, I would like to thank my thesis advisory committee members: Dr. André Verdel

A. Dr and . Bateman, José Antonio Márquez (EMBL Grenoble) for their input, advice and discussions during my TAC meetings

, I would like to thank my jury members: Prof. Claire Vourc'h, Dr. Maite Huarte, Dr. Alberto Inga, Dr. Reini Fernandez de Luco and Dr

, I also want to thank Ombeline Pessey for excellent technical assistance

, Eleni Anastasakou for in vitro SHAPE of MEG3v3 and HRF of MEG3v1

, Isabel Chillon for flow cytometry, RT-PCR and optimization of functional assays

, Mani Karuppasamy for EM imaging; and all members, current and past, of the Marcia lab for helpful discussion

D. I-would-like-to-thank-jean-marie-teulon and . Pellequer, ) for AFM data acquisition

P. Dr and . Annibale, ) for AFM PSD analysis

A. Dr and . Inga, Italy) for pGL-p21/MDM2 RE vectors

, Grenoble) for assistance with SV-AUC

M. Prof and . Jamin,

, Biophysical platform) for their assistance with SEC-MALLS

. Dr, Adam Round and scientists at the BioSAXS beamline BM29 (ESRF, Grenoble) for assistance with SAXS data collection and processing

S. Acajjaoui and . Dr, Montserrat Soler Lopez (ESRF Grenbole) for support with DLS; the Chemical Biology Core Facility (EMBL Heidelberg) for synthetizing the SHAPE reagent 1M7

Y. Dr and . Zhou, Massachusetts General Hospital, Boston) for sharing the pCMS-d2EGFP-MEG3, pCI-control, pCI-MEG3, p53-Luc,pCMVbeta, and pCI-p14ARF vectors

, Yale University) for sharing RScape scripts before publication

M. Dr and . Paulsen, Dr. Mylène Peyzet (IAB Grenoble), and Dr

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