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Angioedème bradykinique et médecine d'urgence : vers une optimisation des stratégies de prise en charge

Abstract : We aimed to optimize the bradykinin-mediated angioedema management in the emergency setting to lead to a reduction in morbi-mortality and socio-economic coasts accompanying this disease. Our work made it possible to show that upper airway attack were associated with intensive care unit admission. Swelling of the larynx or tongue is significantly more frequent in drug-induced AE than the hereditary form, whereas attacks of abdominal pain are more common in patients with hereditary angioedema. Home icatibant self-injection helps avoid hospital admission in hereditary angioedema. We showed also that attacks of laryngeal edema and the progression of the edema were risk factors associated with hospital admission from the emergency department in ACEI-AAE. Finally, our work could propose a new strategy in bradykinin-mediated angioedema patients with the use of a call center during their attacks. The set of factors identified in this work must be taken into account to improve emergency physicians’ practices during emergency care of bradykinin-mediated angioedema patients.
Keywords : Morbi-mortality
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Nicolas Javaud. Angioedème bradykinique et médecine d'urgence : vers une optimisation des stratégies de prise en charge. Santé publique et épidémiologie. Université Sorbonne Paris Cité, 2016. Français. ⟨NNT : 2016USPCD098⟩. ⟨tel-02613291⟩

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