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Élaboration de bioverres et de nano-bioverres ostéoinducteurs associés à des molécules à usage thérapeutique

Abstract : This work concerns the elaboration, the physicochemical study and the biological evaluation of pure bioactive glasses associated with chemical elements or molecules for therapeutic use. The different materials synthesized by melting and by sol-gel have a long-range amorphous character and the characteristic thermal properties of the glasses. Two doping elements (Zn and Sr) as well as a molecule (phycocyanin) and a cyanobacterium (Spirulina Platensis) have been introduced into the matrix of bioverres. Their chemical reactivity was studied in vitro by following cell-free solid/liquid physiological exchanges (SBF). In addition, their cytotoxicity (proliferation and cell adhesion) was evaluated in cell tests. The bioactivity of bioactive glasses and nano-glasses has been investigated to elucidate the formation of a layer of carbonate hydroxyapatite. It is the major crystal of the bone matrix on the surface of bioactive glasses. The sol-gel synthesis and the use of the emulsion technique allowed the development of bioactive glass nanoparticles of controlled sizes between 20 and 200 nm. This mastery opens many possibilities of applications in the field of medical nanotechnology. These particles have been used in 2 different application. Our first experiment was to create two types of bone bio-implants composed of nano-glass alone and nano-glass associated with a cyanobacterium. This study aims to compare the effects of cyanobacteria in in vitro and in vivo tests. Our second approach focused on the recovery of a biocompatible alloy and the study of the effects of particle size on the physicochemical characteristics of the layer thus formed.
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Submitted on : Thursday, June 18, 2020 - 4:20:14 PM
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Nicolas Rocton. Élaboration de bioverres et de nano-bioverres ostéoinducteurs associés à des molécules à usage thérapeutique. Matériaux. Université Rennes 1, 2019. Français. ⟨NNT : 2019REN1S086⟩. ⟨tel-02873917⟩

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