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Towards FDG-PET image characterization and classification : application to Alzheimer's disease computer-aided diagnosis

Abstract : Alzheimer's disease (AD) is becoming the dominant type of neurodegenerative brain disease in elderly people, which is incurable and irreversible for now. It is expected to diagnose its early stage, Mild Cognitive Impairment (MCI), then interventions can be applied to delay the onset. Fluorodeoxyglucose positron emission tomography (FDG-PET) is considered as a significant and effective modality to diagnose AD and the corresponding early phase since it can capture metabolic changes in the brain thereby indicating abnormal regions. Therefore, this thesis is devoted to identify AD from Normal Control (NC) and predict MCI conversion under FDG-PET modality. For this purpose, three independent novel methods are proposed. The first method focuses on developing connectivities among anatomical regions involved in FDG-PET images which are rarely addressed in previous methods. Such connectivities are represented by either similarities or graph measures among regions. Then combined with each region's properties, these features are fed into a designed ensemble classification framework to tackle problems of AD diagnosis and MCI conversion prediction. The second method investigates features to characterize FDG-PET images from the view of spatial gradients, which can link the commonly used features, voxel-wise and region-wise features. The spatial gradient is quantified by a 2D histogram of orientation and expressed in a multiscale manner. The results are given by integrating different scales of spatial gradients within different regions. The third method applies Convolutional Neural Network (CNN) techniques to three views of FDG-PET data, thereby designing the main multiview CNN architecture. Such an architecture can facilitate convolutional operations, from 3D to 2D, and meanwhile consider spatial relations, which is benefited from a novel mapping layer with cuboid convolution kernels. Then three views are combined and make a decision jointly. Experiments conducted on public dataset show that the three proposed methods can achieve significant performance and moreover, outperform most state-of-the-art approaches.
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Submitted on : Tuesday, June 16, 2020 - 3:49:08 PM
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Xiaoxi Pan. Towards FDG-PET image characterization and classification : application to Alzheimer's disease computer-aided diagnosis. Optics [physics.optics]. Ecole Centrale Marseille, 2019. English. ⟨NNT : 2019ECDM0008⟩. ⟨tel-02870282⟩

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