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Hallucinations auditives et schizophrénie : vers un modèle de dysfonctionnement du cortex auditif

Abstract : Auditory hallucinations (HAs) are a common and disabling symptom of schizophrenia. The pathophysiology is complex and partially explained. In clinical terms the HAs correspond to real auditory perception in the absence of an auditive stimulus. In a neuropsychological perspective, they are related to a lack of cognitive control over the hearing function. This lack of control leads to perception of a self generated events. In the context of this work, we focused our interest on the temporal lobes, supporting hearing and speech perception. We studied this area as a crossroads of the hallucinatory symptoms. According to this hypothesis, we present here several research to better specify the involvement of temporal regions In the first paper, we show, using a systematic review of the literature, the involvement of the temporal lobe and its pathological interactions with other brain networks. In the second and third papers, we show how non invasive brain stimulation of the temporal lobe and components of fronto temporal network can induce a clinical reduction of HAs. Finally, in a fourth paper, we begin the development of an electrophysiological marker of left temporal dysfunction offering opportunities in studying the effects of neurostimulation in the field of HAs
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Frédéric Haesebaert. Hallucinations auditives et schizophrénie : vers un modèle de dysfonctionnement du cortex auditif. Sciences cognitives. Université Claude Bernard - Lyon I, 2013. Français. ⟨NNT : 2013LYO10310⟩. ⟨tel-02638216⟩

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