Skip to Main content Skip to Navigation

Géométrie des interactions protéiques

Abstract : Protein-Protein Interactions (PPI) are at the centre of many biological processes, and their understanding is therefore of the utmost importance. This work focuses on two different aspect: the first is the prediction of interacting surfaces of the protein through computational means, relying on features such as the conservation of residues, their physico-chemical properties, the local geometry of the protein or a score derived from the protein's behaviour in a crowded environnement, inferred from Complete Cross-Docking (CC-D) calculations. The second part of this work focuses on the detection of interacting partners from a large scale CC-D; this part uses a combination of methods to score the likelihood for two proteins to interact with one another and present how it might be possible to apply such methods for even larger scale.
Complete list of metadatas

Cited literature [133 references]  Display  Hide  Download
Contributor : Abes Star :  Contact
Submitted on : Monday, April 27, 2020 - 10:59:10 AM
Last modification on : Monday, August 31, 2020 - 12:30:19 PM


Version validated by the jury (STAR)


  • HAL Id : tel-02555266, version 1


Chloé Dequeker. Géométrie des interactions protéiques. Bioinformatics [q-bio.QM]. Sorbonne Université, 2018. English. ⟨NNT : 2018SORUS094⟩. ⟨tel-02555266⟩



Record views


Files downloads