Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms, J Autoimmun, vol.52, pp.90-100, 2014. ,
The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes, Autoimmun Rev, vol.12, pp.875-84, 2013. ,
The chemokine CXCL13 is a key molecule in autoimmune Myasthenia Gravis, Blood, vol.108, pp.432-472, 2006. ,
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia, Ann Neurol, vol.66, pp.521-552, 2009. ,
Central role of interferon-beta in thymic events leading to myasthenia gravis, J Autoimmun, vol.52, pp.44-52, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01514459
Etiology of myasthenia gravis: innate immunity signature in pathological thymus, Autoimmun Rev, vol.12, pp.863-74, 2013. ,
The role of microRNAs in the pathogenesis of autoimmune diseases, Autoimmun Rev, vol.15, pp.1171-80, 2016. ,
Many roads to maturity: microRNA biogenesis pathways and their regulation, Nat Cell Biol, vol.11, pp.228-262, 2009. ,
Roles for microRNAs in conferring robustness to biological processes, Cell, vol.149, pp.515-539, 2012. ,
Regulatory mechanisms of microRNA expression, J Transl Med, vol.14, p.143, 2016. ,
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-alpha receptor, Nat Immunol, vol.13, pp.181-188, 2012. ,
Canonical microRNAs in thymic epithelial cells promote central tolerance, Eur J Immunol, vol.44, pp.1313-1322, 2014. ,
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection, J Immunol, vol.189, pp.3894-904, 2012. ,
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression, Eur J Immunol, vol.43, pp.1769-78, 2013. ,
Dynamic modulation of thymic microRNAs in response to stress, PLoS One, vol.6, p.27580, 2011. ,
Differential expression of microRNAs in thymic epithelial cells from Trypanosoma cruzi acutely infected mice: putative role in thymic atrophy, Front Immunol, vol.6, p.428, 2015. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01881328
MAGIA(2): from miRNA and genes expression data integrative analysis to microRNA-transcription factor mixed regulatory circuits (2012 update), Nucleic Acids Res, vol.40, pp.13-21, 2012. ,
Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia, J Immunol, vol.177, pp.7868-79, 2006. ,
Predicting effective microRNA target sites in mammalian mRNAs, Elife, vol.4, 2015. ,
DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows, Nucleic Acids Res, vol.41, pp.169-73, 2013. ,
Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis, Ann Neurol, vol.73, pp.281-93, 2013. ,
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta, J Exp Med, vol.212, pp.927-965, 2015. ,
Associated features in females with an FMR1 premutation, J Neurodev Disord, vol.6, p.30, 2014. ,
Disease-specific signature of serum miR-20b and its targets IL-8 and IL-25, in myasthenia gravis patients, Eur Cytokine Netw, vol.26, pp.61-67, 2015. ,
miR-20b inhibits T cell proliferation and activation via NFAT signaling pathway in thymoma-associated myasthenia gravis, Biomed Res Int, p.9595718, 2016. ,
miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3, J Immunol, vol.192, pp.5599-609, 2014. ,
MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3, Exp Cell Res, vol.358, pp.120-128, 2017. ,
Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b, Ann Clin Transl Neurol, vol.2, pp.43-55, 2015. ,
Altered expression of miR-125a-5p in thymoma-associated myasthenia gravis and its down-regulation of foxp3 expression in Jurkat cells, Immunol Lett, vol.172, pp.47-55, 2016. ,
Thymoma in patient with myasthenia gravis has significantly fewer Forkhead box P3 positive lymphocytes than that without one, Kurume Med J, vol.61, pp.65-71, 2015. ,
Berrih-Aknin S. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis, Blood, vol.105, pp.735-776, 2005. ,
Increased serum levels of the interferon-gamma-inducing cytokine interleukin-18 in myasthenia gravis, Neurology, vol.59, pp.287-296, 2002. ,
Suppression of myasthenia gravis by antigen-specific mucosal tolerance and modulation of cytokines and costimulatory factors, Ann N Y Acad Sci, vol.998, pp.533-539, 2003. ,
Roles of A20 in autoimmune diseases, Immunol Res, vol.64, pp.337-381, 2016. ,
MicroRNAs miR-125a and miR-125b constitutively activate the NF-kappaB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20), Proc Natl Acad Sci U S A, vol.109, pp.7865-70, 2012. ,
Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases, Immunol Rev, vol.269, pp.212-239, 2016. ,
VAV1 and BAFF, via NFkappaB pathway, are genetic risk factors for myasthenia gravis, Ann Clin Transl Neurol, vol.1, pp.329-368, 2014. ,
Decreased miR-7 expression in the skin and sera of patients with dermatomyositis, Acta Derm Venereol, vol.93, pp.273-279, 2013. ,
Circulating microRNAs as biomarkers for rituximab therapy, in neuromyelitis optica (NMO), J Neuroinflammation, vol.13, p.179, 2016. ,
MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation, J Biol Chem, vol.285, pp.1479-89, 2010. ,
CCR7-dependent cortexto-medulla migration of positively selected thymocytes is essential for establishing central tolerance, Immunity, vol.24, pp.165-77, 2006. ,
Autoimmune stigmata in Turner syndrome: when lacks an X chromosome, J Autoimmun, vol.33, pp.25-30, 2009. ,
Immune-mediated disorders among women carriers of fragile X premutation alleles, Am J Med Genet A, vol.158, pp.2473-81, 2012. ,
Differential increases of specific FMR1 mRNA isoforms in premutation carriers, J Med Genet, vol.52, pp.42-52, 2015. ,
A distinct DNAmethylation boundary in the 5?-upstream sequence of the FMR1 promoter binds nuclear proteins and is lost in fragile X syndrome, Am J Hum Genet, vol.85, pp.606-622, 2009. ,
Role of CTCF protein in regulating FMR1 locus transcription, PLoS Genet, vol.9, p.1003601, 2013. ,
Demethylation of miR-10b plays a suppressive role in ccRCC cells, Int J Clin Exp Pathol, vol.8, pp.10595-604, 2015. ,
acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by, HuR. Sci Signal, vol.6, p.63, 2013. ,
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia, Ann Neurol, vol.66, pp.521-531, 2009. ,
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses, Nat Immunol, vol.5, pp.1052-1060, 2004. ,
Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis, Neurology, vol.74, pp.1118-1126, 2010. ,
Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus, Ann Neurol, vol.67, pp.726-738, 2010. ,
Analysis of microRNA expression in the thymus of Myasthenia Gravis patients opens new research avenues, Autoimmun Rev, vol.17, pp.588-600, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01844365
Central role of interferon-beta in thymic events leading to myasthenia gravis, J Autoimmun, vol.52, pp.44-52, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01514459
Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis, Ann Neurol, vol.73, pp.281-293, 2013. ,
Myasthenia Gravis, N Engl J Med, vol.375, pp.2570-2581, 2016. ,
Myasthenia gravisautoantibody characteristics and their implications for therapy, Nat Rev Neurol, vol.12, pp.259-268, 2016. ,
Defects of immunoregulatory mechanisms in myasthenia gravis: role of IL-17, Ann N Y Acad Sci, vol.1274, pp.40-47, 2012. ,
Risk for myasthenia gravis maps to a (151) Pro-->Ala change in TNIP1 and to human leukocyte antigen-B*08, Ann Neurol, vol.72, pp.927-935, 2012. ,
, N Engl J Med, vol.375, issue.26, pp.2570-81, 2016.
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia, Ann Neurol, vol.66, issue.4, pp.521-552, 2009. ,
SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients, Immunobiology, vol.218, issue.3, pp.373-81, 2013. ,
Thymus involvement in early-onset myasthenia gravis ,
URL : https://hal.archives-ouvertes.fr/hal-01789833
, Ann N Y Acad Sci, vol.1412, issue.1, pp.137-182, 2018.
Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays, J Neurol Neurosurg Psychiatry, vol.48, issue.12, pp.1246-52, 1985. ,
Thymic Germinal Centers and Corticosteroids in Myasthenia Gravis: an Immunopathological Study in 1035 Cases and a Critical Review, Clin Rev Allergy Immunol, vol.52, issue.1, pp.108-132, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01338400
The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis, Blood, vol.108, issue.2, pp.432-472, 2006. ,
Randomized Trial of Thymectomy in Myasthenia Gravis, N Engl J Med, vol.375, issue.6, pp.511-533, 2016. ,
Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker, Ann Clin Transl Neurol, vol.1, issue.1, pp.49-58, 2014. ,
Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis, J Neuroimmunol, 2018. ,
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely, Proc Natl Acad Sci, vol.104, issue.17, pp.7080-7085, 2007. ,
MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb, Cell, vol.131, issue.1, pp.146-59, 2007. ,
miR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cells, Sci Rep, vol.5, p.16399, 2015. ,
miR-150 regulates the development of NK and iNKT cells, J Exp Med, vol.208, issue.13, pp.2717-2748, 2011. ,
Immuno-miRs: Critical regulators of Tcell development, function and ageing, Immunology, 2014. ,
Intracellular Modulation, Extracellular Disposal and Serum Increase of MiR-150 Mark Lymphocyte Activation, PLoS ONE, vol.8, issue.9, p.75348, 2013. ,
Dynamic Modulation of Thymic MicroRNAs in Response to Stress, PLoS ONE, vol.6, issue.11, p.27580, 2011. ,
Ectopic MicroRNA-150-5p Transcription Sensitizes Glucocorticoid Therapy Response in MM1S Multiple Myeloma Cells but Fails to Overcome Hormone Therapy Resistance in MM1R Cells, PLoS ONE, vol.9, issue.12, p.113842, 2014. ,
Circulating MicroRNAs as biomarkers for disease staging in multiple sclerosis, Ann Neurol, vol.73, issue.6, pp.729-769, 2013. ,
MicroRNA-150 Is a Potential Biomarker of HIV/AIDS Disease Progression and Therapy, PLoS ONE, vol.9, issue.5, p.95920, 2014. ,
Upregulated circulating miR-150 is associated with the risk of intrahepatic cholangiocarcinoma, Oncol Rep, vol.33, issue.2, pp.819-844, 2015. ,
miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in colorectal cancer, Gut, vol.61, issue.10, pp.1447-53, 2012. ,
MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjogren's syndrome, Arthritis Rheum, vol.63, issue.2, pp.535-579, 2011. ,
miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1, J Am Soc Nephrol, vol.24, issue.7, pp.1073-87, 2013. ,
Serum microRNAs as biomarkers of human lymphocyte activation in health and disease, Front Immunol, vol.5, 2014. ,
Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases, J Clin Invest, vol.126, issue.4, pp.1525-1562, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01310502
A novel semi-automated in situ hybridisation protocol for microRNA detection in paraffin embedded tissue sections, J Clin Pathol, vol.68, issue.8, pp.661-665, 2015. ,
Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque, J Immunol Methods, vol.5, issue.3, pp.249-52, 1974. ,
SIDT2 mediates gymnosis, the uptake of naked singlestranded oligonucleotides into living cells, RNA Biol, vol.14, issue.11, pp.1534-1577, 2017. ,
miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb, Cell Rep, vol.20, issue.11, pp.2584-97, 2017. ,
miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes, Lab Invest, vol.89, issue.6, pp.708-724, 2009. ,
MYB -A regulatory factor in hematopoiesis, Gene, vol.665, pp.6-17, 2018. ,
A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases, Sci Transl Med, vol.7, issue.313, pp.313-178, 2015. ,
Altered intrathymic T-cell repertoire in human myasthenia gravis, Ann Neurol, vol.41, issue.6, pp.731-772, 1997. ,
Critical functions for c-Myb at three checkpoints during thymocyte development, Nat Immunol, vol.5, issue.7, pp.721-730, 2004. ,
Thymectomy lowers the myasthenia gravis biomarker miR-150-5p, Neurol Neuroimmunol Neuroinflamm, vol.5, issue.3, 2018. ,
Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjogren's syndrome, PLoS ONE, vol.13, issue.2, p.193157, 2018. ,
Elevated Serum Inflammatory Cytokines in Lupus Nephritis Patients, in Association with Promoted hsa-miR-125a, Clin Lab, vol.62, issue.4, pp.631-639, 2016. ,
Opposite prognostic significance of cellular and serum circulating microRNA-150 in Chronic Lymphocytic Leukemia patients, Mol Med, 2015. ,
MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjogren's syndrome, PLoS ONE, vol.12, issue.3, p.174585, 2017. ,
Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis, Arthritis Res Ther, vol.12, issue.3, p.81, 2010. ,
Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis, Clin Exp Immunol, vol.171, issue.1, pp.91-100, 2013. ,
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes, Nat Med, vol.13, issue.10, pp.1241-1248, 2007. ,
CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells, J Immunol, 2016. ,
Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types, Proc Natl Acad Sci U S A, vol.108, issue.12, p.357, 2011. ,
Functional delivery of viral miRNAs via exosomes, Proc Natl Acad Sci U S A, vol.107, issue.14, pp.6328-6361, 2010. ,
Effe to Regulato T Cell Diffe e tiatio a d I u e Homeostasis Depend on the Transcription Factor Myb, Immunity, vol.46, issue.1, pp.78-91, 2017. ,
Critical roles for c-Myb in hematopoietic progenitor cells, Semin Immunol, vol.20, issue.4, pp.247-56, 2008. ,
Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis, Cell, vol.36, pp.1007-1022, 1984. ,
An anti-sense chalcone synthase gene in transgenic plants inhibits flower pigmentation, Nature, vol.333, p.866, 1988. ,
Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans, Plant Cell, vol.2, pp.279-89, 1990. ,
Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle, Development, vol.113, pp.503-517, 1991. ,
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans, Cell, vol.75, pp.855-62, 1993. ,
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, vol.75, pp.843-54, 1993. ,
URL : https://hal.archives-ouvertes.fr/in2p3-00597159
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature, vol.391, pp.806-817, 1998. ,
Functional siRNAs and miRNAs Exhibit Strand Bias, Cell, vol.115, pp.209-225, 2003. ,
Roles for microRNAs in conferring robustness to biological processes, Cell, vol.149, pp.515-539, 2012. ,
Biogenesis and Function of Ago-Associated RNAs, Trends Genet, vol.33, pp.208-227, 2017. ,
The functions of microRNAs and long non-coding RNAs in embryonic and induced pluripotent stem cells, Genomics Proteomics Bioinformatics, vol.11, pp.275-83, 2013. ,
Identification of novel genes coding for small expressed RNAs, Science, vol.294, pp.853-861, 2001. ,
A uniform system for microRNA annotation, RNA, vol.9, pp.277-286, 2003. ,
The let-7 family of microRNAs, Trends Cell Biol, vol.18, pp.505-521, 2008. ,
Regulation of microRNA biogenesis, Nat Rev Mol Cell Biol, vol.15, pp.509-533, 2014. ,
Functional Anatomy of the Human Microprocessor, Cell, vol.161, pp.1374-87, 2015. ,
Nuclear export of microRNA precursors, Science, vol.303, pp.95-103, 2004. ,
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs, Genes Dev, vol.17, pp.3011-3017, 2003. ,
Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis, Mol Cell, vol.57, pp.397-407, 2015. ,
Argonaute proteins: functional insights and emerging roles, Nat Rev Genet, vol.14, pp.447-59, 2013. ,
Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes, Mol Cell, vol.39, pp.292-301, 2010. ,
Asymmetry in the assembly of the RNAi enzyme complex, Cell, vol.115, pp.199-208, 2003. ,
Biogenesis, turnover, and mode of action of plant microRNAs, Plant Cell, vol.25, pp.2383-99, 2013. ,
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight, Nat Rev Genet, vol.9, pp.102-116, 2008. ,
Diversifying microRNA sequence and function, Nat Rev Mol Cell Biol, vol.14, pp.475-88, 2013. ,
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila, Cell, vol.130, pp.89-100, 2007. ,
Intronic microRNA precursors that bypass Drosha processing, Nature, vol.448, pp.83-89, 2007. ,
Pre-mRNA splicing: awash in a sea of proteins, Mol Cell, vol.12, pp.5-14, 2003. ,
Mirtrons: microRNA biogenesis via splicing, Biochimie, vol.93, pp.1897-904, 2011. ,
Many roads to maturity: microRNA biogenesis pathways and their regulation, Nat Cell Biol, vol.11, pp.228-262, 2009. ,
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis, Proc Natl Acad Sci U S A, vol.107, pp.15163-15171, 2010. ,
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis, Nature, vol.465, pp.584-593, 2010. ,
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity, Science, vol.328, pp.1694-1702, 2010. ,
Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAs, Cell Rep, vol.5, pp.715-741, 2013. ,
Therapeutic targeting of microRNAs: current status and future challenges, Nat Rev Drug Discov, vol.13, pp.622-660, 2014. ,
Argonauteassociated short introns are a novel class of gene regulators, Nat Commun, vol.7, p.11538, 2016. ,
Chromatin structure analyses identify miRNA promoters, Genes Dev, vol.22, pp.3172-83, 2008. ,
Genome-wide epigenetic regulation of miRNAs in cancer, Cancer Res, vol.73, pp.473-480, 2013. ,
Structure and activity of putative intronic miRNA promoters, RNA, vol.16, pp.495-505, 2010. ,
Mechanisms of control of microRNA biogenesis, J Biochem, vol.148, pp.381-92, 2010. ,
Rapid alteration of microRNA levels by histone deacetylase inhibition, Cancer Res, vol.66, pp.1277-81, 2006. ,
Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization, Nucleic Acids Res, vol.38, pp.6610-6619, 2010. ,
Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile, Cell Rep, vol.5, pp.1070-81, 2013. ,
Glycogen synthase kinase 3 beta (GSK3beta) phosphorylates the RNAase III enzyme Drosha at S300 and S302, PLoS ONE, vol.6, p.20391, 2011. ,
Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling, Cell, vol.139, pp.112-134, 2009. ,
Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8, EMBO Rep, vol.13, pp.142-151, 2012. ,
The Microprocessor complex mediates the genesis of microRNAs, Nature, vol.432, pp.235-275, 2004. ,
Dicer is regulated by cellular stresses and interferons, Mol Immunol, vol.46, pp.1222-1230, 2009. ,
ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing, Cell, vol.153, pp.575-89, 2013. ,
The role of RNA editing by ADARs in RNAi, Mol Cell, vol.10, pp.809-826, 2002. ,
Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets, Mol Cell, vol.50, pp.356-67, 2013. ,
Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies, Biochem J, vol.413, pp.429-465, 2008. ,
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2, Nature, vol.497, pp.383-390, 2013. ,
ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm, Mol Cell, vol.42, pp.489-99, 2011. ,
Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells, Cell Host Microbe, vol.14, pp.435-480, 2013. ,
MicroRNAs: target recognition and regulatory functions, Cell, vol.136, pp.215-248, 2009. ,
Principles of MicroRNA-Target Recognition, PLoS Biol, vol.3, p.85, 2005. ,
Target mRNAs are repressed as efficiently by microRNAbinding sites in the 5' UTR as in the 3' UTR, Proc Natl Acad Sci, vol.104, pp.9667-72, 2007. ,
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs, Nature, vol.433, pp.769-73, 2005. ,
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing, Mol Cell, vol.27, pp.91-105, 2007. ,
Prediction of mammalian microRNA targets, Cell, vol.115, pp.787-98, 2003. ,
Most mammalian mRNAs are conserved targets of microRNAs, Genome Res, vol.19, pp.92-105, 2009. ,
Widespread changes in protein synthesis induced by microRNAs, Nature, vol.455, pp.58-63, 2008. ,
Tools for Sequence-Based miRNA Target Prediction: What to Choose?, Int J Mol Sci, vol.17, 1987. ,
MicroRNA targets in Drosophila, Genome Biol, vol.5, p.1, 2003. ,
Human MicroRNA targets, PLoS Biol, vol.2, p.363, 2004. ,
A combined computational-experimental approach predicts human microRNA targets, Genes Dev, vol.18, pp.1165-78, 2004. ,
Gene silencing by microRNAs: contributions of translational repression and mRNA decay, Nat Rev Genet, vol.12, pp.99-110, 2011. ,
Towards a molecular understanding of microRNA-mediated gene silencing, Nat Rev Genet, vol.16, pp.421-454, 2015. ,
A role for the P-body component GW182 in microRNA function, Nat Cell Biol, vol.7, pp.1261-1267, 2005. ,
RNA decay machines: deadenylation by the Ccr4-not and Pan2-Pan3 complexes, Biochim Biophys Acta, vol.1829, pp.561-70, 2013. ,
Uridylation by TUT4 and TUT7 marks mRNA for degradation, Cell, vol.159, pp.1365-76, 2014. ,
Structural and functional insights into eukaryotic mRNA decapping, Wiley Interdiscip Rev RNA, vol.2, pp.193-208, 2011. ,
The Functions of MicroRNAs: mRNA Decay and Translational Repression, Trends Cell Biol, vol.25, pp.651-65, 2015. ,
GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation, EMBO J, vol.32, pp.1052-65, 2013. ,
Translational repression by deadenylases, J Biol Chem, vol.285, pp.28506-28519, 2010. ,
CCR4 and CAF1 deadenylases have an intrinsic activity to remove the post-poly(A) sequence, RNA, vol.22, pp.1550-1559, 2016. ,
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function, Proc Natl Acad Sci U S A, vol.102, pp.16961-16967, 2005. ,
Short RNAs repress translation after initiation in mammalian cells, Mol Cell, vol.21, pp.533-575, 2006. ,
Human let-7a miRNA blocks protein production on actively translating polyribosomes, Nat Struct Mol Biol, vol.13, pp.1108-1122, 2006. ,
Evidence that microRNAs are associated with translating messenger RNAs in human cells, Nat Struct Mol Biol, vol.13, pp.1102-1109, 2006. ,
Molecular insights into microRNA-mediated translational repression in plants, Mol Cell, vol.52, pp.591-601, 2013. ,
MicroRNAs block assembly of eIF4F translation initiation complex in Drosophila, Mol Cell, vol.56, pp.67-78, 2014. ,
MicroRNAs mediate gene silencing via multiple different pathways in drosophila, Mol Cell, vol.48, pp.825-861, 2012. ,
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution, Cell, vol.123, pp.1133-1179, 2005. ,
The biological functions of miRNAs: lessons from in vivo studies, Trends Cell Biol, vol.25, pp.137-184, 2015. ,
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability, PLoS Genet, vol.3, p.215, 2007. ,
MicroRNA control of protein expression noise, Science, vol.348, pp.128-160, 2015. ,
Stochastic gene expression in a single cell, Science, vol.297, pp.1183-1189, 2002. ,
Regulation of noise in the expression of a single gene, Nat Genet, vol.31, pp.69-73, 2002. ,
Mammalian microRNAs predominantly act to decrease target mRNA levels, Nature, vol.466, pp.835-875, 2010. ,
Network motifs: theory and experimental approaches, Nat Rev Genet, vol.8, pp.450-61, 2007. ,
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation, Nucleic Acids Res, vol.39, pp.5692-703, 2011. ,
A hexanucleotide element directs microRNA nuclear import, Science, vol.315, pp.97-100, 2007. ,
Characterizing lightregulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs, Cell, vol.141, pp.618-649, 2010. ,
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB, Neuron, vol.63, pp.803-820, 2009. ,
MicroRNA assassins: factors that regulate the disappearance of miRNAs, Nat Struct Mol Biol, vol.17, pp.5-10, 2010. ,
Degradation of microRNAs by a family of exoribonucleases in Arabidopsis, Science, vol.321, pp.1490-1492, 2008. ,
Active turnover modulates mature microRNA activity in Caenorhabditis elegans, Nature, vol.461, pp.546-555, 2009. ,
, International Programme on Chemical Safety Biomarkers in Risk Assessment: Validity and Validation, 2001.
The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes, PLoS ONE, vol.7, p.30679, 2012. ,
Extracellular vesicles: exosomes, microvesicles, and friends, J Cell Biol, vol.200, pp.373-83, 2013. ,
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases, Cell Res, vol.18, pp.997-1006, 2008. ,
Membrane vesicles as conveyors of immune responses, Nat Rev Immunol, vol.9, pp.581-93, 2009. ,
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis, Cancer Sci, vol.101, pp.2087-92, 2010. ,
Epigenetic control of autoimmune diseases: from bench to bedside, Clin Immunol, vol.157, pp.1-15, 2015. ,
MicroRNA-150 Is a Potential Biomarker of HIV/AIDS Disease Progression and Therapy, PLoS ONE, vol.9, p.95920, 2014. ,
Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker, Ann Clin Transl Neurol, vol.1, pp.49-58, 2014. ,
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells, Nat Methods, vol.4, pp.721-727, 2007. ,
Emerging roles for natural microRNA sponges, Curr Biol, vol.20, pp.858-61, 2010. ,
Natural RNA circles function as efficient microRNA sponges, Nature, vol.495, pp.384-392, 2013. ,
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs, Cell, vol.147, pp.344-57, 2011. ,
A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA, Cell, vol.147, pp.358-69, 2011. ,
Sequence-specific inhibition of small RNA function, PLoS Biol, vol.2, p.98, 2004. ,
Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing, RNA, vol.10, pp.544-50, 2004. ,
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases, Nat Rev Drug Discov, vol.16, pp.203-225, 2017. ,
A direct comparison of anti-microRNA oligonucleotide potency, Pharm Res, vol.27, pp.1788-99, 2010. ,
Design of antisense oligonucleotides stabilized by locked nucleic acids, Nucleic Acids Res, vol.30, pp.1911-1919, 2002. ,
Treatment of HCV infection by targeting microRNA, N Engl J Med, vol.368, pp.1685-94, 2013. ,
Small-molecule inhibitors of microrna miR-21 function, Angew Chem Int Ed Engl, vol.47, pp.7482-7486, 2008. ,
Sequence-based design of bioactive small molecules that target precursor microRNAs, Nat Chem Biol, vol.10, pp.291-298, 2014. ,
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing, Proc Natl Acad Sci U S A, vol.108, pp.4394-4403, 2011. ,
Transfection of microRNA Mimics Should Be Used with Caution, Front Genet, vol.6, p.340, 2015. ,
miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents, Future Med Chem, vol.6, pp.1967-84, 2014. ,
Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages, Mol Ther, vol.19, pp.395-404, 2011. ,
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat Biotechnol, vol.29, pp.341-346, 2011. ,
Prolonged gene expression in muscle is achieved without active immune tolerance using microrRNA 142.3p-regulated rAAV gene transfer, Hum Gene Ther, vol.24, pp.393-405, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-02338036
Eaton myasthenic syndrome -diagnosis, pathogenesis and therapy, Clin Neurophysiol, vol.125, pp.2328-2364, 2014. ,
The first american case of myasthenia gravis, Arch Neurol, vol.45, pp.185-192, 1988. ,
De anima brutorum quae hominis vitalis ac sentitiva est : exercitationes duae. Londini : Prostant apud Gulielm. Wells, & Rob. Scot, p.1672 ,
Unravelling the pathogenesis of myasthenia gravis, Nat Rev Immunol, vol.2, p.797, 2002. ,
Ueber einen scheinbar heilbaren bulbärparalytischen Symptomencomplex mit Betheiligung der Extremitäten, Deutsche Zeitschrift fuer Nervenheilkunde, vol.4, pp.312-52, 1893. ,
Zur kasuistik der bulbären lähmungen, Arch Psychiatr Nervenkr, vol.9, pp.336-50, 1879. ,
On cerebritis, hysteria, and bulbar paralysis, as illustrative of arrest function of the cerebrospinal centers. Guy's Hosp Rep, vol.1877, pp.7-55 ,
Ueber myasthenia gravis pseudoparalytica, Berl Klin Wschr, vol.32, pp.1-7, 1895. ,
Treatment of myasthenia gravis with physostigmine, The Lancet, vol.223, pp.1200-1201, 1934. ,
Isolation of neurotoxins from the venom of Bungarus multicinctus and their modes of neuromuscular blocking action, Arch Int Pharmacodyn Ther, vol.144, pp.241-57, 1963. ,
Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors, Science, vol.182, p.293, 1973. ,
Autoimmune response to acetylcholine receptor, Science, vol.180, pp.871-873, 1973. ,
Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis, Lancet, vol.2, pp.340-342, 1975. ,
Myasthenia gravis: passive transfer from man to mouse, Science, vol.190, pp.397-406, 1975. ,
Remission of myasthenia gravis following plasma-exchange, Lancet, vol.2, pp.1373-1379, 1976. ,
Ultrastructural localization of the terminal and lytic ninth complement component (C9) at the motor end-plate in myasthenia gravis, J Neuropathol Exp Neurol, vol.39, pp.160-72, 1980. ,
Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies, Nat Med, vol.7, pp.365-373, 2001. ,
Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis, Ann Neurol, vol.69, pp.418-440, 2011. ,
Titin antibodies in myasthenia gravis, Neurology, vol.43, p.1581, 1993. ,
Antiryanodine receptor antibodies and FK506 in myasthenia gravis, Neurology, vol.62, pp.1894-1900, 2004. ,
Autoantibodies to Agrin in Myasthenia Gravis Patients, PLoS ONE, vol.9, p.91816, 2014. ,
Anti-agrin autoantibodies in myasthenia gravis, Neurology, vol.82, pp.1976-83, 2014. ,
Cortactin autoantibodies in myasthenia gravis, Autoimmun Rev, vol.13, pp.1003-1010, 2014. ,
A systematic review of population based epidemiological studies in Myasthenia Gravis, BMC Neurol, vol.10, p.46, 2010. ,
A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis, J Autoimmun, vol.52, pp.139-184, 2014. ,
The epidemiology of myasthenia gravis, Ann N Y Acad Sci, vol.998, pp.407-419, 2003. ,
Diagnostic and clinical classification of autoimmune myasthenia gravis, J Autoimmun, pp.143-151, 2014. ,
Myasthenia gravis: subgroup classification and therapeutic strategies, Lancet Neurol, vol.14, pp.1023-1059, 2015. ,
IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis, Brain, vol.131, pp.1940-52, 2008. ,
Repeated acetylcholine receptor antibody-concentrations and association to clinical myasthenia gravis development, PLoS ONE, vol.9, p.114060, 2014. ,
Juvenile myasthenia gravis, Muscle Nerve, vol.39, pp.423-454, 2009. ,
Myasthenia gravis -autoantibody characteristics and their implications for therapy, Nat Rev Neurol, vol.12, pp.259-68, 2016. ,
Autoimmune myasthenia gravis: autoantibody mechanisms and new developments on immune regulation, Curr Opin Neurol, vol.26, pp.569-76, 2013. ,
Anti-MuSK antibody myasthenia gravis: clinical findings and response to treatment in two large cohorts, Muscle Nerve, vol.44, pp.36-40, 2011. ,
MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4, Proc Natl Acad Sci U S A, vol.110, pp.20783-20791, 2013. ,
Three types of striational antibodies in myasthenia gravis, Autoimmune Dis, p.740583, 2011. ,
Thymoma-associated myasthenia gravis: On the search for a pathogen signature, J Autoimmun, vol.52, pp.29-35, 2014. ,
Myasthenia gravis: A comprehensive review of immune dysregulation and etiological mechanisms, J Autoimmun, vol.52, pp.90-100, 2014. ,
Treatment of autoimmune myasthenia gravis, Neurology, vol.61, pp.1652-61, 2003. ,
Efficacy and safety of rituximab for myasthenia gravis: a systematic review and meta-analysis, J Neurol, vol.262, pp.1115-1124, 2015. ,
Long-lasting treatment effect of rituximab in MuSK myasthenia, Neurology, vol.78, pp.189-93, 2012. ,
Efficacy of Rituximab in Refractory Generalized anti-AChR Myasthenia Gravis, J Neuromuscul Dis, vol.5, pp.241-250, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02377514
Randomized Trial of Thymectomy in Myasthenia Gravis, N Engl J Med, vol.375, pp.511-533, 2016. ,
Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor, Science, vol.291, pp.484-490, 2001. ,
Neuromuscular Junction Formation, Aging, and Disorders, Annu Rev Physiol, vol.80, pp.159-88, 2018. ,
Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting, Physiol Rev, vol.95, pp.809-52, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01837619
Myasthenia gravis: the role of complement at the neuromuscular junction, Ann N Y Acad Sci, 2017. ,
Safety factor at the neuromuscular junction, Prog Neurobiol, vol.64, pp.393-429, 2001. ,
Anatomy of the antigenic structure of a large membrane autoantigen, the muscle-type nicotinic acetylcholine receptor, Immunol Rev, vol.163, pp.89-120, 1998. ,
Acetylcholine receptor: an allosteric protein, Science, vol.225, pp.1335-1380, 1984. ,
Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia, Neuropsychopharmacology, vol.37, pp.16-42, 2012. ,
Myasthenia gravis: past, present, and future, J Clin Invest, vol.116, pp.2843-54, 2006. ,
Complement regulators and inhibitory proteins, Nat Rev Immunol, vol.9, pp.729-769, 2009. ,
Antigenic structure of the human muscle nicotinic acetylcholine receptor main immunogenic region, J Mol Neurosci, vol.40, pp.217-237, 2010. ,
Myology: basic and clinical. McGraw-Hill Companies, 1994. ,
Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses, Nature, vol.489, pp.438-480, 2012. ,
Regulation of acetylcholine receptor gene expression in human myasthenia gravis muscles. Evidences for a compensatory mechanism triggered by receptor loss, J Clin Invest, vol.102, pp.249-63, 1998. ,
Regulation of acetylcholine receptor alpha subunit variants in human myasthenia gravis. Quantification of steady-state levels of messenger RNA in muscle biopsy using the polymerase chain reaction, J Clin Invest, vol.94, pp.16-24, 1994. ,
IL-6 and Akt are involved in muscular pathogenesis in myasthenia gravis, Acta Neuropathol Commun, vol.3, p.1, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01116534
Muscle satellite cells are functionally impaired in myasthenia gravis: consequences on muscle regeneration, Acta Neuropathol, vol.2017, pp.1-20 ,
URL : https://hal.archives-ouvertes.fr/hal-02376547
The weight of the human thymus gland at necropsy, J Anat, vol.131, pp.483-97, 1980. ,
Mechanisms of thymus organogenesis and morphogenesis, Development, vol.138, pp.3865-78, 2011. ,
Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium, Nature, vol.441, pp.988-91, 2006. ,
Thymus medulla consisting of epithelial islets each derived from a single progenitor, Nature, vol.414, pp.763-771, 2001. ,
Formation of a functional thymus initiated by a postnatal epithelial progenitor cell, Nature, vol.441, pp.992-998, 2006. ,
Thymus involvement in early-onset myasthenia gravis, Ann N Y Acad Sci, vol.1412, pp.137-182, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01789833
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus, Nature, vol.436, pp.1181-1186, 2005. ,
Thymic myoid cells express high levels of muscle genes, J Neuroimmunol, vol.148, pp.97-105, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-02522239
Thymic myoid cells protect thymocytes from apoptosis and modulate their differentiation: implication of the ERK and Akt signaling pathways, Cell Death Differ, vol.12, pp.463-72, 2005. ,
The multifaceted biology of plasmacytoid dendritic cells, Nat Rev Immunol, vol.15, pp.471-85, 2015. ,
Heterogeneity of thymic dendritic cells, Semin Immunol, vol.17, pp.304-316, 2005. ,
Cutting Edge: A possible role for CD4+ thymic macrophages as professional scavengers of apoptotic thymocytes, J Immunol, vol.171, pp.2773-2780, 2003. ,
Thymic Epithelial Cells, Annu Rev Immunol, vol.35, pp.85-118, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-01399345
Journey through the thymus: stromal guides for T-cell development and selection, Nat Rev Immunol, vol.6, pp.127-162, 2006. ,
Thymic epithelial cells: working class heroes for T cell development and repertoire selection, Trends Immunol, vol.33, pp.256-63, 2012. ,
Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development, J Exp Med, vol.194, pp.127-161, 2001. ,
The Mechanisms of T Cell Selection in the Thymus, Trends Immunol, vol.38, pp.805-821, 2017. ,
Cellular and molecular immunology, 2012. ,
CCR7 signals are essential for cortex-medulla migration of developing thymocytes, J Exp Med, vol.200, pp.493-505, 2004. ,
Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity, J Immunol, vol.199, pp.1250-60, 2017. ,
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see), Nat Rev Immunol, vol.14, pp.377-91, 2014. ,
Developing a new paradigm for thymus organogenesis, Nat Rev Immunol, vol.4, pp.278-89, 2004. ,
The features of myasthenia gravis with autoantibodies to MuSK, J Neurol Neurosurg Psychiatry, vol.76, pp.1099-102, 2005. ,
Thymoma: state of the art, J Clin Oncol, vol.17, pp.2280-2289, 1999. ,
Association of HLA-A in autoimmune myasthenia gravis with thymoma, J Neuroimmunol, vol.210, pp.120-123, 2009. ,
Thymoma related myasthenia gravis in humans and potential animal models, Exp Neurol, vol.270, pp.55-65, 2015. ,
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia, Ann Neurol, vol.66, pp.521-552, 2009. ,
SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients, Immunobiology, vol.218, pp.373-81, 2013. ,
The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis, Blood, vol.108, pp.432-472, 2006. ,
Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis, Oncotarget, vol.7, pp.7550-62, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01293674
Properties of human thymic B cells, Immunology, vol.75, pp.596-600, 1992. ,
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction, Immunity, vol.42, pp.1048-61, 2015. ,
Dynamics of B cells in germinal centres, Nat Rev Immunol, vol.15, pp.137-185, 2015. ,
Ectopic lymphoid-like structures in infection, cancer and autoimmunity, Nat Rev Immunol, vol.14, pp.447-62, 2014. ,
Thymic Germinal Centers and Corticosteroids in Myasthenia Gravis: an Immunopathological Study in 1035 Cases and a Critical Review, Clin Rev Allergy Immunol, vol.52, pp.108-132, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01338400
Acetylcholine receptor antibody-producing cells in thymus and lymph nodes in myasthenia gravis, Clin Immunol Immunopathol, vol.34, pp.141-147, 1985. ,
Lymphoid organ development: from ontogeny to neogenesis, Nat Immunol, vol.7, pp.344-53, 2006. ,
Berrih-Aknin S. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis, Blood, vol.105, pp.735-776, 2005. ,
Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low/-) T cells in patients with myasthenia gravis, Clin Immunol, vol.145, pp.209-232, 2012. ,
Increased serum interleukin-17 levels in patients with myasthenia gravis, Muscle Nerve, vol.44, pp.278-80, 2011. ,
Both Treg cells and Tconv cells are defective in the Myasthenia gravis thymus: Roles of IL-17 and TNF-?, J Autoimmun, 2014. ,
Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions, Autoimmun Rev, vol.1, pp.29-35, 2002. ,
Genetic basis of myasthenia gravis -A comprehensive review, J Autoimmun, 2014. ,
Tumour necrosis factor-alpha polymorphism and secretion in myasthenia gravis, J Neuroimmunol, vol.94, pp.165-71, 1999. ,
Risk for myasthenia gravis maps to a (151) Pro-->Ala change in TNIP1 and to human leukocyte antigen-B*08, Ann Neurol, vol.72, pp.927-962, 2012. ,
A genome-wide association study of myasthenia gravis, JAMA Neurol, vol.72, pp.396-404, 2015. ,
TNFAIP3 gene rs7749323 polymorphism is associated with late onset myasthenia gravis, Medicine, vol.96, p.6798, 2017. ,
VAV1 and BAFF, via NFkappaB pathway, are genetic risk factors for myasthenia gravis, Ann Clin Transl Neurol, vol.1, pp.329-368, 2014. ,
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus, Nature, vol.448, pp.934-941, 2007. ,
Methylome and transcriptome profiling in Myasthenia Gravis monozygotic twins, J Autoimmun, vol.82, pp.62-73, 2017. ,
Basic concepts of epigenetics: impact of environmental signals on gene expression, Epigenetics, vol.7, pp.119-149, 2012. ,
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis, Int J Mol Sci, p.17, 2016. ,
Sex differences in autoimmune disease, Nat Immunol, vol.2, pp.777-80, 2001. ,
Aire regulates negative selection of organ-specific T cells, Nat Immunol, vol.4, pp.350-354, 2003. ,
Estrogenmediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases, J Clin Invest, vol.126, pp.1525-1562, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01310502
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator, Nat Commun, vol.7, p.11350, 2016. ,
Genetic and hormonal factors in female-biased autoimmunity, Autoimmun Rev, vol.9, pp.494-502, 2010. ,
Infections and autoimmunity--friends or foes?, Trends Immunol, vol.30, pp.409-423, 2009. ,
Transient myasthenia gravis during HIV infection, Muscle Nerve, vol.18, pp.914-920, 1995. ,
West nile virus infection and myasthenia gravis, Muscle Nerve, vol.49, pp.26-35, 2014. ,
Human foamy virus infection in myasthenia gravis, Lancet, vol.343, p.666, 1994. ,
Myasthenia gravis and hepatitis C virus infection, J Viral Hepat, vol.3, pp.329-361, 1996. ,
Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis, Neurology, vol.74, pp.1118-1144, 2010. ,
Myasthenia gravis associated with HTLV-I infection and atypical brain lesions, Muscle Nerve, vol.35, pp.525-533, 2007. ,
Concomitant chronic inflammatory demyelinating polyneuropathy and myasthenia gravis following cytomegalovirus infection, J Neurol Sci, vol.240, pp.103-109, 2006. ,
Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus, Ann Neurol, vol.67, pp.726-764, 2010. ,
Intrathymic Epstein-Barr virus infection is not a prominent feature of myasthenia gravis, Ann Neurol, vol.70, pp.508-522, 2011. ,
Lack of evidence for Epstein-Barr virus infection in myasthenia gravis thymus, Ann Neurol, vol.70, pp.515-523, 2011. ,
Epstein-Barr virus in myasthenia gravis thymus: a matter of debate, Ann Neurol, vol.70, p.519, 2011. ,
High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis, Eur J Neurol, vol.19, pp.842-848, 2012. ,
The Long and Complicated Relationship between Epstein-Barr Virus and Epithelial Cells, J Virol, p.91, 2017. ,
Microarrays Reveal Distinct Gene Signatures in the Thymus of Seropositive and Seronegative Myasthenia Gravis Patients and the Role of CC Chemokine Ligand 21 in Thymic Hyperplasia, J Immunol, vol.177, pp.7868-79, 2006. ,
Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis, Ann Neurol, vol.73, pp.281-93, 2013. ,
Central role of interferon-beta in thymic events leading to myasthenia gravis, J Autoimmun, vol.52, pp.44-52, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01514459
Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models, Frontiers in Immunology, vol.8, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01585119
Anti-MuSK-and anti-AChRpositive myasthenia gravis induced by d-penicillamine, J Neuroimmunol, vol.250, pp.94-102, 2012. ,
Anti-acetylcholine receptor antibodies in Dpenicillamine-associated myasthenia gravis, Lancet, vol.1, p.1254, 1978. ,
Myasthenia gravis during interferon alfa therapy, Neurology, vol.45, pp.382-385, 1995. ,
Exacerbation of myasthenia gravis during interferonalpha treatment, J Neurol Sci, vol.144, pp.221-223, 1996. ,
Exacerbation of myasthenia gravis in a patient after interferon-beta treatment for chronic active hepatitis C, J Neurol Sci, vol.165, pp.182-185, 1999. ,
Development of myasthenia gravis in two patients with multiple sclerosis following interferon beta treatment, J Neurol Neurosurg Psychiatry, vol.75, p.1079, 2004. ,
IFN-alpha treatment suppresses the development of experimental autoimmune myasthenia gravis, J Immunol, vol.154, pp.6203-6211, 1995. ,
Vitamin D deficiency in patients with myasthenia gravis and improvement of fatigue after supplementation of vitamin D3: a pilot study, Eur J Neurol, vol.19, pp.1554-60, 2012. ,
Remission of Severe Myasthenia Gravis After Massive-Dose Vitamin D Treatment, Am J Case Rep, vol.17, pp.51-55, 2016. ,
Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis, J Immunol, vol.174, pp.5324-5355, 2005. ,
Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors -Recommendations for methods and experimental designs, Exp Neurol, vol.270, pp.18-28, 2015. ,
Induction of myasthenia by immunization against muscle-specific kinase, J Clin Invest, vol.116, pp.1016-1040, 2006. ,
Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat musclespecific kinase (MuSK), J Neuroimmunol, vol.175, pp.107-124, 2006. ,
Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis, J Clin Invest, vol.123, pp.5190-202, 2013. ,
Immunization of mice with LRP4 induces myasthenia similar to MuSK-associated myasthenia gravis, Exp Neurol, vol.297, pp.158-67, 2017. ,
Preconditioned mesenchymal stem cells treat myasthenia gravis in a humanized preclinical model, JCI Insight, vol.2, p.89665, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01510169
MicroRNAs as regulatory elements in immune system logic, Nat Rev Immunol, vol.16, pp.279-94, 2016. ,
Physiological and pathological roles for microRNAs in the immune system, Nat Rev Immunol, vol.10, pp.111-133, 2010. ,
MicroRNA regulation of lymphocyte tolerance and autoimmunity, J Clin Invest, vol.125, pp.2242-2251, 2015. ,
The role of microRNAs in the pathogenesis of autoimmune diseases, Autoimmun Rev, vol.15, pp.1171-80, 2016. ,
Contribution of MicroRNAs to autoimmune diseases, Cell Mol Life Sci, vol.73, pp.2041-51, 2016. ,
MicroRNA in immunity and autoimmunity, J Mol Med, 2013. ,
Analysis of Serum miRNA Profiles of Myasthenia Gravis Patients, PLoS ONE, vol.9, p.91927, 2014. ,
Assessing sample and miRNA profile quality in serum and plasma or other biofluids, Methods, vol.59, pp.1-6, 2013. ,
Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients, J Neurol Sci, 2015. ,
Thymectomy lowers the myasthenia gravis biomarker miR-150-5p, Neurol Neuroimmunol Neuroinflamm, vol.5, 2018. ,
Disease-specific signature of serum miR-20b and its targets IL-8 and IL-25, in myasthenia gravis patients, Eur Cytokine Netw, vol.26, pp.61-67, 2015. ,
miR-20b Inhibits T Cell Proliferation and Activation via NFAT Signaling Pathway in Thymoma-Associated Myasthenia Gravis, Biomed Res Int, 2016. ,
miR-15b is Downregulated in Myasthenia Gravis Patients and Directly Regulates the Expression of Interleukin-15 (IL-15) in Experimental Myasthenia Gravis Mice, Med Sci Monit, vol.21, pp.1774-80, 2015. ,
Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis, J Neuroimmunol, vol.292, pp.21-27, 2016. ,
Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells, Int Immunopharmacol, vol.14, pp.217-240, 2012. ,
MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1, J Clin Immunol, vol.33, pp.567-76, 2013. ,
Altered expression of miR-146a in myasthenia gravis, Neurosci Lett, vol.555, pp.85-90, 2013. ,
Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis, Immunology, vol.144, pp.56-67, 2015. ,
Delivery of an miR155 inhibitor by anti-CD20 single-chain antibody into B cells reduces the acetylcholine receptorspecific autoantibodies and ameliorates experimental autoimmune myasthenia gravis, Clin Exp Immunol, vol.176, pp.207-228, 2014. ,
A novel infection-and inflammation-associated molecular signature in peripheral blood of myasthenia gravis patients, Immunobiol, vol.221, pp.1227-1263, 2016. ,
MiR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10, Clin Immunol, vol.164, pp.106-119, 2016. ,
Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response, J Neuroimmune Pharmacol, vol.8, pp.1287-302, 2013. ,
Decreased microRNA miR-181c expression in peripheral blood mononuclear cells correlates with elevated serum levels of IL-7 and IL-17 in patients with myasthenia gravis, Clin Exp Med, vol.16, pp.413-434, 2016. ,
T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer, J Exp Med, vol.201, pp.1367-73, 2005. ,
Aberrant T cell differentiation in the absence of Dicer, J Exp Med, vol.202, pp.261-270, 2005. ,
Dicerdependent microRNA pathway controls invariant NKT cell development, J Immunol, vol.183, pp.2506-2518, 2009. ,
Loss of microRNAs in thymus perturbs invariant NKT cell development and function, Cell Mol Immunol, vol.7, pp.447-53, 2010. ,
Dicer-dependent microRNA pathway safeguards regulatory T cell function, J Exp Med, vol.205, pp.1993-2004, 2008. ,
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity, J Exp Med, vol.205, pp.1983-91, 2008. ,
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-[alpha] receptor, Nat Immunol, vol.13, pp.181-188, 2012. ,
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection, J Immunol, vol.189, pp.3894-904, 2012. ,
Canonical microRNAs in thymic epithelial cells promote central tolerance, Eur J Immunol, vol.44, pp.1313-1322, 2014. ,
Aberrant decrease of microRNA19b regulates TSLP expression and contributes to Th17 cells development in myasthenia gravis related thymomas, J Neuroimmunol, vol.288, pp.34-43, 2015. ,
Altered expression of miR-125a-5p in thymomaassociated myasthenia gravis and its down-regulation of foxp3 expression in Jurkat cells, Immunol Lett, vol.172, pp.47-55, 2016. ,
MicroRNA expression profiling of thymic epithelial tumors, Lung Cancer, vol.85, pp.197-204, 2014. ,
miR-548k regulates CXCL13 expression in myasthenia gravis patients with thymic hyperplasia and in Jurkat cells, J Neuroimmunol, 2018. ,
MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus, Arthritis Rheum, vol.62, pp.3425-3460, 2010. ,
Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn's disease, World J Gastroenterol, vol.23, pp.7888-98, 2017. ,
MicroRNAs miR-125a and miR-125b constitutively activate the NF-?B path a ta geti g the tu o necrosis factor alpha-induced protein 3 (TNFAIP3, A20), Proc Natl Acad Sci U S A, vol.109, pp.7865-70, 2012. ,
MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD, JCI Insight, vol.2, p.90443, 2017. ,
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1beta, J Exp Med, vol.212, pp.927-965, 2015. ,
Mutations affecting the actin regulator WD repeat-containing protein 1 lead to aberrant lymphoid immunity, J Allergy Clin Immunol, 2018. ,
Increased serum levels of the interferon-gamma-inducing cytokine interleukin-18 in myasthenia gravis, Neurology, vol.59, pp.287-296, 2002. ,
Suppression of myasthenia gravis by antigen-specific mucosal tolerance and modulation of cytokines and costimulatory factors, Ann N Y Acad Sci, vol.998, pp.533-539, 2003. ,
miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3, J Immunol, vol.192, pp.5599-609, 2014. ,
Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b, Ann Clin Transl Neurol, vol.2, pp.43-55, 2015. ,
FMR1 Genotype with Autoimmunity-Associated Polycystic Ovary-Like Phenotype and Decreased Pregnancy Chance, PLoS ONE, vol.5, p.15303, 2010. ,
Role of CTCF protein in regulating FMR1 locus transcription, PLoS Genet, vol.9, p.1003601, 2013. ,
Bioinformatics analysis of the factors controlling type I IFN gene expression in autoimmune disease and virus-induced immunity, Front Immunol, vol.4, p.291, 2013. ,
Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity, Elife, vol.5, 2016. ,
CTLA-4 methylation regulates the pathogenesis of myasthenia gravis and the expression of related cytokines, Medicine (Baltimore), vol.97, p.620, 2018. ,
Gravis: paradox versus paradigm in autoimmunity, J Autoimmun, vol.52, pp.1-28, 2014. ,
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release, Immunity, vol.39, pp.521-557, 2013. ,
An imbalance between regulatory T cells and T helper 17 cells in acetylcholine receptor-positive myasthenia gravis patients, Ann N Y Acad Sci, vol.1413, pp.154-62, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02357792
miR-29ab1 Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis, J Immunol, vol.189, pp.1567-76, 2012. ,
The Thymus in Myasthenia Gravis : Changes Typical for the Human Disease Are Absent in Experimental Autoimmune Myasthenia Gravis of the Lewis Rat, Am J Pathol, p.139, 1991. ,
Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice, Cell Mol Life Sci, vol.74, pp.2095-106, 2017. ,
Type I interferons in infectious disease, Nat Rev Immunol, vol.15, pp.87-103, 2015. ,
Host immune system gene targeting by a viral miRNA, Science, vol.317, pp.376-81, 2007. ,
Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed, PLoS Pathog, vol.2, p.23, 2006. ,
EBV MicroRNA BART16 Suppresses Type I IFN Signaling, J Immunol, 2017. ,
Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases, Trends Immunol, vol.24, pp.584-592, 2003. ,
Reshaping the mosaic of autoimmunity, Semin Arthritis Rheum, vol.35, pp.341-344, 2006. ,
Germinal centers, Annu Rev Immunol, vol.30, pp.429-57, 2012. ,
In vivo imaging of germinal centres reveals a dynamic open structure, Nature, vol.446, pp.83-90, 2007. ,
Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells, Blood, vol.77, pp.149-58, 1991. ,
Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens, Immunol Cell Biol, vol.93, pp.727-761, 2015. ,
Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor, J Immunol, vol.180, pp.8146-52, 2008. ,
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex, J Immunol, vol.168, pp.3235-3276, 2002. ,
The regulation of exosome secretion: a novel function of the p53 protein, Cancer Res, vol.66, pp.4795-801, 2006. ,
Exosomes: an emerging factor in stress-induced immunomodulation, Semin Immunol, vol.26, pp.394-401, 2014. ,
Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis, Neurol Neuroimmunol Neuroinflamm, vol.3, p.219, 2016. ,
Elevated circulating miR-150 and miR-342-3p in patients with irritable bowel syndrome, Exp Mol Pathol, vol.96, pp.422-427, 2014. ,
MYB -A regulatory factor in hematopoiesis, Gene, vol.665, pp.6-17, 2018. ,
A validated gene regulatory network and GWAS identifies early regulators of T cellassociated diseases, Sci Transl Med, vol.7, pp.313-178, 2015. ,
Critical functions for c-Myb at three checkpoints during thymocyte development, Nat Immunol, vol.5, pp.721-730, 2004. ,
Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity, References 1. Truffault, vol.136, pp.108-124, 2015. ,
A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis, J. Autoimmun, vol.52, pp.139-145, 2013. ,
Antigen processing and presentation in the thymus: implications for T cell repertoire selection, Curr. Opin. Immunol, vol.46, pp.53-57, 2017. ,
Thymic myoid cells protect thymocytes from apoptosis and modulate their differentiation: implication of the ERK and Akt signaling pathways, Cell Death Differ, vol.12, pp.463-472, 2005. ,
Projection of an immunological self shadow within the thymus by the aire protein, Science, vol.298, pp.1395-1401, 2002. ,
Fezf2 orchestrates a thymic program of self-antigen expression for immune tolerance, Cell, vol.163, pp.975-987, 2015. ,
, Ann. N.Y. Acad. Sci, vol.00, pp.1-9, 2017.
Thymic myoid cells express high levels of muscle genes, J. Neuroimmunol, vol.148, pp.97-105, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-02522239
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus, Nature, vol.448, pp.934-937, 2007. ,
Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases, J. Clin. Invest, vol.126, pp.1525-1537, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01310502
Establishment of a human thymic myoid cell line. Phenotypic and functional characteristics, Am.J.Pathol, vol.155, pp.1229-1240, 1999. ,
The thymic medulla is required for Foxp3 + regulatory but not conventional CD4 + thymocyte development, J. Exp. Med, vol.210, pp.675-681, 2013. ,
Human thymus medullary epithelial cells promote regulatory Tcell generation by stimulating interleukin-2 production via ICOS ligand, Cell Death Dis, vol.5, p.1420, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01311608
Hassall's corpuscles instruct dendritic cells to induce CD4 + CD25 + regulatory T cells in human thymus, Nature, vol.436, pp.1181-1185, 2005. ,
The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases, Ann. N.Y. Acad. Sci, vol.505, pp.50-70, 1987. ,
Functional defect of regulatory CD4(+)CD25 + Tc e l l si nt h et h y m u s of patients with autoimmune myasthenia gravis, Blood, vol.105, pp.735-741, 2005. ,
Impaired regulatory function in circulating CD4(+) CD25(high)CD127(low/?) T cells in patients with myasthenia gravis, Clin. Immunol, vol.145, pp.209-223, 2012. ,
Both Treg cells and Tconv cells are defective in the myasthenia gravis thymus: roles of IL-17 and TNF-?, J. Autoimmun, vol.52, pp.53-63, 2014. ,
The human thymus contains a novel population of B lymphocytes, Lancet, vol.2, pp.1488-1491, 1987. ,
Thymic B cells are licensed to present self antigens for central T cell tolerance induction, Immunity, vol.42, pp.1048-1061, 2015. ,
The human thymus perivascular space is a functional niche for viral-specific plasma cells, Sci. Immunol, vol.1, 2016. ,
, Clin. Exp. Immunol, vol.13, pp.243-252, 1973.
B cells in epithelial and perivascular compartments of human adult thymus, Hum. Pathol, vol.32, pp.926-934, 2001. ,
The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis, Blood, vol.108, pp.432-440, 2006. ,
Intrathymic Tfh/B cells interaction leads to ectopic GCs formation and anti-AChR antibody production: central role in triggering MG occurrence, Mol. Neurobiol, vol.53, pp.120-131, 2016. ,
In vitro antiacetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes: correlations with thymic histology and thymic epithelial-cell interactions, J. Clin. Immunol, vol.7, pp.225-234, 1987. ,
,
, Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis, J. Immunol, vol.145, pp.2115-2122
Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients, J. Clin. Invest, vol.81, pp.902-908, 1988. ,
Acetylcholine receptor antibody synthesis in lymphocyte cultures, J. Clin. Lab. Immunol, vol.5, pp.137-142, 1981. ,
Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor, J. Autoimmun, vol.52, pp.101-112, 2014. ,
Individual germinal centres of myasthenia gravis human thymuses contain polyclonal activated B cells that express all the Vh and Vk families, Clin. Exp. Immunol, vol.83, pp.262-266, 1991. ,
Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia, J. Immunol, vol.177, pp.7868-7879, 2006. ,
Preconditioned mesenchymal stem cells treat myasthenia gravis in a humanized preclinical model, JCI Insight, vol.2, p.89665, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01510169
Randomized trial of thymectomy in myasthenia gravis, N. Engl. J. Med, vol.375, pp.511-522, 2016. ,
Homing and cellular traffic in lymph nodes, Nat. Rev. Immunol, vol.3, pp.867-878, 2003. ,
SDF-1/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients, Immunobiology, vol.218, pp.373-381, 2013. ,
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia, Ann. Neurol, vol.66, pp.521-531, 2009. ,
B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization, Immunity, vol.24, pp.203-215, 2006. ,
Lymphocyte trafficking across high endothelial venules: dogmas and enigmas, Nat. Rev. Immunol, vol.4, pp.360-370, 2004. ,
Chemokines and cell migration in secondary lymphoid organs, Science, vol.286, pp.2098-2102, 1999. ,
Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis, J. Immunol, vol.174, pp.5324-5331, 2005. ,
New York Academy of Sciences. cells of myasthenic thymus leads to IL-6 and RANTES overexpression: effects on survival and migration of peripheral TandBcells, Ann. N.Y. Acad. Sci, vol.00, pp.7021-7028, 2005. ,
Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity, J. Autoimmun, vol.52, pp.74-89, 2014. ,
Chemokines and lymphopoiesis in human thymus, Trends Immunol, vol.22, pp.277-281, 2001. ,
Dendritic cellsinhyperplasticthymusesfrompatientswithmyasthenia gravis, Muscle Nerve, vol.27, pp.582-589, 2003. ,
B cellattracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5, J. Exp. Med, vol.187, pp.655-660, 1998. ,
Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis, Oncotarget, vol.7, pp.7550-7562, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01293674
The thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat, Am. J. Pathol, vol.139, pp.995-1008, 1991. ,
Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site, J. Clin. Invest, vol.118, pp.801-811, 2008. ,
MCP-1/CCR2 interactions direct migration, Eur. J. Immunol, vol.42, pp.2644-2654, 2012. ,
IFN-alpha subtypes differentially affect human T cell motility, J. Immunol, vol.173, pp.1663-1670, 2004. ,
Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis, Neurology, vol.74, pp.1118-1126, 2010. ,
Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus, Ann. Neurol, vol.67, pp.726-738, 2010. ,
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors, Nat. Immunol, vol.11, pp.373-384, 2010. ,
Review on Toll-like receptor activation in myasthenia gravis: application to the development of new experimental models, Clin. Rev. Allergy Immunol, vol.52, pp.133-147, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01321397
Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis, Ann. Neurol, vol.73, pp.281-293, 2013. ,
Epstein-Barr virus (EBV)-encoded small RNA is released from EBVinfected cells and activates signaling from Toll-like receptor, 2009. ,
, J. Exp. Med, vol.206, pp.2091-2099
Immunomodulatory activity of interferon-beta, Ann. Clin. Transl. Neurol, vol.1, pp.622-631, 2014. ,
Interferon and granulopoiesis signatures in systemic lupus erythematosus blood, J. Exp. Med, vol.197, pp.711-723, 2003. ,
The regulation of inflammation by interferons and their STATs, JAKSTAT, vol.2, p.23820, 2013. ,
Interferon alpha and neuromuscular disorders, J. Neuroimmunol, vol.207, pp.3-17, 2009. ,
Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferonomega and interleukin-12 in patients with thymoma and/or myasthenia gravis, Clin. Exp. Immunol, vol.132, pp.128-136, 2003. ,
Effects of cytokines on acetylcholine receptor expression: implications for myasthenia gravis, J. Immunol, vol.174, pp.5941-5949, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-02522187
Regulatory and pathogenic mechanisms in human autoimmune myasthenia gravis, Ann. N.Y. Acad. Sci, vol.1132, pp.135-142, 2008. ,
Central role of interferon-beta in thymic events leading to myasthenia gravis, J. Autoimmun, vol.52, pp.44-52, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01514459
Thymomaassociated myasthenia gravis: on the search for a pathogen signature, J. Autoimmun, vol.52, pp.29-35, 2014. ,
Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker, Ann. Clin. Transl. Neurol, vol.1, pp.49-58, 2014. ,
Analysis of serum miRNA profiles of myasthenia gravis patients, PLoS One, vol.9, p.91927, 2014. ,
Disease-specific signature of serum miR-20b and its targets IL-8 and IL-25, in myasthenia gravis patients, Eur. Cytokine Netw, vol.26, pp.61-66, 2015. ,
MiR-320a is downregulated in patients with myasthenia gravis and modulates inflammatory cytokines production by targeting mitogenactivated protein kinase 1, J. Clin. Immunol, vol.33, pp.567-576, 2013. ,
A novel infection-and inflammation-associated molecular signature in peripheral blood of myasthenia gravis patients, Immunobiology, vol.221, pp.1227-1236, 2016. ,
Characterization of human thymic exosomes, PLoS One, vol.8, p.67554, 2013. ,
Differential expression of microRNAs in thymic epithelial cells from trypanosoma cruzi acutely infected mice: putative role in thymic atrophy, Front. Immunol, vol.6, p.428, 2015. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01881328
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-[alpha] receptor, Nat. Immunol, vol.13, pp.181-187, 2012. ,
MicroRNA-205 maintains T cell development following stress by regulating Forkhead box N1 and selected chemokines, J. Biol. Chem, vol.291, pp.23237-23247, 2016. ,
, Frontiers in Immunology | www.frontiersin.org, vol.00, p.1029, 2017.
Ectopic lymphoid structures: powerhouse of autoimmunity, Front Immunol, vol.7, p.430, 2016. ,
SDF-1/ CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients, Immunobiology, vol.218, issue.3, pp.373-81, 2013. ,
Tertiary lymphoid organs in central nervous system autoimmunity, Front Immunol, vol.7, p.451, 2016. ,
hymic germinal centers and corticosteroids in myasthenia gravis: an immunopathological study in 1035 cases and a critical review, Clin Rev Allergy Immunol, vol.52, issue.1, pp.108-132, 2017. ,
Randomized trial of thymectomy in myasthenia gravis, N Engl J Med, vol.375, issue.6, pp.511-533, 2016. ,
Preconditioned mesenchymal stem cells treat myasthenia gravis in a humanized preclinical model, JCI Insight, vol.2, issue.7, p.89665, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01510169
he thymus in autoimmune myasthenia gravis: paradigm for a tertiary lymphoid organ, Rev Neurol, issue.8-9, pp.640-649, 2013. ,
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia, Ann Neurol, vol.66, issue.4, pp.521-552, 2009. ,
High endothelial venules and lymphatic vessels in tertiary lymphoid organs: characteristics, functions, and regulation, Front Immunol, vol.7, p.491, 2016. ,
he chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis, Blood, vol.108, issue.2, pp.432-472, 2006. ,
Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia, J Immunol, vol.177, issue.11, pp.7868-79, 2006. ,
Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis, J Immunol, vol.157, issue.8, pp.3752-60, 1996. ,
Intrathymic Th/B cells interaction leads to ectopic GCs formation and anti-AChR antibody production: central role in triggering MG occurrence, Mol Neurobiol, vol.53, issue.1, pp.120-151, 2016. ,
hymus in myasthenia gravis. Isolation of T-lymphocyte lines speciic for the nicotinic acetylcholine receptor from thymuses of myasthenic patients, J Clin Invest, vol.81, issue.3, pp.902-910, 1988. ,
hymic B cells from myasthenia gravis patients are activated B cells phenotypic and functional analysis, J Immunol, vol.145, issue.7, pp.2115-2137, 1990. ,
Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor, J Autoimmun, vol.52, pp.101-113, 2014. ,
hymus and myasthenia gravis: what can we learn from DNA microarrays?, J Neuroimmunol, pp.57-63, 2008. ,
Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis, Ann Neurol, vol.73, issue.2, pp.281-93, 2013. ,
Central role of interferon-beta in thymic events leading to myasthenia gravis, J Autoimmun, vol.52, pp.44-52, 2014. ,
Estrogen-mediated downregulation of AIRE inluences sexual dimorphism in autoimmune diseases, J Clin Invest, vol.126, issue.4, pp.1525-1562, 2016. ,
Etiology of myasthenia gravis: innate immunity signature in pathological thymus, Autoimmun Rev, vol.12, issue.9, pp.863-74, 2013. ,
he role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases, J Leukoc Biol, vol.94, issue.6, pp.1191-1200, 2013. ,
Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution, Am J Pathol, vol.167, issue.1, pp.129-168, 2005. ,
Innate immunity in myasthenia gravis thymus: pathogenic efects of tolllike receptor 4 signaling on autoimmunity, J Autoimmun, vol.52, pp.74-89, 2014. ,
Increased expression of toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active Epstein-Barr virus infection, Immunobiology, vol.221, issue.4, pp.516-543, 2016. ,
Review on tolllike receptor activation in myasthenia gravis: application to the development of new experimental models, Clin Rev Allergy Immunol, vol.52, issue.1, pp.133-180, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01321397
Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization, Exp Neurol, vol.270, pp.11-18, 2015. ,
he thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat, Am J Pathol, vol.139, issue.5, pp.995-1008, 1991. ,
Novel CXCL13 transgenic mouse: inlammation drives pathogenic efect of CXCL13 in experimental myasthenia gravis, Oncotarget, vol.7, issue.7, pp.7550-62, 2016. ,
Characterization of anti-acetylcholine receptor (AChR) antibodies from mice difering in susceptibility for experimental autoimmune myasthenia gravis (EAMG), Clin Exp Immunol, vol.92, issue.3, pp.506-519, 1993. ,
Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity, Immunol Rev, vol.220, pp.251-69, 2007. ,
TLR2 and TLR4 in autoimmune diseases: a comprehensive review, Clin Rev Allergy Immunol, vol.47, issue.2, pp.136-183, 2014. ,
his work was supported by grants from the "Agence Nationale de la Recherche" (ANR-06-MRAR-001-01), from the European Community (FIGHT-MG/ HEALTH-2009-242-210), and from the ,
, Frontiers in Immunology | www.frontiersin.org, vol.8, p.1029, 2017.
Van Crevel R. Innate immune recognition of Mycobacterium tuberculosis, Clin Dev Immunol, 2011. ,
Characterization of peripheral blood acetylcholine receptor-binding B cells in experimental myasthenia gravis, Cell Immunol, vol.271, issue.2, pp.292-300, 2011. ,
Toll-like receptor 3 ligand and retinoic acid enhance germinal center formation and increase the tetanus toxoid vaccine response, Clin Vaccine Immunol, vol.16, issue.10, pp.1476-84, 2009. ,
TLR agonists selectively promote terminal plasma cell diferentiation of B cell subsets specialized in thymus-independent responses, J Immunol, vol.178, issue.12, pp.7779-86, 2007. ,
Selective utilization of toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response, Immunity, vol.34, issue.3, pp.375-84, 2011. ,
MyD88 is required for the formation of long-term humoral immunity to virus infection, J Immunol, vol.178, issue.8, pp.5124-5155, 2007. ,
Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity, Proc Natl Acad Sci U S A, vol.109, issue.40, pp.16276-81, 2012. ,
B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers, J Immunol, vol.193, issue.9, pp.4400-4414, 2014. ,
TLR7 inluences germinal center selection in murine SLE, PLoS One, vol.10, issue.3, p.119925, 2015. ,
Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection, J Immunol, vol.191, issue.2, pp.810-818, 2013. ,
he Yaa locus and IFN-alpha ine-tune germinal center B cell selection in murine systemic lupus erythematosus, J Immunol, vol.189, issue.9, pp.4305-4317, 2012. ,
Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner, J Immunol, vol.184, issue.9, pp.4615-4624, 2010. ,
Follicular dendritic cell activation by TLR ligands promotes autoreactive B cell responses, Immunity, vol.46, pp.106-125, 2017. ,
CpG motifs in bacterial DNA trigger direct B-cell activation, Nature, vol.374, issue.6522, pp.546-555, 1995. ,
Distinct response of human B cell subpopulations in recognition of an innate immune signal, CpG DNA, J Immunol, vol.169, issue.5, pp.2368-73, 2002. ,
Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses, Proc Natl Acad Sci U S A, vol.111, issue.31, pp.3224-3257, 2014. ,
Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and toll-like receptors, Nature, issue.6881, pp.603-610, 2002. ,
TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice, Proc Natl Acad Sci U S A, vol.111, issue.4, pp.1497-502, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02022450
Lymphoid follicle destruction and immunosuppression ater repeated CpG oligodeoxynucleotide administration, Nat Med, vol.10, issue.2, pp.187-92, 2004. ,
Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus, Ann Neurol, issue.6, pp.726-764, 2010. ,
Acute endotoxin-induced thymic atrophy is characterized by intrathymic inlammatory and wound healing responses, PLoS One, vol.6, issue.3, p.17940, 2011. ,
A novel model for lymphocytic iniltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL21, J Immunol, vol.173, issue.8, pp.4791-4799, 2004. ,
Patterns of B-lymphocyte gene expression elicited by lipopolysaccharide mitogen, Immunology, vol.30, issue.6, pp.799-810, 1976. ,
TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases, J Immunol, issue.7, pp.3867-75, 2013. ,
TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones, J Exp Med, issue.12, pp.2641-57, 2009. ,
Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and ainity maturation, Immunity, vol.33, issue.1, pp.84-95, 2010. ,
he role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases, Ann N Y Acad Sci, vol.505, pp.50-70, 1987. ,
,
Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjogren's syndrome-like disease, Oral Dis, vol.17, issue.8, pp.801-808, 2011. ,
Analysis of humoral immune response in experimental autoimmune pancreatitis in mice, Pancreas, vol.39, issue.2, pp.224-255, 2010. ,
Inducible bronchus-associated lymphoid tissue: taming inlammation in the lung, Front Immunol, vol.7, p.258, 2016. ,
Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice, Exp Biol Med, issue.6, pp.715-738, 2014. ,
, Conlict of Interest Statement: he authors declare that the research was con
Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms, J Autoimmun, vol.52, pp.90-100, 2014. ,
Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies, Nat Med, vol.7, pp.365-368, 2001. ,
Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis, Ann Neurol, vol.69, pp.418-422, 2011. ,
Autoantibodies to agrin in myasthenia gravis patients, PLoS One, vol.9, p.91816, 2014. ,
Myasthenia gravis, Neurologist, vol.8, pp.2-21, 2002. ,
The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases, 1987. ,
, Ann N Y Acad Sci, vol.505, pp.50-70
The thymus and the pathogenesis of myasthenia gravis, Clin Immunol Immunopathol, vol.78, pp.1-5, 1996. ,
Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis, Brain, vol.126, pp.2304-2311, 2003. ,
A comparison of long-term post-thymectomy outcome of anti-AChR-positive, anti-AChR-negative and anti-MuSKpositive patients with non-thymomatous myasthenia gravis, Expert Opin Biol Ther, vol.9, pp.1-8, 2009. ,
Thymic epithelial cells: working class heroes for T cell development and repertoire selection, Trends Immunol, vol.33, pp.256-263, 2012. ,
An essential role for thymic mesenchyme in early T cell development, J Exp Med, vol.191, pp.1051-1056, 2000. ,
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels, J Exp Med, vol.202, pp.33-45, 2005. ,
CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia, Ann Neurol, vol.66, pp.521-531, 2009. ,
Thymic remodeling associated with hyperplasia in myasthenia gravis, Autoimmunity, vol.43, pp.1-12, 2010. ,
, , 2013.
, /CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients, Immunobiology, vol.218, pp.373-381
The thymus in autoimmune myasthenia gravis: paradigm for a tertiary lymphoid organ, Rev Neurol, vol.169, pp.640-649, 2013. ,
Lymphatic vessels and tertiary lymphoid organs, J Clin Invest, vol.124, pp.953-959, 2014. ,
Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis, J Immunol, vol.157, pp.3752-3760, 1996. ,
In vitro antiacetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes: correlations with thymic histology and thymic epithelial-cell interactions, J Clin Immunol, vol.7, pp.225-234, 1987. ,
Thymic B cells from myasthenia gravis patients are activated B cells phenotypic and functional analysis, J Immunol, vol.145, pp.2115-2122, 1990. ,
Thymus in myasthenia gravis. Isolation of Tlymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients, J Clin Invest, vol.81, pp.902-908, 1988. ,
Antiacetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis clinical correlations, J Autoimmun, vol.4, pp.197-211, 1991. ,
Studies in myasthenia gravis: effects of thymectomy. Results on 185 patients with nonthymomatous and thymomatous myasthenia gravis, Am J Med, vol.50, pp.465-474, 1971. ,
Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis, J Immunol, vol.174, pp.5324-5331, 2005. ,
Innate immunity in myasthenia gravis thymus: pathogenic effects of Toll-like receptor 4 signaling on autoimmunity, J Autoimmun, vol.52, pp.74-89, 2014. ,
B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5, J Exp Med, vol.187, pp.655-660, 1998. ,
Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjogren's syndrome, Arthritis Rheum, vol.52, pp.1773-1784, 2005. ,
The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis, Blood, vol.108, pp.432-440, 2006. ,
Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia, J Immunol, vol.177, pp.7868-7879, 2006. ,
Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia, J Neuroimmunol, vol.221, pp.101-106, 2010. ,
Expression of immune molecules CD25 and CXCL13 correlated with clinical severity of myasthenia gravis, J Mol Neurosci, vol.50, pp.317-323, 2013. ,
Interferon alpha and neuromuscular disorders, J Neuroimmunol, vol.207, pp.3-17, 2009. ,
Anti-cytokine autoantibodies in autoimmunity: preponderance of neutralizing autoantibodies against interferon-alpha, interferonomega and interleukin-12 in patients with thymoma and/or myasthenia gravis, Clin Exp Immunol, vol.132, pp.128-136, 2003. ,
Autoantibodies against type I interferons as an additional diagnostic criterion for autoimmune polyendocrine syndrome type I, J Clin Endocrinol Metab, vol.93, pp.4389-4397, 2008. ,
Effects of cytokines on acetylcholine receptor expression: implications for myasthenia gravis, J Immunol, vol.174, pp.5941-5949, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-02522187
Regulatory and pathogenic mechanisms in human autoimmune myasthenia gravis, Ann N YAcad Sci, vol.1132, pp.135-142, 2008. ,
Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses, Immunology, vol.131, pp.107-117, 2010. ,
Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis, Ann Neurol, vol.73, pp.281-293, 2013. ,
Central role of interferon-beta in thymic events leading to myasthenia gravis, J Autoimmun, vol.52, pp.44-52, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01514459
Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis, Oncotarget, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01293674
Thymoma-associated myasthenia gravis: on the search for a pathogen signature, J Autoimmun, vol.52, pp.29-35, 2014. ,
The Bhygiene hypothesis^for autoimmune and allergic diseases: an update, Clin Exp Immunol, vol.160, pp.1-9, 2010. ,
Antiviral immune responses: triggers of or triggered by autoimmunity?, Nat Rev Immunol, vol.9, pp.246-258, 2009. ,
The thymus is a common target organ in infectious diseases, PLoS Pathog, vol.2, p.62, 2006. ,
Detection of poliovirus-infected macrophages in thymus of patients with myasthenia gravis, Neurology, vol.74, pp.1118-1126, 2010. ,
Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus, Ann Neurol, vol.67, pp.726-738, 2010. ,
Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease, Adv Exp Med Biol, vol.711, pp.82-102, 2011. ,
Innate immune modulation in EBV infection, vol.2, p.1, 2011. ,
The role of pattern-recognition receptors in innate immunity: update on toll-like receptors, Nat Immunol, vol.11, pp.373-384, 2010. ,
Toll-like receptor signaling pathways, Front Immunol, vol.5, p.461, 2014. ,
Toll-like receptors in the pathogenesis of autoimmune diseases, Adv Pharm Bull, vol.5, pp.605-614, 2015. ,
Toll-like receptor pathways in autoimmune diseases, Clin Rev Allergy Immunol, vol.50, pp.1-17, 2016. ,
TRIF mediates toll-like receptor 5-induced signaling in intestinal epithelial cells, J Biol Chem, vol.285, pp.37570-37578, 2010. ,
High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway, Nat Commun, vol.4, p.1852, 2013. ,
A role for the adaptor proteins TRAM and TRIF in tolllike receptor 2 signaling, J Biol Chem, vol.290, pp.3209-3222, 2015. ,
Space and time: new considerations about the relationship between toll-like receptors (TLRs) and type I interferons (IFNs), Cytokine, vol.74, pp.171-174, 2015. ,
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists, J Biol Chem, vol.288, pp.442-454, 2013. ,
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases, Nat Commun, vol.6, p.6119, 2015. ,
UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling, PLoS One, vol.6, p.28500, 2011. ,
TLR9 expressed on plasma membrane acts as a negative regulator of human B cell response, J Autoimmun, vol.51, pp.23-29, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01011784
Toll-like receptors and autoimmunity, Autoimmun Rev, vol.7, pp.204-208, 2008. ,
Use of defined TLR ligands as adjuvants within human vaccines, Immunol Rev, vol.239, pp.178-196, 2011. ,
The effects of TLR activation on T-cell development and differentiation, Clin Dev Immunol, vol.2012, p.836485, 2012. ,
Innate pathways to Bcell activation and tolerance, Ann N Y Acad Sci, vol.1183, pp.58-68, 2010. ,
Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands, J Biol Chem, 2012. ,
B cell autonomous TLR signaling and autoimmunity, Autoimmun Rev, vol.7, pp.313-316, 2008. ,
Toll-like receptor driven B cell activation in the induction of systemic autoimmunity, Semin Immunol, vol.23, pp.106-112, 2011. ,
Possible involvement of toll-like receptors in the pathogenesis of myasthenia gravis, Inflammation, vol.36, pp.121-130, 2013. ,
Altered expression of miR-146a in myasthenia gravis, Neurosci Lett, vol.555, pp.85-90, 2013. ,
Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines, J Immunol, vol.168, pp.554-561, 2002. ,
Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution, Am J Pathol, vol.167, pp.129-139, 2005. ,
Increased expression of toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active Epstein-Barr virus infection, Immunobiology, vol.221, pp.516-527, 2016. ,
Epstein-Barr virus promotes interferon-alpha production by plasmacytoid dendritic cells, Arthritis Rheum, vol.62, pp.1693-1701, 2010. ,
Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3, J Exp Med, vol.206, pp.2091-2099, 2009. ,
Epstein-Barr virus induces MCP-1 secretion by human monocytes via TLR2, J Virol, vol.81, pp.8016-8024, 2007. ,
Toll-like receptor 7 stimulates the expression of Epstein-Barr virus latent membrane protein 1, PLoS One, vol.7, p.43317, 2012. ,
Experimental autoimmune myasthenia gravis (EAMG): from immunochemical characterization to therapeutic approaches, J Autoimmun, vol.54, pp.51-59, 2014. ,
Guidelines for standard preclinical experiments in the mouse model of myasthenia gravis induced by acetylcholine receptor immunization, Exp Neurol, 2015. ,
Experimental autoimmune myasthenia gravis in the mouse, Curr Protoc Immunol Chapter, vol.15, p.18, 2013. ,
Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors-recommendations for methods and experimental designs, Exp Neurol, vol.270, pp.18-28, 2015. ,
Modes of action of Freund's adjuvants in experimental models of autoimmune diseases, J Leukoc Biol, vol.70, pp.849-860, 2001. ,
CD4+ T and B cells cooperate in the immunoregulation of experimental autoimmune myasthenia gravis, J Neuroimmunol, vol.179, pp.152-162, 2006. ,
Induction of skewed Th1/Th2 T-cell differentiation via subcutaneous immunization with Freund'sadjuvant, Exp Dermatol, vol.11, pp.126-134, 2002. ,
Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice, J Exp Med, vol.186, pp.385-391, 1997. ,
Mice with IFN-gamma receptor deficiency are less susceptible to experimental autoimmune myasthenia gravis, J Immunol, vol.162, pp.3775-3781, 1999. ,
IL-17-producing CD4(+) T cells contribute to the loss of B-cell tolerance in experimental autoimmune myasthenia gravis, Eur J Immunol, vol.45, pp.1339-1347, 2015. ,
Adjuvant-enhanced antibody responses in the absence of tolllike receptor signaling, Science, vol.314, pp.1936-1938, 2006. ,
Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity, J Immunol, vol.175, pp.6303-6310, 2005. ,
MyD88 signaling controls autoimmune myocarditis induction, Circulation, vol.113, pp.258-265, 2006. ,
Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice, Arthritis Rheum, vol.56, pp.1618-1628, 2007. ,
The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model, Invest Ophthalmol Vis Sci, vol.51, pp.3092-3099, 2010. ,
Anti-acetylcholine receptor antibodies induced in mice by syngeneic receptor without adjuvants, Immunology, vol.58, pp.151-155, 1986. ,
Pathogenic autoimmunity to affinity-purified mouse acetylcholine receptor induced without adjuvant in BALB/c mice, Eur J Immunol, vol.23, pp.973-976, 1993. ,
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells, J Exp Med, vol.205, pp.869-882, 2008. ,
Vaccination with a MHC class II peptide in alum and inactive pertussis strongly ameliorates clinical MG in C57BL/6 mice, J Neuroimmunol, vol.171, pp.8-16, 2006. ,
A comparison of commercially available adjuvants for use in research, J Immunol Methods, vol.153, pp.31-40, 1992. ,
Induction of experimental autoimmune myasthenia gravis with acetylcholine receptors using a nonionic block copolymer as adjuvant, Immunol Investig, vol.22, pp.267-282, 1993. ,
LPS/TLR4 signal transduction pathway, Cytokine, vol.42, pp.145-151, 2008. ,
Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria, Trends Biochem Sci, vol.39, pp.574-576, 2014. ,
TLR2 and TLR4 in autoimmune diseases: a comprehensive review, Clin Rev Allergy Immunol, vol.47, pp.136-147, 2014. ,
CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis, J Neuroimmunol, vol.249, pp.1-7, 2012. ,
The adjuvant effect in infection and autoimmunity, Clin Rev Allergy Immunol, vol.34, pp.279-282, 2008. ,
LPS and Freund's adjuvant initiate different inflammatory circuits in experimental autoimmune thyroiditis, Eur Cytokine Netw, vol.14, pp.52-59, 2003. ,
Nucleic acid-sensing TLRs as modifiers of autoimmunity, J Immunol, vol.177, pp.6573-6578, 2006. ,
Experimental myasthenia gravis. A murine system, J Exp Med, vol.151, pp.204-223, 1980. ,
Acetylcholine receptor antibody-producing cells in thymus and lymph nodes in myasthenia gravis, Clin Immunol Immunopathol, vol.34, pp.141-146, 1985. ,
Arthritogenic properties of double-stranded (viral) RNA, J Immunol, vol.172, pp.5656-5663, 2004. ,
Early development of primary biliary cirrhosis in female C57BL/6 mice because of poly I:C administration, Liver Int, vol.25, pp.595-603, 2005. ,
Analysis of humoral immune response in experimental autoimmune pancreatitis in mice, Pancreas, vol.39, pp.224-231, 2010. ,
Viral double-stranded RNA aggravates lupus nephritis through toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells, J Am Soc Nephrol, vol.16, pp.1326-1338, 2005. ,
Genetic susceptibility to polyI:C-induced IFNalpha/betadependent accelerated disease in lupus-prone mice, Genes Immun, vol.7, pp.555-567, 2006. ,
Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjogren's syndrome-like disease, Oral Dis, vol.17, pp.801-807, 2011. ,
Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide, Proc Natl Acad Sci U S A, vol.99, pp.5539-5544, 2002. ,
Toll-like receptor 3 ligand polyinosinic:polycytidylic acid enhances autoimmune disease in a retinal autoimmunity model, Int Immunopharmacol, vol.11, pp.769-773, 2011. ,
The multi-hit hypothesis of primary biliary cirrhosis: polyinosinicpolycytidylic acid (poly I:C) and murine autoimmune cholangitis, Clin Exp Immunol, vol.166, pp.110-120, 2011. ,
Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta, J Immunol, vol.177, pp.7505-7509, 2006. ,
Induction of endogenous type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis, Acta Neuropathol, vol.130, pp.107-118, 2015. ,
Injectable interferon beta-1b for the treatment of relapsing forms of multiple sclerosis, J Inflamm Res, vol.3, pp.25-31, 2010. ,
Experimental autoimmune myasthenia: a model of myasthenia gravis in rats and guinea pigs, J Exp Med, vol.141, pp.1365-1375, 1975. ,
Strain differences in the autoimmune response of mice to acetylcholine receptors, Nature, vol.263, pp.329-330, 1976. ,
The thymus in myasthenia gravis. Changes typical for the human disease are absent in experimental autoimmune myasthenia gravis of the Lewis rat, Am J Pathol, vol.139, pp.995-1008, 1991. ,
Experimental autoimmune myasthenia gravis: cellular and humoral immune responses, Ann N Y Acad Sci, vol.274, pp.283-299, 1976. ,
IDO mediates TLR9-driven protection from experimental autoimmune diabetes, J Immunol, vol.183, pp.6303-6312, 2009. ,
Activation of the alternative NFkappaB pathway improves disease symptoms in a model of Sjogren'ss y n d r o m e, PLoS One, vol.6, p.28727, 2011. ,
In vivo administration of TLR9 agonist reduces the severity of experimental autoimmune encephalomyelitis. The role of plasmacytoid dendritic cells and B lymphocytes, CNS Neurosci Ther, vol.20, pp.787-790, 2014. ,
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling, J Leukoc Biol, vol.83, pp.692-701, 2008. ,
TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors, J Leukoc Biol, vol.94, pp.885-902, 2013. ,
TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements, J Biol Chem, vol.280, pp.37107-37117, 2005. ,
Beyond dsRNA: tolllike receptor 3 signalling in RNA-induced immune responses, Biochem J, vol.458, pp.195-201, 2014. ,
Molecular and cellular regulation of toll-like receptor-4 activity induced by lipopolysaccharide ligands, Front Immunol, vol.5, p.473, 2014. ,
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system, Semin Immunopathol, vol.29, pp.275-288, 2007. ,
RNA recognition by human TLR8 can lead to autoimmune inflammation, J Exp Med, vol.210, pp.2903-2919, 2013. ,
Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses, Expert Opin Ther Targets, vol.14, pp.787-796, 2010. ,
Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88, J Immunol, vol.174, pp.2942-2950, 2005. ,
Tolllike receptor 10 is involved in induction of innate immune responses to influenza virus infection, Proc Natl Acad Sci U S A, vol.111, pp.3793-3798, 2014. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00958470
Tolllike receptor 11 (TLR11) interacts with flagellin and profilin through disparate mechanisms, PLoS One, vol.11, p.148987, 2016. ,
Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis, Autoimmun Rev, vol.7, pp.65-70, 2007. ,
Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines, Vaccine, vol.29, pp.3356-3362, 2011. ,
Role of regulatory T cells in a new mouse model of experimental autoimmune myositis, Am J Pathol, vol.174, pp.989-998, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00420196
Experimental autoimmune hepatitis: disease induction, time course and T-cell reactivity, Hepatology, vol.11, pp.24-30, 1990. ,
Experimental autoimmune cholangitis: a mouse model of immune-mediated cholangiopathy, Liver, vol.20, pp.351-356, 2000. ,
Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis, Am J Pathol, vol.174, pp.1212-1220, 2009. ,
Immunization of naive BALB/c mice with human beta2-glycoprotein I breaks tolerance to the murine molecule, Arthritis Rheum, vol.46, pp.1399-1404, 2002. ,
, Clinic Rev Allerg Immunol