Skip to Main content Skip to Navigation
Theses

Development of novel therapeutic strategies for periodontal regeneration by modulation of inflammatory response

Abstract : Control of periodontal infection and inflammation is crucial for optimal periodontal wound healing and regeneration. For this purpose, three different and novel strategies were developed and tested for their impact on periodontal wound healing parameters in vitro and in vivo. Firstly, an ibuprofen-functionalized polycaprolactone (IBU-PCL) membrane was developed as an anti-inflammatory barrier membrane that successfully reduced inflammatory markers expression in gingival cells in vitro and decreased soft tissue inflammation, thus, improving periodontal tissue healing in an experimental periodontitis model in vivo. Secondly, chlorhexidine and ibuprofen containing in-situ forming implant (CHX-IBU ISFI) was developed to target both infection and inflammation that successfully reduced Porphyromonas gingivalis growth and inflammatory response of gingival cells in vitro as well as improved soft tissue periodontal wound healing in vivo. Lastly, a thermosensitive chitosan-based hydrogel functionalized with atorvastatin encapsulated in a nano-emulsion (ATV-KELP NE) was characterized and used to treat an induced bone defect in vivo that resulted in improved soft and hard tissue healing by counteracting infection and modulation of immuno-inflammatory response.
Complete list of metadatas

Cited literature [557 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02885068
Contributor : Abes Star :  Contact
Submitted on : Tuesday, June 30, 2020 - 1:15:17 PM
Last modification on : Friday, October 23, 2020 - 5:03:13 PM

File

Batool_Fareeha_2019_ED414.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02885068, version 1

Collections

Citation

Fareeha Batool. Development of novel therapeutic strategies for periodontal regeneration by modulation of inflammatory response. Bioengineering. Université de Strasbourg, 2019. English. ⟨NNT : 2019STRAJ068⟩. ⟨tel-02885068⟩

Share

Metrics

Record views

69

Files downloads

23