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Theses

Characterization of deformation and rupture micro-mechanisms in aortic aneurysm wall

Abstract : The wall of the ascending thoracic aorta retains a complex heterogeneous microstructural organization which can be subjected to aneurysms, irreversible dilatations associated with degenerative remodeling processes of the microstructure. The latter results in an altered mechanical behavior of such key tissue whose utmost consequences are rupture or dissection.The following hypothesis is addressed: the phenomena which occur at the microscopic fibrous structure of collagen and elastin are involved or even responsible for the macroscopic mechanical response of ascending thoracic aortic aneurysms, in particular when close to rupture. Towards an improved understanding of the structure-to-mechanics relationship, an experimental methodology enabled the consistent coupling of several test benches: a mechanical inflation test, an optical device for high resolution measurements of the specimen thickness, a image correlation set-up for full-field displacement measurements and a two-photon microscopy bench. Patient-specific analyses were conducted on ex-vivo specimens of animal and human thoracic aortae, in particular human ascending thoracic aortic aneurysms, up to rupture. The analyses focus on the relationship between local mechanical state and microstructural morphology of the principal fibrous components of the outer aortic layer, usually seen as ultimate resistive barrier before rupture. The connection between these data and fundamental information inherent to clinics or morphometry are analyzed. The resulting contribution consists of advanced observations of the fibrous recruitment and reactions to the loading scenario and quantitative links with mechanics and clinics
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  • HAL Id : tel-02868977, version 1

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Cristina Cavinato. Characterization of deformation and rupture micro-mechanisms in aortic aneurysm wall. Other. Université de Lyon, 2019. English. ⟨NNT : 2019LYSEM003⟩. ⟨tel-02868977⟩

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