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Dispositifs nanofluidiques à électro-préconcentration sélective

Abstract : Detecting trace biomolecules remains one of the current challenges for biochips. Nanofluidic devices appear today as a promising way to simultaneously concentrate and detect biomolecules. This electropreconcentration is possible thanks to the selective permeability of the fluidic nanoslit, which behaves under electric field as a molecular selective "super-filter". This nanofilter makes it possible to trap the analytes upstream or downstream of the slot, in one or the other of the reservoirs (anodic or cathodic). During this Ph.D., I developed and studied nanofluidic devices based on two different geometries: single horizontal nanoslits and vertical nanochannel arrays, in a barcode geometry. For horizontal nanoslits, I studied the evolution of the conductance as a function of the ionic strength and the nanoslit geometry. Based on a pressure-assisted electro-preconcentration protocol, I have established "electric field/ pressure" diagrams allowing predicting stabilization of a focal point where the analytes will concentrate. I have studied the role of the nanoslit length for two model molecules, fluorescein and ovalbumin. For barcode devices, I developed both a nanostructuration process by electron beam nanolithography coupled with deep etching and a glass-glass bonding protocol. The electroconcentration profils obtained for different nanofentes is discussed based on different dynamic barcodes.
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Submitted on : Tuesday, May 19, 2020 - 7:12:13 AM
Last modification on : Wednesday, October 14, 2020 - 4:10:36 AM


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  • HAL Id : tel-02612249, version 1


Sokhna Mery Ngom. Dispositifs nanofluidiques à électro-préconcentration sélective. Micro et nanotechnologies/Microélectronique. Université Paris Saclay (COmUE), 2019. Français. ⟨NNT : 2019SACLS459⟩. ⟨tel-02612249⟩



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