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Métacognition et personnalité chez des patients porteurs d'un gliome diffus de bas grade : un eclairage nouveau sur le potentiel plastique du cerveau humain

Abstract : Recent findings in the field of neuropsychology have allowed to move from a localized to a dynamic network approach of brain functions. This paradigmatic shift, from a static to a reshaping brain, has been supported by the investigation of patients with low-grade glioma, a neurological tumor known to trigger processes of compensation and rescue of brain functions. However, it is currently unestablished whether this neuroplastic compensation may extend to higher-order cognitive functions, specifically those involved in self-consciousness. By using both anatomo-functional correlational methods based on lesions localization and structural disconnection approach, the purpose of this work was to assess the extent to which the neurosurgical resections of low-grade glioma affect metacognitive processes and personality traits. First, we showed that frontal lobectomies, both unilateral and bilateral, did not induce metaperceptive impairments despite the established role of the prefrontal cortex in metacognition. Likewise, our results suggest that massive surgical resections did not significantly affect personality traits. However, some of them such as positive schizotypy, and a few behavioral modifications, such as anosognosia, were found to be associated with the disruption of some white matter bundles.
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Anne-Laure Lemaitre. Métacognition et personnalité chez des patients porteurs d'un gliome diffus de bas grade : un eclairage nouveau sur le potentiel plastique du cerveau humain. Psychologie. Université Charles de Gaulle - Lille III, 2019. Français. ⟨NNT : 2019LIL3H059⟩. ⟨tel-02537962⟩

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