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The roles of Trim15 and UCHL3 in the ubiquitin-mediated cell cycle regulation

Abstract : Mitosis is tightly controlled by ubiquitin signaling and is crucial to maintain genome integrity. In this work, I investigated the function of the deubiquitinating enzyme UCHL3 and the E3 ubiquitin ligase TRIM15. I observed that TRIM15 regulates cell adhesion and motility. UCHL3 was identified in a high-content screen, as a critical factor controlling the chromosome alignment and segregation. Interestingly, it has been previously reported that UCHL3 levels are altered in various cancer types. Using a proteomic approach, we identified Aurora B kinase as a potential mediator of these phenotypes. Since aneuploidy is a hallmark of many cancers, and cell adhesion plays an important role in tumor invasion and metastasis, my results suggest that both proteins could play a role in carcinogenesis.
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Katerina Jerabkova. The roles of Trim15 and UCHL3 in the ubiquitin-mediated cell cycle regulation. Cellular Biology. Université de Strasbourg; Univerzita Karlova (Prague), 2019. English. ⟨NNT : 2019STRAJ034⟩. ⟨tel-02884583⟩

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