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Géométrie des interactions protéiques

Abstract : Protein-Protein Interactions (PPI) are at the centre of many biological processes, and their understanding is therefore of the utmost importance. This work focuses on two different aspect: the first is the prediction of interacting surfaces of the protein through computational means, relying on features such as the conservation of residues, their physico-chemical properties, the local geometry of the protein or a score derived from the protein's behaviour in a crowded environnement, inferred from Complete Cross-Docking (CC-D) calculations. The second part of this work focuses on the detection of interacting partners from a large scale CC-D; this part uses a combination of methods to score the likelihood for two proteins to interact with one another and present how it might be possible to apply such methods for even larger scale.
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  • HAL Id : tel-02555266, version 1

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Chloé Dequeker. Géométrie des interactions protéiques. Bioinformatics [q-bio.QM]. Sorbonne Université, 2018. English. ⟨NNT : 2018SORUS094⟩. ⟨tel-02555266⟩

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