L. Agier, A. Deroubaix, N. Martiny, P. Yaka, A. Djibo et al., Seasonality of meningitis in Africa and climate forcing: aerosols stand out, J. R. Soc. Interface, vol.10, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00771443

L. Agier, A. Deroubaix, N. Martiny, P. Yaka, A. Djibo et al., Seasonality of meningitis in Africa and climate forcing: aerosols stand out, J. R. Soc. Interface, vol.10, pp.20120814-20120814, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00771443

L. Agier, N. Martiny, O. Thiongane, J. E. Mueller, J. Paireau et al., Towards understanding the epidemiology of Neisseria meningitidis in the African meningitis belt: a multi-disciplinary overview, Int. J. Infect. Dis, vol.54, pp.103-112, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01483563

L. F. Aguirre, STRUCTURE OF A NEOTROPICAL SAVANNA BAT COMMUNITY, J. Mammal, vol.83, pp.775-784, 2002.

N. H. Anderson and D. M. Titterington, Some methods for investigating spatial clustering, with epidemiological applications, J. R. Stat. Soc. Ser. A Stat. Soc, vol.160, pp.87-105, 1997.

M. Artois, A. Caron, F. A. Leighton, C. Bunn, and B. Vallat, La faune sauvage et les maladies émergentes, 2006.

P. P. Aubry, Méningite cérébro-spinale à méningocoques 11, 2018.

P. P. Aubry, Du Programme Elargi de Vaccinations aux Programmes Nationaux de Vaccination systématique 17, 2018.

A. S. Azman and J. Lessler, Reactive vaccination in the presence of disease hotspots, Proc. R. Soc. B Biol. Sci, vol.282, 2014.

S. Azzali and M. Menenti, Mapping vegetation-soil-climate complexes in southern Africa using temporal Fourier analysis of NOAA-AVHRR NDVI data, Int. J. Remote Sens, vol.21, pp.973-996, 2000.

S. Blanc, G. Boëtsch, F. Renaud, F. Simard, and H. Broutin, Écologie de la santé : pour une nouvelle lecture de nos maux | CNRS [WWW Document, 2017.

P. Boisier, H. B. Maïnassara, F. Sidikou, S. Djibo, K. K. Kairo et al., Casefatality ratio of bacterial meningitis in the African meningitis belt: We can do better, Vaccine, vol.25, pp.24-29, 2007.

H. Broutin, S. Philippon, G. Constantin-de-magny, M. Courel, B. Sultan et al., Comparative study of meningitis dynamics across nine African countries: a global perspective, Int. J. Health Geogr, vol.6, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00338710

B. S. Camara, A. Delamou, E. Diro, A. H. Béavogui, A. M. El-ayadi et al., Effect of the 2014/2015 Ebola outbreak on reproductive health services in a rural district of Guinea: an ecological study, Trans. R. Soc. Trop. Med. Hyg, vol.111, pp.22-29, 2017.

D. A. Caugant and M. C. Maiden, Meningococcal carriage and disease-Population biology and evolution, Vaccine, vol.27, pp.64-70, 2009.

,

C. Chatfield, The Analysis of Time Series: An Introduction, Sixth Edition, 2016.

J. Chippaux, H. Debois, and P. Saliou, Revue critique des stratégies de contrôle des épidémies de méningite à méningocoque en Afrique subsaharienne, Bull. Société Pathol. Exot, vol.94, pp.37-44, 2002.

M. Kulldorff, L. Huang, L. Pickle, and L. Duczmal, An elliptic spatial scan statistic, Stat. Med, vol.25, pp.3929-3943, 2006.

M. Kulldorff and N. Nagarwalla, Spatial disease clusters: Detection and inference, Stat. Med, vol.14, pp.799-810, 1995.

M. Kulldorff and N. Nagarwalla, Spatial disease clusters: detection and inference, Stat. Med, vol.14, pp.799-810, 1995.

L. Lapeyssonnie, La méningite cérébrospinale en Afrique, Bull. World Health Organ, vol.28, 1963.

J. A. Leake, M. L. Kone, A. A. Yada, L. F. Barry, G. Traore et al., Early detection and response to meningococcal disease epidemics in sub-Saharan Africa: appraisal of the WHO strategy, Bull. World Health Organ, vol.80, pp.342-349, 2002.

. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmos. Environ, vol.70, pp.245-253, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmos. Environ, vol.70, pp.245-253, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

N. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmos. Environ, vol.70, pp.245-253, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

N. Martiny, N. Dessay, P. Yaka, O. Toure, B. Sultan et al., Le climat, un facteur de risque pour la santé en Afrique de l'Ouest. La Météorologie 73-79, 2012.

I. Mohammed, G. Iliyasu, and A. G. Habib, Emergence and control of epidemic meningococcal meningitis in sub-Saharan Africa, Pathog. Glob. Health, vol.111, pp.1-6, 2017.

A. M. Molesworth, M. C. Thomson, S. J. Connor, M. P. Cresswell, A. P. Morse et al., Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa, Trans. R. Soc. Trop. Med. Hyg, vol.96, pp.90089-90090, 2002.

A. M. Molesworth, M. C. Thomson, S. J. Connor, M. P. Cresswell, A. P. Morse et al., Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa, Trans. R. Soc. Trop. Med. Hyg, vol.96, pp.242-249, 2002.

S. S. Morse, Factors in the Emergence of, Emerging Infectious Diseases journal -CDC, vol.1, issue.1, 1995.

,

C. Moulin and I. Chiapello, Evidence of the control of summer atmospheric transport of African dust over the Atlantic by Sahel sources from TOMS satellites, SUMMER ATMOSPHERIC TRANSPORT OF AFRICAN DUST, vol.31, 1979.

H. R. Mount and S. D. Boyle, Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention 96, p.9, 2017.

J. E. Mueller and B. D. Gessner, A hypothetical explanatory model for meningococcal meningitis in the African meningitis belt, Int. J. Infect. Dis, vol.14, pp.553-559, 2010.

J. E. Mueller, M. Woringer, S. Porgho, Y. Madec, H. Tall et al., The association between respiratory tract infection incidence and localised, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01598638

K. J. Olival and P. Daszak, The ecology of emerging neurotropic viruses, J. Neurovirol, vol.11, pp.441-446, 2005.

I. Thoelen, P. Lemey, I. Van-der-donck, K. Beuselinck, A. M. Lindberg et al., Molecular typing and epidemiology of enteroviruses identified from an outbreak of aseptic meningitis in Belgium during the summer of 2000, J. Med. Virol, vol.70, pp.420-429, 2003.

P. M. Tukei, Emerging and re-emerging Infectious diseases: a global health threat, Afr. J. Health Sci, vol.3, p.27, 1996.

A. F. Abdussalam, A. J. Monaghan, D. F. Steinhoff, V. M. Dukic, M. H. Hayden et al., The Impact of Climate Change on Meningitis in Northwest Nigeria: An Assessment Using CMIP5 Climate Model Simulations, Weather Clim. Soc, vol.6, pp.371-379, 2014.

L. Agier, A. Deroubaix, N. Martiny, P. Yaka, A. Djibo et al., Seasonality of meningitis in Africa and climate forcing: aerosols stand out, J. R. Soc. Interface, vol.10, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00771443

L. Agier, N. Martiny, O. Thiongane, J. E. Mueller, J. Paireau et al., Towards understanding the epidemiology of Neisseria meningitidis in the African meningitis belt: a multi-disciplinary overview, Int. J. Infect. Dis, vol.54, pp.103-112, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01483563

A. , Ceinture africaine de la méningite : de la génomique aux stratégies de surveillance, de lutte et de prévention, Bull Soc Pathol Exot, vol.5, 2006.

E. Bertherat, A. Yada, M. H. Djingarey, and B. Koumare, First major epidemic caused by Neisseria meningitidis serogroup W135 in Africa?, 2002.

, Med. Trop. Rev. Corps Sante Colon, vol.62, pp.301-304

J. P. Besancenot, M. Boko, and P. C. Oke, Weather conditions and cerebrospinal meningitis in Benin (gulf of Guinea, p.9, 1997.

P. Boisier, H. B. Maïnassara, F. Sidikou, S. Djibo, K. K. Kairo et al., Case-fatality ratio of bacterial meningitis in the African meningitis belt: We can do better, Vaccine, vol.25, pp.24-29, 2007.

H. Broutin, S. Philippon, G. Constantin-de-magny, M. Courel, B. Sultan et al., Comparative study of meningitis dynamics across nine African countries: a global perspective, Int. J. Health Geogr, vol.6, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00338710

M. Ceyhan, S. Anis, L. Htun-myint, R. Pawinski, M. Soriano-gabarró et al., Meningococcal disease in the Middle East and North Africa: an important public health consideration that requires further attention, Int. J. Infect. Dis, vol.16, pp.574-582, 2012.

J. S. Cheesbrough, A. P. Morse, and S. D. Green, Meningococcal meningitis and carriage in western Zaire: a hypoendemic zone related to climate?, Epidemiol. Infect, vol.114, pp.75-92, 1995.

J. Chippaux, H. Debois, and P. Saliou, Revue critique des stratégies de contrôle des épidémies de méningite à méningocoque en Afrique subsaharienne, Bull. Société Pathol. Exot, vol.94, pp.37-44, 1916.

N. Crum-cianflone and E. Sullivan, Meningococcal Vaccinations, Infect. Dis. Ther, vol.5, pp.89-112, 2016.

L. E. Cuevas, I. Jeanne, A. Molesworth, M. Bell, E. C. Savory et al., Risk mapping and early warning systems for the control of meningitis in Africa, Meningococcal Meningitis in the African Meningitis Belt: Epidemiology and Vaccines, vol.25, pp.12-17, 2007.

I. Delrieu, S. Yaro, T. A. Tamekloé, B. Njanpop-lafourcade, H. Tall et al., Emergence of Epidemic Neisseria meningitidis Serogroup X Meningitis in Togo and Burkina Faso, PLoS ONE, vol.6, 2011.

S. Demissew and J. Mikissa, MEMBERS OF THE MANAGEMENT COMMITTEE WHO PROVIDED GUIDANCE FOR THE PRODUCTION OF THIS ASSESSMENT, p.52, 2018.

G. Djohy, A. H. Edja, and M. S. Djohy, Représentations populaires de la méningite épidémique dans un contexte de changement climatique au Nord-Bénin, Sci. Soc. Sante, vol.33, pp.47-74, 2015.

T. J. Doyle, M. K. Glynn, and S. L. Groseclose, Completeness of notifiable infectious disease reporting in the United States: an analytical literature review, Am. J. Epidemiol, vol.155, pp.866-874, 2002.

D. R. Feikin, J. A. Scott, and B. D. Gessner, Use of vaccines as probes to define disease burden, The Lancet, vol.383, pp.61682-61689, 2014.

A. Funk, K. Uadiale, C. Kamau, D. A. Caugant, U. Ango et al., Sequential outbreaks due to a new strain of Neisseria meningitidis serogroup C in northern Nigeria, PLoS Curr, vol.6, pp.2013-2027, 2014.

C. P. García-pando, M. C. Stanton, P. J. Diggle, S. Trzaska, R. L. Miller et al., Soil Dust Aerosols and Wind as Predictors of Seasonal Meningitis Incidence in Niger, Environ. Health Perspect, vol.122, pp.679-686, 2014.

C. P. García-pando, M. C. Thomson, M. C. Stanton, P. J. Diggle, T. Hopson et al., Meningitis and climate: from science to practice, Earth Perspect, vol.1, 2014.

B. Greenwood, Meningococcal meningitis in Africa, Trans. R. Soc. Trop. Med. Hyg, vol.93, pp.341-353, 1999.

B. M. Greenwood, A. M. Greenwood, A. K. Bradley, K. Williams, M. Hassan-king et al., Factors influencing susceptibility to meningococcal disease during an epidemic in The Gambia, West Africa, J. Infect, vol.14, pp.167-184, 1987.

J. Guégan, B. D. Thoisy, A. Ayouba, and J. Cappelle, Forêts tropicales, changements d'usage des sols et risques infectieux émergents 22, 2018.

C. A. Hart and L. E. Cuevas, Meningococcal disease in Africa, Ann. Trop. Med. Parasitol, vol.91, pp.777-785, 1997.

J. Jusot, D. R. Neill, E. M. Waters, M. Bangert, M. Collins et al., Airborne dust and high temperatures are risk factors for invasive bacterial disease, J. Allergy Clin. Immunol, vol.139, pp.977-986, 2017.

P. Kumar and I. C. Verma, Antibiotic therapy for bacterial meningitis in children in developing countries, Bull. World Health Organ, vol.71, pp.183-188, 1993.

B. A. Kwambana-adams, R. C. Amaza, C. Okoi, M. Rabiu, A. Worwui et al., Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria. Sci. Rep, vol.8, 2018.

F. M. Laforce, M. Djingarey, S. Viviani, and M. Preziosi, Successful African introduction of a new Group A meningococcal conjugate vaccine: Future challenges and next steps, Hum. Vaccines Immunother, vol.14, pp.1098-1102, 2018.

L. Lapeyssonnie, La méningite cérébrospinale en Afrique, Bull. World Health Organ, vol.28, 1963.

J. F. Lindahl and D. Grace, The consequences of human actions on risks for infectious diseases: a review, Infect. Ecol. Epidemiol, vol.5, 2015.

C. Lingani, C. Bergeron-caron, J. M. Stuart, K. Fernandez, M. H. Djingarey et al., Meningococcal Meningitis Surveillance in the African Meningitis Belt, pp.2004-2013, 2015.

, Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am, vol.61

N. Luo, C. Perera, J. Holton, H. Ayles, and A. Zumla, Spread of Neisseria meningitidis Group A Clone II1-1Meningitis Epidemic into Zambia 3, 1998.

N. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmos. Environ, vol.70, pp.245-253, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

N. Martiny, N. Dessay, P. Yaka, O. Toure, B. Sultan et al., Le climat, un facteur de risque pour la santé en Afrique de l'Ouest, 2012.

R. Mihigo, J. Okeibunor, B. Masresha, P. Mkanda, A. Poy et al., IMMUNIZATION AND VACCINE DEVELOPMENT: Progress towards High and Equitable Immunization Coverage in the Africa Region, J. Immunol. Sci, pp.1-9, 2018.

A. M. Molesworth, L. E. Cuevas, S. J. Connor, A. P. Morse, and M. C. Thomson, Environmental Risk and Meningitis Epidemics in Africa, Emerg. Infect. Dis, vol.9, 2003.

A. M. Molesworth, M. C. Thomson, S. J. Connor, M. P. Cresswell, A. P. Morse et al., Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa, Trans. R. Soc. Trop. Med. Hyg, vol.96, pp.90089-90090, 2002.

A. L. Morris, J. Guégan, D. Andreou, L. Marsollier, K. Carolan et al., Deforestation-driven food-web collapse linked to emerging tropical infectious disease, Mycobacterium ulcerans, Sci. Adv, vol.2, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01421033

J. E. Mueller and B. D. Gessner, A hypothetical explanatory model for meningococcal meningitis in the African meningitis belt, Int. J. Infect. Dis. IJID Off. Publ. Int. Soc. Infect. Dis, vol.14, pp.553-559, 2010.

J. Obiero and J. Onyando, Climate, in: Developments in Earth Surface Processes, pp.39-50, 2013.

J. Paireau, H. B. Ma?nassara, J. Jusot, J. Collard, I. Idi et al., Spatio-Temporal Factors Associated with Meningococcal Meningitis Annual Incidence at the Health Centre Level in Niger, PLoS Negl. Trop. Dis, vol.8, 2004.
URL : https://hal.archives-ouvertes.fr/hal-01343080

J. A. Patz and S. H. Olson, Climate change and health: global to local influences on disease risk, Ann. Trop. Med. Parasitol, vol.100, pp.535-549, 2006.

J. A. Patz, S. H. Olson, C. K. Uejio, and H. K. Gibbs, Disease Emergence from Global Climate and Land Use Change, Med. Clin. North Am., New and Emerging Infectious Diseases, vol.92, pp.1473-1491, 2008.

H. Peltola, Burden of Meningitis and Other Severe Bacterial Infections of Children in Africa: Implications for Prevention, Clin. Infect. Dis, vol.32, pp.64-75, 2001.

S. Philippon, H. Broutin, G. Constantin-de-magny, K. Toure, C. H. Diakite et al., Meningococcal meningitis in Mali: a long-term study of persistence and spread, Int. J. Infect. Dis, vol.13, pp.103-109, 2009.

R. Russo, E. C. Savory, L. E. Cuevas, M. A. Yassin, C. A. Hart et al., Evaluation of the meningitis epidemics risk model in Africa, Epidemiol. Infect, vol.40, pp.1047-1051, 2006.

F. Sidikou, M. Zaneidou, I. Alkassoum, S. Schwartz, B. Issaka et al., Emergence of epidemic Neisseria meningitidis serogroup C in Niger, 2015: an analysis of national surveillance data, Lancet Infect. Dis, vol.16, pp.1288-1294, 2016.
URL : https://hal.archives-ouvertes.fr/pasteur-01357718

D. W. Sintayehu, Impact of climate change on biodiversity and associated key ecosystem services in Africa: a systematic review, Ecosyst. Health Sustain, vol.4, pp.225-239, 2018.

B. Sultan, K. Labadi, J. Guégan, and S. Janicot, Climate Drives the Meningitis Epidemics Onset in West Africa, PLoS Med, vol.2, 2005.

C. L. Trotter, C. Lingani, K. Fernandez, L. V. Cooper, A. Bita et al., Impact of MenAfriVac in nine countries of the African meningitis belt, 2010-15: an analysis of surveillance data, Lancet Infect. Dis, vol.17, pp.867-872, 2015.

D. Van-de-beek, C. Cabellos, O. Dzupova, S. Esposito, M. Klein et al., ESCMID guideline: diagnosis and treatment of acute bacterial meningitis, Clin. Microbiol. Infect, vol.22, pp.37-62, 2016.

R. Verma and P. Khanna, Meningococcal vaccine. Hum. Vaccines Immunother, vol.8, pp.1904-1906, 2012.

, WHO, 2015. WHO | Meningococcal meningitis

, WHO | Control of epidemic meningococcal disease. WHO practical guidelines, WHO, 1998.

, World Health Organization. Guidelines on the control of epidemic meningococcal disease, 1998.

L. Lapeyssonnie and W. H. Organization, La méningite cérébrospinale en Afrique. Bull. World Health Organ, vol.28, 1963.

A. M. Molesworth, M. C. Thomson, S. J. Connor, M. P. Cresswell, A. P. Morse et al., Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa, Trans R Soc Trop Med Hyg, vol.96, issue.3, pp.242-251, 2002.

C. L. Trotter and B. M. Greenwood, Meningococcal carriage in the African meningitis belt, 2007.
URL : https://hal.archives-ouvertes.fr/hal-02263733

L. Agier, N. Martiny, O. Thiongane, J. E. Mueller, J. Paireau et al., Towards understanding the epidemiology of Neisseria meningitidis in the African meningitis belt: a multi-disciplinary overview, Int J Infect Dis, vol.54, pp.103-115, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01483563

B. Sultan, K. Labadi, J. Guégan, and S. Janicot, Climate Drives the Meningitis Epidemics Onset in West Africa. Hales S, editor, PLoS Med, vol.2, issue.1, p.6, 2005.

A. M. Molesworth, L. E. Cuevas, S. J. Connor, A. P. Morse, and M. C. Thomson, Environmental Risk and Meningitis Epidemics in Africa, Emerg Infect Dis, vol.9, issue.10, pp.1287-93, 2003.

L. Agier, A. Deroubaix, N. Martiny, P. Yaka, A. Djibo et al., Seasonality of meningitis in Africa and climate forcing: aerosols stand out, J R Soc Interface, vol.10, issue.79, pp.20120814-20120814, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00771443

N. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmos Environ, vol.70, pp.245-53, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

J. E. Mueller and B. D. Gessner, A hypothetical explanatory model for meningococcal meningitis in the African meningitis belt, Int J Infect Dis, vol.14, issue.7, pp.553-562, 2010.

A. Santaniello-newton and P. R. Hunter, Management of an outbreak of meningococcal meningitis in a Sudanese refugee camp in Northern Uganda, Epidemiol Infect, vol.124, issue.1, pp.75-81, 2000.

S. Materu, H. S. Cox, P. Isaakidis, B. Baruani, T. Ogaro et al., Serogroup X in Meningococcal Disease, Western Kenya. Emerg Infect Dis, vol.13, pp.944-949, 2007.

C. N. Gituro, A. Nyerere, M. O. Ngayo, E. Maina, J. Githuku et al., Etiology of bacterial meningitis: a crosssectional study among patients admitted in a semi-urban hospital in, Pan Afr Med J, vol.28, issue.1, 2017.

P. Cunin, M. Fonkoua, B. Kollo, B. A. Bedifeh, P. Bayanak et al., Serogroup A Neisseria meningitidis outside Meningitis Belt in Southwest Cameroon, Emerg Infect Dis, vol.9, issue.10, pp.1351-1354, 2003.

M. Sáfadi, Epidemiology and prevention of meningococcal disease: a critical appraisal of vaccine policies, Expert Rev Vaccines, 2011.

J. Chippaux, H. Debois, and P. Saliou, Revue critique des stratégies de contrôle des épidémies de méningite à méningocoque en Afrique subsaharienne, Bull Société Pathol Exot, vol.94, issue.1, pp.37-44, 2002.

B. Greenwood, Editorial: 100 years of epidemic meningitis in West Africa -has anything changed? Trop Med Int Health, vol.11, pp.773-80, 2006.

. Ministère-du-plan, Rapport sur l'Enquête démographique et de la santé de la, vol.482, 2007.

S. Azzali and M. Menenti, Mapping vegetation-soil-climate complexes in southern Africa using temporal Fourier analysis of NOAA-AVHRR NDVI data, International Journal of Remote Sensing, vol.21, issue.5, pp.973-996, 2000.

M. Kulldorff, A spatial scan statistic, Commun Stat-Theory Methods, vol.26, issue.6, pp.1481-1496, 1997.

M. Kulldorff, Tests of spatial randomness adjusted for an inhomogeneity: a general framework, J Am Stat Assoc, vol.101, issue.475, pp.1289-1305, 2006.

M. Kulldorff and N. Nagarwalla, Spatial disease clusters: detection and inference, Stat Med, vol.14, issue.8, pp.799-810, 1995.

, PNDS 2011-2015), 2010.

. Ministère-de-la-santé-publique, Guide pour la surveillance intégrée de la maladie et riposte en République Démocratique du, p.262, 2011.

C. Chatfield, The Analysis of Time Series, vol.352, 2003.

R. B. Cleveland, W. S. Cleveland, J. E. Mcrae, and I. Terpenning, STL: A Seasonal-Trend Decomposition Procedure Based on Loess, Journal of Official Statistics, vol.6, pp.3-73, 1990.

A. Dokumentov, R. J. Hyndman, and . Others, STR: A Seasonal-Trend Decomposition Procedure Based on Regression

P. Yaka, B. Sultan, H. Broutin, S. Janicot, S. Philippon et al., Relationships between climate and year-toyear variability in meningitis outbreaks: a case study in Burkina Faso and Niger, Int J Health Geogr, vol.7, issue.1, p.34, 2008.

S. Trzaska, M. Thomson, M. Madajewicz, T. Dinku, P. Ceccatu et al., Environnemental factors and population dynamics as determinants of meningococcal meningitis epidemics in the sahel : an investigation of NASA and NOAA products, 2011.

P. Nicolas, Épidémies de méningite à méningocoques dans la ceinture de la méningite (1995-2011) et introduction du vaccin méningococcique A conjugué, Med Trop, vol.22, pp.246-258, 2012.

, On line ».Meningococcal disease: 2013 epidemic season in the African Meningitis Belt, 2014.

, One line». utilisation du MenAfriVac?, 2019.

C. L. Trotter, C. Lingani, K. Fernandez, L. V. Cooper, A. Bita et al., Impact of MenAfriVac in nine countries of the African meningitis belt, 2010-15: an analysis of surveillance data, Lancet Infect Dis, vol.17, issue.8, pp.867-72, 2017.

B. Sultan, Influence du climat sur la survenue des épidémies de méningite en Afrique de l'ouest. médecine/sciences, vol.21, pp.470-471, 2005.

R. Ministère-de-la-santé-publique-de-la, Rapport d'investigation de l'épidémie de méningite dans la zone de santé d, 2002.

H. Broutin, S. Philippon, C. De-magny, G. Courel, M. Sultan et al., Comparative study of meningitis dynamics across nine African countries: a global perspective, Int J Health Geogr, vol.6, issue.1, p.29, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00338710

C. Viboud, O. N. Bjørnstad, D. L. Smith, L. Simonsen, M. A. Miller et al., Synchrony, Waves, and Spatial Hierarchies in the Spread of Influenza, Science, vol.312, issue.5772, pp.447-51, 2006.

M. Lipsitch and C. Viboud, Influenza seasonality: Lifting the fog, Proc Natl Acad Sci, vol.106, issue.10, pp.3645-3651, 2009.

J. Guégan, B. D. Thoisy, A. Ayouba, and J. Cappelle, Forêts tropicales, changements d'usage des sols et risques infectieux émergents, vol.22, 2018.

M. E. Meadows, Global Change and Southern Africa, Geogr. Res, vol.44, pp.135-145, 2006.

S. Feng, A. B. Krueger, and M. Oppenheimer, Linkages among climate change, crop yields and Mexico-US crossborder migration, Proc Natl Acad Sci U S A, vol.107, issue.32, pp.14257-62, 2010.

B. Greenwood, Meningococcal meningitis in Africa, Trans R Soc Trop Med Hyg, vol.93, issue.4, pp.341-53, 1999.

T. Koutangni, B. Maïnassara, H. Mueller, and J. E. , Incidence, Carriage and Case-Carrier Ratios for Meningococcal Meningitis in the African Meningitis Belt: A Systematic Review and Meta-Analysis, PLoS ONE, vol.10, issue.2, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02460566

A. M. Molesworth, M. C. Thomson, S. J. Connor, M. P. Cresswell, A. P. Morse et al., Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa, Trans R Soc Trop Med Hyg, vol.96, issue.3, pp.242-251, 2002.

N. E. Basta, A. Berthe, M. Keita, U. Onwuchekwa, B. Tamboura et al., Meningococcal carriage within households in the African meningitis belt: A longitudinal pilot study, J Infect, vol.76, issue.2, pp.140-148, 2018.

B. Sultan, K. Labadi, J. Guégan, and S. Janicot, Climate Drives the Meningitis Epidemics Onset in West Africa. Hales S, editor, PLoS Med, vol.2, issue.1, p.6, 2005.

J. E. Mueller, S. Yaro, M. S. Ouédraogo, N. Levina, B. Njanpop-lafourcade et al., Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults, PloS One, vol.7, issue.12, p.52464, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00933249

D. M. Daugla, J. P. Gami, K. Gamougam, N. Naibei, L. Mbainadji et al., Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study

, Lancet Lond Engl, vol.383, issue.9911, pp.40-47, 2014.

C. L. Trotter, C. Lingani, K. Fernandez, L. V. Cooper, A. Bita et al., Impact of MenAfriVac in nine countries of the African meningitis belt, 2010-15: an analysis of surveillance data, Lancet Infect Dis, vol.17, issue.8, pp.867-72, 2017.

, WHO. WHO | Pneumococcal conjugate vaccines

. Who, , 2009.

E. N. Pavlovski?, N. Evgeni?, N. D. Levine, and E. N. Pavlovski?, Evgeni? N, 1884-1965. Natural nidality of transmissible diseases, with special reference to the landscape epidemiology of zooanthroponoses, pp.1884-1965, 1966.

R. K. Meentemeyer, S. E. Haas, and T. Václavík, Landscape epidemiology of emerging infectious diseases in natural and human-altered ecosystems, Annu Rev Phytopathol, vol.50, pp.379-402, 2012.

L. Agier, A. Deroubaix, N. Martiny, P. Yaka, A. Djibo et al., Seasonality of meningitis in Africa and climate forcing: aerosols stand out, J R Soc Interface, vol.10, issue.79, pp.20120814-20120814, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00771443

N. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmos Environ, vol.70, pp.245-53, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

J. Paireau, . Ma?nassara, . Hb, J. Jusot, J. Collard et al., Spatio-Temporal Factors Associated with Meningococcal Meningitis Annual Incidence at the Health Centre Level in Niger, PLoS Negl Trop Dis, vol.8, issue.5, p.2899, 2004.
URL : https://hal.archives-ouvertes.fr/hal-01343080

M. Lipsitch and C. Viboud, Influenza seasonality: Lifting the fog, Proc Natl Acad Sci, vol.106, issue.10, pp.3645-3651, 2009.

A. Deroubaix, N. Martiny, I. Chiapello, and B. Marticorena, Suitability of OMI aerosol index to reflect mineral dust surface conditions: Preliminary application for studying the link with meningitis epidemics in the Sahel, Remote Sens Environ, vol.133, pp.116-143, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00828686

T. J. Irving, K. B. Blyuss, C. Colijn, and C. L. Trotter, Modelling meningococcal meningitis in the African meningitis belt, Epidemiol Infect, vol.140, issue.5, pp.897-905, 2012.

S. Tartof, A. Cohn, F. Tarbangdo, M. H. Djingarey, N. Messonnier et al., Identifying optimal vaccination strategies for serogroup A Neisseria meningitidis conjugate vaccine in the African meningitis belt, PloS One, vol.8, issue.5, p.63605, 2013.

A. Karachaliou, A. Conlan, M. Preziosi, and C. L. Trotter, Modeling Long-term Vaccination Strategies With MenAfriVac in the African Meningitis Belt, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.61, issue.5, pp.594-600, 2015.

J. Paireau, F. Girond, J. Collard, H. B. Maïnassara, and J. Jusot, Analysing Spatio-Temporal Clustering of Meningococcal Meningitis Outbreaks in Niger Reveals Opportunities for Improved Disease Control, PLoS Negl Trop Dis, vol.6, issue.3, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-01704781

H. Tall, S. Hugonnet, P. Donnen, M. Dramaix-wilmet, L. Kambou et al., Definition and characterization of localised meningitis epidemics in Burkina Faso: a longitudinal retrospective study, BMC Infect Dis, vol.12, issue.2, 2012.

J. Chippaux, H. Debois, and P. Saliou, Revue critique des stratégies de contrôle des épidémies de méningite à méningocoque en Afrique subsaharienne, Bull Société Pathol Exot, vol.94, issue.1, pp.37-44, 2002.

B. Greenwood, Editorial: 100 years of epidemic meningitis in West Africa -has anything changed? Trop Med Int Health, vol.11, pp.773-80, 2006.

S. Azzali and M. Menenti, Mapping vegetation-soil-climate complexes in southern Africa using temporal Fourier analysis of NOAA-AVHRR NDVI data, Int J Remote Sens, vol.21, issue.5, pp.973-96, 2000.

, PNDS 2011-2015), 2010.

. Ministère-de-la-santé-publique, Guide pour la surveillance intégrée de la maladie et riposte en République Démocratique du, p.262, 2011.

M. Karanika, V. A. Vasilopoulou, A. T. Katsioulis, P. Papastergiou, M. N. Theodoridou et al., Diagnostic clinical and laboratory findings in response to predetermining bacterial pathogen: data from the Meningitis Registry, PloS One, vol.4, issue.7, p.6426, 2009.

M. C. Brouwer, A. R. Tunkel, and D. Van-de-beek, Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis, Clin Microbiol Rev, vol.23, issue.3, pp.467-92, 2010.

A. M. Oordt-speets, R. Bolijn, R. C. Van-hoorn, A. Bhavsar, and M. H. Kyaw, Global etiology of bacterial meningitis: A systematic review and meta-analysis, PLoS ONE [Internet], 2018.

, WorldClim Version2 | WorldClim -Global Climate Data, p.13, 2016.

. Srtm and . Srtm, Shuttle Radar Topogr.) -ESDAC -European Commission, 2007.

, id=d863d51225b94c948bd7cf85e4c432b6 33. NASA. LANCE: NASA Near Real-Time Data and Imagery | Earthdata, 2019.

, Active Fire Data | Earthdata, 2009.

, Ministère de la Santé Publique (MSP) et ICF International. Enquête Démographique et de Santé en République Démocratique du Congo, 2013.

M. Müller, Generalized Linear Models, 2004.

M. P. Kain, B. M. Bolker, and M. W. Mccoy, A practical guide and power analysis for GLMMs: detecting among treatment variation in random effects, PeerJ [Internet, vol.3, 2015.

R. Z. Yahya, J. M. Arrieta, M. Cusack, and C. M. Duarte, Airborne Prokaryote and Virus Abundance Over the Red Sea. Front Microbiol, vol.10, 2019.

C. Delacollette, M. Barutwanayo, P. Mpitabakana, . Epidemiologie, . Paludisme-au et al., Médecine Afr Noire, vol.4, 1990.

R. Bødker, J. Akida, D. Shayo, W. Kisinza, H. A. Msangeni et al., Relationship between altitude and intensity of malaria transmission in the Usambara Mountains, Tanzania, J Med Entomol, vol.40, issue.5, pp.706-723, 2003.

X. Wu, Y. Lu, S. Zhou, L. Chen, and B. Xu, Impact of climate change on human infectious diseases: Empirical evidence and human adaptation, Environ Int, vol.86, pp.14-23, 2016.

J. Jusot, D. R. Neill, E. M. Waters, M. Bangert, M. Collins et al., Airborne dust and high temperatures are risk factors for invasive bacterial disease, J Allergy Clin Immunol, vol.139, issue.3, pp.977-986, 2017.

A. Chavy, A. Ferreira-dales-nava, S. Luz, J. D. Ramírez, G. Herrera et al., Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome, PLoS Negl Trop Dis, vol.13, issue.8, p.7629, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02392724

K. Karacabey, The Effect of Nutritional Elements on the Immune System, J Obes Weight Loss Ther, p.2019, 2012.

E. L. Cooper and M. J. Ma, Understanding nutrition and immunity in disease management, J Tradit Complement Med, vol.7, issue.4, pp.386-91, 2017.

, World Health Organization. Guidelines on the control of epidemic meningococcal disease, 1998.

O. Serdeczny, S. Adams, F. Baarsch, D. Coumou, A. Robinson et al., Climate change impacts in Sub-Saharan Africa: from physical changes to their social repercussions. Reg Environ Change, vol.17, pp.1585-600, 2017.

A. Mosavi-jarrahi, A. Esteghamati, F. Asgari, M. Heidarnia, Y. Mousavi-jarrahi et al., Temporal analysis of the incidence of meningitis in the Tehran metropolitan area, Popul Health Metr, vol.7, p.19, 1999.

S. Yezli, The threat of meningococcal disease during the Hajj and Umrah mass gatherings: A comprehensive review, Travel Med Infect Dis, vol.24, pp.51-59, 2018.

, Pneumococcal conjugate vaccines, Who.int. Available at, 2016.

A. Chavy, A. Ferreira-dales-nava, S. L. Luz, J. D. Ramírez, G. Herrera et al., Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome, PLoS Negl Trop Dis, vol.13, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02392724

S. Philippon, H. Broutin, G. Constantin-de-magny, K. Toure, C. H. Diakite et al., Meningococcal meningitis in Mali: a long-term study of persistence and spread, Int. J. Infect. Dis, vol.13, pp.103-109, 2009.

P. Rohani, D. J. Earn, and B. T. Grenfell, Opposite patterns of synchrony in sympatric disease metapopulations, Science, vol.286, pp.968-971, 1999.

,

Y. , Nous analysons ensuite la pertinence de ce travail comme système d'alerte précoce permettant de prédire le seuil épidémique de mise en alerte des systèmes de veille et de surveillance des autorités sanitaires congolaises. Nous discutons, enfin, de l'amélioration des dispositifs de veille et de surveillance au fur et à mesure que des données nouvelles, accessibles et gratuites, favoriseront l'amélioration de ce type de modèles prédictifs et, en retour, En nous servant de la cartographie de séries temporelles de poussières et de particules solides supra-atmosphériques associées au cycle de déclenchement de cas de méningites, nous présentons nos premiers résultats, 2017.

, Un article scientifique est actuellement en cours de préparation à partir de ce travail

. Ii and . References,

J. F. Guégan, G. Suzán, S. Kati-coulibaly, D. N. Bonpamgue, and J. Moatti, Sustainable Development Goal #3, "health and well-being", and the need for more integrative thinking, Veterinaria México OA, vol.5, 2018.

W. Yang, Z. Li, Y. Lan, J. Ma, L. Jin et al., China Infectious Diseases Automated-Alert and Response System (CIDARS), in: Early Warning for Infectious Disease Outbreak, pp.133-161, 2017.

. Références,

L. Agier, A. Deroubaix, N. Martiny, P. Yaka, A. Djibo et al., Seasonality of meningitis in Africa and climate forcing: aerosols stand out, J. R. Soc. Interface, vol.10, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00771443

L. G. Baas-becking, Geobiologie of inleiding tot de milieukunde, 1934.

B. A. Begley, J. Martin, G. T. Tufty, and D. W. Suh, Evaluation of a Remote Telemedicine Screening System for Severe Retinopathy of Prematurity, J. Pediatr. Ophthalmol. Strabismus, vol.56, pp.157-161, 2019.

S. L. Bhatia, K. B. Sharma, and R. Natarajan, An outbreak of meningococcal meningitis in Delhi, Indian J. Med. Res, vol.56, pp.259-263, 1968.

A. J. Bory, .. Biscaye, P. E. Grousset, and F. E. , Two distinct seasonal Asian source regions for mineral dust deposited in Greenland (NorthGRIP), Geophys. Res. Lett, vol.30, 2003.

L. E. Cuevas, I. Jeanne, A. Molesworth, M. Bell, E. C. Savory et al., Risk mapping and early warning systems for the control of meningitis in Africa, Vaccine, vol.25, issue.1, pp.12-17, 2007.

R. A. Duce, C. K. Unni, B. J. Ray, J. M. Prospero, and J. T. Merrill, Long-range atmospheric transport of soil dust from Asia to the tropical north pacific: temporal variability, Science, vol.209, pp.1522-1524, 1980.

H. Eskes,

T. M. Fenchel and B. J. Finlay, The Ubiquity of Small Species: Patterns of Local and Global Diversity, 2004.

B. Fia?kiewicz-kozie?, B. Smieja-król, M. Frontasyeva, M. S?owi?ski, K. Marcisz et al., Anthropogenic-and natural sources of dust in peatland during the, Anthropocene. Sci. Rep, vol.6, 2016.

B. J. Finlay, Global dispersal of free-living microbial eukaryote species, Science, vol.296, pp.1061-1063, 2002.

C. P. García-pando, M. C. Stanton, P. J. Diggle, S. Trzaska, R. L. Miller et al., Soil Dust Aerosols and Wind as Predictors of Seasonal Meningitis Incidence in Niger, Environ. Health Perspect, vol.122, pp.679-686, 2014.

,

B. M. Greenwood, I. S. Blakebrough, A. K. Bradley, S. Wali, and H. C. Whittle, Meningococcal disease and season in sub-Saharan Africa, Lancet Lond. Engl, vol.1, issue.84, pp.91830-91830, 1984.

D. W. Griffin, Atmospheric Movement of Microorganisms in Clouds of Desert Dust and Implications for Human Health, Clin. Microbiol. Rev, vol.20, pp.459-477, 2007.

D. W. Griffin, Atmospheric Movement of Microorganisms in Clouds of Desert Dust and Implications for Human Health, Clin. Microbiol. Rev, vol.20, pp.459-477, 2007.

D. W. Griffin, V. H. Garrison, J. R. Herman, and E. A. Shinn, African desert dust in the Caribbean atmosphere: Microbiology and public health, Aerobiologia, vol.17, 2001.

D. W. Griffin, C. A. Kellogg, V. H. Garrison, J. T. Lisle, T. C. Borden et al., Atmospheric microbiology in the northern Caribbean during African dust events, Aerobiologia, vol.19, 2003.

F. Grousset, P. Ginoux, A. Bory, and P. Biscaye, Case study of a Chinese dust plume reaching the French Alps, Geophys Res Lett, vol.30, 2003.

A. Hervàs, L. Camarero, I. Reche, and E. O. Casamayor, Viability and potential for immigration of airborne bacteria from Africa that reach high mountain lakes in Europe, Environ. Microbiol, vol.11, pp.1612-1623, 2009.

Y. Iwasaka, H. Minoura, and K. Nagaya, The transport and spacial scale of Asian dust-storm clouds: a case study of the dust-storm event of, Tellus B, vol.35, pp.189-196, 1979.

Y. Iwasaka, M. Yamato, R. Imasu, and A. Ono, Transport of Asian dust (KOSA) particles; importance of weak KOSA events on the geochemical cycle of soil particles, Tellus B Chem. Phys. Meteorol, vol.40, pp.494-503, 1988.

M. Jackou-boulama, R. Michel, L. Ollivier, J. B. Meynard, P. Nicolas et al., , 2005.

, Med. Trop. Rev. Corps Sante Colon, vol.65, pp.329-333

C. A. Kellogg and D. W. Griffin, Aerobiology and the global transport of desert dust, Trends Ecol. Evol, vol.21, pp.638-644, 2006.

L. M. Kinlin, C. V. Spain, V. Ng, C. C. Johnson, A. N. White et al., Environmental Exposures and Invasive Meningococcal Disease: An Evaluation of Effects on Varying Time Scales, Am. J. Epidemiol, vol.169, pp.588-595, 2009.

E. Korzeniewska, Emission of bacteria and fungi in the air from wastewater treatment plants -a review, Front. Biosci, vol.3, pp.393-407, 2011.

T. Koutangni, H. Boubacar-maïnassara, and J. E. Mueller, Incidence, Carriage and Case-Carrier Ratios for Meningococcal Meningitis in the African Meningitis Belt: A Systematic Review and Meta-Analysis, PLoS ONE, vol.10, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02460566

H. Li, J. Qi, L. Dong, and D. Gao, , 2017.

, Huan Jing Ke Xue Huanjing Kexue, vol.38, pp.3169-3177

B. Marticorena, B. Chatenet, J. L. Rajot, S. Traoré, M. Coulibaly et al., Temporal variability of mineral dust concentrations over West Africa: analyses of a pluriannual monitoring from the AMMA Sahelian Dust Transect, Atmospheric Chem. Phys, vol.10, pp.8899-8915, 2010.

N. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmos. Environ, vol.70, pp.245-253, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

N. Martiny, N. Dessay, P. Yaka, O. Toure, B. Sultan et al., Le climat, un facteur de risque pour la santé en Afrique de l'Ouest, pp.73-79, 2012.

A. M. Molesworth, L. E. Cuevas, S. J. Connor, A. P. Morse, and M. C. Thomson, Environmental risk and meningitis epidemics in Africa, Emerg. Infect. Dis, vol.9, pp.1287-1293, 2003.

A. M. Molesworth, M. C. Thomson, S. J. Connor, M. P. Cresswell, A. P. Morse et al., Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa, Trans. R. Soc. Trop. Med. Hyg, vol.96, pp.90089-90090, 2002.

J. E. Mueller and B. D. Gessner, A hypothetical explanatory model for meningococcal meningitis in the African meningitis belt, Int. J. Infect. Dis. IJID Off. Publ. Int. Soc. Infect. Dis, vol.14, pp.553-559, 2010.

K. A. Murray, J. Olivero, B. Roche, S. Tiedt, and J. Guégan, Pathogeography: leveraging the biogeography of human infectious diseases for global health management, Ecography, vol.41, pp.1411-1427, 2018.

P. Oke, Harmattan et méningite cérébro-spinale au Bénin, 1994.

J. Paireau, H. B. Maïnassara, J. Jusot, J. Collard, I. Idi et al., Spatio-Temporal Factors Associated with Meningococcal Meningitis Annual Incidence at the Health Centre Level in Niger, PLoS Negl. Trop. Dis, vol.8, 2004.
URL : https://hal.archives-ouvertes.fr/hal-01343080

H. Palmgren, Meningococcal disease and climate, Glob. Health Action, vol.2, 2009.

J. Park, T. Ichijo, M. Nasu, and N. Yamaguchi, Investigation of bacterial effects of Asian dust events through comparison with seasonal variability in outdoor airborne bacterial community, Sci. Rep, vol.6, 2016.

J. M. Prospero, E. Blades, G. Mathison, and R. Naidu, Interhemispheric transport of viable fungi and bacteria from Africa to the Caribbean with soil dust, Aerobiologia, vol.21, pp.1-19, 2005.

X. Rodó, M. Pascual, F. J. Doblas-reyes, A. Gershunov, D. A. Stone et al., Climate change and infectious diseases: Can we meet the needs for better prediction?, Clim. Change, vol.118, pp.625-640, 2013.

E. C. Savory, L. E. Cuevas, M. A. Yassin, C. A. Hart, A. M. Molesworth et al., Evaluation of the meningitis epidemics risk model in Africa, Epidemiol. Infect, vol.134, pp.1047-1051, 2006.

D. S. Stephens, B. Greenwood, and P. Brandtzaeg, Epidemic meningitis, meningococcaemia, and Neisseria meningitidis, Lancet Lond. Engl, vol.369, pp.61016-61018, 2007.

B. Sultan, K. Labadi, J. Guégan, and S. Janicot, Climate Drives the Meningitis Epidemics Onset in West Africa, PLoS Med, vol.2, 2005.

C. L. Swain, D. R. Martin, D. Sim, T. W. Jordan, and J. K. Mackichan, Survival of Neisseria meningitidis outside of the host: environmental effects and differences among strains, Epidemiol. Infect, vol.145, pp.3525-3534, 2017.

M. C. Thomson, A. M. Molesworth, M. H. Djingarey, K. R. Yameogo, F. Belanger et al., Potential of environmental models to predict meningitis epidemics in Africa, Trop. Med. Int. Health TM IH, vol.11, pp.781-788, 2006.

C. L. Trotter and B. M. Greenwood, Meningococcal carriage in the African meningitis belt, Lancet Infect. Dis, vol.7, pp.797-803, 2007.
URL : https://hal.archives-ouvertes.fr/hal-02263733

Y. Tzeng, L. E. Martin, and D. S. Stephens, Environmental Survival of Neisseria meningitidis, Epidemiol. Infect, vol.142, pp.187-190, 2014.

I. Uno, K. Eguchi, K. Yumimoto, T. Takemura, A. Shimizu et al., Asian dust transported one full circuit around the globe, 2009.

S. Vujosevic and E. Midena, Diabetic Retinopathy in Italy: Epidemiology Data and Telemedicine Screening Programs, J. Diabetes Res, p.3627465, 2016.

, WHO | Control of epidemic meningococcal disease. WHO practical guidelines, WHO, 1998.

M. Woringer, N. Martiny, S. Porgho, B. W. Bicaba, A. Bar-hen et al., Atmospheric Dust, Early Cases, and Localized Meningitis Epidemics in the African Meningitis Belt: An Analysis Using High Spatial Resolution Data, Environ. Health Perspect, vol.126, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01963567

R. Z. Yahya, J. M. Arrieta, M. Cusack, and C. M. Duarte, Airborne Prokaryote and Virus Abundance Over the Red Sea, Front. Microbiol, vol.10, 2019.

P. Yaka, B. Sultan, H. Broutin, S. Janicot, S. Philippon et al., Relationships between climate and year-to-year variability in meningitis outbreaks: a case study in Burkina Faso and Niger, Int. J. Health Geogr, vol.7, 2008.

N. Yamaguchi, T. Ichijo, A. Sakotani, T. Baba, and M. Nasu, Global dispersion of bacterial cells on Asian dust, Sci. Rep, vol.2, 2012.

I. References,

A. Addisu, W. Adriaensen, A. Balew, M. Asfaw, E. Diro et al., Neglected tropical diseases and the sustainable development goals: an urgent call for action from the front line, Ethiopia SORT IT Neglected Tropical Diseases Group, vol.4, 2019.

J. Amat-roze, La santé en Afrique sub-saharienne, entre avancées, recul et renouveau (Health in sub-Saharan Africa, between progress, setbacks andrenewal), vol.87, pp.105-118, 2010.

,

I. Arita and D. A. Henderson, Smallpox and monkeypox in non-human primates, Bull World Health Organ, vol.39, pp.277-283, 1968.

G. L. Armstrong, L. A. Conn, and R. W. Pinner, Trends in infectious disease mortality in the United States during the 20th century, JAMA, vol.281, pp.61-66, 1999.

M. A. Bauer, K. Kainz, D. Carmona-gutierrez, and F. Madeo, Microbial wars: Competition in ecological niches and within the microbiome, Microb Cell, vol.5, pp.215-219, 2018.

M. Camara, E. Ouattara, A. Duvignaud, R. Migliani, O. Camara et al., Impact of the Ebola outbreak on Trypanosoma brucei gambiense infection medical activities in coastal Guinea, PLoS Negl Trop Dis, vol.11, 2014.

A. Chavy, A. Ferreira-dales-nava, S. L. Luz, J. D. Ramírez, G. Herrera et al., Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome, PLoS Negl Trop Dis, vol.13, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02392724

A. De-graft-aikins, N. Unwin, C. Agyemang, P. Allotey, C. Campbell et al., Tackling Africa's chronic disease burden: from the local to the global, Global Health, vol.6, 2010.

K. Deribe, K. Meribo, T. Gebre, A. Hailu, A. Ali et al., The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination, Parasit Vectors, vol.5, 2012.

A. Deroubaix, N. Martiny, I. Chiapello, and B. Marticorena, Suitability of OMI aerosol index to reflect mineral dust surface conditions: Preliminary application for studying the link with meningitis epidemics in the Sahel, Remote Sensing of Environment, vol.133, pp.116-127, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00828686

R. H. Doshi, S. A. Guagliardo, J. B. Doty, A. D. Babeaux, A. Matheny et al., Epidemiologic and Ecologic Investigations of Monkeypox, Emerging Infectious Diseases journal -CDC, vol.25, issue.2, 2017.

F. Smith, K. Guégan, and J. , Changing Geographic Distributions of Human Pathogens, Evolution, and Systematics, vol.41, pp.231-250, 2010.

F. Fenollar and O. Mediannikov, Emerging infectious diseases in Africa in the 21st century, New Microbes New Infect, vol.26, pp.10-18, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02100888

,

N. L. Gottdenker, D. G. Streicker, C. L. Faust, and C. R. Carroll, Anthropogenic land use change and infectious diseases: a review of the evidence, Ecohealth, vol.11, pp.619-632, 2014.

B. T. Grenfell, O. N. Bjørnstad, and J. Kappey, Travelling waves and spatial hierarchies in measles epidemics, Nature, vol.414, pp.716-723, 2001.

J. Guégan, G. Suzàn-azpiri, S. Kati-coulibaly, D. Nkoko-bonpamgue, and J. Moatti, L'ODD 3, ou la nécessité d'une approche de santé globale, Un défi pour la planète : les Objectifs de développement durable en débat. IRD, pp.107-120, 2017.

J. F. Guégan, G. Suzán, S. Kati-coulibaly, D. N. Bonpamgue, and J. Moatti, Sustainable Development Goal #3, "health and well-being", and the need for more integrative thinking, Veterinaria México OA, vol.5, 2018.

J. Gyapong and B. Boatin, Neglected Tropical Diseases -Sub-Saharan Africa, 2016.

J. Gyapong, M. Gyapong, N. Yellu, K. Anakwah, A. George et al., Integration of control of neglected tropical diseases into health-care systems: Challenges and opportunities, Lancet, vol.375, issue.09, pp.61249-61255, 2010.

M. H. Hayden, M. Dalaba, T. Awine, P. Akweongo, G. Nyaaba et al., Knowledge, Attitudes, and Practices Related to Meningitis in Northern Ghana, Am J Trop Med Hyg, vol.89, pp.265-270, 2013.

D. Haydon, S. Cleaveland, L. Taylor, and M. Karen-laurenson, Identifying Reservoirs of Infection: A Conceptual and Practical Challenge, Emerging infectious diseases, vol.8, pp.1468-73, 2003.

M. F. Holick and T. C. Chen, Vitamin D deficiency: a worldwide problem with health consequences, Am. J. Clin. Nutr, vol.87, pp.1080-1086, 2008.

,

P. J. Hotez and S. Aksoy, An interfaith dialogue on the neglected tropical diseases, PLoS Negl Trop Dis, vol.5, 2011.

P. J. Hotez and A. Kamath, Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden, PLoS Negl Trop Dis, vol.3, 2009.

K. E. Jones, N. G. Patel, M. A. Levy, A. Storeygard, D. Balk et al., Global trends in emerging infectious diseases, Nature, vol.451, pp.990-993, 2008.

M. Kagabadouno, O. Camara, . Camara, . Mamadou, H. Ilboudo et al., Ebola outbreak brings to light an unforeseen impact of tsetse control on sleeping sickness transmission in Guinea, 2018.

M. Kappas, U. Gross, and D. Kelleher, Global Health: A Challenge for Interdisciplinary Research, 2012.

J. F. Lindahl and D. Grace, The consequences of human actions on risks for infectious diseases: a review, Infect Ecol Epidemiol, vol.5, 2015.

M. Lipsitch and C. Viboud, Influenza seasonality: Lifting the fog, Proc Natl Acad Sci U S A, vol.106, pp.3645-3646, 2009.

B. M. Mandja, A. Brembilla, P. Handschumacher, D. Bompangue, J. Gonzalez et al., Temporal and Spatial Dynamics of Monkeypox in Democratic Republic of Congo, 2000.
URL : https://hal.archives-ouvertes.fr/hal-02537217

N. Martiny and I. Chiapello, Assessments for the impact of mineral dust on the meningitis incidence in West Africa, Atmospheric Environment, vol.70, pp.245-253, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00796525

B. Mcpake, S. Witter, S. Ssali, H. Wurie, J. Namakula et al., Ebola in the context of conflict affected states and health systems: case studies of Northern Uganda and Sierra Leone, Confl Health, vol.9, 2015.

A. Mills, Vertical vs horizontal health programmes in Africa: idealism, pragmatism, resources and efficiency, Soc Sci Med, vol.17, issue.83, pp.90137-90142, 1971.

D. H. Molyneux, P. J. Hotez, and A. Fenwick, Rapid-Impact Interventions": How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor, PLOS Medicine, vol.2, 2005.

D. H. Molyneux, L. Savioli, and D. Engels, Neglected tropical diseases: progress towards addressing the chronic pandemic, Lancet, vol.389, pp.312-325, 2017.

, , pp.30171-30175

J. E. Mueller, M. Woringer, S. Porgho, Y. Madec, H. Tall et al., The association between respiratory tract infection incidence and localised meningitis epidemics: an analysis of high-resolution surveillance data from, Burkina Faso. Sci Rep, vol.7, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01598638

C. J. Murray and A. D. Lopez, Mortality by cause for eight regions of the world: Global Burden of Disease Study, Lancet, vol.349, issue.96, pp.7493-7497, 1997.

K. A. Murray, J. Olivero, B. Roche, S. Tiedt, and J. Guégan, Pathogeography: leveraging the biogeography of human infectious diseases for global health management, Ecography, vol.41, pp.1411-1427, 2018.

R. Nair and A. Maseeh, Vitamin D: The "sunshine" vitamin, J Pharmacol Pharmacother, vol.3, pp.118-126, 2012.

S. A. Omoleke, O. Alabi, F. Shuaib, F. Braka, S. G. Tegegne et al., Environmental, economic and socio-cultural risk factors of recurrent seasonal epidemics of cerebrospinal meningitis in Kebbi state, northwestern Nigeria: a qualitative approach, BMC Public Health, vol.18, 2018.

S. Ravi and E. Gauldin, Biosecurity and bioterrorism : biodefense strategy, practice, and science 12, 2014.

M. G. Reynolds, J. B. Doty, A. M. Mccollum, V. A. Olson, and Y. Nakazawa, Monkeypox re-emergence in Africa: a call to expand the concept and practice of One Health, Expert Rev Anti Infect Ther, vol.17, pp.129-139, 2019.

,

J. Ricossé and J. Husser, Bilan et avenir de la lutte contre les grandes endémies en Afrique occidentale francophone. Cahiers d'Études africaines 22, pp.145-168, 1982.

S. Riedel, Edward Jenner and the history of smallpox and vaccination, Proc, vol.18, pp.21-25, 2005.

A. Roca, M. O. Afolabi, Y. Saidu, and B. Kampmann, Ebola: A holistic approach is required to achieve effective management and control, J Allergy Clin Immunol, vol.135, pp.856-867, 2015.

P. Rohani, D. J. Earn, and B. T. Grenfell, Opposite patterns of synchrony in sympatric disease metapopulations, Science, vol.286, pp.968-971, 1999.

,

P. Rohani, C. J. Green, N. B. Mantilla-beniers, and B. T. Grenfell, Ecological interference between fatal diseases, Nature, vol.422, pp.885-888, 2003.

R. K. Singh, V. Balamurugan, V. Bhanuprakash, G. Venkatesan, and M. Hosamani, Emergence and Reemergence of Vaccinia-Like Viruses: Global Scenario and Perspectives, Indian J Virol, vol.23, pp.1-11, 2012.

K. F. Smith, M. Goldberg, S. Rosenthal, L. Carlson, J. Chen et al., Global rise in human infectious disease outbreaks, J R Soc Interface, vol.11, 2014.

W. A. Stolk, M. C. Kulik, E. A. Le-rutte, J. Jacobson, J. H. Richardus et al., Between-Country Inequalities in the Neglected Tropical Disease Burden in 1990 and 2010, with Projections for 2020, PLoS Negl Trop Dis, vol.10, 2016.

B. Sultan, K. Labadi, J. Guégan, and S. Janicot, Climate Drives the Meningitis Epidemics Onset in West Africa, PLoS Medicine, vol.2, 2005.

A. J. Tatem, D. J. Rogers, and S. I. Hay, Socio-Cultural Factors Associated with Epidemics: The Case of, Adv. Parasitol, vol.62, pp.293-343, 2006.

, WHO | Ebola virus disease -Democratic Republic of the Congo, WHO, 2019.

, WHO | Vertical-horizontal synergy of the health workforce, WHO, 2005.

B. A. Wilcox and D. J. Gubler, Disease ecology and the global emergence of zoonotic pathogens, Environ Health Prev Med, vol.10, pp.263-272, 2005.

,

, Annexes Annexe 1 : Les autres catégories de regroupement mensuels de distribution d'aérosols (AOD) et poussières minérales (DUAOD)

, Professionnel de santé (Infirmier, médecin?)

. Autre,

, Poster présenté à la MRF conference 5th-6th, vol.4, 2019.

, Streptococcus pneunomiae (Sp) et Haemophilus influenzae type b (Hib), le rhino-pharynx de l'homme étant la niche écologique des bactéries. La transmission est aérienne, directe, Résumé Les méningites bactériennes restent un problème de santé publique internationale avec un fardeau principalement localisé en Afrique. Elles sont principalement dues à trois bactéries : Neisseria meningitidis (Nm)

, Alors que la ceinture de la méningite qui s'étend du Sénégal jusqu'à l'Ethiopie, est largement étudiée, l'écologie des méningites en dehors de cette zone particulière est encore peu connue. L'objectif de cette thèse est d'explorer l'écologie des méningites bactériennes en République démocratique du Congo (RDC) à partir des données épidémiologiques, génétiques et socio-environnementales pour la période de, 2000.

, nous avons identifié des zones de santé à risque, regroupées en 8 clusters spatiaux. Ces clusters nous ont permis de mettre en évidence une saisonnalité des méningites bactériennes peu marquée et variable d'une région à une autre en RDC, ce qui contraste avec les dynamiques décrites dans la ceinture de la méningite, En dépit du faible taux de confirmation biologique des cas (14%)

, Les zones urbanisées où les populations montrent un indice économique de bien-être médiocre à bas, de latitude et de longitude élevées, d'altitude moyenne à faible, de végétation constituée de savanes ou de savanes arborées, à valeurs moyennes de température, constituent autant de facteurs de risque importants, seuls ou en synergie

, Ces résultats laissent préfigurer une possibilité de mise au point d'un système d'alerte précoce. Au final, nous proposons un modèle conceptuel explicatif des méningites en RDC, La distribution d'aérosols et de poussières sur le territoire congolais précède d'environ 2 à 3 semaines les démarrages épidémiques de méningites bactériennes

, La reconnaissance de méningites bactériennes comme priorités internationales notamment en dehors de la ceinture dont les caractéristiques restent encore à mieux comprendre, pourrait contribuer à l'atteinte des objectifs du développement durable, et plus particulièrement de ceux qui concernent l'ODD 3 « santé et bien-être pour toutes et tous