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Caractérisation des fonctions de TRCF et de RADA dans l'expression et la maintenance des génomes des organelles chez Arabidopsis thaliana

Abstract : The mitochondria and chloroplasts have their own genomes whose expression and maintenance depend on factors encoded by the nuclear genome. The plant mitochondrial DNA (mtDNA) is characterized by important recombination activities that modulate its structure and contribute to its evolution. During my thesis, I characterized the RADA helicase that is involved in the late stages of organelle homologous recombination. RADA has similar functions to its bacterial homolog (RadA), but seems to play a more important role in plant organelles. The expression of the chloroplast genome (cpDNA) relies on two types of RNA polymerases: NEP encoded by the nuclear genome and PEP encoded by the cpDNA. During my thesis, I also studied the role of TRCF, an homolog of the Mfd factor which is addressed to chloroplasts. In bacteria, Mfd is involved in the release of stalled RNA polymerases by lesions and the recruitment of repair factors. In Arabidopsis, TRCF is no longer involved in repair but appears to play a role in the regulation of chloroplast gene expression.
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Nicolas Chevigny. Caractérisation des fonctions de TRCF et de RADA dans l'expression et la maintenance des génomes des organelles chez Arabidopsis thaliana. Biologie végétale. Université de Strasbourg, 2019. Français. ⟨NNT : 2019STRAJ042⟩. ⟨tel-02570609⟩

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