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Développement d'outils bimodaux pour l'imagerie oncologique in vivo exploitant les modalités optique et nucléaire.

Abstract : Oncologic healthcare and remission prognosis rely on a reliable and accurate diagnosis. Molecular imaging, including optical and nuclear imaging, is currently used for the management cancer therapy. Recently, a new class of bio-imaging agent called MOMIA (MOnomolecular Multimodal Imaging Agent) emerged by combining the synergistic strengths of several modalities on the same molecular structure. We envisioned to merge optical and nuclear imaging in order to develop a molecular tool offering a non-invasive, highly resolutive and sensitive detection. Our approach relies on a universal bimodal clickable scaffold with a selected targeting ligand. Two distinct enzymatic targets have been explored in the oncologic context: caspase-3 as a key component in an apoptotic program and tyrosine kinase inhibitors involved in lung cancer therapy. These multimodal sensors have a promising potential in translational clinical applications.
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Submitted on : Friday, June 19, 2020 - 4:31:11 PM
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Morgane Detraz. Développement d'outils bimodaux pour l'imagerie oncologique in vivo exploitant les modalités optique et nucléaire.. Autre. Normandie Université, 2019. Français. ⟨NNT : 2019NORMR138⟩. ⟨tel-02875411⟩

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