Skip to Main content Skip to Navigation
Theses

Approche multimodale de connectivité fonctionnelle et structurelle pour l’analyse du déclin cognitif au cours du vieillissement : étude au sein de la cohorte des 3Cités

Abstract : Aging is associated with changes in the brain, the heterogeneity of which partly explains the inter-individual variability of cognitive decline. These changes concern both the structural and functional aspects. Multimodal brain imaging has provided some insights into the structure-function relationship, but this has been little studied in the context of aging. In this work, functional rest (CF) and structural (CS) connectivity from native space were explored in 120 elderly subjects (cohort 3C) to study their relationship to cognitive trajectories modeled on the 12 years of follow-up. In our sample, elevated interhemispheric CF levels are associated with global changes in cerebral parenchyma (gray matter atrophy and white matter injury burden) and episodic memory decline. The diffusion parameters corrected for free-water, extracted from the cingulum tract are associated with the decline in verbal fluency. On the other hand, high CF and low CS between posterior ventral cingulate cortex (vPCC) and precuneus A7m are associated with episodic memory decline, regardless of hippocampal volume. Finally, the elderly subjects present a deficit of short-term reorganization of the rest-functional architecture after a learning task. Thus, cerebral aging is associated with different patterns of CF changes (increase, decrease, short-term reorganization deficit) thus providing to the brain a more complex response repertoire than CS.
Complete list of metadatas

Cited literature [893 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-02648821
Contributor : Abes Star :  Contact
Submitted on : Friday, May 29, 2020 - 10:30:15 AM
Last modification on : Friday, October 23, 2020 - 4:56:12 PM

File

2019PSLEP011_archivage.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-02648821, version 1

Collections

Citation

Manon Edde. Approche multimodale de connectivité fonctionnelle et structurelle pour l’analyse du déclin cognitif au cours du vieillissement : étude au sein de la cohorte des 3Cités. Sciences cognitives. Université Paris sciences et lettres, 2019. Français. ⟨NNT : 2019PSLEP011⟩. ⟨tel-02648821⟩

Share

Metrics

Record views

100

Files downloads

34