S. B. Abramson, A. , and M. , Developments in the scientific understanding of osteoarthritis, Arthritis Res. Ther, vol.11, p.227, 2009.

M. E. Adams and H. Muir, The glycosaminoglycans of canine menisci, Biochem. J, vol.197, pp.385-389, 1981.

J. A. Alkrad, Y. Mrestani, D. Stroehl, S. Wartewig, and R. Neubert, Characterization of enzymatically digested hyaluronic acid using NMR, Raman, IR, and UV-Vis spectroscopies, J. Pharm. Biomed. Anal, vol.31, pp.545-550, 2003.

A. A. Allen, G. L. Caldwell, and F. H. Fu, Anatomy and biomechanics of the meniscus, Oper. Tech. Orthop, vol.5, pp.2-9, 1995.

R. Altman, E. Asch, D. Bloch, G. Bole, D. Borenstein et al., Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee, Arthritis Rheum, vol.29, pp.1039-1049, 1986.

S. Amin, M. P. Lavalley, A. Guermazi, M. Grigoryan, D. J. Hunter et al., The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis, Arthritis Rheum, vol.52, pp.3152-3159, 2005.

C. C. Annarelli, J. Fornazero, J. Bert, and J. Colombani, Crack patterns in drying protein solution drops, Eur. Phys. J. E, vol.5, pp.599-603, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00001124

M. Arican, S. D. Carter, C. May, and D. Bennett, Hyaluronan in canine arthropathies, J. Comp. Pathol, vol.111, pp.185-195, 1994.

M. Attur, J. Samuels, S. Krasnokutsky, A. , and S. B. , Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?, Best Pract. Res. Clin. Rheumatol, vol.24, pp.71-79, 2010.

M. Attur, S. Krasnokutsky-samuels, J. Samuels, A. , and S. B. , Prognostic biomarkers in osteoarthritis, Curr. Opin. Rheumatol, vol.25, pp.136-144, 2013.

E. Ayhan, H. Kesmezacar, A. , and I. , Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis, World J. Orthop, vol.5, pp.351-361, 2014.

M. Bachy, I. Sherifi, F. Zadegan, D. Petrover, H. Petite et al., Anterior cruciate ligament surgery in the rabbit, J. Orthop. Surg, vol.8, p.27, 2013.

E. De-bakker, V. Stroobants, F. Vandael, B. Van-ryssen, and E. Meyer, Canine synovial fluid biomarkers for early detection and monitoring of osteoarthritis, Vet. Rec, vol.180, pp.328-329, 2017.

E. A. Balazs, The Physical Properties of Synovial Fluid and the Special Role of Hyaluronic Acid, Disorders of the Knee, pp.63-75, 1974.

E. A. Balazs, The role of hyaluronan in the structure and function of the biomatrix of connective tissues, Struct. Chem, vol.20, pp.233-243, 2009.

E. A. Balazs and J. L. Denlinger, Viscosupplementation: a new concept in the treatment of osteoarthritis, J. Rheumatol. Suppl, vol.39, pp.3-9, 1993.

R. Bansil, I. V. Yannas, and H. E. Stanley, Raman spectroscopy: a structural probe of glycosaminoglycans, Biochim. Biophys. Acta, vol.541, pp.535-542, 1978.

D. L. Batiste, A. Kirkley, S. Laverty, L. M. Thain, A. R. Spouge et al., Ex vivo characterization of articular cartilage and bone lesions in a rabbit ACL transection model of osteoarthritis using MRI and micro-CT, Osteoarthritis Cartilage, vol.12, pp.986-996, 2004.

A. C. Bay-jensen, D. Reker, C. F. Kjelgaard-petersen, A. Mobasheri, M. A. Karsdal et al., Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria, Osteoarthritis Cartilage, vol.24, pp.9-20, 2016.

D. Bazin, C. Chappard, C. Combes, X. Carpentier, S. Rouzière et al., Diffraction techniques and vibrational spectroscopy opportunities to characterise bones, Osteoporos. Int, vol.20, pp.1065-1075, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00430187

C. Belcher, R. Yaqub, F. Fawthrop, M. Bayliss, and M. Doherty, Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees, Ann. Rheum. Dis, vol.56, pp.299-307, 1997.

N. Bellamy, The WOMAC Knee and Hip Osteoarthritis Indices: Development, validation, globalization and influence on the development of the AUSCAN Hand Osteoarthritis Indices, Clin. Exp. Rheumatol, vol.23, pp.148-153, 2005.

N. Bellamy, W. W. Buchanan, C. H. Goldsmith, J. Campbell, and L. W. Stitt, Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee, J. Rheumatol, vol.15, pp.1833-1840, 1988.

A. M. Bendele, Animal models of osteoarthritis, J. Musculoskelet. Neuronal Interact, vol.1, pp.363-376, 2001.

M. J. Benito, D. J. Veale, O. Fitzgerald, W. B. Berg, . Van-den et al., Synovial tissue inflammation in early and late osteoarthritis, Ann. Rheum. Dis, vol.64, pp.1263-1267, 2005.

M. J. Benito, D. J. Veale, O. Fitzgerald, W. B. Berg, . Van-den et al., Synovial tissue inflammation in early and late osteoarthritis, Ann. Rheum. Dis, vol.64, pp.1263-1267, 2005.

F. Berenbaum and J. Auger, Le grand livre de l'arthrose: Le guide indispensable pour soulager efficacement les douleurs liées à l'arthrose (Editions Eyrolles), 2016.

P. Bertin, F. Rannou, L. Grange, J. Dachicourt, P. Bruel et al., , 2014.

, Annual Cost of Patients with Osteoarthritis of the Hip and Knee in France, J. Musculoskelet. Pain, vol.22, pp.356-364

P. Bhuanantanondh, D. Grecov, and E. Kwok, Rheology of Synovial Fluid From Patients With Osteoarthritis and the Effects of Viscosupplements on the Rheology of Synovial Fluid, pp.237-238, 2010.

A. A. Biewener, Tendons and Ligaments: Structure, Mechanical Behavior and Biological Function, Collagen, pp.269-284, 2008.

L. Bin, R. Bennacer, K. Sefiane, and A. Steinchen, Transient Effects in Evaporating Sessile Drops: With and Without Heating, J. Heat Transf, vol.138, pp.91009-091009, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01684859

. Binette and . Schmid, The proteins of synovial fluid : A study od the alpha1/alpha2 globulin ratio, 1965.

J. A. Bispo, . De-sousa, E. E. Vieira, L. Silveira, and A. B. Fernandes, Correlating the amount of urea, creatinine, and glucose in urine from patients with diabetes mellitus and hypertension with the risk of developing renal lesions by means of Raman spectroscopy and principal component analysis, J. Biomed. Opt, vol.18, p.87004, 2013.

M. Blewis, G. Nugent-derfus, T. A. Schmidt, B. L. Schumacher, and R. L. Sah, A model of synovial fluid lubricant composition in normal and injured joints, Eur. Cell. Mater, vol.13, pp.26-38, 2007.

A. Bonifacio, S. Dalla-marta, R. Spizzo, S. Cervo, A. Steffan et al., Surfaceenhanced Raman spectroscopy of blood plasma and serum using Ag and Au nanoparticles: a systematic study, Anal. Bioanal. Chem, vol.406, pp.2355-2365, 2014.

A. Bonifacio, C. Beleites, and V. Sergo, Application of R-mode analysis to Raman maps: a different way of looking at vibrational hyperspectral data, Anal. Bioanal. Chem, vol.407, pp.1089-1095, 2015.

C. Bosser, A. Ogier, L. Imbert, and T. Hoc, Raman Spectroscopy as a Biomarker-Investigative Tool in Bone Metabolism, Biomarkers in Bone Disease, pp.1-27, 2016.

W. Bou-zeid and D. Brutin, Influence of relative humidity on spreading, pattern formation and adhesion of a drying drop of whole blood, Colloids Surf. Physicochem. Eng. Asp, vol.430, pp.1-7, 2013.

M. Bouchgua, K. Alexander, M. André-d'anjou, C. A. Girard, E. N. Carmel et al., Use of routine clinical multimodality imaging in a rabbit model of osteoarthritis -part I, Osteoarthritis Cartilage, vol.17, pp.188-196, 2009.

M. Bouchgua, K. Alexander, E. N. Carmel, M. A. Anjou, G. Beauchamp et al., Use of routine clinical multimodality imaging in a rabbit model of osteoarthritis -part II: bone mineral density assessment, Osteoarthritis Cartilage, vol.17, pp.197-204, 2009.

S. R. Brannan and D. A. Jerrard, Synovial fluid analysis, J. Emerg. Med, vol.30, pp.331-339, 2006.

R. C. Bray, P. T. Salo, I. K. Lo, P. Ackermann, J. B. Rattner et al., Normal ligament structure, physiology and function, Sports Med. Arthrosc. Rev, vol.13, pp.127-135, 2005.

T. Breinlinger and T. Kraft, A simple method for simulating the coffee stain effect, Powder Technol, vol.256, pp.279-284, 2014.

M. P. Brown, T. N. Trumble, J. D. Sandy, and K. A. Merritt, A simplified method of determining synovial fluid chondroitin sulfate chain length, Osteoarthritis Cartilage, vol.15, pp.1443-1445, 2007.

D. Brutin, B. Sobac, B. Loquet, and J. Sampol, Pattern formation in drying drops of blood, J. Fluid Mech, vol.667, pp.85-95, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01460087

J. A. Buckwalter and D. T. Felson, Post-Traumatic Arthritis: Definitions and Burden of Disease, pp.7-15, 2015.

N. Buote, J. Fusco, and R. Radasch, Age, tibial plateau angle, sex, and weight as risk factors for contralateral rupture of the cranial cruciate ligament in Labradors, Vet. Surg. VS, vol.38, pp.481-489, 2009.

D. B. Burr and M. A. Gallant, Bone remodelling in osteoarthritis, Nat. Rev. Rheumatol, vol.8, pp.665-673, 2012.

C. Cadet, E. Maheu, P. Breville, C. Jeandel, J. L. Quintrec et al., Phénotypes cliniques : arthroses plutôt qu'arthrose, vol.7, pp.52-57, 2015.

J. Calvet, C. Orellana, J. Gratacós, A. Berenguer-llergo, A. Caixàs et al., Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion, Arthritis Res. Ther, vol.18, p.207, 2016.

E. Calvo, I. Palacios, E. Delgado, O. Sánchez-pernaute, R. Largo et al., Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis, Osteoarthritis Cartilage, vol.12, pp.878-886, 2004.

S. Castañeda, J. A. Roman-blas, R. Largo, and G. Herrero-beaumont, Subchondral bone as a key target for osteoarthritis treatment, Biochem. Pharmacol, vol.83, pp.315-323, 2012.

B. Chakrabarti and J. W. Park, Glycosaminoglycans: structure and interaction, CRC Crit. Rev. Biochem, vol.8, pp.225-313, 1980.

J. Charron, Mesures Sans Contact, 2004.

X. Chevalier, R. , and P. , Cartilage articulaire normal : anatomie, physiologie, métabolisme, vieillissement, EMC -Rhumatol.-Orthopédie, vol.2, pp.41-58, 2005.

F. Chinas-castillo and H. A. Spikes, Film Formation by Colloidal Overbased Detergents in Lubricated Contacts, Tribol. Trans, vol.43, pp.357-366, 2000.

J. Cibere, H. Zhang, P. Garnero, A. R. Poole, T. Lobanok et al., Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study, Arthritis Rheum, vol.60, pp.1372-1380, 2009.

F. Cimino, B. S. Volk, and D. Setter, Anterior cruciate ligament injury: Diagnosis, management, and prevention, Am. Fam. Physician, vol.82, pp.917-922, 2010.

G. A. Coatney, A. C. Abraham, K. M. Fischenich, K. D. Button, R. C. Haut et al., Efficacy of P188 on lapine meniscus preservation following blunt trauma, J. Mech. Behav. Biomed. Mater, vol.47, pp.57-64, 2015.

P. J. Coleman, D. Scott, R. M. Mason, and J. R. Levick, Role of hyaluronan chain length in buffering interstitial flow across synovium in rabbits, J. Physiol, vol.526, pp.425-434, 2000.

C. , Can synovial fluid viscosity be used as a physical marker for osteoarthritis severity, 2003.

S. Cotofana, R. Buck, W. Wirth, F. Roemer, J. Duryea et al., Cartilage Thickening in Early Radiographic Human Knee Osteoarthritis -Within-Person, Between-Knee Comparison, Arthritis Care Res, vol.64, pp.1681-1690, 2012.

L. B. Dahl, I. M. Dahl, A. Engström-laurent, and K. Granath, Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies, Ann. Rheum. Dis, vol.44, pp.817-822, 1985.

L. Dahlberg, L. Ryd, D. Heinegård, and L. S. Lohmander, Proteoglycan fragments in joint fluid, Acta Orthop. Scand, vol.63, pp.417-423, 1992.

J. Damiano and T. Bardin, Liquide synovial normal et pathologique, EMC -Podol, vol.1, pp.65-79, 2005.

A. F. Darwish, H. S. Abdel-ghany, and Y. M. El-sherbini, Diagnostic and prognostic value of some biochemical markers in early knee osteoarthritis, Egypt. Rheumatol, vol.34, pp.1-8, 2012.

B. Decker, W. F. Mcguckin, B. F. Mckenzie, and C. H. Slocumb, Concentration of Hyaluronic Acid in Synovial Fluid, Clin. Chem, vol.5, pp.465-469, 1959.

R. D. Deegan, Pattern formation in drying drops, Phys. Rev. E, vol.61, pp.475-485, 2000.

R. D. Deegan, O. Bakajin, T. F. Dupont, G. Huber, S. R. Nagel et al., Capillary flow as the cause of ring stains from dried liquid drops, Nature, vol.389, pp.827-829, 1997.

R. D. Deegan, O. Bakajin, T. F. Dupont, G. Huber, S. R. Nagel et al., Contact line deposits in an evaporating drop, Phys. Rev. E, vol.62, pp.756-765, 2000.

J. Degroot, R. A. Bank, I. Tchetverikov, N. Verzijl, and J. M. Tekoppele, Molecular markers for osteoarthritis: the road ahead, pp.585-589, 2002.

K. A. Dehring, N. J. Crane, A. R. Smukler, J. B. Mchugh, B. J. Roessler et al., Identifying Chemical Changes in Subchondral Bone Taken from Murine Knee Joints Using Raman Spectroscopy, Appl. Spectrosc, vol.60, pp.1134-1141, 2006.

K. A. Dehring, A. R. Smukler, B. J. Roessler, and M. D. Morris, Correlating Changes in Collagen Secondary Structure with Aging and Defective Type II Collagen by Raman Spectroscopy, Appl. Spectrosc, vol.60, pp.366-372, 2006.

A. Dell'isola, R. Allan, S. L. Smith, S. S. Marreiros, and M. Steultjens, Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature, BMC Musculoskelet. Disord, vol.17, p.425, 2016.

N. C. Dingari, G. L. Horowitz, J. W. Kang, R. R. Dasari, and I. Barman, Raman Spectroscopy Provides a Powerful Diagnostic Tool for Accurate Determination of Albumin Glycation, PLoS ONE, vol.7, 2012.

R. Ellis, E. Green, and C. P. Winlove, Structural Analysis of Glycosaminoglycans and Proteoglycans by Means of Raman Microspectrometry, Connect. Tissue Res, vol.50, pp.29-36, 2009.

H. Y. Erbil, Evaporation of pure liquid sessile and spherical suspended drops: A review, Adv. Colloid Interface Sci, vol.170, pp.67-86, 2012.

B. Escofier and J. Pagès, Analyses factorielles simples et multiples: objectifs, méthodes et interprétation, 2008.

K. Esmonde-white, Raman Spectroscopy of Soft Musculoskeletal Tissues, Appl. Spectrosc, vol.68, pp.1203-1218, 2014.

K. A. Esmonde-white, G. S. Mandair, F. Raaii, B. J. Roessler, and M. D. Morris, Raman spectroscopy of dried synovial fluid droplets as a rapid diagnostic for knee joint damage, p.68530, 2008.

K. A. Esmonde-white, S. V. Le-clair, B. J. Roessler, and M. D. Morris, Effect of Conformation and Drop Properties on Surface-Enhanced Raman Spectroscopy of Dried Biopolymer Drops, Appl. Spectrosc, vol.62, pp.503-511, 2008.

K. A. Esmonde-white, G. S. Mandair, F. Raaii, J. A. Jacobson, B. S. Miller et al., Raman spectroscopy of synovial fluid as a tool for diagnosing osteoarthritis, J. Biomed. Opt, vol.14, p.34013, 2009.

K. A. Esmonde-white, G. S. Mandair, F. W. Esmonde-white, F. Raaii, B. J. Roessler et al., Osteoarthritis screening using Raman spectroscopy of dried human synovial fluid drops, pp.71660-71660, 2009.

K. A. Esmonde-white, F. W. Esmonde-white, M. D. Morris, and B. J. Roessler, Characterization of biofluids prepared by sessile drop formation, The Analyst, vol.139, pp.2734-2741, 2014.

C. H. Evans, V. B. Kraus, and L. A. Setton, Progress in intra-articular therapy, Nat. Rev. Rheumatol, vol.10, pp.11-22, 2014.

H. Fam, J. T. Bryant, and M. Kontopoulou, Rheological properties of synovial fluids, Biorheology, vol.44, pp.59-74, 2007.

B. Fautrel, P. Hilliquin, S. Rozenberg, F. Allaert, P. Coste et al., Impact of osteoarthritis: Results of a nationwide survey of 10 000 patients consulting for OA, Rev. Rhum. Ed. Fr, vol.72, pp.404-410, 2005.

D. T. Felson, Identifying Different Osteoarthritis Phenotypes through Epidemiology, Osteoarthr. Cartil. OARS Osteoarthr. Res. Soc, vol.18, pp.601-604, 2010.

J. Filik and N. Stone, Drop coating deposition Raman spectroscopy of protein mixtures, The Analyst, vol.132, p.544, 2007.

J. Filik and N. Stone, Analysis of human tear fluid by Raman spectroscopy, Anal. Chim. Acta, vol.616, pp.177-184, 2008.

K. M. Fischenich, G. A. Coatney, J. H. Haverkamp, K. D. Button, C. Decamp et al., Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model, J. Biomech. Eng, vol.136, pp.71001-071001, 2014.

K. M. Fischenich, J. Lewis, K. A. Kindsfater, T. S. Bailey, and T. L. Donahue, Effects of degeneration on the compressive and tensile properties of human meniscus, J. Biomech, vol.48, pp.1407-1411, 2015.

K. M. Fischenich, K. D. Button, G. A. Coatney, R. S. Fajardo, K. M. Leikert et al., Chronic changes in the articular cartilage and meniscus following traumatic impact to the lapine knee, J. Biomech, vol.48, pp.246-253, 2015.

C. Florea, M. K. Malo, J. Rautiainen, J. T. Mäkelä, J. M. Fick et al., Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection, Osteoarthritis Cartilage, vol.23, pp.414-422, 2015.

C. B. Frank, Ligament structure, physiology and function, J. Musculoskelet. Neuronal Interact, vol.4, pp.199-201, 2004.

R. B. Frobell, M. C. Nevitt, M. Hudelmaier, W. Wirth, B. T. Wyman et al., Femorotibial subchondral bone area and regional cartilage thickness: A cross-sectional description in healthy reference cases and various radiographic stages of osteoarthritis in 1,003 knees from the Osteoarthritis Initiative, Arthritis Care Res, vol.62, pp.1612-1623, 2010.

X. Fu, L. Lin, J. Zhang, Y. , and C. , Assessment of the efficacy of joint lavage in rabbits with osteoarthritis of the Knee, J. Orthop. Res, vol.27, pp.91-96, 2009.

M. J. Furey and B. M. Burkhardt, Biotribology: Friction, wear, and lubrication of natural synovial joints, Lubr. Sci, vol.9, pp.255-271, 1997.

S. Gamsjaeger, K. Klaushofer, and E. P. Paschalis, Raman analysis of proteoglycans simultaneously in bone and cartilage: Proteoglycans by Raman analysis, J. Raman Spectrosc, vol.45, pp.794-800, 2014.

R. Gobezie, A. Kho, B. Krastins, D. A. Sarracino, T. S. Thornhill et al., High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis, Arthritis Res. Ther, vol.9, p.36, 2007.

M. B. Goldring and S. R. Goldring, Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis, Ann. N. Y. Acad. Sci, vol.1192, pp.230-237, 2010.

H. M. Gorr, J. M. Zueger, D. R. Mcadams, and J. A. Barnard, Salt-induced pattern formation in evaporating droplets of lysozyme solutions, Colloids Surf. B Biointerfaces, vol.103, pp.59-66, 2013.

H. M. Gorr, Z. Xiong, and J. A. Barnard, Pattern recognition for identification of lysozyme droplet solution chemistry, Colloids Surf. B Biointerfaces, vol.115, pp.170-175, 2014.

L. Grange, Stop à l'arthrose, 2016.

M. H. Gregory, N. Capito, K. Kuroki, A. M. Stoker, J. L. Cook et al., A Review of Translational Animal Models for Knee Osteoarthritis, Arthritis, vol.2012, pp.1-14, 2012.

F. Grosjean, J. Dommergues, and G. Macagno, La statistique en clair, 2011.

M. Guay, Anatomie fonctionnelle de l'appareil locomoteur: os, articulations, muscles (PUM), 2005.

I. Haq, E. Murphy, and J. Dacre, Osteoarthritis. Postgrad. Med. J, vol.79, pp.377-383, 2003.

B. J. Heard, L. Martin, J. B. Rattner, C. B. Frank, D. A. Hart et al., Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid, BMC Musculoskelet. Disord, vol.13, 2012.

N. Hegemann, B. Kohn, L. Brunnberg, and M. F. Schmidt, Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders, Osteoarthritis Cartilage, vol.10, pp.714-721, 2002.

M. Hellio-le-graverand, Y. Ou, T. Schield-yee, L. Barclay, D. Hart et al., The cells of the rabbit meniscus: their arrangement, interrelationship, morphological variations and cytoarchitecture, J. Anat, vol.198, pp.525-535, 2000.

M. Hellio-le-graverand, E. Vignon, I. G. Otterness, and D. A. Hart, Early changes in lapine menisci during osteoarthritis development: Part I: Cellular and matrix alterations, Osteoarthritis Cartilage, vol.9, pp.56-64, 2001.

Y. Henrotin, C. Sanchez, and M. Balligand, Pharmaceutical and nutraceutical management of canine osteoarthritis: Present and future perspectives, Vet. J, vol.170, pp.113-123, 2005.

Y. Henrotin, S. Addison, V. Kraus, and M. Deberg, Type II collagen markers in osteoarthritis: what do they indicate?, Curr. Opin. Rheumatol, vol.19, pp.444-450, 2007.

Y. Henrotin, L. Pesesse, and C. Sanchez, Subchondral bone and osteoarthritis: biological and cellular aspects, Osteoporos. Int, vol.23, pp.847-851, 2012.

Y. Henrotin, L. Pesesse, L. , and C. , Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis, Ther. Adv. Musculoskelet. Dis, vol.6, pp.20-34, 2014.

Y. Henrotin, C. Sanchez, A. C. Bay-jensen, and A. Mobasheri, Osteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives, Ann. Phys. Rehabil. Med, vol.59, pp.145-148, 2016.

G. Herrero-beaumont, R. Guerrero, O. Sánchez-pernaute, C. Acebes, I. Palacios et al., Cartilage and bone biological markers in the synovial fluid of osteoarthritic patients after hyaluronan injections in the knee, Clin. Chim. Acta, vol.308, pp.107-115, 2001.

G. Herrero-beaumont, M. E. Marcos, O. Sánchez-pernaute, R. Granados, L. Ortega et al., Effect of chondroitin sulphate in a rabbit model of atherosclerosis aggravated by chronic arthritis, Br. J. Pharmacol, vol.154, pp.843-851, 2008.

J. Herwig, E. Egner, and E. Buddecke, Chemical changes of human knee joint menisci in various stages of degeneration, Ann. Rheum. Dis, vol.43, pp.635-640, 1984.

H. Hu and R. G. Larson, Marangoni Effect Reverses Coffee-Ring Depositions, J. Phys. Chem. B, vol.110, pp.7090-7094, 2006.

Z. Huang, Y. Sun, J. Wang, S. Du, Y. Li et al., Rapid and nondestructive method for evaluation of embryo culture media using drop coating deposition Raman spectroscopy, J. Biomed. Opt, vol.18, p.127003, 2013.

M. Huber, S. Trattnig, and F. Lintner, Anatomy, biochemistry, and physiology of articular cartilage, Invest. Radiol, vol.35, pp.573-580, 2000.

A. Y. Hui, W. J. Mccarty, K. Masuda, G. S. Firestein, and R. L. Sah, A systems biology approach to synovial joint lubrication in health, injury, and disease, Interdiscip. Rev. Syst. Biol. Med, vol.4, pp.15-37, 2012.

D. J. Hunter and D. T. Felson, Osteoarthritis. Br. Med. J, vol.332, pp.639-642, 2006.

V. L. Johnson and D. J. Hunter, The epidemiology of osteoarthritis, Best Pract. Res. Clin. Rheumatol, vol.28, pp.5-15, 2014.

I. A. Karampas, M. G. Orkoula, and C. G. Kontoyannis, A quantitative bioapatite/collagen calibration method using Raman spectroscopy of bone, J. Biophotonics, vol.6, pp.573-586, 2013.

J. H. Kellgren and J. S. Lawrence, Radiological assessment of osteo-arthrosis, Ann. Rheum. Dis, vol.16, pp.494-502, 1957.

P. Knox, J. R. Levick, and J. N. Mcdonald, Synovial Fluid -Its Mass, Macromolecular Content and Pressure in Major Limb Joints of the Rabbit, Q. J. Exp. Physiol, vol.73, pp.33-45, 1988.

F. C. Ko, C. Dragomir, D. A. Plumb, S. R. Goldring, T. M. Wright et al., In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae, Arthritis Rheum, vol.65, pp.1569-1578, 2013.

E. Ko?i?ová, A. Vodáková, and M. Procházka, DCDR Spectroscopy as Efficient Tool for Liposome Studies: Aspect of Preparation Procedure Parameters. Spectrosc, Int. J, vol.27, pp.349-353, 2012.

E. Ko?i?ová, A. Antalík, and M. Procházka, Drop coating deposition Raman spectroscopy of liposomes: role of cholesterol, Chem. Phys. Lipids, vol.172, pp.1-5, 2013.

V. Kopecký and V. Baumruk, Structure of the ring in drop coating deposited proteins and its implication for Raman spectroscopy of biomolecules, Vib. Spectrosc, vol.42, pp.184-187, 2006.

C. Krafft, G. Steiner, C. Beleites, and R. Salzer, Disease recognition by infrared and Raman spectroscopy, J. Biophotonics, vol.2, pp.13-28, 2009.

N. Kumahashi, P. Swärd, S. Larsson, L. S. Lohmander, R. Frobell et al., Type II collagen C2C epitope in human synovial fluid and serum after knee injury -associations with molecular and structural markers of injury, Osteoarthritis Cartilage, vol.23, pp.1506-1512, 2015.

R. Kumar, K. M. Grønhaug, N. K. Afseth, V. Isaksen, C. De-lange-davies et al., Optical investigation of osteoarthritic human cartilage (ICRS grade) by confocal Raman spectroscopy: a pilot study, Anal. Bioanal. Chem, vol.407, pp.8067-8077, 2015.

R. Kumar, G. Singh, K. Grønhaug, N. Afseth, C. De-lange-davies et al., , 2015.

, Single Cell Confocal Raman Spectroscopy of Human Osteoarthritic Chondrocytes: A Preliminary Study, Int. J. Mol. Sci, vol.16, pp.9341-9353

. Kushner, Permeability of human synovial membrance to plasma proteins, 1971.

E. L. Kuyinu, G. Narayanan, L. S. Nair, and C. T. Laurencin, Animal models of osteoarthritis: classification, update, and measurement of outcomes, J. Orthop. Surg, vol.11, 2016.

E. Lamcharfi, C. Cohen-solal, M. Parquet, C. Lutton, J. Dupré et al., Determination of molecular associations of some hydrophobic and hydrophilic bile acids by infrared and Raman spectroscopy, Eur. Biophys. J, vol.25, pp.285-291, 1997.

K. Lampropoulou-adamidou, P. Lelovas, E. V. Karadimas, C. Liakou, I. K. Triantafillopoulos et al., Useful animal models for the research of osteoarthritis, Eur. J. Orthop. Surg. Traumatol, vol.24, pp.263-271, 2013.

P. Landreau, P. Christel, and P. Djian, Caractéristiques biomécaniques des ligaments et des ménisques du genou, 2003.

J. G. Larkin, G. D. Lowe, R. D. Sturrock, and C. D. Forbes, THE CORRELATION OF CLINICAL ASSESSMENT OF SYNOVIAL FLUID WITH ITS MEASURED VISCOSITY, Rheumatology, vol.23, pp.195-197, 1984.

R. G. Larson, Transport and deposition patterns in drying sessile droplets, AIChE J, vol.60, pp.1538-1571, 2014.

P. Lasch, Spectral pre-processing for biomedical vibrational spectroscopy and microspectroscopic imaging, Chemom. Intell. Lab. Syst, vol.117, pp.100-114, 2012.

S. Laverty, C. A. Girard, J. M. Williams, E. B. Hunziker, and K. P. Pritzker, The OARSI histopathology initiative -recommendations for histological assessments of osteoarthritis in the rabbit, Osteoarthritis Cartilage, vol.18, pp.53-65, 2010.

V. Legré-boyer, Viscosupplementation: Techniques, indications, results, Orthop. Traumatol. Surg. Res, vol.101, pp.101-108, 2015.

J. R. Levick, Permeability of Rheumatoid and Normal Human Synovium to Specific Plasma Proteins, Arthritis Rheum, vol.24, pp.1550-1560, 1981.

J. R. Levick and J. N. Mcdonald, Fluid movement across synovium in healthy joints: role of synovial fluid macromolecules, Ann. Rheum. Dis, vol.54, pp.417-423, 1995.

A. Levillain, Caractérisation multi-échelle des ménisques du genou : effet de l'arthrose, 2016.

A. Levillain, C. Boulocher, S. Kaderli, E. Viguier, D. Hannouche et al., , 2015.

, Meniscal biomechanical alterations in an ACLT rabbit model of early osteoarthritis, Osteoarthritis Cartilage, vol.23, pp.1186-1193

A. Levillain, H. Magoariec, C. Boulocher, A. Decambron, V. Viateau et al., Viscoelastic properties of rabbit osteoarthritic menisci: A correlation with matrix alterations, J. Mech. Behav. Biomed. Mater, vol.65, pp.1-10, 2017.

A. Levillain, H. Magoariec, C. Boulocher, A. Decambron, V. Viateau et al., Effects of a viscosupplementation therapy on rabbit menisci in an anterior cruciate ligament transection model of osteoarthritis, J. Biomech, vol.58, pp.147-154, 2017.

G. Li, J. Yin, J. Gao, T. S. Cheng, N. J. Pavlos et al., Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes, Arthritis Res. Ther, vol.15, p.223, 2013.

P. Li, D. Raitcheva, M. Hawes, N. Moran, X. Yu et al., Hylan G-F 20 maintains cartilage integrity and decreases osteophyte formation in osteoarthritis through both anabolic and anti-catabolic mechanisms, Osteoarthritis Cartilage, vol.20, pp.1336-1346, 2012.

C. A. Lieber and A. Mahadevan-jansen, Automated Method for Subtraction of Fluorescence from Biological Raman Spectra, Appl. Spectrosc, vol.57, pp.1363-1367, 2003.

N. S. Lim, Z. Hamed, C. H. Yeow, C. Chan, and Z. Huang, Early detection of biomolecular changes in disrupted porcine cartilage using polarized Raman spectroscopy, J. Biomed. Opt, vol.16, p.17003, 2011.

T. M. Link, L. S. Steinbach, S. Ghosh, M. Ries, Y. Lu et al., Osteoarthritis: MR Imaging Findings in Different Stages of Disease and Correlation with Clinical Findings, Radiology, vol.226, pp.373-381, 2003.

A. J. Lipowitz, P. L. Wong, and J. B. Stevens, Synovial membrane changes after experimental transection of the cranial cruciate ligament in dogs, Am. J. Vet. Res. USA, 1985.

A. Litwic, M. H. Edwards, E. M. Dennison, C. , and C. , Epidemiology and burden of osteoarthritis, Br. Med. Bull, vol.105, pp.185-199, 2013.

A. Litwic, M. H. Edwards, E. M. Dennison, C. , and C. , Epidemiology and burden of osteoarthritis, Br. Med. Bull, vol.105, pp.185-199, 2013.

R. F. Loeser, S. R. Goldring, C. R. Scanzello, and M. B. Goldring, Osteoarthritis: A Disease of the Joint as an Organ, Arthritis Rheum, vol.64, pp.1697-1707, 2012.

D. Loeuille, I. Chary-valckenaere, J. Champigneulle, A. Rat, F. Toussaint et al., Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: Correlating magnetic resonance imaging findings with disease severity, Arthritis Rheum, vol.52, pp.3492-3501, 2005.
URL : https://hal.archives-ouvertes.fr/hal-02880560

S. Lohmander, Proteoglycans of joint cartilage. Structure, function, turnover and role as markers of joint disease, Baillieres Clin. Rheumatol, vol.2, pp.37-62, 1988.

L. S. Lohmander, L. A. Hoerrner, and M. W. Lark, Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis, Arthritis Rheum, vol.36, pp.181-189, 1993.

M. Lotz and R. F. Loeser, Effects of aging on articular cartilage homeostasis, Bone, vol.51, pp.241-248, 2012.

H. Madry, C. N. Dijk, . Van, and M. Mueller-gerbl, The basic science of the subchondral bone, Knee Surg. Sports Traumatol. Arthrosc, vol.18, pp.419-433, 2010.

H. Madry, E. Kon, V. Condello, G. M. Peretti, M. Steinwachs et al., Early osteoarthritis of the knee, Knee Surg. Sports Traumatol. Arthrosc, vol.24, pp.1753-1762, 2016.

E. Maheu, Lecture et point de vue critiques: The New 2014 OARSI guidelines for the non-surgical treatment of gonarthrosis critical analysis and summary, Cah. Année Gérontologique, vol.7, pp.74-77, 2015.

N. Mainreck, S. Brézillon, G. D. Sockalingum, F. Maquart, M. Manfait et al., Rapid Characterization of Glycosaminoglycans Using a Combined Approach by Infrared and Raman Microspectroscopies, J. Pharm. Sci, vol.100, pp.441-450, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00554829

M. Majumder, C. S. Rendall, J. A. Eukel, J. Y. Wang, N. Behabtu et al., Overcoming the "Coffee-Stain" Effect by Compositional Marangoni-Flow-Assisted Drop-Drying, J. Phys. Chem. B, vol.116, pp.6536-6542, 2012.

J. T. Mäkelä, Z. S. Rezaeian, S. Mikkonen, R. Madden, S. Han et al., Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection, Osteoarthritis Cartilage, vol.22, pp.869-878, 2014.

E. A. Makris, P. Hadidi, and K. A. Athanasiou, The knee meniscus: Structure-function, pathophysiology, current repair techniques, and prospects for regeneration, Biomaterials, vol.32, pp.7411-7431, 2011.

G. S. Mandair and M. D. Morris, Contributions of Raman spectroscopy to the understanding of bone strength, 2015.

G. S. Mandair, K. A. Dehring, B. J. Roessler, and M. D. Morris, Detection of potential osteoarthritis biomarkers using surface enhanced Raman spectroscopy in the near-infrared, p.60930, 2006.

N. Männicke, M. Schöne, M. Gottwald, F. Göbel, M. L. Oelze et al., 3-D High-Frequency Ultrasound Backscatter Analysis of Human Articular Cartilage, Ultrasound Med. Biol, vol.40, pp.244-257, 2014.

J. M. Mansour, F. A. Wentorf, and K. M. Degoede, In Vivo Kinematics of the Rabbit Knee in Unstable Models of Osteoarthrosis, Ann. Biomed. Eng, vol.26, pp.353-360, 1998.

S. Marini, G. Francesco-fasciglione, G. Monteleone, M. Maiotti, U. Tarantino et al., A correlation between knee cartilage degradation observed by arthroscopy and synovial proteinases activities, Clin. Biochem, vol.36, pp.295-304, 2003.

D. Mazzucco, G. Mckinley, R. D. Scott, and M. Spector, Rheology of joint fluid in total knee arthroplasty patients, J. Orthop. Res, vol.20, pp.1157-1163, 2002.

W. J. Mccarty, J. C. Cheng, B. C. Hansen, T. Yamaguchi, G. S. Firestein et al., , 2012.

, The biophysical mechanisms of altered hyaluronan concentration in synovial fluid after anterior cruciate ligament transection, Arthritis Rheum, vol.64, pp.3993-4003

A. M. Mccoy, Animal Models of Osteoarthritis: Comparisons and Key Considerations, Vet. Pathol, vol.52, pp.803-818, 2015.

A. Migliore, F. Giovannangeli, M. Granata, and B. Laganà, Hylan G-F 20: Review of its Safety and Efficacy in the Management of Joint Pain in Osteoarthritis, Clin. Med. Insights Arthritis Musculoskelet. Disord, pp.55-68, 2010.

L. W. Moreland, Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action, Arthritis Res Ther, vol.5, p.54, 2003.

M. D. Morris and G. S. Mandair, Raman Assessment of Bone Quality, Clin. Orthop. Relat. Res, vol.469, pp.2160-2169, 2011.

C. Muehlethaler, G. Massonnet, and P. Esseiva, The application of chemometrics on Infrared and Raman spectra as a tool for the forensic analysis of paints, Forensic Sci. Int, vol.209, pp.173-182, 2011.

L. A. Mundt and K. Shanahan, Chapter 11 -Synovial fluid, Graff's Textbook of Routine Urinalysis and Body Fluids, pp.253-262, 2010.

T. Nakano, C. M. Dodd, and P. G. Scott, Glycosaminoglycans and proteoglycans from different zones of the porcine knee meniscus, J. Orthop. Res, vol.15, pp.213-220, 1997.

P. Noble, B. Collin, J. Lecomte-beckers, A. Magnée, J. M. Denoix et al., The synovial joint: A perfect tribological system, 2010.

, Ann. Med. Veterinaire, vol.154, pp.83-93

J. S. Nyman, A. J. Makowski, C. A. Patil, T. P. Masui, E. C. O'quinn et al., Measuring differences in compositional properties of bone tissue by confocal Raman spectroscopy, Calcif. Tissue Int, vol.89, pp.111-122, 2011.

J. S. Nyman, A. J. Makowski, C. A. Patil, T. P. Masui, E. C. O'quinn et al., Measuring Differences in Compositional Properties of Bone Tissue by Confocal Raman Spectroscopy, Calcif. Tissue Int, vol.89, pp.111-122, 2011.

E. H. Oei, J. Van-tiel, W. H. Robinson, and G. E. Gold, Quantitative Radiologic Imaging Techniques for Articular Cartilage Composition: Toward Early Diagnosis and Development of Disease-Modifying Therapeutics for Osteoarthritis, Arthritis Care Res, vol.66, pp.1129-1141, 2014.

P. Ornetti, G. Nourissat, F. Berenbaum, J. Sellam, P. Richette et al., Quelle place pour les PRP (plasma riche en plaquettes) dans l'arthrose ?, Rev. Rhum, vol.81, pp.466-471, 2014.

C. Ortiz, D. Zhang, Y. Xie, A. E. Ribbe, and D. Ben-amotz, Validation of the drop coating deposition Raman method for protein analysis, Anal. Biochem, vol.353, pp.157-166, 2006.

H. E. Panula, L. S. Lohmander, S. Rönkkö, U. Agren, H. J. Helminen et al., Elevated levels of synovial fluid PLA2, stromelysin (MMP-3) and TIMP in early osteoarthrosis after tibial valgus osteotomy in young beagle dogs, Acta Orthop. Scand, vol.69, pp.152-158, 1998.

E. Pascual, J. , and V. , Synovial fluid analysis, Best Pract. Res. Clin. Rheumatol, vol.19, pp.371-386, 2005.

L. Pauchard, F. Parisse, A. , and C. , Influence of salt content on crack patterns formed through colloidal suspension desiccation, Phys. Rev. E, vol.59, pp.3737-3740, 1999.

K. Pavelka, ?. Forejtová, M. Olejárová, J. Gatterová, L. ?enolt et al., Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis, Osteoarthritis Cartilage, vol.12, pp.277-283, 2004.

K. Pernelle, L. Imbert, C. Bosser, J. Auregan, M. Cruel et al., , 2017.

, Microscale mechanical and mineral heterogeneity of human cortical bone governs osteoclast activity, Bone, vol.94, pp.42-49

J. Peters, A. Luczak, V. Ganesh, E. Park, and K. , Protein Secondary Structure Determination Using Drop Coat Deposition Confocal Raman Spectroscopy, Spectrosc. St. Monica, vol.31, pp.31-39, 2016.

W. Petersen and B. Tillmann, Collagenous fibril texture of the human knee joint menisci, Anat. Embryol. (Berl.), vol.197, pp.317-324, 1998.

W. Petersen and B. Tillmann, Structure and vascularization of the cruciate ligaments of the human knee joint, Anat. Embryol. (Berl.), vol.200, pp.325-334, 1999.

G. A. Petsko, D. Ringe, and M. D. Charmot, Structure et fonction des protéines, vol.1, 2008.

J. L. Pichardo-molina, C. Frausto-reyes, O. Barbosa-garcía, R. Huerta-franco, J. L. González-trujillo et al., Raman spectroscopy and multivariate analysis of serum samples from breast cancer patients, Lasers Med. Sci, vol.22, pp.229-236, 2007.

H. D. Plickert, A. Bondzio, R. Einspanier, A. Tichy, and L. Brunnberg, Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis, Res. Vet. Sci, vol.94, pp.728-734, 2013.

A. R. Poole, Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis, Rheum. Dis. Clin. N. Am, vol.29, pp.803-818, 2003.

A. R. Poole, M. Ionescu, A. Swan, and P. A. Dieppe, Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis, J. Clin. Invest, vol.94, pp.25-33, 1994.

A. R. Poole, T. Kojima, T. Yasuda, F. Mwale, M. Kobayashi et al., Composition and structure of articular cartilage: a template for tissue repair, Clin. Orthop, pp.26-33, 2001.

T. Poonpet and S. Honsawek, Adipokines: Biomarkers for osteoarthritis?, World J. Orthop, vol.5, pp.319-327, 2014.

B. M. Praest, H. Greiling, and R. Kock, Assay of synovial fluid parameters: hyaluronan concentration as a potential marker for joint diseases, Clin. Chim. Acta, vol.266, pp.117-128, 1997.

M. Pudlas, E. Brauchle, T. J. Klein, D. W. Hutmacher, and K. Schenke-layland, Non-invasive identification of proteoglycans and chondrocyte differentiation state by Raman microspectroscopy, J. Biophotonics, vol.6, pp.205-211, 2013.

L. J. Raggatt and N. C. Partridge, Cellular and Molecular Mechanisms of Bone Remodeling, J. Biol. Chem, vol.285, pp.25103-25108, 2010.

J. R. Ralphs and M. Benjamin, The joint capsule: structure, composition, ageing and disease, J. Anat, vol.184, pp.503-509, 1994.

Y. Rengel, C. Ospelt, and S. Gay, Proteinases in the joint: clinical relevance of proteinases in joint destruction, Arthritis Res. Ther, vol.9, p.221, 2007.

G. Rizkalla, A. Reiner, E. Bogoch, and A. R. Poole, Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease, J. Clin. Invest, vol.90, pp.2268-2277, 1992.

P. H. Rodrigues-júnior, K. De-sá-oliveira, C. E. Almeida, D. De, L. F. Oliveira et al., FT-Raman and chemometric tools for rapid determination of quality parameters in milk powder: Classification of samples for the presence of lactose and fraud detection by addition of maltodextrin, Food Chem, vol.196, pp.584-588, 2016.

F. W. Roemer, M. D. Crema, S. Trattnig, and A. Guermazi, Advances in Imaging of Osteoarthritis and Cartilage, Radiology, vol.260, pp.332-354, 2011.

. Roughley, The structure and function of cartilage proteoglycans, 2006.

A. Rygula, K. Majzner, K. M. Marzec, A. Kaczor, M. Pilarczyk et al., Raman spectroscopy of proteins: a review: Raman spectroscopy of proteins, J. Raman Spectrosc, vol.44, pp.1061-1076, 2013.

S. Sabaratnam, V. Arunan, P. J. Coleman, R. M. Mason, and J. R. Levick, Size selectivity of hyaluronan molecular sieving by extracellular matrix in rabbit synovial joints, J. Physiol, vol.567, pp.569-581, 2005.

R. L. Sah, A. S. Yang, A. C. Chen, J. J. Hant, R. B. Halili et al., Physical properties of rabbit articular cartilage after transection of the anterior cruciate ligament, J. Orthop. Res, vol.15, pp.197-203, 1997.

L. J. Sandell, Biomarkers in Osteoarthritis, HSS J, vol.8, pp.33-34, 2012.

T. A. Schmidt, N. S. Gastelum, Q. T. Nguyen, B. L. Schumacher, and R. L. Sah, Boundary lubrication of articular cartilage: Role of synovial fluid constituents, Arthritis Rheum, vol.56, pp.882-891, 2007.

B. Schmidt-rohlfing, M. Thomsen, C. Niedhart, D. C. Wirtz, and U. Schneider, Correlation of bone and cartilage markers in the synovial fluid with the degree of osteoarthritis, Rheumatol. Int, vol.21, pp.193-199, 2002.

K. Sefiane, Patterns from drying drops, Adv. Colloid Interface Sci, vol.206, pp.372-381, 2014.

L. A. Setton, V. C. Mow, F. J. Müller, J. C. Pita, and D. S. Howell, Mechanical Properties of Canine Articular Cartilage Are Significantly Altered Following Transection of the Anterior Cruciate Ligament, J. Orthop. Res, vol.12, pp.451-463, 1994.

L. A. Setton, V. C. Mow, and D. S. Howell, Mechanical behavior of articular cartilage in shear is altered by transection of the anterior cruciate ligament, J. Orthop. Res, vol.13, pp.473-482, 1995.

L. A. Setton, D. M. Elliott, and V. C. Mow, Altered mechanics of cartilage with osteoarthritis: human osteoarthritis and an experimental model of joint degeneration, Osteoarthritis Cartilage, vol.7, pp.2-14, 1999.

V. N. Shabalin and S. N. Shatokhina, Diagnostic markers in the structures of human biological liquids, Singapore Med. J, vol.48, pp.440-446, 2007.

A. Shane-anderson and R. F. Loeser, Why is osteoarthritis an age-related disease?, Best Pract. Res. Clin. Rheumatol, vol.24, pp.15-26, 2010.

C. S. Shin and J. H. Lee, Arthroscopic Treatment for Osteoarthritic Knee, Knee Surg. Relat. Res, vol.24, pp.187-192, 2012.

D. F. Shriver and M. P. Atkins, Chapitre 4 -Les symétries des vibrations moléculaires, Chimie inorganique, 2001.

V. Sikirzhytski, K. Virkler, and I. K. Lednev, Discriminant Analysis of Raman Spectra for Body Fluid Identification for Forensic Purposes, Sensors, vol.10, pp.2869-2884, 2010.

P. A. Simkin, The human knee: A window on the microvasculature, Tissue Barriers, vol.3, p.970465, 2015.

P. A. Simkin and J. E. Bassett, Pathways of Microvascular Permeability in the Synovium of Normal and Diseased Human Knees, J. Rheumatol, vol.38, pp.2635-2642, 2011.

M. D. Smith, The Normal Synovium, Open Rheumatol. J, vol.5, pp.100-106, 2011.

G. N. Smith, E. A. Mickler, S. L. Myers, and K. D. Brandt, Effect of intraarticular hyaluronan injection on synovial fluid hyaluronan in the early stage of canine post-traumatic osteoarthritis, J. Rheumatol, vol.28, pp.1341-1346, 2001.

B. Sobac and D. Brutin, Desiccation of a sessile drop of blood: Cracks, folds formation and delamination, Colloids Surf. Physicochem. Eng. Asp, vol.448, pp.34-44, 2014.

D. H. Sohn, J. Sokolove, O. Sharpe, J. C. Erhart, P. E. Chandra et al., Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4, Arthritis Res. Ther, vol.14, p.7, 2012.

J. Sokolove and C. M. Lepus, Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations, Ther. Adv. Musculoskelet. Dis, vol.5, pp.77-94, 2013.

S. Fox, A. J. Bedi, A. Rodeo, and S. A. , The Basic Science of Articular Cartilage: Structure, Composition, and Function, Sports Health Multidiscip. Approach, vol.1, pp.461-468, 2009.

R. A. De-souza, M. Xavier, N. M. Mangueira, A. P. Santos, A. L. Pinheiro et al.,

, Raman spectroscopy detection of molecular changes associated with two experimental models of osteoarthritis in rats, Lasers Med. Sci, vol.29, pp.797-804

G. Stachowiak and A. W. Batchelor, Chapter 6 -Characterization of test specimens, In Experimental Methods in Tribology, pp.115-164, 2004.

E. J. Strauss, J. A. Hart, M. D. Miller, R. D. Altman, and J. E. Rosen, Hyaluronic Acid Viscosupplementation and Osteoarthritis, Am. J. Sports Med, vol.37, pp.1636-1644, 2009.

S. Sutton, A. Clutterbuck, P. Harris, T. Gent, S. Freeman et al., The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis, Vet. J, vol.179, pp.10-24, 2009.

M. A. Sweigart, C. F. Zhu, D. M. Burt, P. D. Deholl, C. M. Agrawal et al., Intraspecies and interspecies comparison of the compressive properties of the medial meniscus, Ann. Biomed. Eng, vol.32, pp.1569-1579, 2004.

C. Tadokoro and K. Nakano, Spontaneous Change in Effective Viscosity of a Liquid Crystal by Surface Anchoring in an EHD Contact, pp.139-141, 2012.

M. Takahashi, K. Naito, M. Abe, T. Sawada, and A. Nagano, Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis, Arthritis Res. Ther, vol.6, p.208, 2004.

I. Taleb, G. Thiéfin, C. Gobinet, V. Untereiner, B. Bernard-chabert et al., Diagnosis of hepatocellular carcinoma in cirrhotic patients: a proof-ofconcept study using serum micro-Raman spectroscopy, The Analyst, vol.138, p.4006, 2013.

Y. Tanaka, S. Nakayamada, and Y. Okada, Osteoblasts and osteoclasts in bone remodeling and inflammation, Curr. Drug Targets Inflamm. Allergy, vol.4, pp.325-328, 2005.

I. Tchetverikov, MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis, Ann. Rheum. Dis, vol.64, pp.694-698, 2005.

E. Teeple, G. D. Jay, K. A. Elsaid, and B. C. Fleming, Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis, AAPS J, vol.15, pp.438-446, 2013.

N. Tiwari, S. Chabra, S. Mehdi, P. Sweet, T. B. Krasieva et al., Imaging of normal and pathologic joint synovium using nonlinear optical microscopy as a potential diagnostic tool, J. Biomed. Opt, vol.15, pp.56001-056001, 2010.

R. Tuma, Raman spectroscopy of proteins: from peptides to large assemblies, J. Raman Spectrosc, vol.36, pp.307-319, 2005.

S. Uesaka, Y. Nakayama, Y. Shirai, Y. , and K. , Serum and synovial fluid levels of chondroitin sulfate in patients with osteoarthritis of the knee joint, J. Nippon Med. Sch. Nippon Ika Daigaku Zasshi, vol.68, pp.165-170, 2001.

I. Uthman, J. Raynauld, and B. Haraoui, Intra-articular therapy in osteoarthritis, Postgrad. Med. J, vol.79, pp.449-453, 2003.

M. Z. Vardaki, Chemical Mapping of Human Osteoarthritic Femoral Head Section Using micro-Raman spectroscopy, 2013.

E. Vignon, M. Arlot, D. Hartmann, B. Moyen, and G. Ville, Hypertrophic repair of articular cartilage in experimental osteoarthrosis, Ann. Rheum. Dis, vol.42, pp.82-88, 1983.

K. Virkler and I. K. Lednev, Raman spectroscopic signature of blood and its potential application to forensic body fluid identification, Anal. Bioanal. Chem, vol.396, pp.525-534, 2010.

A. W. Visser, A. Ioan-facsinay, R. De-mutsert, R. L. Widya, M. Loef et al., Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study, Arthritis Res. Ther, vol.16, p.19, 2014.

N. Volpi, Anti-inflammatory activity of chondroitin sulphate: new functions from an old natural macromolecule, Inflammopharmacology, vol.19, pp.299-306, 2011.

K. A. Waller, L. X. Zhang, K. A. Elsaid, B. C. Fleming, M. L. Warman et al., Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis, Proc. Natl. Acad. Sci, vol.110, pp.5852-5857, 2013.

P. J. Watson, T. A. Carpenter, L. D. Hall, and J. A. Tyler, Cartilage swelling and loss in a spontaneous model of osteoarthritis visualized by magnetic resonance imaging, Osteoarthritis Cartilage, vol.4, pp.197-207, 1996.

J. R. Watterson and J. M. Esdaile, Viscosupplementation: therapeutic mechanisms and clinical potential in osteoarthritis of the knee, J. Am. Acad. Orthop. Surg, vol.8, pp.277-284, 2000.

F. Wei, D. Zhang, N. J. Halas, and J. D. Hartgerink, Aromatic Amino Acids Providing Characteristic Motifs in the Raman and SERS Spectroscopy of Peptides, J. Phys. Chem. B, vol.112, pp.9158-9164, 2008.

B. B. Wheatley, K. M. Fischenich, K. D. Button, R. C. Haut, and T. L. Donahue, An optimized transversely isotropic, hyper-poro-viscoelastic finite element model of the meniscus to evaluate mechanical degradation following traumatic loading, J. Biomech, vol.48, pp.1454-1460, 2015.

H. A. Wieland, M. Michaelis, B. J. Kirschbaum, and K. A. Rudolphi, Osteoarthritis -an untreatable disease?, Nat. Rev. Drug Discov, vol.4, pp.331-344, 2005.

F. M. Williams and T. D. Spector, Biomarkers in osteoarthritis, Arthritis Res. Ther, vol.10, p.101, 2008.

J. C. Wyant, White light interferometry, pp.98-107, 2002.

T. A. Yakhno and V. G. Yakhno, Structural evolution of drying drops of biological fluids, Tech. Phys, vol.54, pp.1219-1227, 2009.

T. A. Yakhno, A. A. Sanin, R. G. Ilyazov, G. V. Vildanova, R. A. Khamzin et al., Drying Drop Technology as a Possible Tool for Detection Leukemia and Tuberculosis in Cattle, J. Biomed. Sci. Eng, vol.8, pp.1-23, 2015.

H. Yamada, S. Miyauchi, H. Hotta, M. Morita, Y. Yoshihara et al., Levels of chondroitin sulfate isomers in synovial fluid of patients with hip osteoarthritis, J. Orthop. Sci. Off. J. Jpn. Orthop. Assoc, vol.4, pp.250-254, 1999.

S. Yang, B. Li, M. N. Slipchenko, A. Akkus, N. G. Singer et al., Laser wavelength dependence of background fluorescence in Raman spectroscopic analysis of synovial fluid from symptomatic joints: Analysis of synovial fluid from symptomatic joints, J. Raman Spectrosc, vol.44, pp.1089-1095, 2013.

H. Yoshida, T. Kojima, K. Kurokouchi, S. Takahashi, H. Hanamura et al., Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice: a cross-sectional observational study, Osteoarthritis Cartilage, vol.21, pp.831-838, 2013.

M. Yoshioka, R. D. Coutts, D. Amiel, and S. A. Hacker, Characterization of a model of osteoarthritis in the rabbit knee, Osteoarthritis Cartilage, vol.4, pp.87-98, 1996.

E. Yusuf and M. Kloppenburg, Epidemiological studies on adipokines and osteoarthritis, Int. J. Clin. Rheumatol, vol.8, pp.327-334, 2013.

D. Zhang, M. F. Mrozek, Y. Xie, and D. Ben-amotz, Chemical Segregation and Reduction of Raman Background Interference Using Drop Coating Deposition, Appl. Spectrosc, vol.58, pp.929-933, 2004.

W. Zhang, R. W. Moskowitz, G. Nuki, S. Abramson, R. D. Altman et al., OARSI recommendations for the management of hip and knee osteoarthritis, Part I: Critical appraisal of existing treatment guidelines and systematic review of current research evidence, Osteoarthritis Cartilage, vol.15, pp.981-1000, 2007.

Q. Zhou, B. Wei, S. Liu, F. Mao, X. Zhang et al., Cartilage matrix changes in contralateral mobile knees in a rabbit model of osteoarthritis induced by immobilization, BMC Musculoskelet. Disord, vol.16, p.224, 2015.

, Consulté le 06, p.1, 2017.

, Consulté le 07, vol.24, 2017.

, Consulté le 09, p.8, 2017.