Skip to Main content Skip to Navigation
Theses

Mémoire métabolique et épigénétique des trajectoires pondérales maternelles préconceptionnelles, au cours du développement et à long terme

Abstract : Maternal obesity can predispose to metabolic pathologies in adulthood. Preconceptional weight loss is recommended for obese women, but its effects on the health of the offspring are still poorly understood. The objectives of this thesis were to study the effects of preconceptional maternal weight trajectories on the metabolic phenotype of offspring in adulthood and to address the underlying epigenetic mechanisms at gestation term. The study is based on a mouse model comprising three maternal groups (control, obese and weight loss) and two offspring groups (normal or high-fat diet). Multifactorial analyzes revealed a major effect of sex and post-weaning diet on the phenotype of offspring, as well as a conditioning effect by maternal physiology in males under high-fat diet. A metabolomic analysis of the liver, hypothalamus and olfactory bulb of adult male offspring confirmed the major effect of post-weaning diet on several metabolic pathways, and identified 3 metabolites common to all three tissues. In addition, this study revealed a programming effect by maternal obesity in the liver. At term of gestation, we also started a preliminary study concerning the post-translational modifications of the histones, in particular their acetylation. This work brings novel elements concerning the actors and the mechanisms of the programming and the developmental conditioning of the offspring by the preconceptional maternal weight trajectories.
Complete list of metadatas

Cited literature [520 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02796829
Contributor : Abes Star :  Contact
Submitted on : Friday, June 5, 2020 - 2:06:10 PM
Last modification on : Tuesday, October 20, 2020 - 11:21:10 AM

File

SAFI_STIBLER_Sofiane_2019.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02796829, version 1

Citation

Sofiane Safi-Stibler. Mémoire métabolique et épigénétique des trajectoires pondérales maternelles préconceptionnelles, au cours du développement et à long terme. Biologie du développement. Sorbonne Université, 2019. Français. ⟨NNT : 2019SORUS357⟩. ⟨tel-02796829⟩

Share

Metrics

Record views

57

Files downloads

60