, oxaliplatine et carboplatine), notamment vis-à-vis des thiolates. Ces données fourniront des pistes précieuses pour expliquer plus finement les résistances moindres rencontrées par l'oxaliplatine

B. Rosenberg, L. Van-camp, and T. Krigas, Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode, Nature, vol.205, issue.4972, pp.698-699, 1965.

A. Brozovic, A. Ambriovi-ristov, and M. Osmak, The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin, Critical Reviews in Toxicology, vol.40, issue.4, pp.347-359, 2010.

M. Victor, M. A. Gonzalez, C. Fuertes, J. M. Alonso, and . Perez, Is Cisplatin-Induced Cell Death Always Produced by Apoptosis?, Molecular Pharmacology, vol.59, issue.4, pp.657-663, 2001.

M. A. Fuertes, C. Alonso, . M. José, and . Pérez, Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance, Chemical Reviews, vol.103, issue.3, pp.645-662, 2003.

E. R. Jamieson, J. Stephen, and . Lippard, Structure, Recognition, and Processing of Cisplatin DNA Adducts, vol.99, pp.2467-2498, 1999.

L. R. Kelland, Preclinical Perspectives on Platinum Resistance:. Drugs, vol.59, pp.1-8, 2000.

M. Knipp, Metallothioneins and platinum(II) anti-tumor compounds, Current Medicinal Chemistry, vol.16, issue.5, pp.522-537, 2009.

K. Micetich, L. A. Zwelling, and K. W. Kohn, Quenching of DNA:Platinum(II) Monoadducts as a Possible Mechanism of Resistance to cis

. Diamminedichloroplatinum, L1210 Cells, vol.43, pp.3609-3613, 1983.

F. Arnesano and G. Natile, Platinum on the road": Interactions of antitumoral cisplatin with proteins, Pure and Applied Chemistry, vol.80, issue.12, 2008.

M. Fuertes, J. Castilla, C. Alonso, and J. Pérez, Cisplatin Biochemical Mechanism of Action: From Cytotoxicity to Induction of Cell Death Through Interconnections Between Apoptotic and Necrotic Pathways, Current Medicinal Chemistry, vol.10, issue.3, pp.257-266, 2003.

D. B. Zamble, J. Stephen, and . Lippard, The Response of Cellular Proteins to Cisplatin-Damaged DNA, Bernhard Lippert, éditeur : Cisplatin, pp.71-110, 2006.

M. Yamada, E. O'regan, R. Brown, and . Karran, Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins, Nucleic Acids Research, vol.25, issue.3, pp.491-496, 1997.

A. Bellacosa, Functional interactions and signaling properties of mammalian DNA mismatch repair proteins, Cell Death & Differentiation, vol.8, issue.11, pp.1076-1092, 2001.

D. Wang, J. Stephen, and . Lippard, Cellular processing of platinum anticancer drugs, Nature Reviews Drug Discovery, vol.4, issue.4, pp.307-320, 2005.

J. H. Toney, B. A. Donahue, P. J. Kellett, S. L. Bruhn, J. M. Essigmann et al., Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II), Proceedings of the National Academy of Sciences, vol.86, pp.8328-8332, 1989.

R. and B. Martin, Platinum Complexes: Hydrolysis and Binding to N(7) and N(1) of Purines. In Bernhard Lippert, éditeur : Cisplatin, pp.181-205, 2006.

P. Juin and F. M. , Vallette : Modifications de la perméabilité membranaire mitochondriale au cours de l'apoptose : ouverture ou rupture ? médecine/sciences, vol.16, p.261, 2000.

F. Devun, Régulation du Pore de Transition de Perméabilité mitochondrial et toxicité induite par les analogues de l'ubiquinone dans les hépatocytes cancéreux, 2008.

G. Kroemer, N. Zamzami, A. Santos, and . Susin, Mitochondrial control of apoptosis, Immunology Today, vol.18, issue.1, pp.44-51, 1997.

G. Kroemer and J. C. Reed, Mitochondrial control of cell death, Nature Medicine, vol.6, issue.5, pp.513-519, 2000.

O. A. Olivero, P. K. Chang, D. M. Lopez-larraza, M. C. Semino-mora, and M. C. Poirier, Preferential formation and decreased removal of cisplatinDNA adducts in Chinese hamster ovary cell mitochondrial DNA as compared to nuclear DNA, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.391, issue.1-2, pp.79-86, 1997.

S. P. Ledoux, G. L. Wilson, E. J. Beecham, T. Stevnsner, K. Wassermann et al., Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells, Carcinogenesis, vol.13, issue.11, pp.1967-1973, 1992.

G. Speelmans, H. H. Wendy, . Sips, J. H. Ruud, R. W. Grisel et al., The interaction of the anti-cancer drug cisplatin with phospholipids is specific for negatively charged phospholipids and takes place at low chloride ion concentration, Biochimica et Biophysica Acta (BBA) -Biomembranes, vol.1283, issue.1, pp.60-66, 1996.

G. Speelmans, R. W. Staffhorst, and K. Versluis, Reedijk et Ben de Kruijff : Cisplatin Complexes with Phosphatidylserine in Membranes, vol.36, pp.10545-10550, 1997.

R. Bose, M. Verheij, A. Haimovitz-friedman, K. Scotto, Z. Fuks et al., Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals, Cell, vol.82, issue.3, pp.405-414, 1995.

P. Köpf-maier and S. K. Mühlhausen, Changes in the cytoskeleton pattern of tumor cells by cisplatin in vitro, Chemico-Biological Interactions, vol.82, issue.3, pp.295-316, 1992.

T. Peleg-shulman and D. Gibson, CisplatinProtein Adducts Are Efficiently Removed by Glutathione but Not by 5-Guanosine Monophosphate, Journal of the American Chemical Society, vol.123, issue.13, pp.3171-3172, 2001.

N. Rathindra, . Bose, K. Soumitra, S. Ghosh, and . Moghaddas, Kinetic analysis of the cis-diamminedichloroplatinum(II)-cysteine reaction: Implications to the extent of platinum-DNA binding, Journal of Inorganic Biochemistry, vol.65, issue.3, pp.199-205, 1997.

R. K. Duman, R. T. Heath, N. Rathindra, and . Bose, Inhibition of Escherichia coli DNA polymerase-I by the anti-cancer drug cis -diaminedichloroplatinum(II): what roles do polymerases play in cis -platin-induced cytotoxicity?, FEBS Letters, vol.455, issue.1-2, pp.49-54, 1999.

E. Volckova, F. Evanics, W. W. Yang, N. Rathindra, and . Bose, Unwinding of DNA polymerases by the antitumor drug, cis-diamminedichloroplatinum(ii), Chemical Communications, pp.1128-1129, 2003.

L. Maurmann, N. Rathindra, and . Bose, Unwinding of zinc finger domain of DNA polymerase I by cis-diamminedichloroplatinum(ii), Dalton Transactions, vol.39, issue.34, p.7968, 2010.

M. Morelli, A. Ostuni, P. L. Cristinziano, D. Tesauro, and A. Bavoso, Interaction of cisplatin with a CCHC zinc finger motif, Journal of Peptide Science, vol.19, issue.4, pp.227-232, 2013.

S. Yuan, X. Ding, Y. Cui, K. Wei, Y. Zheng et al., Cisplatin Preferentially Binds to Zinc Finger Proteins Containing C3h1 or C4 Motifs: Cisplatin Preferentially Binds to Zinc Finger Proteins Containing C3h1 or C4 Motifs

, European Journal of Inorganic Chemistry, vol.2017, issue.12, pp.1778-1784, 2017.

I. Atilio, Q. Anzellotti, M. J. Liu, J. Bloemink, N. Scarsdale et al., Targeting Retroviral Zn Finger-DNA Interactions: A Small-Molecule Approach Using the Electrophilic Nature of trans-Platinum-Nucleobase Compounds

, Chemistry & Biology, vol.13, issue.5, pp.539-548, 2006.

H. John, . Laity, M. Brian, . Lee, E. Peter et al., Zinc finger proteins: new insights into structural and functional diversity, vol.11, pp.39-46, 2001.

M. Cassandri, A. Smirnov, F. Novelli, C. Pitolli, M. Agostini et al., Zinc-finger proteins in health and disease, Cell Death Discovery, vol.3, p.17071, 2017.

C. Söti, A. Rácz, and P. Csermely, A Nucleotide-dependent Molecular Switch Controls ATP Binding at the C-terminal Domain of Hsp90: N-terminal nucleotide binding unmasks a C-terminal binding pocket, Journal of Biological Chemistry, vol.277, issue.9, pp.7066-7075, 2002.

J. D. Holding, W. E. Lindup, C. Van-laer, G. C. Vreeburg, V. Schilling et al., Stell : Phase I trial of a cisplatin-albumin complex for the treatment of cancer of the head and neck, British Journal of Clinical Pharmacology, vol.33, issue.1, pp.75-81

A. I. Ivanov, J. Christodoulou, J. A. Parkinson, K. J. Barnham, A. Tucker et al., Cisplatin Binding Sites on Human Albumin, vol.273, pp.14721-14730, 1998.

K. Katano, A. Kondo, R. Safaei, A. Holzer, G. Samimi et al., Acquisition of resistance to cisplatin is accompanied by changes in the cellular pharmacology of copper, Cancer Research, vol.62, issue.22, pp.6559-6565, 2002.

D. Kilari, Role of copper transporters in platinum resistance, World Journal of Clinical Oncology, vol.7, issue.1, p.106, 2016.

S. E. Crider, R. J. Holbrook, and K. J. Franz, Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1

, Metallomics, vol.2, issue.1, pp.74-83, 2010.

M. Komatsu, T. Sumizawa, M. Mutoh, Z. Chen, K. Terada et al., Toshihiro Sugiyama et Shin-ichi Akiyama : Copper-transporting P-Type Adenosine Triphosphatase (ATP7b) Is Associated with Cisplatin Resistance, Cancer Research, vol.60, issue.5, pp.1312-1316, 2000.

T. Uchiumi, E. Hinoshita, S. Haga, T. Nakamura, T. Tanaka et al., Isolation of a Novel Human Canalicular Multispecific Organic Anion Transporter, cMOAT2/MRP3, and Its Expression in Cisplatin-Resistant Cancer Cells with Decreased ATP-Dependent Drug Transport, Biochemical and Biophysical Research Communications, vol.252, issue.1, pp.103-110, 1998.

Y. Wang, V. Hodgkinson, S. Zhu, G. A. Weisman, and M. J. Petris, Advances in the Understanding of Mammalian Copper Transporters, International Review Journal, vol.2, issue.2, pp.129-137, 2011.

T. Ishikawa, C. D. Wright, and H. Ishizuka, GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and downregulated by cell differentiation, Journal of Biological Chemistry, vol.269, issue.46, pp.29085-29093, 1994.

T. Ishikawa, ATP/Mg2+-dependent cardiac transport system for glutathione Sconjugates. A study using rat heart sarcolemma vesicles, Journal of Biological Chemistry, vol.264, issue.29, pp.17343-17348, 1989.

T. Ishikawa, The ATP-dependent glutathione S-conjugate export pump, Trends in Biochemical Sciences, vol.17, issue.11, pp.463-468, 1992.

T. Ishikawa and F. Ali-osman, Glutathione-associated cisdiamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance, Journal of Biological Chemistry, vol.268, issue.27, pp.20116-20125, 1993.

G. Zhang, W. Hu, Z. Du, S. Lv, W. Zheng et al., A comparative study on interactions of cisplatin and ruthenium arene anticancer complexes with metallothionein using MALDI-TOF-MS, International Journal of Mass Spectrometry, vol.307, issue.1-3, pp.79-84, 2011.

H. David, S. Petering, . Krezoski, M. Niloofar, and . Tabatabai, 12 Metallothionein Toxicology: Metal Ion Trafficking and Cellular Protection, Helmut Sigel, Astrid Sigel et Roland K.O. Sigel, éditeurs : Metallothioneins and Related Chelators, 2015.

R. P. Sharma and I. R. , Edwards : cis-platinum: Subcellular distribution and binding to cytosolic ligands, Biochemical Pharmacology, vol.32, issue.18, pp.2665-2669, 1983.

C. Jacob, W. Maret, and B. L. Vallee, Control of zinc transfer between thionein, metallothionein, and zinc proteins, Proceedings of the National Academy of Sciences, vol.95, issue.7, pp.3489-3494, 1998.

C. Jacob, W. Maret, and B. L. Vallee, Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes, Proceedings of the National Academy of Sciences, vol.96, issue.5, pp.1910-1914, 1999.

C. Jacob, W. Maret, and B. L. Vallee, Ebselen, a Selenium-Containing Redox Drug, vol.248, pp.569-573, 1998.

S. Kelley, B. Basu, M. Teicher, D. Hacker, J. Hamer et al., Overexpression of metallothionein confers resistance to anticancer drugs, Science, issue.4874, pp.1813-1815, 1988.

S. L. Kelley and M. Rozencweig, Resistance to platinum compounds: Mechanisms and beyond, European Journal of Cancer and Clinical Oncology, vol.25, issue.8, pp.1135-1140, 1989.

M. José, A. Estrela, E. Ortega, and . Obrador, Glutathione in Cancer Biology and Therapy, vol.43, pp.143-181, 2008.

D. Eaton, Concise review of the glutathione S-transferases and their significance to toxicology, Toxicological Sciences, vol.49, issue.2, pp.156-164, 1999.

E. Volckova, L. P. Dudones, N. Rathindra, and . Bose, HPLC Determination of Binding of Cisplatin to DNA in the Presence of Biological Thiols: Implications of Dominant Platinum-Thiol Binding to Its Anticancer Action, Pharmaceutical Research, vol.19, issue.2, pp.124-131, 2002.

L. Munna, W. R. Agarwal, M. V. Taylor, O. B. Chernov, G. R. Chernova et al., The p53 Network, vol.273, pp.1-4, 1998.

R. P. Perez, Cellular and molecular determinants of cisplatin resistance, European Journal of Cancer, vol.34, issue.10, pp.1535-1542, 1998.

S. Dasari and P. B. Tchounwou, Cisplatin in cancer therapy: Molecular mechanisms of action, European Journal of Pharmacology, vol.740, pp.364-378, 2014.

A. Brozovic, D. Majhen, V. Roje, N. Mikac, S. Jakopec et al., Ambriovic-Ristov : v 3 Integrin-Mediated Drug Resistance in Human Laryngeal Carcinoma Cells Is Caused by Glutathione-Dependent Elimination of Drug-Induced Reactive Oxidative Species, Molecular Pharmacology, vol.74, issue.1, pp.298-306, 2008.

J. Thomas-hartmann and H. Lipp, Toxicity of platinum compounds, vol.4, pp.889-901, 2005.

J. R. Kouvaris, V. E. Kouloulias, and L. J. Vlahos, Amifostine: The First Selective-Target and Broad-Spectrum Radioprotector, The Oncologist, vol.12, issue.6, pp.738-747, 2007.

, Shabanah : Propionyll-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitinedepleted rat model, Pharmacological Research, vol.53, issue.3, pp.278-286, 2006.

A. Miyajima, . Nakashima, M. Yoshioka, H. Tachibana, . Tazaki et al., Role of reactive oxygen species in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder cancer cells, British Journal of Cancer, vol.76, issue.2, pp.206-210, 1997.

G. Karki, Physiology of Urine Formation, 2017.

A. Amin and M. Buratovich, New Platinum and Ruthenium Complexes -the Latest Class of Potential Chemotherapeutic Drugs -a Review of Recent Developments in the Field. Mini-Reviews in Medicinal Chemistry, vol.9, pp.1489-1503, 2009.

S. Hardeep, N. V. Oberoi, A. V. Nukolova, T. K. Kabanov, and . Bronich, Nanocarriers for delivery of platinum anticancer drugs, Advanced Drug Delivery Reviews, vol.65, pp.1667-1685, 2013.

A. Bergamo and G. Sava, Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs, Dalton Transactions, vol.40, p.7817, 2011.

F. D. Hélio and . Santos, Reactivity of auranofin with S-, Se-and N-containing amino acids, Computational and Theoretical Chemistry, vol.1048, pp.95-101, 2014.

A. Nakaya, M. Sagawa, A. Muto, H. Uchida, Y. Ikeda et al., The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-B activity, Leukemia Research, vol.35, issue.2, pp.243-249, 2011.

N. Farrell, Transition Metal Complexes as Drugs and Chemotherapeutic Agents

, Springer Science & Business Media, décembre 2012. Google-Books-ID: DVjtCAAAQBAJ

C. Peter, R. F. Dedon, and . Borch, Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles, Biochemical Pharmacology, vol.36, issue.12, pp.1955-1964, 1987.

T. G. Appleton, J. R. Hall, S. F. Ralph, S. M. Craig, and . Thompson, NMR study of acid-base equilibria and other reactions of ammineplatinum complexes with aqua and hydroxo ligands, Inorganic Chemistry, vol.28, issue.10, 1989.

B. Odenheimer and W. Wolf, Reactions of cisplatin with sulfur-containing amino acids and peptides I. Cysteine and glutathione, Inorganica Chimica Acta, vol.66, pp.41-43, 1982.

M. Knipp, A. V. Karotki, S. Chesnov, G. Natile, and J. Peter, Sadler, Viktor Brabec et Milan Vaák : Reaction of Zn 7 Metallothionein with cis -and trans -[Pt(N-donor)2 Cl2] Anticancer Complexes: trans-PtII Complexes Retain Their N-Donor Ligands, Journal of Medicinal Chemistry, vol.50, issue.17, pp.4075-4086, 2007.

M. Chandrasekharan, M. R. Udupa, and G. Aravamudan, Cysteine complexes of palladium(II) and platinum(II), Inorganica Chimica Acta, vol.7, pp.88-90, 1973.

M. El-khateeb, T. G. Appleton, L. R. Gahan, and G. Bruce,

S. J. Charles, A. Berners-price, and . Bolton, Reactions of cisplatin hydrolytes with methionine, cysteine, and plasma ultrafiltrate studied by a combination of HPLC and NMR techniques, Journal of Inorganic Biochemistry, vol.77, issue.1-2, pp.13-21, 1999.

T. G. Appleton, J. W. Connor, and R. John, Hall : S,O-versus S,N-chelation in the reactions of the cis-diamminediaquaplatinum(II) cation with methionine and Smethylcysteine, Inorganic Chemistry, vol.27, issue.1, pp.130-137, 1988.

G. Pneumatikakis and N. , Hadjiliadis : Complexes of Cysteine and Cysteinemethylester with Pd(II) and Pt(II), Journal of Inorganic and Nuclear Chemistry, vol.41, issue.3, pp.429-435, 1979.

J. Susan, P. W. Berners-price, and . Kuchel, Reaction of cis-and trans-[PtCl2(NH3)2] with reduced glutathione studied by 1h, 13c, 195pt and 15n-{1H} DEPT NMR, Journal of Inorganic Biochemistry, vol.38, issue.4, pp.305-326, 1990.

J. Susan, . Berners-price, and W. Philip, Kuchel : Reaction of cis-and trans-[PtCl2(NH3)2] with reduced glutathione inside human red blood cells, studied by 1h and 15n-{1H} DEPT NMR, Journal of Inorganic Biochemistry, vol.38, issue.4, pp.327-345, 1990.

Y. Kasherman, S. Sturup, and D. Gibson, Trans labilization of am(m)ine ligands from platinum(II) complexes by cancer cell extracts, JBIC Journal of Biological Inorganic Chemistry, vol.14, issue.3, pp.387-399, 2009.

T. G. Appleton, J. W. Connor, J. R. Hall, and D. Paul, Prenzler : NMR Study of the reactions of the cis-diamminediaquaplatinum(II) cation with glutathione and amino acids containing a thiol group, Inorganic Chemistry, vol.28, issue.11, pp.2030-2037, 1989.

, Proceedings of the third international conference on bioinorganic chemistry; The Netherlands 1987. Recueil des Travaux Chimiques des Pays-Bas, vol.106, pp.165-439, 2010.

Z. Chval, M. Sip, V. Jaroslav, and . Burda, The trans effect in square-planar platinum(II) complexes-a density functional study, Journal of Computational Chemistry, vol.29, issue.14, pp.2370-2381, 2008.

T. Zimmermann, M. Zeizinger, V. Jaroslav, and . Burda, Cisplatin interaction with cysteine and methionine, a theoretical DFT study, Journal of Inorganic Biochemistry, vol.99, issue.11, pp.2184-2196, 2005.

B. Chen and L. Zhou, Computational study on mechanisms of the anticancer drug: Cisplatin and novel polynuclear platinum(II) interaction with sulfur-donor biomolecules and DNA purine bases, Computational and Theoretical Chemistry, vol.1074, pp.36-49, 2015.

P. A. Dirac, Note on Exchange Phenomena in the Thomas Atom. Mathematical Proceedings of the Cambridge Philosophical Society, vol.26, p.376

S. H. Vosko, L. Wilk, and M. Nusair, Accurate spin-dependent electron liquid correlation energies for local spin density calculations: a critical analysis, Canadian Journal of Physics, vol.58, issue.8, pp.1200-1211, 1980.

C. Lee, W. Yang, and R. G. Parr, Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density, Physical Review B, vol.37, issue.2, pp.785-789, 1988.

K. S. Singwi, A. Sjölander, M. P. Tosi, and R. H. Land, Electron Correlations at Metallic Densities, IV. Physical Review B, vol.1, issue.3, pp.1044-1053, 1970.

A. D. Becke, Density-functional exchange-energy approximation with correct asymptotic behavior, Physical Review A, vol.38, issue.6, pp.3098-3100, 1988.

R. Bible, 11-19) ne sera pas citée dans la présente étude scientifique, vol.28

A. D. Becke, Density functional thermochemistry. III. The role of exact exchange, The Journal of Chemical Physics, vol.98, issue.7, pp.5648-5652, 1993.

P. J. Stephens, F. J. Devlin, C. F. Chabalowski, and M. J. Frisch, Ab Initio Calculation of Vibrational Absorption and Circular Dichroism Spectra Using Density Functional Force Fields, The Journal of Physical Chemistry, vol.98, issue.45, pp.11623-11627, 1994.

D. Paschoal, B. L. Marcial, J. F. Lopes, B. Wagner, . De-almeida et al., The role of the basis set and the level of quantum mechanical theory in the prediction of the structure and reactivity of cisplatin, Journal of Computational Chemistry, vol.33, issue.29, pp.2292-2302, 2012.

L. Onsager, Electric Moments of Molecules in Liquids, Journal of the American Chemical Society, vol.58, issue.8, pp.1486-1493

S. Miertu, E. Scrocco, and J. Tomasi, Electrostatic interaction of a solute with a continuum. A direct utilizaion of AB initio molecular potentials for the prevision of solvent effects, Chemical Physics, vol.55, issue.1, pp.117-129, 1981.

E. Cancès, B. Mennucci, and J. Tomasi, A new integral equation formalism for the polarizable continuum model: Theoretical background and applications to isotropic and anisotropic dielectrics, The Journal of Chemical Physics, vol.107, issue.8, pp.3032-3041, 1997.

H. David and . Wertz, Relationship between the gas-phase entropies of molecules and their entropies of solvation in water and 1-octanol, Journal of the American Chemical Society, vol.102, issue.16, pp.5316-5322, 1980.

P. Y. Ayala and H. B. Schlegel, Identification and treatment of internal rotation in normal mode vibrational analysis, The Journal of Chemical Physics, vol.108, issue.6, pp.2314-2325, 1998.

|. Freq and . Gaussian,

J. Tomasi and M. Persico, Molecular Interactions in Solution: An Overview of Methods Based on Continuous Distributions of the Solvent, Chemical Reviews, vol.94, issue.7, pp.2027-2094, 1994.

E. Henon, Calcul theorique de constantes de vitesse de reactions thermiques, pour un comportement reel des gaz. Application a l'etude de reactions elementaires dans les domaines de la combustion, 1997.

C. Peng, P. Y. Ayala, H. , B. Schlegel, and M. J. Frisch, Using redundant internal coordinates to optimize equilibrium geometries and transition states, Journal of Computational Chemistry, vol.17, issue.1, pp.49-56, 1996.

A. Thomas, W. N. Halgren, and . Lipscomb, The synchronous-transit method for determining reaction pathways and locating molecular transition states, Chemical Physics Letters, vol.49, issue.2, pp.225-232, 1977.

C. Peng and H. B. Schlegel, Combining Synchronous Transit and Quasi-Newton Methods to Find Transition States, Israel Journal of Chemistry, vol.33, issue.4, pp.449-454, 1993.

H. B. Schlegel, G. E. Scuseria, M. A. Robb, J. R. Cheeseman, G. Scalmani et al.,

B. Gomperts, H. P. Mennucci, J. V. Hratchian, A. F. Ortiz, J. L. Izmaylov et al.,

Y. F. Williams-, F. Ding, F. Lipparini, J. Egidi, B. Goings et al.,

B. Foresman, M. J. Frisch, G. W. Trucks, . Inc, . C. Wallingford et al.,

. Chr, M. S. Møller, and . Plesset, Note on an Approximation Treatment for Many-Electron Systems, Physical Review, vol.46, issue.7, pp.618-622, 1934.

J. Lau and D. V. Deubel, Loss of Ammine from Platinum(II) Complexes: Implications for Cisplatin Inactivation, Storage, and Resistance, vol.11, pp.2849-2855, 2005.

M. L. Jan, A. Martin, and . Sundermann, Correlation consistent valence basis sets for use with the StuttgartDresdenBonn relativistic effective core potentials: The atoms GaKr and InXe, The Journal of Chemical Physics, vol.114, issue.8, pp.3408-3420, 2001.

M. Enescu and A. Manceau, High-level ab initio calculation of the stability of mercurythiolate complexes, Theoretical Chemistry Accounts, vol.133, issue.3, pp.1-9, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01059579

F. Torrico and R. R. Pappalardo, Enrique Sánchez Marcos et José M. Martínez : Hydration Structure and Dynamic Properties of the Square Planar Pt

, Aquaion Compared to the Pd(II) Case, Theoretical Chemistry Accounts, vol.115, issue.2-3, pp.196-203, 2005.

C. P. Kelly, C. J. Cramer, and D. G. Truhlar, Aqueous Solvation Free Energies of Ions and IonWater Clusters Based on an Accurate Value for the Absolute Aqueous Solvation Free Energy of the Proton, The Journal of Physical Chemistry B, vol.110, issue.32, pp.16066-16081, 2006.

J. H. Jensen, Predicting accurate absolute binding energies in aqueous solution: thermodynamic considerations for electronic structure methods, Physical Chemistry Chemical Physics, vol.17, issue.19, pp.12441-12451, 2015.

J. Maryadele and É. O'neil, The Merck Index :An Encyclopedia of Chemicals, Drugs, and Biologicals, 2013.

C. Jacob, G. I. Giles, M. Niroshini, H. Giles, and . Sies, Sulfur and Selenium: The Role of Oxidation State in Protein Structure and Function, Angewandte Chemie International Edition, vol.42, issue.39, pp.4742-4758, 2003.

S. Foley and . Enescu, A Raman spectroscopy and theoretical study of zinccysteine complexation, Vibrational Spectroscopy, vol.44, issue.2, pp.256-265, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00675158

T. Minervini, B. Cardey, and S. Foley, Christophe Ramseyer et Mironel Enescu : Fate of cisplatin and its main hydrolysed forms in the presence of thiolates: a comprehensive computational and experimental study, Metallomics, vol.11, pp.833-844, 2019.

F. Aprile and D. S. Martin, Chlorotriammineplatinum(II) Ion. Acid Hydrolysis and Isotopic Exchange of Chloride Ligand, Inorganic Chemistry, vol.1, issue.3, pp.551-557, 1962.

J. Susan, T. A. Berners-price, U. Frenkiel, J. D. Frey, . Ranford et al., Hydrolysis products of cisplatin: pK a determinations via[1h, 15n] NMR spectroscopy, Journal of the Chemical Society, Chemical Communications, p.789, 1992.

Z. Chval and M. Sip, Pentacoordinated transition states of cisplatin hydrolysisab initio study, Journal of Molecular Structure: THEOCHEM, vol.532, issue.1-3, pp.59-68, 2000.

K. Hindmarsch, D. A. House, M. Mark, and . Turnbull, The hydrolysis products of cis-diamminedichloroplatinum(II) 9. Chloride and bromide anation kinetics for some, Inorganica Chimica Acta, vol.257, issue.1, pp.11-18, 1997.

J. Lau and D. V. Deubel, Hydrolysis of the Anticancer Drug Cisplatin: Pitfalls in the Interpretation of Quantum Chemical Calculations, Journal of Chemical Theory and Computation, vol.2, issue.1, pp.103-106, 2006.

J. Lau and B. Ensing, Hydrolysis of cisplatin -a first-principles metadynamics study, Physical Chemistry Chemical Physics, vol.12, issue.35, p.10348, 2010.

A. Melchior, E. S. Marcos, R. R. Pappalardo, M. José, and . Martínez, Comparative study of the hydrolysis of a third-and a first-generation platinum anticancer complexes, Theoretical Chemistry Accounts, vol.128, issue.4-6, pp.627-638, 2011.

E. Sian, D. A. Miller, and . House, The hydrolysis products of cisdichlorodiammineplatinum(II) 2. The kinetics of formation and anation of the cisdiamminedi(aqua)platinum(II) cation, Inorganica Chimica Acta, vol.166, issue.2, pp.189-197, 1989.

E. Sian, D. A. Miller, and . House, The hydrolysis products of cisdiamminedichloroplatinum(II). I. The kinetics of formation and anation of the cisdiammine(aqua)chloroplatinum(II) cation in acidic aqueous solution, Inorganica Chimica Acta, vol.161, issue.1, pp.131-137, 1989.

J. W. Reishus and D. S. Martin, Acid Hydrolysis and Isotopic Exchange of the Chloride Ligands 1, cis-Dichlorodiammineplatinum(II), vol.83, pp.2457-2462, 1961.

T. Yotsuyanagi, M. Usami, Y. Noda, and M. Nagata, Computational consideration of cisplatin hydrolysis and acid dissociation in aqueous media: effect of total drug concentrations, International Journal of Pharmaceutics, vol.246, issue.1-2, pp.95-104, 2002.

F. Legendre, V. Bas, J. Kozelka, and J. , Chottard : A complete kinetic study of GG versus AG plantination suggests that the doubly aquated derivatives of cisplatin are the actual DNA binding species. Chemistry (Weinheim an Der Bergstrasse, vol.6, 2000.

A. Samanta, G. Kr, I. Ghosh, S. Mitra, . Mukherjee et al., Moi : Ligand substitution reaction on a platinum(II) complex with bio-relevant thiols: kinetics, mechanism and bioactivity in aqueous medium, RSC Adv, vol.4, issue.82, pp.43516-43524, 2014.

E. Stanley, J. D. Livingstone, and . Nolan, Metal chelates of biologically important compounds. I. Complexes of DL-ethionine and S-methyl-L-cysteine, Inorganic Chemistry, vol.7, issue.7, pp.1447-1451, 1968.

R. E. Norman, J. D. Ranford, J. Peter, and . Sadler, Studies of platinum(II) methionine complexes: metabolites of cisplatin, Inorganic Chemistry, vol.31, issue.5, pp.877-888, 1992.

J. K. Burdett, Substitution reactions at square-planar d8 metal centers and the kinetic cis and trans effects. A general molecular orbital description, Inorganic Chemistry, vol.16, issue.12, pp.3013-3025, 1977.

W. C. Cole and W. Wolf, Preparation and metabolism of a cisplatin/serum protein complex, Chemico-Biological Interactions, vol.30, issue.2, pp.223-235, 1980.

R. Kassim, C. Ramseyer, and M. Enescu, Oxidation reactivity of zinccysteine clusters in metallothionein, vol.18, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00811959

I. Chernyaev, , vol.4, 1926.

E. James, E. A. Huheey, . Keiter, L. Richard, and . Keiter, Inorganic chemistry: principles of structure and reactivity, p.26974220, 1993.

C. E. Housecroft and A. G. Sharpe, Inorganic Chemistry. Pearson Education, 2005. Google-Books-ID: _1gFM51qpAMC

S. F. and A. Kettle, Physical inorganic chemistry: a coordination chemistry approach, p.437682874, 1998.

J. L. Shaw, C. R. Dockery, S. E. Lewis, L. Harris, and R. Bettis, The Trans Effect: A Guided-Inquiry Experiment for Upper-Division Inorganic Chemistry, Journal of Chemical Education, vol.86, issue.12, p.1416, 2009.

J. Chatt, L. A. Duncanson, and L. M. Venanzi, Directing effects in inorganic substitution reactions, Recueil des Travaux Chimiques des Pays-Bas, vol.75, issue.6, pp.681-686

L. E. Orgel, An electronic interpretation of the trans effect in platinous complexes, Journal of Inorganic and Nuclear Chemistry, vol.2, issue.3, pp.137-140, 1956.

H. C. Freeman and M. L. Golomb, Model compounds for metal protein interaction: crystal structure of three platinum(II) complexes of L-and DL-methionine and glycyl-Lmethionine, J. Chem. Soc. D, vol.0, issue.22, pp.1523-1524, 1970.

T. Zimmermann, Z. Chval, V. Jaroslav, and . Burda, Cisplatin Interaction with Cysteine and Methionine in Aqueous Solution: Computational DFT/PCM Study, The Journal of Physical Chemistry B, vol.113, issue.10, pp.3139-3150, 2009.

T. Shoeib, L. Barry, and . Sharp, Monomeric cisplatin complexes with glutathione: Coordination modes and binding affinities, Inorganica Chimica Acta, vol.405, pp.258-264

A. Klamt and G. Schüürmann, COSMO: a new approach to dielectric screening in solvents with explicit expressions for the screening energy and its gradient, J. Chem. Soc., Perkin Trans. 2, issue.5, pp.799-805, 1993.

S. Miertus and J. Tomasi, Approximate evaluations of the electrostatic free energy and internal energy changes in solution processes, Chemical Physics, vol.65, issue.2, pp.239-245, 1982.

V. Barone, M. Cossi, and J. Tomasi, A new definition of cavities for the computation of solvation free energies by the polarizable continuum model, The Journal of Chemical Physics, vol.107, issue.8, pp.3210-3221, 1997.

O. Hohage and W. S. Sheldrick, Cisplatin mediates selective downstream hydrolytic cleavage of Met-(Gly)n-His segments (n=1,2) in methionine-and histidinecontaining peptides: The role of ammine loss trans to the initial Pt-S(Met) anchor in facilitating amide hydrolysis, Journal of Inorganic Biochemistry, vol.100, issue.9, pp.1506-1513, 2006.

T. G. Appleton, J. W. Connor, J. R. Hall, and P. D. Prenzler, Proceedings of the third international conference on bioinorganic chemistry; the netherlands 1987, vol.106, p.382

A. Andersson, H. Hedenmalm, B. Elfsson, and . Hans-ehrsson, Determination of the acid dissociation constant for cis-diammineaquachloroplatinum(II) ion. A hydrolysis product of cisplatin, Journal of Pharmaceutical Sciences, vol.83, issue.6, pp.859-862, 1994.

L. Kumar, N. R. Kandasamy, and T. S. Srivastava, Synthesis and spectroscopic studies of potential antiviral, Inorganica Chimica Acta, vol.67, pp.139-143

J. Reedijk, Why Does Cisplatin Reach Guanine-N7 with Competing S-Donor Ligands Available in the Cell?, Chemical Reviews, vol.99, issue.9, pp.2499-2510, 1999.

D. Hagrman, Kinetic study on the reaction of cisplatin with metallothionein, Drug Metabolism and Disposition, vol.31, issue.7, pp.916-923, 2003.

R. Bose, Biomolecular Targets for Platinum Antitumor Drugs. Mini-Reviews in Medicinal Chemistry, vol.2, pp.103-111, 2002.

T. Hadi, T. Ramseyer, . Gautier, . Ps-bellaye, . Lopez et al., Ldl and hdl lipoproteins as the nano-carriers of cisplatin: targeting specific tumor cells and reducing the toxicity, Nature Communications, 2018.

M. David, P. Lécorché, M. Masse, A. Faucon, K. Abouzid et al., Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos, PLOS ONE, vol.13, issue.2, p.191052, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01765841

K. J. Barnham, M. I. Djuran, P. Del, S. Murdoch, J. D. Ranford et al., Ring-Opened Adducts of the Anticancer Drug Carboplatin with Sulfur Amino Acids, Inorganic Chemistry, vol.35, issue.4, pp.1065-1072, 1996.

U. Frey, J. D. Ranford, J. Peter, and . Sadler, Ring-opening reactions of the anticancer drug carboplatin: NMR characterization of cis, Inorganic Chemistry, vol.32, issue.8, pp.1333-1340, 1993.

R. J. Knox, F. Friedlos, D. A. Lydall, and J. John, Roberts : Mechanism of Cytotoxicity of Anticancer Platinum Drugs: Evidence That cis-Diamminedichloroplatinum(II) and cis-Diammine-(1,1-cyclobutanedicarboxylato)platinum(II) Differ Only in the Kinetics of Their Interaction with DNA, Cancer Research, vol.46, issue.4, pp.1972-1979, 1986.

J. D. Ranford, P. J. Sadler, K. Balmanno, and R. David, Newell : 1h NMR studies of human urine: Urinary elimination of the anticancer drug carboplatin, Magnetic Resonance in Chemistry, vol.29, issue.13, pp.125-129, 1991.

L. Canovese, L. Cattalini, G. Chessa, L. Martin, and . ?tobe, Kinetics of the displacement of cyclobutane-1,1-dicarboxylate from diammine(cyclobutane-1,1-dicarboxylato)platinum( II ) in aqueous solution, Journal of the Chemical Society, vol.0, issue.8, pp.2135-2140, 1988.

A. J. Pasqua, D. J. Kerwood, Y. Shi, J. Goodisman, and C. James, Dabrowiak : Stability of carboplatin and oxaliplatin in their infusion solutions is due to self-association, Dalton Transactions, vol.40, p.4821, 2011.

Z. Wang, M. Wu, and S. Gou, Toward a better understanding of the oxaliplatin mode of action upon the steric hindrance of 1,2-diaminocyclohexane and its analogue, Journal of Inorganic Biochemistry, vol.157, pp.1-7, 2016.

V. Foltinová, L. Vihálková-indlerová, V. Horváth, P. Sova, J. Hofmanová et al., Mechanisms of effects of platinum (II) and (IV) complexes. comparison of cisplatin and oxaliplatin with satraplatin and LA-12. New Pt (IV)-based drugs : a minireview. Scripta medica Facultatis medicae, vol.81, pp.105-116, 2008.

K. Myint, Y. Li, J. Paxton, and M. Mckeage, Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles, PLOS ONE, vol.10, issue.7, p.130727, 2015.

N. D. Tinker, H. L. Sharma, and C. A. Mcauliffe, Qualitative Investigation, Both in Vivo and in Vitro, of the Metabolites Formed by Cisplatin and Paraplatin Involving High Performance Liquid Chromatography Analysis, Marino Nicolini, éditeur : Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy, pp.144-159

U. S. Springer and M. A. Boston, , 1988.