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Etude de l'implication de CRMP4, un partenaire de MAP6, dans la voie de signalisation sémaphorine 3E

Abstract : Study of the involvement of the MAP6 partners, CRMP4, in the semaphorin 3E signaling pathway.During embryonic development, neurons establish billion of connections between them. Those connections are not random. On the contrary, they are precisely targeted thanks to the driving by cellular environment guidance cues. A wrong branching of those neurons can lead to dramatic impairment of sensory, motor and cognitive function of the central nervous system resulting in neurologic or psychiatric disorders such as Schizophrenia. Thus, mutation of proteins implicated on neurons guidance like MAP6 or CRMP4 can lead to susceptibility for those kind of pathology occurrence. In fact, MAP6 deletion ( MAP6 KO mice) leads to diverse neuronal connectivity alterations associated to schizophrenia-like behavior disorders. Among axonal tracts affected we notice the absence of the fornix known for its implication on Schizophrenia. In MAP6 KO mice, this fornix disruption is partly due to the loss of semaphorin 3E (Sema3E) dependant signaling pathway. This project shows the involvement of CRMP4, a partner of MAP6, in the Sema3E signaling pathway. Furthermore, it characterized the impact of the CRMP4 deletion (CRMP4 KO) on fornix formation. Finally, neuroanatomical studies allowed us to identify unknown alteration of MAP6 KO mice connectivity alteration.
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Submitted on : Tuesday, May 26, 2020 - 11:14:12 PM
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  • HAL Id : tel-02628498, version 1

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Benoit Boulan. Etude de l'implication de CRMP4, un partenaire de MAP6, dans la voie de signalisation sémaphorine 3E. Biologie animale. Université Grenoble Alpes, 2018. Français. ⟨NNT : 2018GREAV001⟩. ⟨tel-02628498⟩

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