T. Thalmair, M. Kebschull, S. Böhm, and H. Wachtel, Microsurgical access flap in conjunction with enamel matrix derivative for the treatment of intra-bony defects: a controlled clinical trial, J. Clin. Periodontol, vol.36, pp.784-790, 2009.

J. E. Frencken, P. Sharma, L. Stenhouse, D. Green, D. Laverty et al., Global epidemiology of dental caries and severe periodontitis -a comprehensive review, J. Clin. Periodontol, vol.44, pp.94-105, 2017.

X. Fu, L. Jin, P. Ma, Z. Fan, W. et al., Allogeneic stem cells from deciduous teeth in treatment for periodontitis in miniature swine, J. Periodontol, vol.85, pp.845-851, 2014.

K. Fujimori, T. Yoneda, T. Tomofuji, D. Ekuni, T. Azuma et al., Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study, Molecules, vol.24, 2019.

N. Fujishiro, H. Anan, T. Hamachi, and K. Maeda, The role of macrophages in the periodontal regeneration using Emdogain gel, J. Periodont. Res, vol.43, pp.143-155, 2008.

K. M. Galler, J. D. Hartgerink, A. C. Cavender, G. Schmalz, and R. N. Souza, A customized self-assembling peptide hydrogel for dental pulp tissue engineering, Tissue Eng Part A, vol.18, pp.176-184, 2012.

F. Ganji, M. J. Abdekhodaie, S. A. , and A. R. , Gelation time and degradation rate of chitosan-based injectable hydrogel, J Sol-Gel Sci Technol, vol.42, pp.47-53, 2007.

S. Ganta, D. Deshpande, A. Korde, A. , and M. , A review of multifunctional nanoemulsion systems to overcome oral and CNS drug delivery barriers, Mol. Membr. Biol, vol.27, pp.260-273, 2010.

S. Ganta, M. Talekar, A. Singh, T. P. Coleman, and M. M. Amiji, Nanoemulsions in translational research-opportunities and challenges in targeted cancer therapy, AAPS PharmSciTech, vol.15, pp.694-708, 2014.

E. Gemmell and G. J. Seymour, Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease, Periodontol, vol.35, pp.21-41, 2000.

P. Goes, N. A. Lima, J. A. Rodrigues, N. M. Benevides, G. A. Brito et al., Antiinflammatory and Anti-resorptive Effects of Atorvastatin on Alveolar Bone Loss in Wistar Rats, Braz Dent J, vol.27, pp.267-272, 2016.

J. M. Goodson, Clinical measurements of periodontitis, J. Clin. Periodontol, vol.13, pp.446-460, 1986.

J. M. Goodson, A. D. Haffajee, S. S. Socransky, R. Kent, R. Teles et al., Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites, J. Clin. Periodontol, vol.39, pp.526-536, 2012.

O. Goudouri, E. Kontonasaki, and A. R. Boccaccini, 17 -Layered scaffolds for periodontal regeneration, Biomaterials for Oral and Dental Tissue Engineering, pp.279-295, 2017.

D. Graves, Cytokines that promote periodontal tissue destruction, J. Periodontol, vol.79, pp.1585-1591, 2008.

D. T. Graves, N. Nooh, T. Gillen, M. Davey, S. Patel et al., IL-1 plays a critical role in oral, but not dermal, wound healing, J. Immunol, vol.167, pp.5316-5320, 2001.

F. Graziani, D. Karapetsa, B. Alonso, and D. Herrera, Nonsurgical and surgical treatment of periodontitis: how many options for one disease?, Periodontol, vol.75, pp.152-188, 2000.

H. S. Grover, S. Kapoor, and A. Singh, Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis -A clinicobiochemical study, J Oral Biol Craniofac Res, vol.6, pp.85-92, 2016.

M. J. Gupte and P. X. Ma, Nanofibrous Scaffolds for Dental and Craniofacial Applications, J Dent Res, vol.91, pp.227-234, 2012.

G. C. Gurtner, S. Werner, Y. Barrandon, and M. T. Longaker, Wound repair and regeneration, Nature, vol.453, pp.314-321, 2008.

D. J. Hackam and H. R. Ford, Cellular, biochemical, and clinical aspects of wound healing, Surg Infect, vol.3, issue.1, pp.23-35, 2002.

G. Hajishengallis, Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response, Trends Immunol, vol.35, pp.3-11, 2014.

G. Hajishengallis, Periodontitis: from microbial immune subversion to systemic inflammation, Nature Reviews Immunology, vol.15, p.30, 2015.

G. Hajishengallis and J. M. Korostoff, Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later, Periodontol, vol.75, pp.116-151, 2000.

G. Hajishengallis and R. J. Lamont, Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology, Mol Oral Microbiol, vol.27, pp.409-419, 2012.

G. Hajishengallis, T. Maekawa, T. Abe, E. Hajishengallis, and J. D. Lambris, Complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches, Adv Exp Med Biol, vol.865, pp.57-74, 2015.

C. H. Hämmerle, W. V. Giannobile, and W. , Biology of soft tissue wound healing and regeneration--consensus report of Group 1 of the 10th European Workshop on Periodontology, Group 1 of the European Workshop on Periodontology, vol.15, pp.1-5, 2014.

L. Harmouche, A. Courval, A. Mathieu, C. Petit, O. Huck et al., Impact of tooth-related factors on photodynamic therapy effectiveness during active periodontal therapy: A 6-months split-mouth randomized clinical trial, Photodiag Photodyn Ther, vol.27, pp.167-172, 2019.

B. Hassan, I. Fouilloux, B. Baroukh, A. Llorens, M. Biosse-duplan et al., Coordination of early cellular reactions during activation of bone resorption in the rat mandible periosteum: An immunohistochemical study. Heliyon 3, e00430, Periodontol, vol.62, pp.218-231, 2000.

S. C. Heo, E. S. Jeon, I. H. Lee, H. S. Kim, M. B. Kim et al., Tumor necrosis factor-?-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms, J. Invest. Dermatol, vol.131, pp.1559-1567, 2011.

D. Herrera, P. Matesanz, A. Bascones-martínez, and M. Sanz, Local and systemic antimicrobial therapy in periodontics, J Evid Based Dent Pract, vol.12, pp.50-60, 2012.

S. C. Holt, J. Ebersole, J. Felton, M. Brunsvold, and K. S. Kornman, Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis, Science, vol.239, pp.55-57, 1988.

A. Hoornaert, C. Arros, M. Heymann, and P. Layrolle, Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration, Biomed Mater, vol.11, p.45012, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01702004

O. Huck, H. Tenenbaum, and J. Davideau, Relationship between periodontal diseases and preterm birth: recent epidemiological and biological data, J Pregnancy, p.164654, 2011.

O. Huck, R. Elkaim, J. Davideau, and H. Tenenbaum, Porphyromonas gingivalisimpaired innate immune response via NLRP3 proteolysis in endothelial cells, Innate Immun, vol.21, pp.65-72, 2015.

O. Huck, J. Al-hashemi, L. Poidevin, O. Poch, J. Davideau et al., Identification and Characterization of MicroRNA Differentially Expressed in Macrophages Exposed to Porphyromonas gingivalis Infection, Infect. Immun, vol.85, 2017.

O. Huck, J. You, X. Han, B. Cai, J. Panek et al., Reduction of Articular and Systemic Inflammation by Kava-241 in a Porphyromonas gingivalis-Induced Arthritis Murine Model, Inf Immun, vol.86, pp.356-374, 2018.

E. Ioannidou, Y. Hall, H. Swede, and J. Himmelfarb, Periodontitis associated with chronic kidney disease among Mexican Americans, J Public Health Dent, vol.73, pp.112-119, 2013.

S. Ivanovski, Periodontal regeneration, Aust Dent J, vol.54, issue.1, pp.118-128, 2009.

S. Ivanovski, C. Vaquette, S. Gronthos, D. W. Hutmacher, and P. M. Bartold, Multiphasic scaffolds for periodontal tissue engineering, J. Dent. Res, vol.93, pp.1212-1221, 2014.

H. Jakhu, G. Gill, and A. Singh, Role of integrins in wound repair and its periodontal implications, J Oral Biol Craniofac Res, vol.8, pp.122-125, 2018.

L. J. Jin, I. B. Lamster, J. S. Greenspan, N. B. Pitts, C. Scully et al., Global burden of oral diseases: emerging concepts, management and interplay with systemic health, Oral Dis, vol.22, pp.609-619, 2016.

D. Joshi, T. Garg, A. K. Goyal, and G. Rath, Advanced drug delivery approaches against periodontitis, Drug Deliv, vol.23, pp.363-377, 2016.

S. Kagami, T. Owada, H. Kanari, Y. Saito, A. Suto et al., Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells, Int. Immunol, vol.21, pp.679-689, 2009.

A. Kantarci and T. E. Van-dyke, Resolution of Inflammation in Periodontitis, J. Periodontol, vol.76, pp.2168-2174, 2005.

A. Kantarci, H. Hasturk, and T. E. Van-dyke, Animal models for periodontal regeneration and peri-implant responses, Periodontol, vol.68, pp.66-82, 2000.

A. Kasaj, C. Reichert, H. Götz, B. Röhrig, R. Smeets et al., In vitro evaluation of various bioabsorbable and nonresorbable barrier membranes for guided tissue regeneration, Head Face Med, vol.4, p.22, 2008.

N. J. Kassebaum, E. Bernabé, M. Dahiya, B. Bhandari, C. J. Murray et al., Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression, J. Dent. Res, vol.93, pp.1045-1053, 2014.

J. A. Katancik, A. Kumarswamy, G. Branch-mays, and J. V. Califano, 11 -Infections of the Periodontal Apparatus, pp.189-202, 2016.

J. Katz, I. Bhattacharyya, F. Farkhondeh-kish, F. M. Perez, R. M. Caudle et al., Expression of the receptor of advanced glycation end products in gingival tissues of type 2 diabetes patients with chronic periodontal disease: a study utilizing immunohistochemistry and RT-PCR, J. Clin. Periodontol, vol.32, pp.40-44, 2005.

A. Kaur, S. Gupta, A. Tyagi, R. K. Sharma, J. Ali et al., Development of Nanoemulsion Based Gel Loaded with Phytoconstituents for the Treatment of Urinary Tract Infection and in Vivo Biodistribution Studies, Advanced Pharmaceutical Bulletin, vol.7, p.611, 2017.

S. Kempe and K. Mäder, In situ forming implants -an attractive formulation principle for parenteral depot formulations, J Controlled Release, vol.161, pp.668-679, 2012.

W. W. Khodir, V. Guarino, M. Alvarez-perez, C. Cafiero, A. et al., Trapping tetracycline-loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy, J Bioact Compat Polymers, vol.28, pp.258-273, 2013.

J. H. Kim, H. M. Jin, K. Kim, I. Song, B. U. Youn et al., The mechanism of osteoclast differentiation induced by IL-1, J. Immunol, vol.183, pp.1862-1870, 2009.

Y. Kim, M. Kim, J. H. Kang, H. J. Kim, J. Park et al., Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns, Hum. Genomics, vol.10, p.28, 2016.

D. F. Kinane, P. G. Stathopoulou, and P. N. Papapanou, Periodontal diseases, Nature Reviews Disease Primers, vol.3, 2017.

L. Kocgozlu, R. Elkaim, H. Tenenbaum, and S. Werner, Variable cell responses to P. gingivalis lipopolysaccharide, J. Dent. Res, vol.88, pp.741-745, 2009.

T. Kocher, M. Langenbeck, A. Rühling, and H. C. Plagmann, Subgingival polishing with a teflon-coated sonic scaler insert in comparison to conventional instruments as assessed on extracted teeth. (I) Residual deposits, J. Clin. Periodontol, vol.27, pp.243-249, 2000.

K. S. Kornman, Mapping the pathogenesis of periodontitis: a new look, J. Periodontol, vol.79, pp.1560-1568, 2008.

H. Kranz and R. Bodmeier, Structure formation and characterization of injectable drug loaded biodegradable devices: In situ implants versus in situ microparticles, European Journal of Pharmaceutical Sciences, vol.34, pp.164-172, 2008.

E. Lalla and P. N. Papapanou, Diabetes mellitus and periodontitis: a tale of two common interrelated diseases, Nature Reviews Endocrinology, vol.7, pp.738-748, 2011.

C. X. Lam, M. M. Savalani, S. Teoh, and D. W. Hutmacher, Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: accelerated versus simulated physiological conditions, Biomed Mater, vol.3, p.34108, 2008.

R. J. Lamont and G. Hajishengallis, Polymicrobial synergy and dysbiosis in inflammatory disease, Trends Mol Med, vol.21, pp.172-183, 2015.

N. P. Lang and P. M. Bartold, Periodontal health, J Periodontol, vol.89, pp.9-16, 2018.

O. Lapérine, A. Cloitre, J. Caillon, O. Huck, I. M. Bugueno et al., Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis, PLOS One, vol.11, 2016.

H. Larjava, L. Koivisto, L. Häkkinen, and J. Heino, Epithelial integrins with special reference to oral epithelia, J. Dent. Res, vol.90, pp.1367-1376, 2011.

L. Larsson, A. M. Decker, L. Nibali, S. P. Pilipchuk, T. Berglundh et al., Regenerative Medicine for Periodontal and Peri-implant Diseases, J. Dent. Res, vol.95, pp.255-266, 2016.

S. C. Lea, G. Landini, and A. D. Walmsley, Thermal imaging of ultrasonic scaler tips during tooth instrumentation, J. Clin. Periodonto, vol.31, pp.370-375, 2004.

B. Lee, C. Lee, Y. Wang, H. Chen, C. Lai et al., Controlled-release of tetracycline and lovastatin by poly(d,l-lactide-coglycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs, Int J Nanomedicine, vol.11, pp.285-297, 2016.

M. Lemaitre, P. Monsarrat, V. Blasco-baque, P. Loubières, R. Burcelin et al., Periodontal Tissue Regeneration Using Syngeneic Adipose-Derived Stromal Cells in a Mouse Model, Stem Cells Transl Med, vol.6, pp.656-665, 2017.

D. Liang, B. S. Hsiao, C. , and B. , Functional electrospun nanofibrous scaffolds for biomedical applications, Adv. Drug Deliv. Rev, vol.59, pp.1392-1412, 2007.

G. J. Linden, A. Lyons, and F. A. Scannapieco, Periodontal systemic associations: review of the evidence, J. Clin. Periodontol, vol.40, pp.8-19, 2013.

L. Ling, S. Hung, C. Lee, Y. Chen, and K. Wu, The influence of membrane exposure on the outcomes of guided tissue regeneration: clinical and microbiological aspects, J. Periodont. Res, vol.38, pp.57-63, 2003.

Q. L. Loh and C. Choong, Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size, Tissue Eng Part B Rev, vol.19, pp.485-502, 2013.

A. Lundmark, N. Gerasimcik, T. Båge, A. Jemt, A. Mollbrink et al., Gene expression profiling of periodontitis-affected gingival tissue by spatial transcriptomics, p.9370, 2018.

M. Madi and A. Kassem, Topical simvastatin gel as a novel therapeutic modality for palatal donor site wound healing following free gingival graft procedure, Acta Odontol. Scand, vol.76, pp.212-219, 2018.

W. Marcenes, N. J. Kassebaum, E. Bernabé, A. Flaxman, M. Naghavi et al., Global burden of oral conditions in 1990-2010: a systematic analysis, J. Dent. Res, vol.92, pp.592-597, 2013.

J. Marchesan, M. S. Girnary, L. Jing, M. Z. Miao, S. Zhang et al., An experimental murine model to study periodontitis, Nat Protoc, vol.13, pp.2247-2267, 2018.

A. Mariotti, Periodontal Diseases. XPharm, pp.1-5, 2007.

S. S. Martande, M. Kumari, A. R. Pradeep, S. P. Singh, D. K. Suke et al., Platelet-Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial, J. Periodontol, vol.87, pp.1039-1046, 2016.

P. Martin and S. J. Leibovich, Inflammatory cells during wound repair: the good, the bad and the ugly, Trends Cell Biol, vol.15, pp.599-607, 2005.

R. Martin-cabezas, J. Davideau, H. Tenenbaum, and O. Huck, Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: a systematic review and meta-analysis, J. Clin. Periodontol, vol.43, pp.520-530, 2016.

M. Martínez-ballesta, Á. Gil-izquierdo, C. García-viguera, and R. Domínguez-perles, Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New "Smart-Foods" for Health, vol.7, p.72, 2018.

B. H. Maskrey, I. L. Megson, P. D. Whitfield, and A. G. Rossi, Mechanisms of resolution of inflammation: a focus on cardiovascular disease, Arterioscler. Thromb. Vasc Biol, vol.31, pp.1001-1006, 2011.

I. L. Meek, M. A. Van-de-laar, and H. E. Vonkeman, Non-Steroidal Anti-Inflammatory Drugs: An Overview of Cardiovascular Risks, Pharmaceuticals, vol.3, pp.2146-2162, 2010.

A. H. Melcher, On the repair potential of periodontal tissues, J. Periodontol, vol.47, pp.256-260, 1976.

T. S. Miranda, S. L. Heluy, D. F. Cruz, H. D. Da-silva, M. Feres et al., The ratios of pro-inflammatory to anti-inflammatory cytokines in the serum of chronic periodontitis patients with and without type 2 diabetes and/or smoking habit, Clin Oral Investig, vol.23, pp.641-650, 2019.

D. G. Miranda, S. M. Malmonge, D. M. Campos, N. G. Attik, P. Grosgogeat et al., A chitosan-hyaluronic acid scaffold for periodontal tissue engineering, J. Biomed. Mater Res. B. Appl. Biomater, vol.104, pp.1691-1702, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02380865

A. Mombelli, N. Cionca, A. , and A. , Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery?, Periodontol, vol.55, pp.205-216, 2000.

D. Morand, O. Huck, L. Keller, N. Jessel, H. Tenenbaum et al., , 2015.

, Active Nanofibrous Membrane Effects on Gingival Cell Inflammatory Response. Materials, vol.8, pp.7217-7229

D. N. Morand, J. Davideau, F. Clauss, N. Jessel, H. Tenenbaum et al., Cytokines during periodontal wound healing: potential application for new therapeutic approach, Oral Dis, vol.23, pp.300-311, 2017.

F. W. Muniz, K. Taminski, J. Cavagni, R. K. Celeste, P. Weidlich et al., The effect of statins on periodontal treatment-a systematic review with metaanalyses and meta-regression, Clin Oral Investig, vol.22, pp.671-687, 2018.

C. J. Murray, T. Vos, R. Lozano, M. Naghavi, A. D. Flaxman et al., Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, Lancet, vol.380, pp.2197-2223, 1990.
URL : https://hal.archives-ouvertes.fr/hal-00827610

T. Nagayasu-tanaka, J. Anzai, S. Takaki, N. Shiraishi, A. Terashima et al., Action Mechanism of Fibroblast Growth Factor-2 (FGF-2) in the Promotion of Periodontal Regeneration in Beagle Dogs, Biotech Histochem, vol.10, pp.295-300, 2007.

C. E. Nemcovsky and I. Beitlitum, Combination Therapy for Reconstructive Periodontal Treatment in the Lower Anterior Area: Clinical Evaluation of a Case Series, Dent J, vol.6, p.50, 2018.

M. K. Noh, M. Jung, S. H. Kim, S. R. Lee, K. H. Park et al., Assessment of IL-6, IL-8 and TNF-? levels in the gingival tissue of patients with periodontitis, Exp Ther Med, vol.6, pp.847-851, 2013.

G. D. Norata and A. L. Catapano, Statins and periodontal inflammation: a pleiotropic effect of statins or a pleiotropic effect of LDL-cholesterol lowering?, Atherosclerosis, vol.234, pp.381-382, 2014.

M. E. Nunn, J. Fan, X. Su, R. A. Levine, H. Lee et al., Development of prognostic indicators using classification and regression trees for survival, Periodontol, vol.58, pp.134-142, 2000.

S. Nyman, J. Lindhe, T. Karring, and H. Rylander, New attachment following surgical treatment of human periodontal disease, J. Clin. Periodontol, vol.9, pp.290-296, 1982.

A. I. Özdo?an, Y. D. ?larslan, K. Kösemehmeto?lu, G. Akca, H. B. Kutlu et al., In vivo evaluation of chitosan based local delivery systems for atorvastatin in treatment of periodontitis, Int J Pharm, vol.550, pp.470-476, 2018.

P. N. Papapanou and C. Susin, Periodontitis epidemiology: is periodontitis underrecognized, over-diagnosed, or both, Periodontol, vol.75, pp.45-51, 2000.

P. N. Papapanou, M. Sanz, N. Buduneli, T. Dietrich, M. Feres et al., Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions, J Clin Periodontol, vol.45, pp.162-170, 2018.

S. Park, S. An, W. Han, and J. Park, Three-dimensional measurement of periodontal surface area for quantifying inflammatory burden, J Periodontal Implant Sci, vol.47, pp.154-164, 2017.

M. H. Patel, J. V. Kumar, and M. E. Moss, Diabetes and tooth loss: an analysis of data from the National Health and Nutrition Examination Survey, J Am Dent Assoc, vol.144, pp.478-485, 2003.

P. E. Petersen and H. Ogawa, The global burden of periodontal disease: towards integration with chronic disease prevention and control, Periodontol, vol.60, pp.15-39, 2000.

C. Petit, S. Schmeltz, A. Burgy, H. Tenenbaum, O. Huck et al., Risk factors associated with long-term outcomes after active and supporting periodontal treatments: impact of various compliance definitions on tooth loss, Clin Oral Investig, 2019.

C. Petit, F. Batool, I. M. Bugueno, P. Schwinté, N. Benkirane-jessel et al., Contribution of Statins towards Periodontal Treatment: A Review, Mediators Inflamm, p.6367402, 2019.

B. L. Pihlstrom, B. S. Michalowicz, J. , and N. W. , Periodontal diseases, Lancet, vol.366, pp.1809-1820, 2005.

D. Polak, C. Martin, I. Sanz-sánchez, N. Beyth, and L. Shapira, Are antiinflammatory agents effective in treating gingivitis as solo or adjunct therapies? A systematic review, J Clin Periodontol, vol.42, pp.139-151, 2015.

C. J. Poston, T. C. Pierce, Y. Li, C. W. Brinson, Z. Lu et al., Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis, Oral Dis, vol.22, pp.438-444, 2016.

A. R. Pradeep and M. S. Thorat, Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial, J. Periodontol, vol.81, pp.214-222, 2010.

A. R. Pradeep, S. Karvekar, K. Nagpal, K. Patnaik, C. N. Guruprasad et al., Efficacy of locally delivered 1.2% rosuvastatin gel to non-surgical treatment of patients with chronic periodontitis: a randomized, placebo-controlled clinical trial, J. Periodontol, vol.86, pp.738-745, 2015.

. Prateeksha, S. K. Barik, and B. N. Singh, Nanoemulsion-loaded hydrogel coatings for inhibition of bacterial virulence and biofilm formation on solid surfaces, Sci Rep, vol.9, p.6520, 2019.

P. M. Preshaw and S. M. Bissett, Periodontitis: oral complication of diabetes, Endocrinol. Metab. Clin. North Am, vol.42, pp.849-867, 2013.

Z. Qu and E. L. Chaikof, Interface between hemostasis and adaptive immunity, Curr Opin Immunol, vol.22, pp.634-642, 2010.

B. Rai, J. Kaur, S. C. Anand, and R. Jacobs, Salivary stress markers, stress, and periodontitis: a pilot study, J. Periodontol, vol.82, pp.287-292, 2011.

T. E. Rams, J. D. Sautter, C. Y. Hsiao, and A. J. Van-winkelhoff, Phenotypic identification of periodontal Prevotella intermedia/nigrescens group isolates validated by MALDI-TOF mass spectrometry, Anaerobe, vol.54, pp.201-204, 2018.

G. Rasperini, S. P. Pilipchuk, C. L. Flanagan, C. H. Park, G. Pagni et al., 3D-printed Bioresorbable Scaffold for Periodontal Repair, J Dent Res, vol.94, pp.153-157, 2015.

D. H. Reneker and A. L. Yarin, Electrospinning jets and polymer nanofibers, Polymer, vol.49, pp.2387-2425, 2008.

M. Reners and M. Brecx, Stress and periodontal disease, Int J Dent Hyg, vol.5, pp.199-204, 2007.

M. A. Reynolds, M. E. Aichelmann-reidy, G. L. Branch-mays, and J. C. Gunsolley, The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review, Ann. Periodontol, vol.8, pp.227-265, 2003.

M. C. Robson, Cytokine manipulation of the wound, Clin Plast Surg, vol.30, pp.57-65, 2003.

M. Rosin, S. T. Kähler, M. Hessler, C. Schwahn, A. Kuhr et al., The effect of a dexibuprofen mouth rinse on experimental gingivitis in humans, J. Clin. Periodontol, vol.32, pp.617-621, 2005.

C. A. Rouzer and L. J. Marnett, Cyclooxygenases: structural and functional insights, J Lipid Res, vol.50, pp.29-34, 2009.

D. Rusu, M. Boariu, . Stratul, -. I. ?tefan, F. Bojin et al., Interaction between a 3D collagen matrix used for periodontal soft tissue regeneration and T-lymphocytes: An in vitro pilot study, Exp Ther Med, vol.17, pp.990-996, 2019.

K. Saadi-thiers, O. Huck, P. Simonis, P. Tilly, J. Fabre et al., Periodontal and systemic responses in various mice models of experimental periodontitis: respective roles of inflammation duration and Porphyromonas gingivalis infection, J. Periodontol, vol.84, pp.396-406, 2013.

M. Sanz, F. D'aiuto, J. Deanfield, and F. Fernandez-avilés, European workshop in periodontal health and cardiovascular disease-scientific evidence on the association between periodontal and cardiovascular diseases: a review of the literature, Eur Heart J Suppl, vol.12, pp.3-12, 2010.

M. Sanz, C. Dahlin, D. Apatzidou, Z. Artzi, D. Bozic et al., Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration, J. Clin. Periodontol, vol.46, pp.82-91, 2019.

D. K. Sarker, Engineering of nanoemulsions for drug delivery, Curr Drug Deliv, vol.2, pp.297-310, 2005.

V. Sarrazy, F. Billet, L. Micallef, B. Coulomb, and A. Desmoulière, Mechanisms of pathological scarring: role of myofibroblasts and current developments, Wound Repair Regen, vol.19, issue.1, pp.10-15, 2011.

T. Saxlin, L. Suominen-taipale, M. Knuuttila, P. Alha, Y. et al., Dual effect of statin medication on the periodontium, J. Clin. Periodontol, vol.36, pp.997-1003, 2009.

J. Schmitz, A. Owyang, E. Oldham, Y. Song, E. Murphy et al., IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines, Immunity, vol.23, pp.479-490, 2005.

P. Schwinté, A. Mariotte, P. Anand, L. Keller, Y. Idoux-gillet et al., Anti-inflammatory effect of active nanofibrous polymeric membrane bearing nanocontainers of atorvastatin complexes, Nanomedicine, vol.12, pp.2651-2674, 2017.

A. Sculean, G. C. Chiantella, P. Windisch, and N. Donos, Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain), Int J Periodontics Restorative Dent, vol.20, pp.374-381, 2000.

A. Sculean, D. Nikolidakis, and F. Schwarz, Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials -biological foundation and preclinical evidence: a systematic review, J. Clin. Periodontol, vol.35, pp.106-116, 2008.

A. Sculean, R. Alessandri, R. Miron, G. E. Salvi, and D. D. Bosshardt, Enamel Matrix Proteins and Periodontal Wound Healing and Regeneration, Clin Adv Periodontics, vol.1, pp.101-117, 2011.

C. N. Serhan and N. Chiang, Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus, Br. J. Pharmacol, vol.153, issue.1, pp.200-215, 2008.

G. Serino, B. Rosling, P. Ramberg, S. S. Socransky, and J. Lindhe, Initial outcome and long-term effect of surgical and non-surgical treatment of advanced periodontal disease, J. Clin. Periodontol, vol.28, pp.910-916, 2001.

J. Serrano, M. Escribano, S. Roldán, C. Martín, and D. Herrera, Efficacy of adjunctive anti-plaque chemical agents in managing gingivitis: a systematic review and meta-analysis, J. Clin. Periodontol, vol.42, pp.106-138, 2015.

R. Sheshala, S. Y. Quah, G. C. Tan, V. S. Meka, N. Jnanendrappa et al., Investigation on solution-to-gel characteristic of thermosensitive and mucoadhesive biopolymers for the development of moxifloxacin-loaded sustained release periodontal in situ gels, Drug Deliv Transl Res, vol.9, pp.434-443, 2019.

A. Simões, L. Chen, Z. Chen, Y. Zhao, S. Gao et al., Differential microRNA profile underlies the divergent healing responses in skin and oral mucosal wounds, 2019.

S. P. Singh, O. Huck, N. G. Abraham, and S. Amar, Kavain Reduces Porphyromonas gingivalis-Induced Adipocyte Inflammation: Role of PGC-1? Signaling, J Immunol, vol.1, issue.5, pp.1491-1499, 2018.

S. S. Socransky and A. D. Haffajee, Periodontal microbial ecology, Periodontol, vol.38, pp.135-187, 2000.

T. Sorsa, U. K. Gursoy, S. Nwhator, M. Hernandez, T. Tervahartiala et al., Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases, Periodontol, vol.70, pp.142-163, 2000.

L. H. Sousa, E. V-m-linhares, J. Trycia-alexandre, M. Roberto-lisboa, F. Furlaneto et al., Effects of Atorvastatin on Periodontitis of Rats Subjected to Glucocorticoid-induced Osteoporosis, J. Periodontol, vol.87, pp.1206-1216, 2016.

M. Spite, J. Clària, and C. N. Serhan, Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases, Cell Metab, vol.19, pp.21-36, 2014.

C. Stoecklin-wasmer, P. Guarnieri, R. Celenti, R. T. Demmer, M. Kebschull et al., MicroRNAs and their target genes in gingival tissues, J. Dent. Res, vol.91, pp.934-940, 2012.

J. Su, J. Gu, Z. Dong, M. , and B. , Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice, Int J Mol Sci, vol.14, pp.18457-18469, 2013.

M. Sugano, Y. Negishi, Y. Endo-takahashi, N. Hamano, M. Usui et al., Gene delivery to periodontal tissue using Bubble liposomes and ultrasound, J. Periodont. Res, vol.49, pp.398-404, 2014.

S. C. Sundararaj, M. V. Thomas, R. Peyyala, T. D. Dziubla, and D. A. Puleo, Design of a Multiple Drug Delivery System Directed at Periodontitis, Biomaterials, vol.34, pp.8835-8842, 2013.

C. Susin, T. Fiorini, J. Lee, J. A. De-stefano, D. P. Dickinson et al., Wound healing following surgical and regenerative periodontal therapy, Periodontol, vol.68, pp.83-98, 2000.

M. V. Thomas and D. A. Puleo, Infection, inflammation, and bone regeneration: a paradoxical relationship, J. Dent. Res, vol.90, pp.1052-1061, 2011.

C. Tomasi, A. H. Leyland, and J. L. Wennström, Factors influencing the outcome of non-surgical periodontal treatment: a multilevel approach, J. Clin. Periodontol, vol.34, pp.682-690, 2007.

C. Tomasi, T. Koutouzis, and J. L. Wennström, Locally delivered doxycycline as an adjunct to mechanical debridement at retreatment of periodontal pockets, J. Periodontol, vol.79, pp.431-439, 2008.

M. S. Tonetti, P. Cortellini, N. P. Lang, J. E. Suvan, P. Adriaens et al., Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial, J. Clin. Periodontol, vol.31, pp.770-776, 2004.

M. S. Tonetti and T. E. Van-dyke, Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases, and working group 1 of the joint EFP/AAP workshop, vol.84, pp.24-29, 2013.

M. S. Tonetti, A. L. Christiansen, and P. Cortellini, Vertical subclassification predicts survival of molars with class II furcation involvement during supportive periodontal care, J. Clin. Periodontol, vol.44, pp.1140-1144, 2017.

M. S. Tonetti, S. Jepsen, L. Jin, and J. Otomo-corgel, Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action, J. Clin. Periodontol, vol.44, pp.456-462, 2017.

F. Trindade, F. G. Oppenheim, E. J. Helmerhorst, F. Amado, P. S. Gomes et al., Uncovering the molecular networks in periodontitis, Proteomics Clin Appl, vol.8, pp.748-761, 2014.

E. A. Trofin, P. Monsarrat, and P. Kémoun, Cell therapy of periodontium: from animal to human?, Front Physiol, vol.4, 2013.

L. Trombelli, D. N. Tatakis, C. Scapoli, S. Bottega, E. Orlandini et al., Modulation of clinical expression of plaque-induced gingivitis. II. Identification of "high-responder" and "low-responder" subjects, J. Clin. Periodontol, vol.31, pp.239-252, 2004.

L. Trombelli, R. Farina, C. O. Silva, and D. N. Tatakis, Plaque-induced gingivitis: Case definition and diagnostic considerations, J. Clin. Periodontol, vol.45, pp.44-67, 2018.

J. Tunkel, A. Heinecke, and T. F. Flemmig, A systematic review of efficacy of machine-driven and manual subgingival debridement in the treatment of chronic periodontitis, J. Clin. Periodontol, vol.29, pp.72-81, 2002.

M. Ueda, T. Fujisawa, M. Ono, E. S. Hara, H. T. Pham et al., A systematic review on the clinical efficacy of subgingival debridement in the treatment of chronic periodontitis, J. Clin. Periodontol, vol.5, pp.55-71, 2002.

T. E. Van-dyke, The Management of Inflammation in Periodontal Disease, J Periodontol, vol.79, pp.1601-1608, 2008.

T. E. Van-dyke, Pro-resolving Mediators in the Regulation of Periodontal Disease, Mol Aspects Med, vol.58, pp.21-36, 2017.

C. Vaquette, W. Fan, Y. Xiao, S. Hamlet, D. W. Hutmacher et al., A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone/periodontal ligament complex, Biomaterials, vol.33, pp.5560-5573, 2012.

T. Velnar, T. Bailey, and V. Smrkolj, The wound healing process: an overview of the cellular and molecular mechanisms, J. Int. Med. Res, vol.37, pp.1528-1542, 2009.

V. S. Venkataiah, K. Handa, M. M. Njuguna, T. Hasegawa, K. Maruyama et al., Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo, p.921, 2019.

H. Wachtel, G. Schenk, S. Böhm, D. Weng, O. Zuhr et al., Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: a controlled clinical study, J. Clin. Periodontol, vol.30, pp.496-504, 2003.

H. Wang and H. Greenwell, Surgical periodontal therapy, Periodontology, vol.25, pp.89-99, 2000.

H. Wang, H. Greenwell, J. Fiorellini, W. Giannobile, S. Offenbacher et al., Periodontal regeneration, Science and Therapy Committee, vol.76, pp.1601-1622, 2005.

Y. Wang, H. Li, Y. Feng, P. Jiang, J. Su et al., Dual micelles-loaded gelatin nanofibers and their application in lipopolysaccharide-induced periodontal disease, Int J Nanomedicine, vol.14, pp.963-976, 2019.

Z. Wang, Z. Wang, W. W. Lu, W. Zhen, D. Yang et al., Novel biomaterial strategies for controlled growth factor delivery for biomedical applications, NPG Asia Materials, vol.9, p.435, 2017.

X. Wei, X. Zhang, M. J. Zuscik, M. H. Drissi, E. M. Schwarz et al., Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles, J. Bone Miner. Res, vol.20, pp.1136-1148, 2005.

S. Werner, T. Krieg, and H. Smola, Keratinocyte-fibroblast interactions in wound healing, J. Invest. Dermatol, vol.127, pp.998-1008, 2007.

M. Yamada, N. Takahashi, Y. Matsuda, K. Sato, M. Yokoji et al., A bacterial metabolite ameliorates periodontal pathogen-induced gingival epithelial barrier disruption via GPR40 signaling, p.9008, 2018.

M. Yar, A. Farooq, L. Shahzadi, A. S. Khan, N. Mahmood et al., Novel meloxicam releasing electrospun polymer/ceramic reinforced biodegradable membranes for periodontal regeneration applications, Mater Sci Eng C Mater Biol Appl, vol.64, pp.148-156, 2016.

H. Yeh, J. Lu, S. Chang, and M. Ge, Identification of microbiota in periimplantitis pockets by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, p.774, 2019.

H. Yuan, R. Gupte, S. Zelkha, and S. Amar, Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis, J. Clin. Periodontol, vol.38, pp.1029-1036, 2011.

U. Zagai, K. Fredriksson, S. I. Rennard, J. Lundahl, and C. M. Sköld, Platelets stimulate fibroblast-mediated contraction of collagen gels, Respir Res, vol.4, p.13, 2003.

H. Zhang, S. Liu, Y. Zhou, J. Tan, H. Che et al., Natural mineralized scaffolds promote the dentinogenic potential of dental pulp stem cells via the mitogen-activated protein kinase signaling pathway, Tissue Eng Part A, vol.18, pp.677-691, 2012.

X. Zhang, E. M. Schwarz, D. A. Young, J. E. Puzas, R. N. Rosier et al., , 2002.

, Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair, J. Clin. Invest, vol.109, pp.1405-1415

Y. Zhang, A. D. Bradley, D. Wang, and R. A. Reinhardt, Statins, bone metabolism and treatment of bone catabolic diseases, Pharmacological Research, vol.88, pp.53-61, 2014.

, Synthesis of a novel electrospun polycaprolactone scaffold functionalized with ibuprofen for periodontal regeneration: an in vitro and in vivo study, Materials, 2018.

F. Batool, D. Morand, L. Thomas, I. M. Bugueno, J. Aragon et al., Olivier Huck 2. Periodontal tissues, maxillary jaw bone, and tooth regeneration approaches: from animal models analyses to clinical applications, Nanomaterials, 2018.

, Contribution of statins towards periodontal treatment: a review, Mediators of inflammation, 2019.

C. Petit, *. , F. Batool, *. , and I. M. Bugueno, Nadia Benkirane-Jessel

, In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: proof of concept study in vivo, International Journal of Pharmaceutics

F. Batool, K. Agossa, M. Lizambard, N. Benkirane-jessel, H. Tenenbaum et al.,

, Porphyromonas gingivalis differentially modulates apoptosome apoptotic peptidase activating factor 1 in epithelial cells and fibroblasts, American Journal of Pathology, 2018.

F. Isaac-maximiliano-bugueno, L. Batool, and . Korah, Nadia Benkirane-Jessel

, Porphyromonas gingivalis bypasses epithelial barrier and modulates fibroblastic inflammatory response in an in vitro 3D spheroid model, Scientific Reports, 2018.

F. Isaac-maximiliano-bugueno, L. Batool, S. Keller, and . Kuchler-bopp, Nadia Benkirane-Jessel

, Are sex steroid hormones influencing periodontal conditions: a systematic review, Current Oral Health Reports, 2018.

A. Akcal?, Z. Akcal?, F. Batool, and C. Petit,

, Vienna Austria-1st prize Title: In vitro and in vivo assessment of poly-?-caprolactone membrane functionalized with ibuprofen on periodontal wound healing, Authors: Fareeha Batool, David-Nicolas Morand, Lionel Thomas, Isaac Maximiliano Bugueno, 2017.

, Development of 3D gingival microtissues. Authors: Isaac Maximiliano Bugueno, 2017.

, Modulation of inflammatory response in periodontal wound healing: Perspectives in periodontal regeneration Authors: Fareeha Batool, 2017.

, Amsterdam Netherlands Title: Anti-inflammatory functionalized membrane for periodontal regeneration: in vivo evaluation in periodontitis-induced mouse model Authors, EuroPerio9, 2018.

, Title: Modulation of inflammation and new perspectives in periodontal regeneration Authors: Fareeha Batool, Olivier Huck 8. Poster presentation at Journées postgraduate-universitaires, Faculté de chirurgiedentaire 2018, Strasbourg France-1st prize Title: In vitro and in vivo assessment of poly-?-caprolactone membrane functionalized with ibuprofen on periodontal wound healing, Title: A new 3D in vitro model of gingival tissue to assess host-pathogen interactions, 2018.

D. Morand, L. Thomas, I. M. Bugueno, J. Aragon, S. Irusta et al., Olivier Huck 10. Poster presentation at SFPIO, 2019, Paris France-1 st prize. Title: A novel chlorhexidine and ibuprofen in-situ forming implant for periodontal regeneration: a proof of concept study Authors: Fareeha Batool, Kevimy Agossa, Martin Lizambard, Nadia Benkirane-Jessel, Henri Tenenbaum, Jurgen Siepmann, Florence Siepmann, Olivier Huck 2. Materials and Methods 2.1. Materials Poly (D, L-lactic acid/glycolic acid) 50/50 polymer (PLGA; MW 24-38 KDa), Anti-inflammatory functionalized membrane for periodontal regeneration: in vivo evaluation in periodontitis-induced mouse model Authors: Fareeha Batool, 2018.

, Polycaprolactone (PCL; MW 80 KDa) analytical grade, cyclosporine A (0.1 mg/mL), dexamethasone (used as HPLC internal standard), Pluronic ® F-68 surfactant, ethyl acetate (Class 3 solvent according to the pharmacopeia), acetonitrile, methanol (HPLC grade), and Ibuprofen (50 µg/mL) were all purchased from Sigma-Aldrich, ) and chitosan (Protasan UPCL 113, 500 µg/mL) from NovaMatrix

, Synthesis and Characterization of Cyclosporine A (CsA) Loaded PLGA Nanoparticles Cyclosporine A loaded PLGA (PLGA/CsA) nanoparticles were prepared in a continuous microfluidic reactor using a PEEK-made interdigital micromixer (SIMM-V2, Slit Interdigital Micro Mixer, IMM, Mainz, Germany) by carrying out an oil-in-water (O/W) emulsification process followed by a solvent evaporation procedure as previously described [29]. Scanning electron microscopy

, PCL Scaffold Synthesis and Functionalization PCL was dissolved in a mixture of dichloromethane/dimethylformamide (DCM/DMF 50/50 v/v) at 15% w/v and stirred overnight before use. A standard electrospinning set-up (EC-DIG apparatus, IME Technologies

H. Tan, K. G. Peres, and M. A. Peres, Retention of Teeth and Oral Health-Related Quality of Life, J. Dent. Res, vol.95, pp.1350-1357, 2016.

M. S. Tonetti, A. L. Christiansen, and P. Cortellini, Vertical subclassification predicts survival of molars with class II furcation involvement during supportive periodontal care, J. Clin. Periodontol, vol.44, pp.1140-1144, 2017.

P. Cortellini, J. Buti, G. Pini-prato, and M. S. Tonetti, Periodontal regeneration compared with access flap surgery in human intra-bony defects 20-year follow-up of a randomized clinical trial: Tooth retention, periodontitis recurrence and costs, J. Clin. Periodontol, vol.44, pp.58-66, 2017.

D. Buser, L. Sennerby, and H. De-bruyn, Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions, Periodontol, vol.73, pp.7-21, 2000.

K. Agossa, D. N. Morand, H. Tenenbaum, J. L. Davideau, and O. Huck, Systemic Application of Anti-inflammatory Agents in Periodontal Treatment, Clin. Anti-Inflamm. Anti-Allergy Drugs, vol.2, 2015.

M. Feres, L. C. Figueiredo, G. M. Soares, and M. Faveri, Systemic antibiotics in the treatment of periodontitis, Periodontol, vol.67, pp.131-186, 2000.

L. J. Heitz-mayfield and N. P. Lang, Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts, Periodontol, vol.62, pp.218-231, 2000.

T. Karring, S. Nyman, J. Gottlow, and L. Laurell, Development of the biological concept of guided tissue regeneration-Animal and human studies, Periodontol, vol.1, pp.26-35, 20001993.

R. Martin-cabezas, J. L. Davideau, H. Tenenbaum, and O. Huck, Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: A systematic review and meta-analysis, J. Clin. Periodontol, vol.43, pp.520-530, 2016.

M. Noordijk, J. L. Davideau, S. Eap, O. Huck, F. Fioretti et al., Bone defects and future regenerative nanomedicine approach using stem cells in the mutant Tabby mouse model, Biomed. Mater. Eng, vol.25, pp.111-119, 2015.

M. A. Reynolds, M. E. Aichelmann-reidy, G. L. Branch-mays, and J. C. Gunsolley, The efficacy of bone replacement grafts in the treatment of periodontal osseous defects: A systematic review, Ann. Periodontol, vol.8, pp.227-265, 2003.

P. M. Bartold, C. A. Mcculloch, A. S. Narayanan, and S. Pitaru, Tissue engineering: A new paradigm for periodontal regeneration based on molecular and cell biology, Periodontol, vol.24, pp.253-269, 2000.

N. Huebsch and D. J. Mooney, Inspiration and application in the evolution of biomaterials, Nature, vol.462, pp.426-432, 2009.

D. N. Morand, J. L. Davideau, F. Clauss, N. Jessel, H. Tenenbaum et al., Cytokines during periodontal wound healing: Potential application for new therapeutic approach, Oral Dis, vol.23, pp.300-311, 2017.

M. Strub, X. Van-bellinghen, F. Fioretti, F. Bornert, N. Benkirane-jessel et al., Maxillary Bone Regeneration Based on Nanoreservoirs Functionalized "-Polycaprolactone Biomembranes in a Mouse Model of Jaw Bone Lesion, BioMed Res. Int, 2018.

F. Batool, D. N. Morand, L. Thomas, I. M. Bugueno, J. Aragon et al., Synthesis of a Novel Electrospun Polycaprolactone Scaffold Functionalized with Ibuprofen for Periodontal Regeneration: An In Vitro and, In Vivo Study. Materials, vol.11, 2018.

A. Guzalinuer, H. Muhetaer, H. Wu, and A. Paerhati, Experimental study on the transforming growth factor 3 combined with dental pulp stem cells in early bone integration of implant, Zhonghua Kou Qiang Yi Xue Za Zhi, vol.53, pp.259-263, 2018.

K. Nakajima, R. Kunimatsu, K. Ando, T. Ando, Y. Hayashi et al., Comparison of the bone regeneration ability between stem cells from human exfoliated deciduous teeth, human dental pulp stem cells and human bone marrow mesenchymal stem cells, Biochem. Biophys. Res. Commun, vol.497, pp.876-882, 2018.

C. Tomasi, M. Donati, D. Cecchinato, I. Szathvary, E. Corrà et al., Effect of socket grafting with deproteinized bone mineral: An RCT on dimensional alterations after 6 months, Clin. Oral Implants Res, 2018.

R. E. Jung, V. M. Sapata, C. H. Hämmerle, H. Wu, X. L. Hu et al., Combined use of xenogeneic bone substitute material covered with a native bilayer collagen membrane for alveolar ridge preservation: A randomized controlled clinical trial, Clin. Oral Implants Res, 2018.

W. Colangeli, U. Riccelli, A. Giudice, I. Barca, D. Caruso et al., Jaw bones regeneration using mesenchymal stem cells: A single-center experience, Ann. Ital. Chir, vol.89, pp.20-23, 2018.

L. Peng, L. Ye, and X. D. Zhou, Mesenchymal stem cells and tooth engineering, Int. J. Oral Sci, vol.1, pp.6-12, 2009.

L. Keller, S. Kuchler-bopp, S. A. Mendoza, A. Poliard, and H. Lesot, Tooth engineering: Searching for dental mesenchymal cells sources, Front. Physiol, 2007.

B. Hu, A. Nadiri, S. Bopp-kuchler, F. Perrin-schmitt, and H. Lesot, Dental epithelial histomorphogenesis in vitro, J. Dent. Res, vol.84, pp.521-525, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00187627

A. Nait-lechguer, S. Kuchler-bopp, B. Hu, Y. Haïkel, and H. Lesot, Vascularization of engineered teeth, J. Dent. Res, vol.87, pp.1138-1143, 2008.

S. Eap, T. Bécavin, L. Keller, T. Kökten, F. Fioretti et al., Nanofibers implant functionalized by neural growth factor as a strategy to innervate a bioengineered tooth, Adv. Healthc. Mater, vol.3, pp.386-391, 2014.

T. Kökten, T. Bécavin, L. Keller, J. L. Weickert, S. Kuchler-bopp et al., Immunomodulation stimulates the innervation of engineered tooth organ, PLoS ONE, vol.9, p.86011, 2014.

A. Roozbehi, M. T. Joghataie, M. Mehdizadeh, A. Mirzaei, and H. Delaviz, The effects of cyclosporin-A on functional outcome and axonal regrowth following spinal cord injury in adult rats, Acta Med. Iran, vol.50, pp.226-232, 2012.

S. Kuchler-bopp, A. Larrea, L. Petry, Y. Idoux-gillet, V. Sebastian et al., Promoting bioengineered tooth innervation using nanostructured and hybrid scaffolds, Acta Biomater, vol.50, pp.493-501, 2017.

C. Mendoza-palomares, A. Ferrand, S. Facca, F. Fioretti, G. Ladam et al., Benkirane-Jessel, N. Smart hybrid materials equipped by nanoreservoirs of therapeutics, ACS Nano, vol.6, pp.483-490, 2012.

K. Saadi-thiers, O. Huck, P. Simonis, P. Tilly, J. E. Fabre et al., Periodontal and systemic responses in various mice models of experimental periodontitis: Respective roles of inflammation duration and Porphyromonas gingivalis infection, J. Periodontol, vol.84, pp.396-406, 2013.

M. C. Bottino and V. Thomas, Membranes for Periodontal Regeneration-A Materials Perspective, Front. Oral Biol, vol.17, pp.90-100, 2015.

S. Wei, C. Jian, F. Xu, T. Bao, S. Lan et al., Vancomycin-impregnated electrospun polycaprolactone (PCL) membrane for the treatment of infected bone defects: An animal study, J. Biomater. Appl, vol.32, pp.1187-1196, 2018.

V. Beachley and X. Wen, Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions, Prog. Polym. Sci, vol.35, pp.868-892, 2010.

C. Vaquette, S. Fawzi-grancher, P. Lavalle, C. Frochot, M. L. Viriot et al., In vitro biocompatibility of different polyester membranes, Biomed. Mater. Eng, vol.16, pp.131-136, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00139823

M. Deng, R. James, C. T. Laurencin, and S. G. Kumbar, Nanostructured polymeric scaffolds for orthopaedic regenerative engineering, IEEE Trans. Nanobiosci, vol.11, pp.3-14, 2012.

A. Ferrand, S. Eap, L. Richert, S. Lemoine, D. Kalaskar et al., Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan based nanoreservoirs of growth factors, Macromol. Biosci, vol.14, pp.45-55, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00966560

K. Jepsen and S. Jepsen, Antibiotics/antimicrobials: Systemic and local administration in the therapy of mild to moderately advanced periodontitis, Periodontol, vol.71, pp.82-112, 2000.

C. M. Champagne, J. Takebe, S. Offenbacher, and L. F. Cooper, Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2, vol.30, pp.26-31, 2002.

S. Sharma, D. Sapkota, Y. Xue, S. Rajthala, M. A. Yassin et al., Delivery of VEGFA in bone marrow stromal cells seeded in copolymer scaffold enhances angiogenesis, but is inadequate for osteogenesis as compared with the dual delivery of VEGFA and BMP2 in a subcutaneous mouse model, Stem Cell Res. Ther, vol.9, p.23, 2018.

R. Zhen, J. Yang, Y. Wang, Y. Li, B. Chen et al., Hepatocyte growth factor improves bone regeneration via the bone morphogenetic protein-2-mediated NF-?B signaling pathway, Mol. Med. Rep, vol.17, pp.6045-6053, 2018.

D. Wang, Y. Lin, L. Chen, Y. Mo, P. Huang et al., Guided bone regeneration using a bone tissue engineering complex consisting of a poly-dl-lactide membrane and bone mesenchymal stem cells, Oncotarget, vol.9, pp.16380-16388, 2017.

W. Guo, X. Zheng, W. Zhang, M. Chen, Z. Wang et al., Mesenchymal stem cells in oriented PLGA/ACECM composite scaffolds enhance structure-specific regeneration of hyaline cartilage in a rabbit model, Stem Cells Int, 2018.

J. Garcia, A. Dodge, P. Luepke, H. L. Wang, Y. Kapila et al., Effect of membrane exposure on guided bone regeneration: A systematic review and meta-analysis, Clin. Oral Implants Res, vol.29, pp.328-338, 2018.

G. Li, T. Zhou, S. Lin, S. Shi, and Y. Lin, Nanomaterials for Craniofacial and Dental Tissue Engineering, J. Dent. Res, vol.96, pp.725-732, 2017.

M. J. Caicco, M. J. Cooke, Y. Wang, A. Tuladhar, C. M. Morshead et al., A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke, J. Control. Release, vol.166, pp.197-202, 2013.

P. Cortellini, G. P. Pini-prato, and M. S. Tonetti, No detrimental effect of fibrin glue on the regeneration of intrabony defects. A controlled clinical trial, J. Clin. Periodontol, vol.22, pp.697-702, 1995.