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, mice on days 10 and 21 post-injury. (b) Distribution of CSA of regenerating myofibres for each mouse strain on days 10 and 21 post-injury. Data are means + s.e.m. of 6 mice per strain in 2 distinct experiments. *p<0.05 for Cx3cr1 -/-strain versus wild-type and # p<0.05 for Ccl2 -/-versus Cx3cr1 -/-Ccl2 -/-strains. (c) Quantification of the total number of regenerating myofibres per field on day 4 post-injury. Data are means + s.e.m. of at least 3 different fields taken from 6 different mice per strain. (d) strain. (e) Example of muscle cross-sections of Ccl2 -/-and Cx3cr1 -/-Ccl2 -/-mice immunolabelled with MyoD (red) and myogenin antibodies (green) on day 4 post-injury. (f) Quantification of MyoD-positive and myogenin-positive cells in an average of 5 fields per mouse on day 4 post-injury (magnification of x40). Data are mean + s.e.m. of 2 different mice per strain. ns: not significant
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, Dans un premier temps, nous avons pu mettre en évidence que l'expression des marqueurs d'activation ou de costimulation (activateurs ou inhibiteurs) était spécifiquement augmentée sur les Mo infiltrés chez les souris Sham et CLP. Cependant, les Mo Ly6C high des souris septiques restimulés par la seconde infection ne sont pas capables d'atteindre les mêmes niveaux d'expression que les souris Sham pour les marqueurs CMH-II, CD80, CD86 et PDL1. Wolk et al ont montré que la diminution de l'expression du CD86 et du CMH-II sur les Mo cultivés en présence d'endotoxine (LPS) limitait la capacité à, Caractérisation phénotypique des Mo La caractérisation phénotypique des Mo infiltrés et vasculaires du poumon après la seconde infection a montré des différences majeures, 2000.
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