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, Les sarcomes des tissus mous et des viscères | Fondation ARC pour la recherche sur le cancer
, Les sarcomes osseux | Fondation ARC pour la recherche sur le cancer
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, Cependant, elles possèdent un microenvironnement similaire, plus ou moins riche en Protéoglycanes (PG) et hypoxique. À l'heure actuelle, il n'existe pas d'outil de diagnostic spécifique de ces pathologies qui sont de surcroit toutes deux décrites comme étant à la fois chimio-et radio-résistantes, faisant de la chirurgie le seul traitement efficace. Fort de ce constat, l'UMR 1240 IMoST INSERM/UCA développe depuis plusieurs années des stratégies permettant l'adressage spécifique de molécules diagnostiques ou thérapeutiques vers les charges négatives des PG, grâce à la présence d'un vecteur ammonium quaternaire chargé positivement. Cette stratégie a également été conjuguée au concept de prodrogue activable en hypoxie afin de permettre l'activation sélective de l'agent thérapeutique au sein des zones tumorales hypoxiques. La prodrogue hit, dénommée ICF05016, a préalablement démontré son efficacité anti-tumorale in vivo sur un modèle murin de CHS-MES, Les Chondrosarcomes Squelettiques (CHS-S) et Myxoïdes Extrasquelettiques (-MES) sont deux pathologies tumorales distinctes de par leurs étiologies et leurs localisations anatomiques
, Le premier objectif de ce travail de thèse fut de caractériser la teneur en PG et le statut hypoxique de deux modèles de CHS-S (SWARM, JJ012) ainsi que du modèle de CHS-MES inoculé en paratibial. Pour cela des techniques d'imagerie fonctionnelle