, Patients, p.315

, Patients, p.121

, Patients, p.194

, Figure 1 Click here to access/download;Figure

K. Holloway and L. Van-dijk, Rational use of medicines. The world medicines situation 2011, pp.1-22, 2011.

, World Health Organization. Safety monitoring of medicinal products: guidelines for setting up and running a pharmacovigilance centre, EQUUS, pp.1-28, 2000.

C. M. Chang, E. C. Wu, C. Y. Chen, K. Y. Wu, H. Y. Liang et al., Psychotropic drugs and risk of motor vehicle accidents: a population-based case-control study, Br J Clin Pharmacol, vol.75, issue.4, pp.1125-1158, 2013.

D. S. Budnitz, M. C. Lovegrove, N. Shehab, and C. L. Richards, Emergency Hospitalizations for Adverse Drug Events in Older Americans, N Engl J Med, vol.365, issue.21, pp.2002-2014, 2011.

, Interventions to reduce the burden associated with the prescription of sedative-hypnotics, PLOS ONE, vol.12, p.15, 2018.

S. Billioti-de-gage, B. Begaud, F. Bazin, H. Verdoux, J. F. Dartigues et al., Benzodiazepine use and risk of dementia: prospective population based study, BMJ, vol.345, p.6231, 2012.

S. Billioti-de-gage, A. Pariente, and B. Begaud, Is there really a link between benzodiazepine use and the risk of dementia?, Expert Opin Drug Saf, vol.14, issue.5, pp.733-780, 2015.

D. Shash, T. Kurth, M. Bertrand, C. Dufouil, P. Barberger-gateau et al., psychotropic medication, and dementia: A population-based cohort study, Alzheimers Dement, vol.12, issue.5, pp.604-617, 2015.

W. Gomm, V. Holt, K. Thome, F. Broich, K. Maier et al., Regular Benzodiazepine and Z-Substance Use and Risk of Dementia: An Analysis of German Claims Data, J Alzheimers Dis, vol.54, issue.2, pp.801-809, 2016.

J. C. Woolcott, K. J. Richardson, M. O. Wiens, B. Patel, J. Marin et al., Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons, Arch Intern Med, vol.169, issue.21, pp.1952-60, 2009.

O. J. De-vries, G. Peeters, P. Elders, G. Sonnenberg, M. Muller et al., The elimination half-life of benzodiazepines and fall risk: two prospective observational studies, Age Ageing, vol.42, issue.6, pp.764-70, 2013.

F. Landi, G. Onder, M. Cesari, C. Barillaro, A. Russo et al., Psychotropic medications and risk for falls among community-dwelling frail older people: An observational study, J Gerontol A Biol Sci Med Sci, vol.60, issue.5, pp.622-648, 2005.

P. S. Wang, R. L. Bohn, R. J. Glynn, H. Mogun, and J. Avorn, Hazardous benzodiazepine regimens in the elderly: Effects of half-life, dosage, and duration on risk of hip fracture, Am J Psychiatry, vol.158, issue.6, pp.892-98, 2001.

, International drug monitoring: the role of national centres. WHO Technical report series n?498, Geneva: WHO, vol.1972, pp.1-48

D. M. Bush, Emergency Department Visits for Adverse Reactions Involving the Insomnia Medication Zolpidem. The CBHSQ Report, 2013.

M. K. Church, M. Maurer, F. E. Simons, C. Bindslev-jensen, P. Van-cauwenberge et al., Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper, Allergy, vol.65, issue.4, pp.459-66, 2010.

F. E. Simons, Advances in H1-antihistamines, New Engl J Med, vol.351, issue.21, pp.2203-2220, 2004.

, Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, American Geriatrics Society. American Geriatrics Society, vol.63, issue.11, pp.2227-2273, 2015.

P. Montgomery, D. Jane, and A. , Cognitive behavioural interventions for sleep problems in adults aged 60+, Cochrane Database Syst Rev, issue.1, p.3161, 2003.

G. D. Jacobs, E. F. Pace-schott, R. Stickgold, and M. W. Otto, Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison, Arch Intern Med, vol.164, issue.17, pp.1888-96, 2004.

D. Riemann and M. L. Perlis, The treatments of chronic insomnia: A review of benzodiazepine receptor agonists and psychological and behavioral therapies, Sleep Med Rev, vol.13, issue.3, pp.205-219, 2009.

S. Schutte-rodin, L. Broch, D. Buysse, C. Dorsey, and M. Sateia, Clinical guideline for the evaluation and management of chronic insomnia in adults, Journal of clinical sleep medicine: JCSM: official publication of the American Academy of Sleep Medicine, vol.4, issue.5, pp.487-504, 2008.

D. Riemann, C. Baglioni, C. Bassetti, B. Bjorvatn, D. Groselj et al., European guideline for the diagnosis and treatment of insomnia, J Sleep Res, 2017.

M. J. Sateia, D. J. Buysse, A. D. Krystal, D. N. Neubauer, and J. L. Heald, Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline, J Clin Sleep Med, vol.13, issue.2, pp.307-356, 2017.

M. Olfson, M. King, and M. Schoenbaum, Benzodiazepine Use in the United States, JAMA Psychiatry, vol.72, issue.2, pp.136-178, 2015.

S. M. Bertisch, S. J. Herzig, J. W. Winkelman, and C. Buettner, Interventions to reduce the burden associated with the prescription of sedative-hypnotics, PLOS ONE, vol.37, issue.2, p.15, 2014.

, ANSM. É tat des lieux de la consommation des benzodiazépines en France, 2017.

R. Lagnaoui, N. Moore, M. Longy-boursier, M. Baumevieille, and B. Begaud, Benzodiazepine use in patients hospitalized in a department of internal medicine: frequency and clinical correlates, Pharmacoepidemiol Drug Saf, vol.10, issue.6, pp.531-536, 2001.

A. Zisberg, E. Shadmi, G. Sinoff, N. Gur-yaish, E. Srulovici et al., Hospitalization as a turning point for sleep medication use in older adults: prospective cohort study, Drugs Aging, vol.29, issue.7, pp.565-76, 2012.

A. Somers, H. Robays, K. Audenaert, G. Van-maele, M. Bogaert et al., The use of hypnosedative drugs in a university hospital: has anything changed in 10 years?, Eur J Clin Pharmacol, vol.67, issue.7, p.21279338, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00664100

P. Fagnoni, S. Limat, E. Haffen, T. Henon, M. Jacquet et al., Does hospitalisation affect hypnotic and anxiolytic drug prescribing?, Pharm World Sci, vol.29, issue.6, p.17370138, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00493432

R. L. Gould, M. C. Coulson, N. Patel, E. Highton-williamson, and R. J. Howard, Interventions for reducing benzodiazepine use in older people: meta-analysis of randomised controlled trials, Br J Psychiatry, vol.204, issue.2, pp.98-107, 2014.

A. J. Smith and S. E. Tett, Improving the use of benzodiazepines-is it possible? A non-systematic review of interventions tried in the last 20 years, BMC Health Serv Res, vol.10, p.321, 2010.

A. Liberati, D. G. Altman, J. Tetzlaff, C. Mulrow, P. C. Gotzsche et al., The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration, J Clin Epidemiol, vol.62, issue.10, pp.1-34, 2009.

J. Cohen, A coefficient of agreement for nominal scales, Educational and Psychological Measurement, vol.20, issue.1, pp.37-46, 1960.

J. Higgins and J. Deeks, Cochrane Handbook for Systematic Reviews of Interventions, pp.151-85, 2012.

B. H. Thomas, D. Ciliska, M. Dobbins, and S. Micucci, A process for systematically reviewing the literature: providing the research evidence for public health nursing interventions, Worldviews Evid Based Nurs, vol.1, issue.3, p.17163895, 2004.

N. Jackson and E. Waters, Criteria for the systematic review of health promotion and public health interventions, Health Promot Int, vol.20, issue.4, pp.367-74, 2005.

S. Deburgh, A. Mant, R. P. Mattick, N. Donnelly, W. Hall et al., A Controlled Trial Educational Visiting to Improve Benzodiazepine Prescribing in General-Practice, Aust J Public Health, vol.19, issue.2, pp.142-190, 1995.

K. Rokstad, J. Straand, and P. Fugelli, Can drug treatment be improved by feedback on prescribing profiles combined with therapeutic recommendations? A prospective, controlled trial in general practice, J Clin Epidemiol, vol.48, issue.8, pp.1061-1069, 1995.

D. H. Smith, D. B. Christensen, A. Stergachis, and G. Holmes, A randomized controlled trial of a drug use review intervention for sedative hypnotic medications, Med Care, vol.36, issue.7, pp.1013-1034, 1998.

N. A. Zwar, J. Wolk, J. J. Gordon, and R. W. Sanson-fisher, Benzodiazepine prescribing by GP registrars. A trial of educational outreach, Aust Fam Physician, vol.29, issue.11, pp.1104-1111, 2000.

R. J. Fortuna, F. Zhang, D. Ross-degnan, F. X. Campion, J. A. Finkelstein et al., Reducing the Prescribing of Heavily Marketed Medications: A Randomized Controlled Trial, J Gen Intern Med, vol.24, issue.8, p.19475459, 2009.

J. Avorn, S. B. Soumerai, D. E. Everitt, D. Ross-degnan, M. H. Beers et al., A randomized trial of a program to reduce the use of psychoactive drugs in nursing homes, New Engl J Med, vol.327, issue.3, pp.168-73, 1992.

P. Archambault, P. Boyer, and J. J. Crappier, Reducing hypnosedative prescribing in general practice on France: A longitudinal study, La Revue du Praticien-Medecine Generale, vol.13, issue.453, pp.495-500, 1999.

J. M. Hoebert, P. C. Souverein, A. K. Mantel-teeuwisse, H. Leufkens, and L. Van-dijk, Reimbursement Restriction and Moderate Decrease in Benzodiazepine Use in General Practice, Ann Fam Med, vol.10, issue.1, pp.42-49, 2012.

M. Holm, Intervention against long-term use of hypnotics/sedatives in general practice, Scand J Prim Health Care, vol.8, issue.2, pp.113-130, 1990.

V. R. Jorgensen, B. S. Toft, and M. Fogh, Reducing the use of benzodiazepines and cyclopyrrolones in clinical practice, Pharm Pract, vol.4, issue.2, pp.74-82, 2006.

, Interventions to reduce the burden associated with the prescription of sedative-hypnotics, PLOS ONE, vol.14, p.15, 2018.

V. R. Jorgensen, An approach to reduce benzodiazepine and cyclopyrrolone use in general practice: a study based on a Danish population, CNS Drugs, vol.21, issue.11, pp.947-55, 2007.

A. Oosterhuis and E. C. Klip, The treatment of insomnia through mass media: The results of a televised behavioural training programme, Soc Sci Med, vol.45, issue.8, pp.1223-1252, 1997.

C. Victorri-vigneau, G. Basset, M. Bourin, and P. Jolliet, Is hypnotic use influenced by legislation?, Therapie, vol.58, issue.5, pp.425-455, 2003.

E. Eide and J. Schjot, Assessing the effects of an intervention by a pharmacist on prescribing and administration of hypnotics in nursing homes, Pharm World Sci, vol.23, issue.6, pp.227-258, 2001.

D. Griffith and M. Robinson, Prescribing practice and policy for hypnotics: A model of pharmacy audit, Age Ageing, vol.25, issue.6, pp.490-92, 1996.

F. Onen, N. Bleyzac, P. Maire, J. Ogier, and P. H. Courpron, Increased hypnotics consumption in geriatrics despite the decree dated, La Revue de Geriatrie, vol.22, issue.7, pp.443-489, 1991.

J. V. Agostini, Y. Zhang, and S. K. Inouye, Use of a computer-based reminder to improve sedative-hypnotic prescribing in older hospitalized patients, J Am Geriatr Soc, vol.55, issue.1, p.17233684, 2007.

S. Borson and K. Doane, The impact of OBRA-87 on psychotropic drug prescribing in skilled nursing facilities, Psychiatr Serv, vol.48, issue.10, pp.1289-96, 1997.

L. A. Mcnutt, F. B. Coles, T. Mcauliffe, S. Baird, D. L. Morse et al., Impact of regulation on benzodiazepine prescribing to a low income elderly population, J Clin Epidemiol, vol.47, issue.6, pp.613-638, 1994.

M. Monane, D. M. Matthias, B. A. Nagle, and M. A. Kelly, Improving prescribing patterns for the elderly through an online drug utilization review intervention: a system linking the physician, pharmacist, and computer, JAMA, vol.280, issue.14, pp.1249-52, 1998.

S. G. Zullich, T. H. Grasela, J. B. Fiedlerkelly, and F. M. Gengo, Impact of Triplicate Prescription Program on Psychotropic Prescribing Patterns in Long-Term Care Facilities, Ann Pharmacother, vol.26, issue.4, pp.539-585, 1992.

J. K. Seltzer, T. L. Kurt, L. C. Knodel, B. Dean, C. Burch et al., Drug utilization review of sedative/hypnotic agents in Texas Medicaid patients. Texas Medicaid Vendor Drug Program Drug Utilization Review Board, J Am Pharm Assoc, vol.40, issue.4, pp.495-504, 2000.

B. Sleath and T. Collins, Physician responses to an educational intervention on improving their long-term prescribing of sedatives, Patient Educ Couns, vol.31, issue.3, pp.215-237, 1997.

J. A. Mcdowell, L. C. Mion, T. J. Lydon, and S. K. Inouye, A nonpharmacologic sleep protocol for hospitalized older patients, J Am Geriatr Soc, vol.46, issue.6, pp.700-705, 1998.

A. J. Smith and S. E. Tett, An intervention to improve benzodiazepine use-A new approach, Fam Pract, vol.27, issue.3, pp.320-347, 2010.

J. Snowdon, A follow-up survey of psychotropic drug use in Sydney nursing homes, Med J Aust, vol.170, issue.7, pp.299-301, 1999.

D. L. Carey, R. O. Day, D. R. Cairns, G. A. Pearce, A. D. Wodak et al., An attempt to influence hypnotic and sedative drug use, Med J Aust, vol.156, issue.6, pp.389-92, 1992.

W. B. Dollman, V. T. Leblanc, L. Stevens, P. J. O'connor, E. E. Roughead et al., Achieving a sustained reduction in benzodiazepine use through implementation of an area-wide multi-strategic approach, J Clin Pharm Ther, vol.30, issue.5, p.16164487, 2005.

R. I. Ferguson, C. E. Salmond, and J. B. Maling, The Nelson Prescribing Project-a Programmed Intervention in General-Practice, Pharmacoeconomics, vol.7, issue.6, pp.555-61, 1995.

W. W. Shen, C. Chang, W. C. Hsieh, C. J. Yeh, F. Y. Chiu et al., The flunitrazepam abuse prevention program at a general hospital in Taiwan: A descriptive study, Psychiatry Clin Neurosci, vol.56, issue.4, p.12109961, 2002.

E. Clay, B. Falissard, N. Moore, and M. Toumi, Contribution of prolonged-release melatonin and anti-benzodiazepine campaigns to the reduction of benzodiazepine and z-drugs consumption in nine European countries, Eur J Clin Pharmacol, vol.69, issue.4, p.23114457, 2013.

P. S. Wang, R. L. Bohn, R. J. Glynn, H. Mogun, and J. Avorn, Zolpidem use and hip fractures in older people, J Am Geriatr Soc, vol.49, issue.12, pp.1685-90, 2001.

, Interventions to reduce the burden associated with the prescription of sedative-hypnotics, PLOS ONE, vol.15, p.15, 2018.

, BZDs: Benzodiazepines; CG: Control Group; IG: Intervention Group; min: minimum; max: maximum; ns: non-significant

, SHs: Sedative-Hypnotics; *no statistical analysis performed for these data

S. Daan, D. Beersma, and A. A. Borbely, Timing of Human Sleep -Recovery Process Gated by a Circadian Pacemaker, Am J Physiol, vol.246, issue.2, pp.161-78, 1984.

A. A. Borbely, S. Daan, A. Wirz-justice, and T. Deboer, The two-process model of sleep regulation: a reappraisal, J Sleep Res, vol.25, issue.2, pp.131-174, 2016.

J. D. Clayton, C. P. Kyriacou, and S. M. Reppert, Keeping time with the human genome, Nature, vol.409, issue.6822, pp.829-860, 2001.

C. A. Czeisler, J. F. Duffy, T. L. Shanahan, E. N. Brown, J. F. Mitchell et al.,

, Stability, precision, and near-24-hour period of the human circadian pacemaker, Science, vol.284, issue.5423, pp.2177-81, 1999.

S. M. Reppert and D. R. Weaver, Coordination of circadian timing in mammals, Nature, vol.418, issue.6901, pp.935-976, 2002.

S. R. Pandi-perumal, I. Trakht, V. Srinivasan, D. W. Spence, G. Maestroni et al., Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways, Prog Neurobiol, vol.85, issue.3, pp.335-53, 2008.

N. Zisapel, New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation, Br J Pharmacol, vol.175, pp.3190-3199, 2018.

J. M. Monti, The neurotransmitters of sleep and wake, a physiological reviews series

, Sleep Med Rev, vol.17, issue.4, pp.313-318, 2013.

E. F. Pace-schott and J. A. Hobson, The neurobiology of sleep: genetics, cellular physiology and subcortical networks, Nat Rev Neurosci, vol.3, issue.8, pp.591-605, 2002.

C. B. Saper, T. E. Scammell, and J. Lu, Hypothalamic regulation of sleep and circadian rhythms

, Nature, vol.437, issue.7063, pp.1257-63, 2005.

, The AASM Manual for the Scoring of Sleep and Associated Events. Rules, Terminology and Technical Specifications

R. B. Berry and M. H. Wagner, Fundamentals 7: Sleep Architecture Terminology and Normal Patterns, Wagner RBBH, éditeur. Sleep Medicine Pearls, pp.64-72, 2015.

B. Miner and M. H. Kryger, Sleep in the Aging Population, Sleep Med Clin, vol.12, issue.1, pp.31-39, 2017.

M. M. Ohayon, M. A. Carskadon, C. Guilleminault, and M. V. Vitiello, Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: Developing normative sleep values across the human lifespan, Sleep, vol.27, issue.7, pp.1255-73, 2004.

J. Espiritu, Aging-related sleep changes, Clin Geriatr Med, vol.24, issue.1, pp.1-14, 2008.

B. A. Edwards, D. M. O'driscoll, A. A. Jordan, A. S. Trinder, J. Malhotra et al., Aging and Sleep: Physiology and Pathophysiology, Semin Respir Crit Care Med, vol.31, issue.5, pp.618-651, 2010.

, American Psychiatric Association. Troubles de l'alternance veille-sommeil, Mini DSM

, Critères diagnostics Traduction française coordonnée par MA Crocq et JD Guelfi, p.163, 2016.

, American Academy of Sleep Medicine. International Classification of Sleep Disorders

C. H. Bastien, A. Vallieres, and C. M. Morin, Validation of the Insomnia Severity Index as an outcome measure for insomnia research, Sleep Med, vol.2, issue.4, pp.297-307, 2001.

D. J. Buysse, T. H. Monk, S. R. Berman, and D. J. Kupfer, The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research, Psychiatry Res, vol.28, issue.2, pp.193-213, 1989.

S. Schutte-rodin, L. Broch, D. Buysse, C. Dorsey, and M. Sateia,

, Prise en charge du patient adulte se plaignant d'insomnie en médecine générale, HAS

M. Zinkhan, K. Berger, S. Hense, M. Nagel, A. Obst et al., Agreement of different methods for assessing sleep characteristics: a comparison of two actigraphs, wrist and hip placement, and self-report with polysomnography, Sleep Med, vol.15, issue.9, pp.1107-1121, 2014.

D. Riemann, C. Baglioni, C. Bassetti, B. Bjorvatn, D. Groselj et al.,

, European guideline for the diagnosis and treatment of insomnia, J Sleep Res, vol.26, issue.6, pp.675-700, 2017.

D. Leger, C. Guilleminault, J. P. Dreyfus, C. Delahaye, and M. Paillard, Prevalence of insomnia in a survey of 12,778 adults in France, Gourier-Fréry C, Chan-Chee C, Léger D. Insomnie, fatigue et somnolence: prévalence et état de santé associé, vol.9, pp.35-42, 2000.

, Bull Épidémiologique Hebd, pp.502-511, 2012.

F. Beck, J. Richard, and D. Léger, Prévalence et facteurs sociodémographiques associés à

, Enquête Baromètre Santé 2010 de l'INPES, Bull Épidémiologique Hebd, pp.497-501, 2012.

S. Hercberg, Sommeil et nutrition. Résultats de l'enquête INSV / MGEN dans le cadre de NutriNet-Santé. Institut National du Sommeil et de la Vigilance, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02421832

D. Leger, B. Poursain, D. Neubauer, and M. Uchiyama, An international survey of sleeping problems in the general population, Curr Med Res Opin, vol.24, issue.1, pp.307-324, 2008.

C. M. Morin, M. Leblanc, L. Bélanger, H. Ivers, C. Mérette et al., Prevalence of Insomnia and its Treatment in Canada, Can J Psychiatry, vol.56, issue.9, pp.540-548, 2011.

X. Cao, S. Wang, B. Zhong, L. Zhang, G. S. Ungvari et al., The prevalence of insomnia in the general population in China: A meta-analysis, PloS One, vol.12, issue.2, p.170772, 2017.

J. G. Ellis, M. L. Perlis, L. F. Neale, C. A. Espie, and C. H. Bastien, The natural history of insomnia: Focus on prevalence and incidence of acute insomnia, J Psychiatr Res, vol.46, issue.10, pp.1278-85, 2012.

M. Enomoto, T. Tsutsui, S. Higashino, M. Otaga, S. Higuchi et al., Sleep-related

G. Isaia, L. Corsinovi, M. Bo, P. Santos-pereira, G. Michelis et al., Insomnia among hospitalized elderly patients: Prevalence, clinical characteristics and risk factors, Arch Gerontol Geriatr, vol.52, issue.2, pp.133-140, 2011.

A. Ho, B. Raja, R. Waldhorn, V. Baez, and I. Mohammed, New onset of insomnia in hospitalized patients in general medical wards: incidence, causes, and resolution rate, J Community Hosp Intern Med Perspect, vol.7, issue.5, pp.309-322, 2017.

J. Gindin, T. Shochat, A. Chetrit, S. Epstein, B. Israel et al., Insomnia in Long-Term Care Facilities: A Comparison of Seven European Countries and Israel: The Services and Health for Elderly in Long TERm care Study, J Am Geriatr Soc, vol.62, issue.11, pp.2033-2042, 2014.

D. Léger, V. Bayon, M. M. Ohayon, P. Philip, P. Ement et al., Insomnia and accidents: cross-sectional study (EQUINOX) on sleep-related home, work and car accidents in 5293 subjects with insomnia from 10 countries, J Sleep Res, vol.23, issue.2, pp.143-52, 2014.

L. E. Laugsand, L. B. Strand, L. J. Vatten, I. Janszky, and J. H. Bjørngaard, Insomnia symptoms and risk for unintentional fatal injuries--the HUNT Study, Sleep, vol.37, issue.11, pp.1777-86, 2014.

D. C. Jarrin, P. K. Alvaro, M. Bouchard, S. D. Jarrin, C. L. Drake et al., Insomnia and hypertension: A systematic review, Sleep Med Rev, vol.41, pp.3-38, 2018.

C. M. Depner, E. R. Stothard, and K. P. Wright, Metabolic consequences of sleep and circadian disorders, Curr Diab Rep, vol.14, issue.7, pp.507-529, 2014.

Q. He, P. Zhang, G. Li, H. Dai, and J. Shi, The association between insomnia symptoms and risk of cardio-cerebral vascular events: A meta-analysis of prospective cohort studies, Eur J Prev Cardiol, vol.24, issue.10, pp.1071-82, 2017.

F. Sofi, F. Cesari, A. Casini, C. Macchi, R. Abbate et al., Insomnia and risk of cardiovascular disease: a meta-analysis, Eur J Prev Cardiol, vol.21, issue.1, pp.57-64, 2014.

G. C. Kabat, X. Xue, V. Kamensky, O. Zaslavsky, K. L. Stone et al., The association of sleep duration and quality with all-cause and cause-specific mortality in the Women's Health Initiative, Sleep Med, vol.50, pp.48-54, 2018.

L. Li, C. Wu, Y. Gan, X. Qu, and Z. Lu, Insomnia and the risk of depression: a meta-analysis of prospective cohort studies, BMC Psychiatry, vol.16, pp.1-16, 2016.

S. Lautenbacher, B. Kundermann, and J. Krieg, Sleep deprivation and pain perception

, Sleep Med Rev, vol.10, issue.5, pp.357-69, 2006.

C. S. Mccrae, J. M. Dzierzewski, and D. Kay, Treatment of Late-life Insomnia, Sleep Med Clin

J. S. Young, J. A. Bourgeois, D. M. Hilty, and K. A. Hardin, Sleep in Hospitalized Medical Patients, Part 2: Behavioral and Pharmacological Management of Sleep Disturbances, J Hosp Med

J. M. Trauer, M. Y. Qian, J. S. Doyle, S. Rajaratnam, and C. D. Cognitive,

, Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis, Ann Intern Med, vol.163, issue.3, pp.191-204, 2015.

M. Jansson-fröjmark and A. Norell-clarke, The cognitive treatment components and therapies of cognitive behavioral therapy for insomnia: A systematic review, Sleep Med Rev

J. C. Levenson, D. B. Kay, D. Buysse, A. Van-straten, T. Van-der-zweerde et al., The Pathophysiology of Insomnia, Chest, vol.147, issue.4, pp.1179-92, 2015.

, Cognitive and behavioral therapies in the treatment of insomnia: A meta-analysis, Sleep Med Rev, vol.38, pp.3-16, 2018.

J. Q. Wu, E. R. Appleman, R. D. Salazar, and J. C. Ong, Cognitive Behavioral Therapy for

, Insomnia Comorbid With Psychiatric and Medical Conditions: A Meta-analysis, JAMA Intern Med, vol.175, issue.9, pp.1461-72, 2015.

J. M. Geiger-brown, V. E. Rogers, W. Liu, E. M. Ludeman, K. D. Downton et al.,

, Cognitive behavioral therapy in persons with comorbid insomnia: A meta-analysis, Sleep Med Rev, vol.23, pp.54-67, 2015.

S. Beaulieu-bonneau, H. Ivers, B. Guay, and C. M. Morin, Long-Term Maintenance of

, Therapeutic Gains Associated With Cognitive-Behavioral Therapy for Insomnia Delivered Alone or Combined With Zolpidem, Sleep, vol.40, issue.3, pp.1-6, 2017.

C. M. Morin, A. Vallieres, B. Guay, H. Ivers, J. Savard et al., Cognitive Behavioral Therapy, Singly and Combined With Medication, for Persistent Insomnia A Randomized Controlled Trial, Jama-J Am Med Assoc, vol.301, issue.19, pp.2005-2020, 2009.

C. M. Morin, S. Beaulieu-bonneau, H. Ivers, A. Vallières, B. Guay et al., Speed and trajectory of changes of insomnia symptoms during acute treatment with cognitivebehavioral therapy, singly and combined with medication, Sleep Med, vol.15, issue.6, pp.701-708, 2014.

D. Riemann and M. L. Perlis, The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies, Sleep Med Rev, vol.13, issue.3, pp.205-219, 2009.

P. Montgomery, D. Jane, and A. , Cognitive behavioural interventions for sleep problems in adults aged 60+, Cochrane Database Syst Rev, issue.1, pp.1-41, 2003.

N. Lovato, L. Lack, H. Wright, and D. J. Kennaway, Evaluation of a Brief Treatment Program of Cognitive Behavior Therapy for Insomnia in Older Adults, Sleep, vol.37, issue.1, pp.117-143, 2014.

J. G. Ellis, T. Cushing, and A. Germain, Treating Acute Insomnia: A Randomized Controlled Trial of a "Single-Shot" of Cognitive Behavioral Therapy for Insomnia

H. Mohler, J. M. Fritschy, and U. Rudolph, A new benzodiazepine pharmacology, J Pharmacol Exp Ther, vol.300, issue.1, pp.2-8, 2002.

U. Rudolph, F. Crestani, D. Benke, I. Brunig, J. A. Benson et al.,

, Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes, Nature, vol.401, issue.6755, pp.796-800, 1999.

D. J. Sanger, T. B. Huedo-medina, I. Kirsch, J. Middlemass, M. Klonizakis et al., The pharmacology and mechanisms of action of new generation, nonbenzodiazepine hypnotic agents, CNS Drugs, vol.18, pp.43-48, 2004.

, Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration, BMJ, vol.345, pp.1-13, 2012.

A. M. Holbrook, R. Crowther, A. Lotter, C. Cheng, and D. King, Meta-analysis of benzodiazepine use in the treatment of insomnia, CMAJ, vol.162, issue.2, pp.225-258, 2000.

J. Glass, K. L. Lanctot, N. Herrmann, B. A. Sproule, and U. E. Busto, Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits, BMJ, vol.331, issue.7526, p.1169, 2005.

G. Dutau, P. Micheau, A. Didier, F. Rancé, F. Brémont et al.,

H. Antihistaminiques, Rev Fr Allergol Immunol Clin, vol.41, issue.1, pp.74-84, 2001.

J. Montoro, J. Bartra, J. Sastre, I. Davila, M. Ferrer et al., H-1 Antihistamines and Benzodiazepines. Pharmacological Interaction and their Impact on Cerebral Function, J Investig Allergol Clin Immunol, vol.23, pp.17-26, 2013.

J. M. Monti and D. Monti, Histamine H-1 receptor antagonists in the treatment of insomnia -Is there a rational basis for use?, Cns Drugs, vol.13, issue.2, pp.87-96, 2000.

K. Yanai, D. Y. Zhang, M. Tashiro, T. Yoshikawa, F. Naganuma et al., Positron emission tomography evaluation of sedative properties of antihistamines, Expert Opin Drug Saf, vol.10, issue.4, pp.613-635, 2011.

A. D. Krystal, E. Richelson, and T. Roth, Review of the histamine system and the clinical effects of H-1 antagonists: Basis for a new model for understanding the effects of insomnia medications, Sleep Med Rev, vol.17, issue.4, pp.263-72, 2013.

F. Monczor, N. Fernandez, C. P. Fitzsimons, C. Shayo, and C. Davio, Antihistaminergics and inverse agonism: Potential therapeutic applications, Eur J Pharmacol, vol.715, issue.1-3, pp.26-32, 2013.

L. Culpepper and M. A. Wingertzahn, Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient Insomnia: A Systematic Review of Efficacy and Safety, Prim Care Companion CNS Disord, vol.17, issue.6, pp.1-28, 2015.

J. P. Vande-griend and A. Sl, Histamine-1 receptor antagonism for treatment of insomnia, J Am Pharm Assoc, vol.52, issue.6, pp.210-219, 2012.

H. Everitt, D. S. Baldwin, B. Stuart, G. Lipinska, A. Mayers et al.,

, Antidepressants for insomnia in adults, Cochrane Database Syst Rev, vol.5, pp.1-116, 2018.

N. Ivgy-may, T. Roth, F. Ruwe, and J. Walsh, Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a 2-week randomized outpatient trial, Sleep Med

E. Ferracioli-oda, A. Qawasmi, and M. H. Bloch, Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders, Plos One, vol.8, issue.5, p.63773, 2013.

A. Kuriyama, M. Honda, and Y. Hayashino, Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis, Sleep Med, vol.15, issue.4, pp.385-92, 2014.

A. G. Wade, G. Crawford, I. Ford, A. Mcconnachie, T. Nir et al., Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for shortand long-term response, Curr Med Res Opin, vol.27, issue.1, pp.87-98, 2011.

T. Kishi, S. Matsunaga, and N. Iwata, Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials, PLoS ONE, vol.10, issue.8, pp.1-11, 2015.

L. Citrome, Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic -what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?, Int J Clin Pract, vol.68, issue.12, pp.1429-1470, 2014.

A. Kuriyama and H. Tabata, Suvorexant for the treatment of primary insomnia: A systematic review and meta-analysis, 85. International Narcotics Control Board. Psychotropic Substances. Statistics for, vol.35, pp.1-7, 2016.

. Ansm, État des lieux de la consommation des benzodiazépines en France, 2017.

S. M. Bertisch, S. J. Herzig, J. W. Winkelman, and C. Buettner, National Use of Prescription Medications for Insomnia: NHANES 1999-2010, Sleep, vol.37, issue.2, pp.343-352, 2014.

O. Abraham, L. Schleiden, and S. M. Albert, Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep, Int J Clin Pharm, vol.39, issue.4, pp.808-825, 2017.

A. Somers, H. Robays, K. Audenaert, G. Van-maele, M. Bogaert et al., The use of hypnosedative drugs in a university hospital: has anything changed in 10 years?, Eur J Clin Pharmacol, vol.67, issue.7, pp.723-732, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00664100

P. Fagnoni, S. Limat, E. Haffen, T. Henon, M. Jacquet et al., Does hospitalisation affect hypnotic and anxiolytic drug prescribing?, Pharm World Sci
URL : https://hal.archives-ouvertes.fr/hal-00493432

L. Frighetto, C. Marra, S. Bandali, K. Wilbur, T. Naumann et al., An assessment of quality of sleep and the use of drugs with sedating properties in hospitalized adult patients

, Health Qual Life Outcomes, vol.2, p.17, 2004.

J. B. Howes, J. Ryan, G. Fairbrother, K. O'neill, and L. G. Howes, Benzodiazepine prescribing in a Sydney teaching hospital, Med J Aust, vol.165, issue.6, pp.305-313, 1996.

C. M. Gillis, J. O. Poyant, J. R. Degrado, L. Ye, K. E. Anger et al.,

E. A. Pek, A. Remfry, C. Pendrith, C. Fan-lun, R. S. Bhatia et al.,

, Inappropriate Benzodiazepine and Sedative Hypnotic Prescriptions among Hospitalized Older Adults, J Hosp Med, vol.12, issue.5, pp.310-316, 2017.

K. Holloway and L. Van-dijk, Rational use of medicines. The world medicines situation 2011

, Haut Comité de la santé publique. Conférence nationale de santé 1998, rapport du HCSP, contribution du HCSP aux réflexions sur la lutte contre l'iatrogénie, Actual Doss En Santé Publique, issue.25, pp.9-12, 1998.

. Communauté-européenne, Directive 2010/84/UE du Parlement européen et du Conseil du 15 décembre 2010 modifiant, en ce qui concerne la pharmacovigilance, la directive

, International drug monitoring. The role of the hospital. Geneva: World Health Organization, pp.1-24, 1969.

P. Queneau, La iatrogénie médicamenteuse et sa prévention : rapport au Secrétaire d'État à la santé, Bernard Kouchner, pp.1-81, 1998.

E. Schmitt, D. Antier, C. Bernheim, E. Dufay, M. Husson et al., Dictionnaire français de l'erreur médicamenteuse. 1ère édition. Clinique SF de P, éditeur, 2006.

T. Morimoto, T. K. Gandhi, A. C. Seger, T. C. Hsieh, and D. W. Bates, Adverse drug events and medication errors: detection and classification methods. Qual Saf Health Care, vol.13, pp.306-320, 2004.

J. R. Nebeker, P. Barach, and M. H. Samore, Clarifying adverse drug events: A clinician's guide to terminology, documentation, and reporting, Ann Intern Med, vol.140, issue.10, pp.795-801, 2004.

. Drees and . Enquête, Nationale sur les Evènements Indésirables graves associés aux Soins

, Description des résultats 2009. Rapport final, pp.1-212, 2011.

D. S. Budnitz, M. C. Lovegrove, N. Shehab, and C. L. Richards, Emergency Hospitalizations for Adverse Drug Events in Older Americans, N Engl J Med, vol.365, issue.21, pp.2002-2014, 2011.

C. N. Kaufmann, A. P. Spira, G. C. Alexander, L. Rutkow, and R. Mojtabai, Emergency department visits involving benzodiazepines and non-benzodiazepine receptor agonists, Am J Emerg Med. 14 avr, vol.35, issue.10, pp.1414-1423, 2017.

H. Allain, D. Bentue-ferrer, E. Polard, Y. Akwa, and A. Patat, Postural instability and consequent falls and hip fractures associated with use of hypnotics in the elderly -A comparative review, Drugs Aging, vol.22, issue.9, pp.749-65, 2005.

J. C. Woolcott, K. J. Richardson, M. O. Wiens, B. Patel, J. Marin et al., Metaanalysis of the Impact of 9 Medication Classes on Falls in Elderly Persons, Arch Intern Med, vol.169, issue.21, pp.1952-60, 2009.

P. S. Wang, R. L. Bohn, R. J. Glynn, H. Mogun, and J. Avorn, Hazardous benzodiazepine regimens in the elderly: Effects of half-life, dosage, and duration on risk of hip fracture, Am J Psychiatry

F. Landi, G. Onder, M. Cesari, C. Barillaro, A. Russo et al., Psychotropic medications and risk for falls among community-dwelling frail older people: An observational study, J Gerontol Ser -Biol Sci Med Sci, vol.60, issue.5, pp.622-628, 2005.

S. M. Park, J. Ryu, D. R. Lee, D. Shin, J. M. Yun et al., Zolpidem use and risk of fractures: a systematic review and meta-analysis, Osteoporos Int, vol.27, issue.10, pp.2935-2979, 2016.

T. P. Khong, F. De-vries, J. S. Goldenberg, O. H. Klungel, N. J. Robinson et al., the United States, Calcif Tissue Int, vol.91, issue.1, pp.24-31, 2012.

S. Billioti-de-gage, A. Pariente, and B. Begaud, Is there really a link between benzodiazepine use and the risk of dementia?, Expert Opin Drug Saf, vol.14, issue.5, pp.733-780, 2015.

R. Penninkilampi and G. D. Eslick, A Systematic Review and Meta-Analysis of the Risk of

, After Controlling for Protopathic Bias, Dementia Associated with Benzodiazepine Use, pp.1-13, 2018.

M. Takada, M. Fujimoto, and K. Hosomi, Association between Benzodiazepine Use and Dementia: Data Mining of Different Medical Databases, Int J Med Sci, vol.13, issue.11, pp.825-859, 2016.

M. M. Islam, U. Iqbal, B. Walther, S. Atique, N. K. Dubey et al.,

, Benzodiazepine Use and Risk of Dementia in the Elderly Population: A Systematic Review and Meta-Analysis, Neuroepidemiology, vol.47, issue.3-4, pp.181-91, 2016.

J. Brandt and C. Leong, Benzodiazepines and Z-Drugs: An Updated Review of Major Adverse Outcomes Reported on in Epidemiologic Research, Drugs RD, vol.17, issue.4, pp.493-507, 2017.

N. Campbell, M. Boustani, T. Limbil, C. Ott, C. Fox et al., The cognitive impact of anticholinergics: a clinical review, Clin Interv Aging, vol.4, pp.225-258, 2009.

N. L. Campbell, A. J. Perkins, P. Bradt, S. Perk, R. C. Wielage et al., Association of Anticholinergic Burden with Cognitive Impairment and Health Care Utilization Among a Diverse Ambulatory Older Adult Population, Pharmacotherapy, vol.36, issue.11, pp.1123-1154, 2016.

K. Ruxton, R. J. Woodman, and A. A. Mangoni, Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and metaanalysis, Br J Clin Pharmacol, vol.80, issue.2, pp.209-229, 2015.

V. Dauphinot, R. Faure, S. Omrani, S. Goutelle, L. Bourguignon et al., Exposure to anticholinergic and sedative drugs, risk of falls, and mortality: an elderly inpatient, multicenter cohort, J Clin Psychopharmacol, vol.34, issue.5, pp.565-70, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02071559

F. Landi, G. Dell'aquila, A. Collamati, A. M. Martone, G. Zuliani et al.,

, Anticholinergic drug use and negative outcomes among the frail elderly population living in a nursing home, J Am Med Dir Assoc, vol.15, issue.11, pp.825-834, 2014.

X. Cai, N. Campbell, B. Khan, C. Callahan, and M. Boustani, Long-term anticholinergic use and the aging brain, Alzheimers Dement J Alzheimers Assoc, vol.9, issue.4, pp.377-85, 2013.

, Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, American Geriatrics Society. American Geriatrics Society, vol.63, issue.11, pp.2227-2273, 2015.

D. O'mahony, O. 'sullivan, D. Byrne, S. O'connor, M. N. Ryan et al.,

, STOPP/START criteria for potentially inappropriate prescribing in older people: version 2, Age Ageing. mars, vol.44, issue.2, pp.213-221, 2015.

A. Renom-guiteras, G. Meyer, P. A. Thurmann, . The, and . Eu,

S. J. Wilson, D. J. Nutt, C. Alford, S. V. Argyropoulos, D. S. Baldwin et al., British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders, J Psychopharmacol, vol.24, issue.11, pp.1577-601, 2010.

A. Qaseem, D. Kansagara, M. A. Forciea, M. Cooke, and T. D. Denberg, Clinical Guidelines Committee of the American College of Physicians. Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians, Ann Intern Med, vol.165, issue.2, pp.125-158, 2016.

S. Lam and L. O. Macina, Therapy Update for Insomnia in the Elderly, Consult Pharm J Am Soc Consult Pharm, vol.32, issue.10, pp.610-632, 2017.

, Quelle place pour les benzodiazépines dans l'insomnie?, HAS, 2017.

P. S. Wang, R. L. Bohn, R. J. Glynn, H. Mogun, and J. Avorn, Zolpidem use and hip fractures in older people, J Am Geriatr Soc, vol.49, issue.12, pp.1685-90, 2001.

H. Xie, J. Kang, and G. H. Mills, Clinical review: The impact of noise on patients' sleep and the effectiveness of noise reduction strategies in intensive care units, Crit Care, vol.13, issue.2, pp.1-8, 2009.

M. Le-guen, A. Nicolas-robin, C. Lebard, I. Arnulf, and O. Langeron, Earplugs and eye masks vs routine care prevent sleep impairment in post-anaesthesia care unit: a randomized study, Br J Anaesth, vol.112, issue.1, pp.89-95, 2014.

J. L. Martin, S. Jouldjian, M. N. Mitchell, K. R. Josephson, and C. A. Alessi, A longitudinal study of poor sleep after inpatient post-acute rehabilitation: the role of depression and pre-illness sleep quality, Am J Geriatr Psychiatry, vol.20, issue.6, pp.477-84, 2012.

A. J. Smith and S. E. Tett, Improving the use of benzodiazepines--is it possible? A nonsystematic review of interventions tried in the last 20 years, BMC Health Serv Res, vol.10, p.321, 2010.

E. Sabuncu, J. David, C. Bernede-bauduin, S. Pepin, M. Leroy et al., Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002.
URL : https://hal.archives-ouvertes.fr/hal-02864258

, PLoS Med, vol.6, issue.6, p.1000084, 2009.

A. Michel-lepage and B. Ventelou, The true impact of the French pay-for-performance program on physicians' benzodiazepines prescription behavior, Eur J Health Econ, vol.17, issue.6, pp.723-755, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01447867

S. Drees and . France, L'état de santé de la population en France. 2017. invs.santepubliquefrance.fr/publications/etat_sante_2017/ESP2017_Ouvrage_complet_vdef.p df 146. National Institute for health and Care Excellence. Transition between inpatient hospital settings and community or care home settings for adults with social care needs | Guidance and guidelines | NICE, 2015.

A. Winfield and E. Burns, Let's all get home safely: a commentary on NICE and SCIE guidelines (NG27) transition between inpatient hospital settings and community or care home settings, Age Ageing, vol.45, issue.6, pp.757-60, 2016.

A. B. Mekonnen, A. J. Mclachlan, and J. E. Brien, Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: a systematic review and meta-analysis, BMJ Open, vol.6, issue.2, pp.1-14, 2016.

A. B. Mekonnen, A. J. Mclachlan, and J. Brien, Pharmacy-led medication reconciliation programmes at hospital transitions: a systematic review and meta-analysis, J Clin Pharm Ther, vol.41, issue.2, pp.128-172, 2016.