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Le fer et le microbiote intestinal : deux nouvelles cibles pour améliorer les capacités fonctionnelles et musculaires en condition d'hypoactivité

Abstract : Hypoactivity is characterized by a lack of mechanical constraints on the musculoskeletal system, and affects a wide range of individuals, from bedridden and hospitalized patients, to astronauts subjected to hypoactivity. Specifically, hypoactivity reduces functional abilities by altering, among others, muscle function and oxygen transport. To improve astronauts’ health during and after missions, or bedridden patients’ care, understanding its underlying mechanisms is necessary. Since they seem to interact with skeletal muscle, iron metabolism and gut microbiota could play a key role in functional disorders related to hypoactivity. The aim of this PhD thesis was to study the crosstalk between gut microbiota, iron and skeletal muscle during hypoactivity and to identify the underlying mechanisms. Based on animal and human models, our work highlights that iron misdistribution occurs during hypoactivity, especially due to hepcidin upregulation. By demonstrating for the first time the effect of gut microbiota on skeletal muscle endurance, our results support that glucose homeostasis plays a key role in this mechanism. Furthermore, some indicators of gut dysbiosis are suggested in hypoactivty. Our work opens promising and innovative countermeasures for therapeutic strategies destined to improve astronauts‘ health and patients’ care.
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Submitted on : Monday, May 11, 2020 - 12:38:16 PM
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Kevin Nay. Le fer et le microbiote intestinal : deux nouvelles cibles pour améliorer les capacités fonctionnelles et musculaires en condition d'hypoactivité. Education. Université Rennes 2, 2019. Français. ⟨NNT : 2019REN20035⟩. ⟨tel-02569434⟩

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