H. Alqahtani, K. Gopal, N. Gupta, K. Jung, A. Alshareef et al., DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer, Cell. Signal, vol.28, pp.42-50, 2016.

C. Alvarez, E. Gotuzzo, A. Vandamme, and K. Verdonck, Family Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review, Front. Microbiol, vol.7, p.1674, 2016.

M. Ameyar-zazoua, C. Rachez, M. Souidi, P. Robin, L. Fritsch et al., Argonaute proteins couple chromatin silencing to alternative splicing, Nat. Struct. Mol. Biol, vol.19, pp.998-1004, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-01393429

R. E. Amir, H. Haecker, M. Karin, and A. Ciechanover, Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase, Oncogene, vol.23, pp.2540-2547, 2004.

V. Andresen, C. A. Pise-masison, U. Sinha-datta, M. Bellon, V. Valeri et al., Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles, Blood, vol.118, pp.1549-1559, 2011.

S. Y. Anvar, G. Allard, E. Tseng, G. M. Sheynkman, E. De-klerk et al., Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing, 2018.

, Genome Biol, vol.19, p.46

B. Arnulf, A. Villemain, C. Nicot, E. Mordelet, P. Charneau et al., Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis, Blood, vol.100, pp.4129-4138, 2002.

G. Arun, V. S. Akhade, S. Donakonda, and M. R. Rao, mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells, Mol. Cell. Biol, vol.32, pp.3140-3152, 2012.

X. T. Bai and C. Nicot, Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis, Front. Microbiol, vol.3, 2012.

L. M. Bandeira, S. N. Uehara, M. A. Asato, G. S. Aguena, C. M. Maedo et al., High prevalence of HTLV-1 infection among Japanese immigrants in non-endemic area of Brazil, PLoS Negl. Trop. Dis, vol.9, pp.43-71, 2015.

C. R. Bangham, A. Araujo, Y. Yamano, G. P. Taylor, E. Batsché et al., The human SWI/SNF subunit Brm is a regulator of alternative splicing, Nat. Struct. Mol. Biol, vol.13, pp.22-29, 2006.

H. H. Baydoun, X. T. Bai, S. Shelton, and C. Nicot, HTLV-I Tax Increases Genetic Instability by Inducing DNA Double Strand Breaks during DNA Replication and Switching Repair to NHEJ, PLOS ONE, vol.7, 2012.

A. Bazarbachi, Y. Plumelle, J. Carlos-ramos, P. Tortevoye, Z. Otrock et al., Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes, J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol, vol.28, pp.4177-4183, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-00531240

D. L. Bentley, Coupling mRNA processing with transcription in time and space, Nat. Rev. Genet, vol.15, pp.163-175, 2014.

A. Bertero, P. A. Fields, V. Ramani, G. Bonora, G. G. Yardimci et al., Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory, Nat. Commun, vol.10, 2019.

F. Bex, A. Mcdowall, A. Burny, G. , and R. , The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins, J. Virol, vol.71, pp.3484-3497, 1997.

M. R. Billman, D. Rueda, C. R. Bangham, G. H. Boekhoudt, Z. Guo et al., Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene, J. Immunol. Baltim. Md, vol.2, pp.4139-4147, 1950.

S. Boireau, P. Maiuri, E. Basyuk, M. De-la-mata, A. Knezevich et al., The transcriptional cycle of HIV-1 in real-time and live cells, J. Cell Biol, vol.179, pp.291-304, 2007.

A. Bonnet, V. Randrianarison-huetz, P. Nzounza, M. Nedelec, M. Chazal et al., Variation in Genome-Wide NF-?B RELA Binding Sites upon Microbial Stimuli and Identification of a Virus Response Profile, J. Immunol. Baltim. Md, vol.9, pp.1295-1305, 2012.

D. Bosisio, I. Marazzi, A. Agresti, N. Shimizu, M. E. Bianchi et al., A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity, EMBO J, vol.25, pp.798-810, 2006.

M. Boxus, J. Twizere, S. Legros, J. Dewulf, R. Kettmann et al., The HTLV-1 Tax interactome, vol.5, p.76, 2008.

M. Bradl, J. Bauer, A. Flügel, H. Wekerle, and H. Lassmann, Complementary contribution of CD4 and CD8 T lymphocytes to T-cell infiltration of the intact and the degenerative spinal cord, Am. J. Pathol, vol.166, pp.1441-1450, 2005.

A. Brauweiler, J. E. Garrus, J. C. Reed, and J. K. Nyborg, Repression of Bax Gene Expression by the HTLV-I Tax Protein: Implications for Suppression of Apoptosis in Virally Infected Cells, Virology, vol.231, pp.135-140, 1997.

J. D. Brown, C. Y. Lin, Q. Duan, G. Griffin, A. Federation et al., NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis, Mol. Cell, vol.56, pp.219-231, 2014.

M. Camats, S. Guil, M. Kokolo, and M. Bach-elias, P68 RNA helicase (DDX5) alters activity of cis-and trans-acting factors of the alternative splicing of H-Ras, PloS One, vol.3, 2008.

G. Caretti, R. L. Schiltz, F. J. Dilworth, M. Di-padova, P. Zhao et al., The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation, Dev. Cell, vol.11, pp.547-560, 2006.

S. Cawley, S. Bekiranov, H. H. Ng, P. Kapranov, E. A. Sekinger et al., Unbiased Mapping of Transcription Factor Binding Sites along Human Chromosomes 21 and 22 Points to Widespread Regulation of Noncoding RNAs, Cell, vol.116, pp.499-509, 2004.

H. Chaib-mezrag, D. Lemaçon, H. Fontaine, M. Bellon, X. T. Bai et al., Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions, Mol. Cancer, vol.13, p.205, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-01092177

A. Chebel, S. Bauwens, L. Gerland, A. Belleville, I. Urbanowicz et al., Telomere uncapping during in vitro T-lymphocyte senescence, Aging Cell, vol.8, pp.52-64, 2009.

F. E. Chen, D. B. Huang, Y. Q. Chen, and G. Ghosh, Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA, Nature, vol.391, pp.410-413, 1998.

L. Chen, D. Liu, Y. Zhang, H. Zhang, and H. Cheng, The autophagy molecule Beclin 1 maintains persistent activity of NF-?B and Stat3 in HTLV-1-transformed T lymphocytes, Biochem. Biophys. Res. Commun, vol.465, pp.739-745, 2015.

M. A. Cherian, H. H. Baydoun, J. Al-saleem, N. Shkriabai, M. Kvaratskhelia et al., Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein, J. Biol. Chem, vol.290, pp.26270-26281, 2015.

S. A. Chevalier, S. Durand, A. Dasgupta, M. Radonovich, A. Cimarelli et al., The transcription profile of Tax-3 is more similar to Tax-1 than Tax-2: insights into HTLV-3 potential leukemogenic properties, PloS One, vol.7, p.41003, 2012.
URL : https://hal.archives-ouvertes.fr/hal-02322767

S. A. Chevalier, J. Turpin, A. Cachat, P. V. Afonso, A. Gessain et al., Gem-Induced Cytoskeleton Remodeling Increases Cellular Migration of HTLV-1-Infected Cells, Formation of Infected-to-Target T-Cell Conjugates and Viral Transmission, PLOS Pathog, vol.10, p.1003917, 2014.
URL : https://hal.archives-ouvertes.fr/pasteur-01380784

Y. Ching, S. Chan, K. Jeang, J. , and D. , The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication, Nat. Cell Biol, vol.8, pp.717-724, 2006.

W. Cho, M. Zhou, M. K. Jang, K. Huang, S. Jeong et al., Modulation of the Brd4/P-TEFb interaction by the human T-lymphotropic virus type 1 tax protein, J. Virol, vol.81, pp.11179-11186, 2007.

R. K. Chodavarapu, S. Feng, Y. V. Bernatavichute, P. Chen, H. Stroud et al., Relationship between nucleosome positioning and DNA methylation, Nature, vol.466, pp.388-392, 2010.

E. L. Clark, A. Coulson, C. Dalgliesh, P. Rajan, S. M. Nicol et al., The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer, Cancer Res, vol.68, pp.7938-7946, 2008.

I. Clerc, N. Polakowski, C. André-arpin, P. Cook, B. Barbeau et al., An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the downregulation of tax-dependent viral transcription by HBZ, J. Biol. Chem, vol.283, pp.23903-23913, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00319711

L. B. Cook, A. G. Rowan, A. Melamed, G. P. Taylor, and C. R. Bangham, HTLV-1-infected T cells contain a single integrated provirus in natural infection, Blood, vol.120, pp.3488-3490, 2012.

L. B. Cook, A. Melamed, H. Niederer, M. Valganon, D. Laydon et al., The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma, Blood, vol.123, pp.3925-3931, 2014.

D. E. Coulter and A. Greenleaf, A Mutation in the Largest Subuniotf RNA Polymerase I1

, Alters RNA Chain Elongationin Vitro, vol.9

P. Cramer, C. G. Pesce, F. E. Baralle, and A. R. Kornblihtt, Functional association between promoter structure and transcript alternative splicing, Proc. Natl. Acad. Sci. U. S. A, vol.94, pp.11456-11460, 1997.

P. Cramer, J. F. Cáceres, D. Cazalla, S. Kadener, A. F. Muro et al., Coupling of Transcription with Alternative Splicing: RNA Pol II Promoters Modulate SF2/ASF and 9G8 Effects on an Exonic Splicing Enhancer, Mol. Cell, vol.4, pp.251-258, 1999.

E. Dardenne, M. Polay-espinoza, L. Fattet, S. Germann, M. Lambert et al., RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation, Cell Rep, vol.7, pp.1900-1913, 2014.

M. Das, A. Renganathan, S. N. Dighe, U. Bhaduri, A. Shettar et al., DDX5/p68 associated lncRNA LOC284454 is differentially expressed in human cancers and modulates gene expression, RNA Biol, vol.15, pp.214-230, 2018.

B. N. Davis, A. C. Hilyard, P. H. Nguyen, G. Lagna, and A. Hata, Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha, Mol. Cell, vol.39, pp.373-384, 2010.

J. Dittmer, C. A. Pise-masison, K. E. Clemens, K. S. Choi, and J. N. Brady, Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter, J. Biol. Chem, vol.272, pp.4953-4958, 1997.

R. I. Ducu, T. Dayaram, and S. J. Marriott, The HTLV-1 Tax oncoprotein represses Ku80 gene expression, Virology, vol.416, pp.1-8, 2011.

G. Dujardin, C. Lafaille, M. De-la-mata, L. E. Marasco, M. J. Muñoz et al., How slow RNA polymerase II elongation favors alternative exon skipping, Mol. Cell, vol.54, pp.683-690, 2014.

S. S. Durkin, X. Guo, K. A. Fryrear, V. T. Mihaylova, S. K. Gupta et al., HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase, J. Biol. Chem, vol.283, pp.36311-36320, 2008.

D. Edwards, C. Fenizia, H. Gold, M. F. De-castro-amarante, C. Buchmann et al., Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence, Viruses, vol.3, pp.861-885, 2011.

L. Einsiedel, R. J. Woodman, M. Flynn, K. Wilson, O. Cassar et al., , 2016.

T. Human, L. J. Einsiedel, H. Pham, R. J. Woodman, C. Pepperill et al., Lymphotropic Virus type 1 infection in an Indigenous Australian population: epidemiological insights from a hospital-based cohort study, BMC Public Health, vol.16, pp.305-309, 2016.

J. Ernst, P. Kheradpour, T. S. Mikkelsen, N. Shoresh, L. D. Ward et al., Mapping and analysis of chromatin state dynamics in nine human cell types, Nature, vol.473, pp.43-49, 2011.

S. Fanucchi, Y. Shibayama, S. Burd, M. S. Weinberg, and M. M. Mhlanga, , 2013.

, Chromosomal Contact Permits Transcription between Coregulated Genes. Cell, vol.155, pp.606-620

B. K. Felber, H. Paskalis, C. Kleinman-ewing, F. Wong-staal, and G. N. Pavlakis, , 1985.

, The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats, Science, vol.229, pp.675-679

F. Fiorini, J. Robin, J. Kanaan, M. Borowiak, V. Croquette et al., HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsensemediated mRNA decay inhibition, Nat. Commun, vol.9, p.431, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02358887

J. M. Fox, N. Mutalima, E. Molyneux, L. M. Carpenter, G. P. Taylor et al., Seroprevalence of HTLV-1 and HTLV-2 amongst mothers and children in Malawi within the context of a systematic review and meta-analysis of HTLV seroprevalence in Africa, Trop. Med. Int. Health TM IH, vol.21, pp.312-324, 2016.

J. E. Freaney, R. Kim, R. Mandhana, and C. M. Horvath, Extensive cooperation of immune master regulators IRF3 and NF?B in RNA Pol II recruitment and pause release in human innate antiviral transcription, Cell Rep, vol.4, pp.959-973, 2013.

D. Fujikawa, M. Yamagishi, S. Nakagawa, N. Kurokawa, A. Soejima et al., EZH2 dependent epigenetic landscape in adult T cell leukemia and Tax immortalized cells, J. Reprod. Immunol, vol.12, pp.197-206, 2000.

F. V. Fuller-pace, The DEAD box proteins DDX5 (p68) and DDX17 (p72): multitasking transcriptional regulators, Biochim. Biophys. Acta, vol.1829, pp.756-763, 2013.

R. Furuta, J. Yasunaga, M. Miura, K. Sugata, A. Saito et al., HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment, PLoS Pathog, vol.13, 2017.

A. Gabet, F. Mortreux, P. Charneau, P. Riou, M. Duc-dodon et al., Inactivation of hTERT transcription by Tax, Oncogene, vol.22, pp.3734-3741, 2003.

G. Gaudray, F. Gachon, J. Basbous, M. Biard-piechaczyk, C. Devaux et al., The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription, J. Virol, vol.76, pp.12813-12822, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00188771

V. Geißler, S. Altmeyer, B. Stein, H. Uhlmann-schiffler, and H. Stahl, The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA, Nucleic Acids Res, vol.41, pp.7875-7888, 2013.

S. Gelfman, N. Cohen, A. Yearim, A. , and G. , DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure, 2013.

, Genome Res, vol.23, pp.789-799

S. Germann, L. Gratadou, E. Zonta, E. Dardenne, B. Gaudineau et al., Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor, Oncogene, vol.31, pp.4536-4549, 2012.

A. Gessain and O. Cassar, Epidemiological Aspects and World Distribution of HTLV-1, Infection. Front. Microbiol, vol.3, p.388, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-01370951

A. Gessain and R. Mahieux, Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects, Rev. Neurol, vol.168, pp.257-269, 2012.

A. Gessain, F. Barin, J. C. Vernant, O. Gout, L. Maurs et al., Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis, Lancet Lond. Engl, vol.2, pp.407-410, 1985.

A. Gessain, O. Cassar, and D. Domanovic, and Europäisches Zentrum für die Prävention und die Kontrolle von Krankheiten, 2015.

D. Ghez, Y. Lepelletier, S. Lambert, J. Fourneau, V. Blot et al., Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry, J. Virol, vol.80, pp.6844-6854, 2006.

G. Ghosh, V. Y. Wang, .. Huang, D. Fusco, and A. , NF-?B regulation: lessons from structures, Immunol. Rev, vol.246, pp.36-58, 2012.

C. Z. Giam and Y. L. Xu, HTLV-I tax gene product activates transcription via preexisting cellular factors and cAMP responsive element, J. Biol. Chem, vol.264, pp.15236-15241, 1989.

N. A. Gillet, N. Malani, A. Melamed, N. Gormley, R. Carter et al., The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones, Blood, vol.117, pp.3113-3122, 2011.

G. Giraud, S. Terrone, and C. F. Bourgeois, Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation, BMB Rep, vol.51, pp.613-622, 2018.

D. U. Gonçalves, F. A. Proietti, J. G. Ribas, M. G. Araújo, S. R. Pinheiro et al., Epidemiology, treatment, and prevention of human Tcell leukemia virus type 1-associated diseases, Clin. Microbiol. Rev, vol.23, pp.577-589, 2010.

I. Gonzalez, R. Munita, E. Agirre, T. A. Dittmer, K. Gysling et al., A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature, Nat. Struct. Mol. Biol, vol.22, pp.370-376, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01153122

W. W. Greenwald, H. Li, P. Benaglio, D. Jakubosky, H. Matsui et al., Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression, Nat. Commun, vol.10, p.1054, 2019.

R. I. Gregory, K. Yan, G. Amuthan, T. Chendrimada, B. Doratotaj et al., The Microprocessor complex mediates the genesis of microRNAs, Nature, vol.432, pp.235-240, 2004.

C. Gross and A. K. Thoma-kress, Molecular Mechanisms of HTLV-1 Cell-to-Cell Transmission, Viruses, vol.8, p.74, 2016.

A. Grover, H. Houlden, M. Baker, J. Adamson, J. Lewis et al., 5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10, J. Biol. Chem, vol.274, pp.15134-15143, 1999.

F. Q. Gunderson, J. , and T. L. , Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assembly, PLoS Genet, vol.5, p.1000682, 2009.

H. Häcker, K. , and M. , Regulation and Function of IKK and IKK-Related Kinases, Sci STKE, pp.13-13, 2006.

K. Haller, Y. Wu, E. Derow, I. Schmitt, K. Jeang et al., Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein, Mol. Cell. Biol, vol.22, pp.3327-3338, 2002.

H. Han, U. Braunschweig, T. Gonatopoulos-pournatzis, R. J. Weatheritt, C. L. Hirsch et al., , 2017.

, Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors, Mol. Cell, vol.65, pp.539-553

J. Han, D. Kim, and K. V. Morris, Promoter-associated RNA is required for RNAdirected transcriptional gene silencing in human cells, Proc. Natl. Acad. Sci, vol.104, pp.12422-12427, 2007.

E. W. Harhaj, L. Good, G. Xiao, and S. C. Sun, Gene expression profiles in HTLV-Iimmortalized T cells: deregulated expression of genes involved in apoptosis regulation, Oncogene, vol.18, pp.1341-1349, 1999.

M. S. Hayden and S. Ghosh, Signaling to NF-?B, Genes Dev, vol.18, pp.2195-2224, 2004.

P. Heger, O. Rosorius, J. Hauber, and R. H. Stauber, Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 rex mutants, Oncogene, vol.18, pp.4080-4090, 1999.

W. F. Hickey, B. L. Hsu, and H. Kimura, T-lymphocyte entry into the central nervous system, J. Neurosci. Res, vol.28, pp.254-260, 1991.

M. Hidaka, J. Inoue, M. Yoshida, and M. Seiki, Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins, EMBO J, vol.7, pp.519-523, 1988.

M. Hiller, Z. Zhang, R. Backofen, and S. Stamm, Pre-mRNA secondary structures influence exon recognition, PLoS Genet, vol.3, p.204, 2007.

P. Hivin, G. Gaudray, C. Devaux, and J. Mesnard, Interaction between C/EBPbeta and Tax down-regulates human T-cell leukemia virus type I transcription, Virology, vol.318, pp.556-565, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00188432

C. Hodges, L. Bintu, L. Lubkowska, M. Kashlev, and C. Bustamante, Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II, Science, vol.325, pp.626-628, 2009.

A. Hönig, D. Auboeuf, M. M. Parker, B. W. O'malley, and S. M. Berget, Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72, Mol. Cell. Biol, vol.22, pp.5698-5707, 2002.

J. Hsin and J. L. Manley, The RNA polymerase II CTD coordinates transcription and RNA processing, Genes Dev, vol.26, pp.2119-2137, 2012.

T. T. Huang and S. Miyamoto, Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha, Mol. Cell. Biol, vol.21, pp.4737-4747, 2001.

J. Huang, T. Ren, H. Guan, Y. Jiang, and H. Cheng, HTLV-1 Tax Is a Critical Lipid Raft Modulator That Hijacks I?B Kinases to the Microdomains for Persistent Activation of NF-?B, J. Biol. Chem, vol.284, pp.6208-6217, 2009.

Q. Huang, Z. Niu, J. Han, X. Liu, Z. Lv et al.,

, HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-?B signaling, Oncotarget, vol.8, pp.51123-51133

N. Hug, D. Longman, and J. F. Cáceres, Mechanism and regulation of the nonsensemediated decay pathway, Nucleic Acids Res, vol.44, pp.1483-1495, 2016.

T. Igakura, J. C. Stinchcombe, P. K. Goon, G. P. Taylor, J. N. Weber et al., Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton, Science, vol.299, pp.1713-1716, 2003.

S. Inaba, K. Okochi, H. Sato, K. Fukada, N. Kinukawa et al., Efficacy of donor screening for HTLV-I and the natural history of transfusion-transmitted infection, Transfusion, vol.39, pp.1104-1110, 1999.

K. Ishitsuka and K. Tamura, Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma, Lancet Oncol, vol.15, pp.517-526, 2014.

R. Iwanaga, K. Ohtani, T. Hayashi, and M. Nakamura, Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I, Oncogene, vol.20, pp.2055-2067, 2001.

R. Iwanaga, E. Ozono, J. Fujisawa, M. A. Ikeda, N. Okamura et al., Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cellcycle progression induced by HTLV-I Tax, Oncogene, vol.27, pp.5635-5642, 2008.

Y. Iwasaki, Human T cell leukemia virus type I infection and chronic myelopathy, Brain Pathol. Zurich Switz, vol.3, pp.1-10, 1993.

M. G. Izban and D. S. Luse, Transcription on nucleosomal templates by RNA polymerase II in vitro: inhibition of elongation with enhancement of sequence-specific pausing, Genes Dev, vol.5, pp.683-696, 1991.

D. A. Jackson, A. B. Hassan, R. J. Errington, and P. R. Cook, Visualization of focal sites of transcription within human nuclei, EMBO J, vol.12, pp.1059-1065, 1993.

A. F. Jacobs, S. M. Nicol, R. G. Hislop, E. G. Jaffray, R. T. Hay et al., SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1, Oncogene, vol.26, pp.5866-5876, 2007.

K. T. Jeang, S. G. Widen, O. J. Semmes, and S. H. Wilson, HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene, Science, vol.247, pp.1082-1084, 1990.

K. J. Jeffery, K. Usuku, S. E. Hall, W. Matsumoto, G. P. Taylor et al., HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy, Proc. Natl. Acad. Sci. U. S. A, vol.96, pp.3848-3853, 1999.

E. D. Jensen, L. Niu, G. Caretti, S. M. Nicol, N. Teplyuk et al., p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation, J. Cell. Biochem, vol.103, pp.1438-1451, 2008.

D. Y. Jin, F. Spencer, and K. T. Jeang, Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1, Cell, vol.93, pp.81-91, 1998.

F. Jin, Y. Li, J. R. Dixon, S. Selvaraj, Z. Ye et al., A high-resolution map of the three-dimensional chromatin interactome in human cells, Nature, vol.503, pp.290-294, 2013.

C. Johnson, D. Van-antwerp, and T. J. Hope, An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha, EMBO J, vol.18, pp.6682-6693, 1999.

K. S. Jones, C. Petrow-sadowski, D. C. Bertolette, Y. Huang, and F. W. Ruscetti, , 2005.

, Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells, J. Virol, vol.79, pp.12692-12702

C. Jung, G. Mittler, F. Oswald, and T. Borggrefe, RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway, Biochim. Biophys. Acta BBA -Mol. Cell Res, vol.1833, pp.1180-1189, 2013.

M. H. Kagey, J. J. Newman, S. Bilodeau, Y. Zhan, D. A. Orlando et al., Mediator and cohesin connect gene expression and chromatin architecture, Nature, vol.467, pp.430-435, 2010.

A. Kar, K. Fushimi, X. Zhou, P. Ray, C. Shi et al., RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site, Mol. Cell. Biol, vol.31, pp.1812-1821, 2011.

K. Kataoka, Y. Nagata, A. Kitanaka, Y. Shiraishi, T. Shimamura et al., Integrated molecular analysis of adult T cell leukemia/lymphoma, Nat. Genet, vol.47, pp.1304-1315, 2015.

J. D. Kearns, S. Basak, S. L. Werner, C. S. Huang, and A. Hoffmann, IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression, J. Cell Biol, vol.173, pp.659-664, 2006.

K. Kehn, C. Fuente, K. Strouss, R. Berro, H. Jiang et al., The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation, Oncogene, vol.24, pp.525-540, 2005.

K. V. Kibler and K. T. Jeang, CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein, J. Virol, vol.75, pp.2161-2173, 2001.

P. D. Kirk, M. Huvet, A. Melamed, G. N. Maertens, and C. R. Bangham, , 2016.

P. Kolovos, T. Georgomanolis, A. Koeferle, J. D. Larkin, L. Brant et al., Binding of nuclear factor ?B to noncanonical consensus sites reveals its multimodal role during the early inflammatory response, Nat. Microbiol, vol.2, pp.1478-1489, 2016.

Y. Koyanagi, Y. Itoyama, N. Nakamura, K. Takamatsu, J. Kira et al., In vivo infection of human T-cell leukemia virus type I in non-T cells, Virology, vol.196, pp.25-33, 1993.

D. Krappmann and C. Scheidereit, A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways, EMBO Rep, vol.6, pp.321-326, 2005.

A. Kuhlmann, J. Villaudy, L. Gazzolo, M. Castellazzi, J. Mesnard et al., HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT), Retrovirology, vol.4, p.92, 2007.
URL : https://hal.archives-ouvertes.fr/hal-02152798

Y. Kuo and C. Giam, Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence, EMBO J, vol.25, pp.1741-1752, 2006.

D. Kurita, J. Yasunaga, A. Tanaka, M. Mohamed, and M. Matsuoka, Dynamic Changes of Chromatin Structure and Transcriptome By Transient Expression of HTLV-1 Tax in ATL Cells, Blood, vol.132, pp.4094-4094, 2018.

C. De-la-fuente, L. Deng, F. Santiago, L. Arce, L. Wang et al., Gene expression array of HTLV type 1-infected T cells: Up-regulation of transcription factors and cell cycle genes, AIDS Res. Hum. Retroviruses, vol.16, pp.1695-1700, 2000.

K. J. Ladner, M. A. Caligiuri, and D. C. Guttridge, Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products, J. Biol. Chem, vol.278, pp.2294-2303, 2003.

M. D. Lairmore and G. Franchini, Human T-cell Leukemia Virus Types 1 and 2. Fields Virol. Phila, Wolters Kluwer Health, vol.2, pp.2071-2105, 2007.

M. Lambert, S. Terrone, G. Giraud, C. Benoit-pilven, D. Cluet et al., The RNA helicase DDX17 controls the transcriptional activity of REST and the expression of proneural microRNAs in neuronal differentiation, Nucleic Acids Res, vol.46, pp.7686-7700, 2018.

J. A. Latham and S. Y. Dent, Cross-regulation of histone modifications, Nat. Struct. Mol. Biol, vol.14, pp.1017-1024, 2007.

A. Lavorgna, M. Matsuoka, and E. W. Harhaj, A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-?B Activation and T-Cell Transformation, PLoS Pathog, vol.10, 2014.

L. Blanc, I. Grange, M. P. Delamarre, L. Rosenberg, A. R. Blot et al., HTLV-1 structural proteins, Virus Res, vol.78, pp.5-16, 2001.

D. K. Lee, B. Kim, J. N. Brady, K. Jeang, and S. Kim, Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element, J. Biol. Chem, vol.277, pp.33766-33775, 2002.

I. Lemasson, M. R. Lewis, N. Polakowski, P. Hivin, M. Cavanagh et al., Human T-cell leukemia virus type 1 (HTLV-1) bZIP protein interacts with the cellular transcription factor CREB to inhibit HTLV-1 transcription, J. Virol, vol.81, pp.1543-1553, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00188402

F. J. Lemoine, S. Kao, and S. J. Marriott, Suppression of DNA Repair by HTLV Type 1 Tax Correlates with Tax trans-Activation of Proliferating Cell Nuclear Antigen Gene Expression, AIDS Res. Hum. Retroviruses, vol.16, pp.1623-1627, 2000.

K. Leung and G. J. Nabel, HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor, Nature, vol.333, pp.776-778, 1988.

T. H. Leung, A. Hoffmann, and D. Baltimore, One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers, Cell, vol.118, pp.453-464, 2004.

G. Li, X. Ruan, R. K. Auerbach, K. S. Sandhu, M. Zheng et al., Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation, Cell, vol.148, pp.84-98, 2012.

L. Li, Y. Song, X. Shi, J. Liu, S. Xiong et al., The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting, Genome Res, vol.28, pp.132-143, 2018.

C. Lim, F. Yao, J. J. Wong, .. George, J. Xu et al., Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation, Mol. Cell, vol.27, pp.622-635, 2007.

C. Lin, L. Yang, J. J. Yang, Y. Huang, and Z. Liu, ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome, Mol. Cell. Biol, vol.25, pp.7484-7493, 2005.

B. Liu, S. Hong, Z. Tang, H. Yu, and C. Giam, HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.63-68, 2005.

B. Liu, L. Sun, Q. Liu, C. Gong, Y. Yao et al., A Cytoplasmic NF-?B Interacting Long Noncoding RNA Blocks I?B Phosphorylation and Suppresses Breast Cancer Metastasis, Cancer Cell, vol.27, pp.370-381, 2015.

J. Lodewick, I. Lamsoul, A. Polania, S. Lebrun, A. Burny et al., , 2009.

, Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-?B pathway, Virology, vol.386, pp.68-78

H. Lu, C. A. Pise-masison, T. M. Fletcher, R. L. Schiltz, A. K. Nagaich et al., Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template, Mol. Cell. Biol, vol.22, pp.4450-4462, 2002.

R. F. Luco, Q. Pan, K. Tominaga, B. J. Blencowe, O. M. Pereira-smith et al., Regulation of alternative splicing by histone modifications, Science, vol.327, pp.996-1000, 2010.

J. R. Lundblad, R. P. Kwok, M. E. Laurance, M. S. Huang, J. P. Richards et al., The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove, J. Biol. Chem, vol.273, pp.19251-19259, 1998.

H. Macaire, A. Riquet, V. Moncollin, M. Biémont-trescol, M. D. Dodon et al., Tax Protein-induced Expression of Antiapoptotic Bfl-1 Protein Contributes to Survival of Human T-cell Leukemia Virus Type 1 (HTLV-1)-infected T-cells, J. Biol. Chem, vol.287, pp.21357-21370, 2012.
URL : https://hal.archives-ouvertes.fr/ensl-00807696

S. E. Macatonia, J. K. Cruickshank, P. Rudge, and S. C. Knight, Dendritic cells from patients with tropical spastic paraparesis are infected with HTLV-1 and stimulate autologous lymphocyte proliferation, AIDS Res. Hum. Retroviruses, vol.8, pp.1699-1706, 1992.

M. Mahgoub, J. Yasunaga, S. Iwami, S. Nakaoka, Y. Koizumi et al., Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells, Proc. Natl. Acad. Sci. U. S. A, vol.115, pp.1269-1278, 2018.

N. Manel, F. J. Kim, S. Kinet, N. Taylor, M. Sitbon et al., The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV, Cell, vol.115, pp.449-459, 2003.
URL : https://hal.archives-ouvertes.fr/hal-02199825

L. M. Mansky, In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy, J. Virol, vol.74, pp.9525-9531, 2000.

X. Mao, Z. Su, and A. K. Mookhtiar, Long non-coding RNA: a versatile regulator of the nuclear factor-jB signalling circuit, vol.10, 2016.

R. J. Marina, D. Sturgill, M. A. Bailly, M. Thenoz, G. Varma et al., TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing, EMBO J, vol.35, pp.335-355, 2016.

J. M. Mariner, V. Lantz, T. A. Waldmann, A. , and N. , Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site, J. Immunol. Baltim. Md, vol.166, pp.2602-2609, 1950.

R. Martone, G. Euskirchen, P. Bertone, S. Hartman, T. E. Royce et al., Distribution of NF-kappaB-binding sites across human chromosome 22, Proc. Natl. Acad. Sci. U. S. A, vol.100, pp.12247-12252, 2003.

M. De-la-mata and A. R. Kornblihtt, RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20, Nat. Struct. Mol. Biol, vol.13, pp.973-980, 2006.

M. De-la-mata, C. R. Alonso, S. Kadener, J. P. Fededa, M. Blaustein et al., A Slow RNA Polymerase II Affects Alternative Splicing In Vivo, Mol. Cell, vol.12, pp.525-532, 2003.

J. Matsumoto, T. Ohshima, O. Isono, and K. Shimotohno, HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein, Oncogene, vol.24, pp.1001-1010, 2005.

M. Matsuoka, Y. , and J. , Human T-cell leukemia virus type 1: replication, proliferation and propagation by Tax and HTLV-1 bZIP factor, Curr. Opin. Virol, vol.3, pp.684-691, 2013.

E. Matsuoka, K. Usuku, M. Jonosono, N. Takenouchi, S. Izumo et al., CD44 splice variant involvement in the chronic inflammatory disease of the spinal cord: HAM/TSP, J. Neuroimmunol, vol.102, pp.1-7, 2000.

A. K. Maunakea, I. Chepelev, K. Cui, and K. Zhao, Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition, Cell Res, vol.23, pp.1256-1269, 2013.

A. Mazurek, W. Luo, A. Krasnitz, J. Hicks, R. S. Powers et al., , p.5, 2012.

, Regulates DNA Replication And Is Required For Cell Proliferation In A Subset Of Breast Cancer Cells, Cancer Discov, vol.2, pp.812-825

K. N. Meekings, J. Leipzig, F. D. Bushman, G. P. Taylor, and C. R. Bangham, , 2008.

, HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP, PLoS Pathog, vol.4, p.1000027

A. Melamed, D. J. Laydon, N. A. Gillet, Y. Tanaka, G. P. Taylor et al.,

, Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection, PLoS Pathog, vol.9, p.1003271

A. Melamed, H. Yaguchi, M. Miura, A. Witkover, T. W. Fitzgerald et al., The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis, vol.7, p.36245, 2018.

T. R. Mercer, S. L. Edwards, M. B. Clark, S. J. Neph, H. Wang et al., DNase I-hypersensitive exons colocalize with promoters and distal regulatory elements, Nat. Genet, vol.45, pp.852-859, 2013.

Y. Mitobe, J. Yasunaga, R. Furuta, and M. Matsuoka, HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival, Cancer Res, vol.75, pp.4143-4152, 2015.

V. Mocquet, J. Neusiedler, F. Rende, D. Cluet, J. Robin et al., The Human T-Lymphotropic Virus Type 1, 2012.

, Tax Protein Inhibits Nonsense-Mediated mRNA Decay by Interacting with INT6/EIF3E and UPF1, J. Virol, vol.86, pp.7530-7543

S. M. Mooney, J. P. Grande, J. L. Salisbury, J. , and R. , Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential, Biochemistry, vol.49, pp.1-10, 2010.

S. L. Morgan, N. C. Mariano, A. Bermudez, N. L. Arruda, F. Wu et al., Manipulation of nuclear architecture through CRISPRmediated chromosomal looping, Nat. Commun, vol.8, p.15993, 2017.

N. Mori, S. Murakami, S. Oda, and S. Eto, Human T-cell leukemia virus type I tax induces intracellular adhesion molecule-1 expression in T cells, Blood, vol.84, pp.350-351, 1994.

N. Mori, M. Fujii, S. Ikeda, Y. Yamada, M. Tomonaga et al., Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells, Blood, vol.93, pp.2360-2368, 1999.

N. Mori, M. Fujii, G. Cheng, S. Ikeda, Y. Yamasaki et al., Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways, Virus Genes, vol.22, pp.279-287, 2001.

N. Mori, M. Morishita, T. Tsukazaki, C. Z. Giam, A. Kumatori et al., Human T-cell leukemia virus type I oncoprotein Tax represses Smaddependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300, Blood, vol.97, pp.2137-2144, 2001.

N. Mori, Y. Yamada, S. Ikeda, Y. Yamasaki, K. Tsukasaki et al., Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells, Blood, vol.100, pp.1828-1834, 2002.

F. Mortreux, I. Leclercq, A. S. Gabet, A. Leroy, E. Westhof et al., Somatic mutation in human T-cell leukemia virus type 1 provirus and flanking cellular sequences during clonal expansion in vivo, J. Natl. Cancer Inst, vol.93, pp.367-377, 2001.
URL : https://hal.archives-ouvertes.fr/hal-00117199

A. Mühleisen, M. Giaisi, R. Köhler, P. H. Krammer, L. et al., Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression, Cell Death Dis, vol.5, p.1575, 2014.

S. Naftelberg, I. E. Schor, G. Ast, and A. R. Kornblihtt, Regulation of alternative splicing through coupling with transcription and chromatin structure, Annu. Rev. Biochem, vol.84, pp.165-198, 2015.

K. Nagafuji, M. Harada, T. Teshima, T. Eto, Y. Takamatsu et al., Hematopoietic progenitor cells from patients with adult Tcell leukemia-lymphoma are not infected with human T-cell leukemia virus type 1, Blood, vol.82, pp.2823-2828, 1993.

M. Nagai, M. B. Brennan, J. A. Sakai, C. A. Mora, and S. Jacobson, CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I, Blood, vol.98, pp.1858-1861, 2001.

R. Nasr, E. Chiari, M. El-sabban, R. Mahieux, Y. Kfoury et al., Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation, Blood, vol.107, pp.4021-4029, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00018768

M. Nejmeddine and C. R. Bangham, The HTLV-1 Virological Synapse. Viruses, vol.2, pp.1427-1447, 2010.

M. Nejmeddine, A. L. Barnard, Y. Tanaka, G. P. Taylor, and C. R. Bangham, , 2005.

, Human T-lymphotropic virus, type 1, tax protein triggers microtubule reorientation in the virological synapse, J. Biol. Chem, vol.280, pp.29653-29660

M. Nejmeddine, V. S. Negi, S. Mukherjee, Y. Tanaka, K. Orth et al., HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the microtubule-organizing center at the virological synapse, Blood, vol.114, pp.1016-1025, 2009.

C. Nicot, HTLV-I Tax-Mediated Inactivation of Cell Cycle Checkpoints and DNA Repair Pathways Contribute to Cellular Transformation: "A Random Mutagenesis Model, J. Cancer Sci, vol.2, 2015.

C. Nicot, R. Opavsky, R. Mahieux, J. M. Johnson, J. N. Brady et al., Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells, AIDS Res. Hum. Retroviruses, vol.16, pp.1629-1632, 2000.

C. Nicot, M. Dundr, J. M. Johnson, J. R. Fullen, N. Alonzo et al., HTLV-1-encoded p30II is a posttranscriptional negative regulator of viral replication, Nat. Med, vol.10, pp.197-201, 2004.

T. Nojima, K. Rebelo, T. Gomes, A. R. Grosso, N. J. Proudfoot et al.,

, RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing, Mol. Cell, vol.72, pp.369-379

A. Okayama, S. Stuver, M. Iga, M. Okamoto, N. Mueller et al., Sequential change of virus markers in seroconverters with community-acquired infection of human T lymphotropic virus type I, J. Infect. Dis, vol.183, pp.1031-1037, 2001.

C. S. Osborne, L. Chakalova, K. E. Brown, D. Carter, A. Horton et al., Active genes dynamically colocalize to shared sites of ongoing transcription, Nat. Genet, vol.36, pp.1065-1071, 2004.

A. Pais-correia, M. Sachse, S. Guadagnini, V. Robbiati, R. Lasserre et al., Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses, Nat. Med, vol.16, pp.83-89, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-00460124

A. Paiva and J. Casseb, Sexual transmission of human T-cell lymphotropic virus type 1, Rev. Soc. Bras. Med. Trop, vol.47, pp.265-274, 2014.

A. Papantonis, J. D. Larkin, Y. Wada, Y. Ohta, S. Ihara et al.,

, Active RNA Polymerases: Mobile or Immobile Molecular Machines?, PLoS Biol, vol.8, p.1000419

A. Papantonis, T. Kohro, S. Baboo, J. D. Larkin, B. Deng et al., TNF? signals through specialized factories where responsive coding and miRNA genes are transcribed: Specialized transcription factories, EMBO J, vol.31, pp.4404-4414, 2012.

J. Peloponese and K. Jeang, Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein, J. Biol. Chem, vol.281, pp.8927-8938, 2006.
URL : https://hal.archives-ouvertes.fr/hal-02137889

J. Peloponese, K. Haller, A. Miyazato, and K. Jeang, Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.18974-18979, 2005.
URL : https://hal.archives-ouvertes.fr/hal-02137892

S. Pène, L. Waast, A. Bonnet, L. Bénit, and C. Pique, A Non-SUMOylated Tax Protein Is Still Functional for NF-?B Pathway Activation, J. Virol, vol.88, pp.10655-10661, 2014.

L. Petropoulos, R. Lin, and J. Hiscott, Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein, Virology, vol.225, pp.52-64, 1996.

A. A. Phillips and J. C. Harewood, Adult T Cell Leukemia-Lymphoma (ATL): State of the Art, Curr. Hematol. Malig. Rep, vol.13, pp.300-307, 2018.

E. H. Phillips, A. Hodson, O. Hermine, A. Bazarbachi, and K. Cwynarski, Striving to cure adult T-cell leukaemia/lymphoma: a role for allogeneic stem cell transplant?, Bone Marrow Transplant, vol.51, pp.1549-1555, 2016.

C. Pique and K. S. Jones, Pathways of cell-cell transmission of HTLV-1, Front. Microbiol, vol.3, 2012.

C. Pique, A. Ureta-vidal, A. Gessain, B. Chancerel, O. Gout et al., Evidence for the Chronic in Vivo Production of Human T Cell Leukemia Virus Type I Rof and Tof Proteins from Cytotoxic T Lymphocytes Directed against Viral Peptides, J. Exp. Med, vol.191, pp.567-572, 2000.

B. R. Pires, R. C. Silva, G. M. Ferreira, A. , and E. , NF-kappaB: Two Sides of the Same Coin, Genes, vol.9, 2018.

C. A. Pise-masison, R. Mahieux, H. Jiang, M. Ashcroft, M. Radonovich et al., Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-?B Pathway and Is Dependent on p53 Phosphorylation, Mol. Cell. Biol, vol.20, pp.3377-3386, 2000.

C. A. Pise-masison, M. Radonovich, R. Mahieux, P. Chatterjee, C. Whiteford et al., Transcription Profile of Cells Infected with Human T-cell Leukemia Virus Type I Compared with Activated Lymphocytes, Cancer Res, vol.62, pp.3562-3571, 2002.

B. J. Poiesz, F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna et al., , 1980.

, Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proc. Natl. Acad. Sci. U. S. A, vol.77, pp.7415-7419

M. M. Pradeepa, H. G. Sutherland, J. Ule, G. R. Grimes, and W. A. Bickmore, , 2012.

, Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing, PLoS Genet, vol.8, p.1002717

F. A. Proietti, A. B. Carneiro-proietti, B. C. Catalan-soares, and E. L. Murphy, , 2005.

, Global epidemiology of HTLV-I infection and associated diseases, Oncogene, vol.24, pp.6058-6068

J. Rappsilber, U. Ryder, A. I. Lamond, and M. Mann, Large-scale proteomic analysis of the human spliceosome, Genome Res, vol.12, pp.1231-1245, 2002.

F. Rayne, A. V. Kajava, J. Lalanne, and R. Z. Mamoun, In vivo homodimerisation of HTLV-1 Gag and MA gives clues to the retroviral capsid and TM envelope protein arrangement, J. Mol. Biol, vol.343, pp.903-916, 2004.

T. Ren, Y. Takahashi, X. Liu, T. P. Loughran, S. Sun et al., HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains, Oncogene, vol.34, pp.334-345, 2015.

J. H. Richardson, A. J. Edwards, J. K. Cruickshank, P. Rudge, and A. G. Dalgleish, In vivo cellular tropism of human T-cell leukemia virus type 1, J. Virol, vol.64, pp.5682-5687, 1990.

D. Rieder, Z. Trajanoski, J. G. Mcnally, and L. Ratner, Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone, J. Virol, vol.73, pp.4856-4865, 1999.

R. F. Roscigno and M. A. Garcia-blanco, SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome, RNA, vol.1, pp.692-706, 1995.

N. Rosewick, K. Durkin, M. Artesi, A. Marçais, V. Hahaut et al., Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis, Nat. Commun, vol.8, p.15264, 2017.

K. L. Rossow, J. , and R. , Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300, Oncogene, vol.22, pp.151-156, 2003.

F. Rouet, R. Rabier, C. Foucher, B. Chancerel, F. Agis et al., Geographical clustering of human T-cell lymphotropic virus type I in Guadeloupe, an endemic Caribbean area, Int. J. Cancer, vol.81, pp.330-334, 1999.

S. Ruben, H. Poteat, T. H. Tan, K. Kawakami, R. Roeder et al., Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product, Science, vol.241, pp.89-92, 1988.

M. Ruiz-velasco, M. Kumar, M. C. Lai, P. Bhat, A. B. Solis-pinson et al., CTCF-Mediated Chromatin Loops between Promoter and Gene Body Regulate Alternative Splicing across Individuals, Cell Syst, vol.5, pp.628-637, 2017.

A. W. Rushing, K. Hoang, N. Polakowski, and I. Lemasson, The Human T-Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor Attenuates Repair of Double-Stranded DNA Breaks via Nonhomologous End Joining, J. Virol, vol.92, 2018.

S. Saccani, S. Pantano, and G. Natoli, Modulation of NF-?B Activity by Exchange of Dimers, Mol. Cell, vol.11, pp.1563-1574, 2003.

V. Saint-andré, E. Batsché, C. Rachez, and C. Muchardt, Histone H3 lysine 9 trimethylation and HP1? favor inclusion of alternative exons, Nat. Struct. Mol. Biol, vol.18, pp.337-344, 2011.

K. Saito, M. Saito, N. Taniura, T. Okuwa, and Y. Ohara, Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells, Virology, vol.403, pp.173-180, 2010.

M. Salehi, S. K. Shokouhi-mostafavi, A. Ghasemian, M. Gholami, A. Kazemi-vardanjani et al., Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, Iran. Biomed. J, vol.21, pp.57-60, 2010.

T. Sallam, M. Jones, B. J. Thomas, X. Wu, T. Gilliland et al., Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA, Nat. Med, vol.24, pp.304-312, 2018.

S. Samaan, L. Tranchevent, E. Dardenne, M. Polay-espinoza, E. Zonta et al., The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways, Nucleic Acids Res, vol.42, pp.2197-2207, 2014.

M. Sarkar, V. Khare, and M. K. Ghosh, The DEAD box protein p68: a novel coactivator of Stat3 in mediating oncogenesis, Oncogene, vol.36, pp.3080-3093, 2017.

H. Sasaki, I. Nishikata, T. Shiraga, E. Akamatsu, T. Fukami et al., Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia, Blood, vol.105, pp.1204-1213, 2005.

Y. Satou, J. Yasunaga, M. Yoshida, and M. Matsuoka, HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells, Proc. Natl. Acad. Sci. U. S. A, vol.103, pp.720-725, 2006.

Y. Satou, A. Utsunomiya, J. Tanabe, M. Nakagawa, K. Nosaka et al., , 2012.

, HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+T cells in virus-infected individuals, Retrovirology, vol.9, p.46

M. L. Schmitz and P. A. Baeuerle, The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B, EMBO J, vol.10, pp.3805-3817, 1991.

S. Schoenfelder, T. Sexton, L. Chakalova, N. F. Cope, A. Horton et al., Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells, Nat. Genet, vol.42, pp.53-61, 2010.

I. E. Schor, N. Rascovan, F. Pelisch, M. Alló, and A. R. Kornblihtt, Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing, Proc. Natl. Acad. Sci, vol.106, pp.4325-4330, 2009.

I. E. Schor, A. Fiszbein, E. Petrillo, and A. R. Kornblihtt, Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation, EMBO J, vol.32, pp.2264-2274, 2013.

J. Schreiber, R. G. Jenner, H. L. Murray, G. K. Gerber, D. K. Gifford et al., Coordinated binding of NF-?B family members in the response of human cells to lipopolysaccharide, Proc. Natl. Acad. Sci, vol.103, pp.5899-5904, 2006.

M. Seiki, S. Hattori, Y. Hirayama, Y. , and M. , Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA, Proc. Natl. Acad. Sci. U. S. A, vol.80, pp.3618-3622, 1983.

R. Sen and D. Baltimore, Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism, Cell, vol.47, pp.921-928, 1986.

R. Shayevitch, D. Askayo, I. Keydar, A. , and G. , The Importance of DNA Methylation of Exons on Alternative Splicing, 2018.

N. Shembade, N. S. Harhaj, M. Yamamoto, S. Akira, and E. W. Harhaj, The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation, J. Virol, vol.81, pp.13735-13742, 2007.

M. Shimoyama, Diagnostic criteria and classification of clinical subtypes of adult Tcell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87), Br. J. Haematol, vol.79, pp.428-437, 1991.

S. Shin, K. L. Rossow, J. P. Grande, J. , and R. , Involvement of RNA helicases p68 and p72 in colon cancer, Cancer Res, vol.67, pp.7572-7578, 2007.

M. Shirinian, Y. Kfoury, Z. Dassouki, H. El-hajj, and A. Bazarbachi, Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-?B activation, 2013.

A. M. Shudofsky and C. Giam, Cells of adult T-cell leukemia evade HTLV-1, 2019.

, Tax/NF-?B hyperactivation-induced senescence, Blood Adv, vol.3, pp.564-569

M. Shuh and D. Derse, Ternary complex factors and cofactors are essential for human T-cell leukemia virus type 1 tax transactivation of the serum response element, J. Virol, vol.74, pp.11394-11397, 2000.

S. Shukla, E. Kavak, M. Gregory, M. Imashimizu, B. Shutinoski et al., CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing, Nature, vol.479, pp.74-79, 2011.

D. Sibon, A. Gabet, M. Zandecki, C. Pinatel, J. Thête et al., HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death, J. Clin. Invest, vol.116, pp.974-983, 2006.

R. J. Sims, S. Millhouse, C. Chen, B. A. Lewis, H. Erdjument-bromage et al., Recognition of Trimethylated Histone H3 Lysine 4, 2007.

, Facilitates the Recruitment of Transcription Post-Initiation Factors and pre-mRNA Splicing, Mol. Cell, vol.28, pp.665-676

A. Smallwood, G. C. Hon, F. Jin, R. E. Henry, J. M. Espinosa et al., CBX3 regulates efficient RNA processing genome-wide, Genome Res, vol.22, pp.1426-1436, 2012.

S. C. Sun, J. Elwood, C. Béraud, and W. C. Greene, Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene, Mol. Cell. Biol, vol.14, pp.7377-7384, 1994.

H. I. Suzuki, K. Yamagata, K. Sugimoto, T. Iwamoto, S. Kato et al., Modulation of microRNA processing by p53, Nature, vol.460, pp.529-533, 2009.

T. Suzuki, H. Hirai, Y. , and M. , Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription, Oncogene, vol.9, pp.3099-3105, 1994.

S. Takeda, M. Maeda, S. Morikawa, Y. Taniguchi, J. Yasunaga et al., Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells, Int. J. Cancer, vol.109, pp.559-567, 2004.

W. F. Tam, L. H. Lee, L. Davis, and R. Sen, Cytoplasmic Sequestration of Rel Proteins by I?B? Requires CRM1-Dependent Nuclear Export, Mol. Cell. Biol, vol.20, pp.2269-2284, 2000.

G. Tanaka, A. Okayama, T. Watanabe, S. Aizawa, S. Stuver et al., The clonal expansion of human T lymphotropic virus type 1-infected T cells: a comparison between seroconverters and long-term carriers, J. Infect. Dis, vol.191, pp.1140-1147, 2005.

M. Tatewaki, K. Yamaguchi, M. Matsuoka, T. Ishii, M. Miyasaka et al., Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax, Blood, vol.86, pp.3109-3117, 1995.

S. Tattermusch, J. A. Skinner, D. Chaussabel, J. Banchereau, M. P. Berry et al., Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy, PLoS Pathog, vol.8, p.1002480, 2012.

M. Thénoz, C. Vernin, H. Mortada, M. Karam, C. Pinatel et al., HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia, Retrovirology, vol.11, p.137, 2005.

M. Y. Tolstorukov, J. A. Goldman, C. Gilbert, V. Ogryzko, R. E. Kingston et al., Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells, Mol. Cell, vol.47, pp.596-607, 2012.

J. Tsukada, M. Misago, Y. Serino, R. Ogawa, S. Murakami et al., Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1, Blood, vol.90, pp.3142-3153, 1997.

T. Tsukahara, M. Kannagi, T. Ohashi, H. Kato, M. Arai et al., Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax, J. Virol, vol.73, pp.7981-7987, 1999.

T. Tsukahara, M. Kannagi, T. Ohashi, H. Kato, M. Arai et al., Induction of Bcl-xL Expression by Human T-Cell Leukemia Virus Type 1 Tax through NF-?B in Apoptosis-Resistant T-Cell Transfectants with Tax, J. Virol, vol.73, pp.7981-7987, 1999.

T. Uchiyama, J. Yodoi, K. Sagawa, K. Takatsuki, and H. Uchino, Adult T-cell leukemia: clinical and hematologic features of 16 cases, Blood, vol.50, pp.481-492, 1977.

K. Ueki, D. A. Fruman, S. M. Brachmann, Y. Tseng, L. C. Cantley et al., Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival, Mol. Cell. Biol, vol.22, pp.965-977, 2002.

N. Van-prooyen, H. Gold, V. Andresen, O. Schwartz, K. Jones et al., Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission, Proc. Natl. Acad. Sci. U. S. A, vol.107, pp.20738-20743, 2010.

D. Y. Vargas, K. Shah, M. Batish, M. Levandoski, S. Sinha et al., Single-Molecule Imaging of Transcriptionally Coupled and Uncoupled Splicing, Cell, vol.147, pp.1054-1065, 2011.

K. Verdonck, E. González, S. Van-dooren, A. Vandamme, G. Vanham et al., Human T-lymphotropic virus 1: recent knowledge about an ancient infection, Lancet Infect. Dis, vol.7, pp.266-281, 2007.

C. Vernin, M. Thenoz, C. Pinatel, A. Gessain, O. Gout et al., HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating OncomiRs, Cancer Res, vol.74, pp.6082-6093, 2014.
URL : https://hal.archives-ouvertes.fr/hal-02487471

K. Wäldele, K. Silbermann, G. Schneider, T. Ruckes, B. R. Cullen et al., Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes, Blood, vol.107, pp.4491-4499, 2006.

E. Wang and F. Cambi, Heterogeneous Nuclear Ribonucleoproteins H and F Regulate the Proteolipid Protein/DM20 Ratio by Recruiting U1 Small Nuclear Ribonucleoprotein through a Complex Array of G Runs, J. Biol. Chem, vol.284, pp.11194-11204, 2009.

R. Wang, Z. Jiao, R. Li, H. Yue, C. et al., p68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF-?B transcription factor p50, Neuro-Oncol, vol.14, pp.1116-1124, 2012.

W. Wang, J. Zhou, J. Shi, Y. Zhang, S. Liu et al., Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis, J. Virol, vol.88, pp.2786-2798, 2014.

D. R. Warner, V. Bhattacherjee, X. Yin, S. Singh, P. Mukhopadhyay et al., Functional interaction between Smad, CREB binding protein, and p68 RNA helicase, Biochem. Biophys. Res. Commun, vol.324, pp.70-76, 2004.

T. Watanabe, Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1-infected T cells, Blood, vol.129, pp.1071-1081, 2017.

M. Watanabe, T. Ohsugi, M. Shoda, T. Ishida, S. Aizawa et al., Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia, Blood, vol.106, pp.2462-2471, 2005.

E. Wattel, M. Cavrois, A. Gessain, and S. Wain-hobson, Clonal expansion of infected cells: a way of life for HTLV-I, J. Acquir. Immune Defic. Syndr. Hum. Retrovirology Off. Publ. Int. Retrovirology Assoc, vol.13, pp.92-99, 1996.

T. K. Weimann, C. Wagner, R. Funk, M. Goos, S. N. Wagner et al., , 2001.

, Hyaluronan-Independent Adhesion of CD44H+ and CD44v10+ Lymphocytes to Dermal Microvascular Endothelial Cells and Keratinocytes, J. Invest. Dermatol, vol.117, pp.949-957

M. S. Weinberg, L. M. Villeneuve, A. Ehsani, M. Amarzguioui, L. Aagaard et al., The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells, RNA N. Y. N, vol.12, pp.256-262, 2006.

H. Wekerle, C. Linington, H. Lassmann, and R. Meyermann, Cellular immune reactivity within the CNS, Trends Neurosci, vol.9, pp.271-277, 1986.

S. Z. Wiktor, E. J. Pate, P. S. Rosenberg, M. Barnett, P. Palmer et al., Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding, J. Hum. Virol, vol.1, pp.37-44, 1997.

B. J. Wilson, G. J. Bates, S. M. Nicol, D. J. Gregory, N. D. Perkins et al., The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner, BMC Mol. Biol, vol.5, p.11, 2004.

X. Wu and S. C. Sun, Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK, EMBO Rep, vol.8, pp.510-515, 2007.

K. Wu, M. E. Bottazzi, C. De-la-fuente, L. Deng, S. D. Gitlin et al., Protein profile of tax-associated complexes, J. Biol. Chem, vol.279, pp.495-508, 2004.

L. Xu, A. Nirwane, and Y. Yao, Basement membrane and blood-brain barrier, Stroke Vasc. Neurol, vol.4, pp.78-82, 2019.

M. Yamagishi, K. Nakano, A. Miyake, T. Yamochi, Y. Kagami et al., Polycomb-mediated loss of miR-31 activates NIK-dependent NF-?B pathway in adult T cell leukemia and other cancers, Cancer Cell, vol.21, pp.121-135, 2012.

Y. Yamano, C. J. Cohen, N. Takenouchi, K. Yao, U. Tomaru et al., , 2004.

, Complexes on CD4+ CD25+T Cells Detected by Peptide-specific, Major Histocompatibility Complexrestricted Antibodies in Patients with HTLV-I-associated Neurologic Disease, Tax11-19 Peptide-Human Histocompatibility Leukocyte Antigen A*, vol.199, pp.1367-1377

R. Yanagihara, C. L. Jenkins, S. S. Alexander, C. A. Mora, and R. M. Garruto, , 1990.

, Human T lymphotropic virus type I infection in Papua New Guinea: high prevalence among the Hagahai confirmed by western analysis, J. Infect. Dis, vol.162, pp.649-654

L. Yang, C. Lin, S. Zhao, H. Wang, and Z. Liu, Phosphorylation of p68 RNA helicase plays a role in platelet-derived growth factor-induced cell proliferation by upregulating cyclin D1 and c-Myc expression, J. Biol. Chem, vol.282, pp.16811-16819, 2007.

X. Yang, B. Huang, M. Li, A. Lamb, N. L. Kelleher et al., Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit, EMBO J, vol.28, pp.1055-1066, 2009.

H. Yao, K. Brick, Y. Evrard, T. Xiao, R. D. Camerini-otero et al., Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA, Genes Dev, vol.24, pp.2543-2555, 2010.

A. Yearim, S. Gelfman, R. Shayevitch, S. Melcer, O. Glaich et al., HP1 is involved in regulating the global impact of DNA methylation on alternative splicing, Cell Rep, vol.10, pp.1122-1134, 2015.

M. J. Yin, L. B. Christerson, Y. Yamamoto, Y. T. Kwak, S. Xu et al., HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation, Cell, vol.93, pp.875-884, 1998.

N. Yoshida and D. Chihara, Incidence of adult T-cell leukemia/lymphoma in nonendemic areas, Curr. Treat. Options Oncol, vol.16, p.7, 2015.

M. Yoshida, I. Miyoshi, and Y. Hinuma, Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease, Proc. Natl. Acad. Sci. U. S. A, vol.79, pp.2031-2035, 1982.

M. Yoshida, M. Seiki, K. Yamaguchi, and K. Takatsuki, Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease, Proc. Natl. Acad. Sci. U. S. A, vol.81, pp.2534-2537, 1984.

M. Yoshida, Y. Satou, J. Yasunaga, J. Fujisawa, and M. Matsuoka, Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZIP factor (HBZ) gene, J. Virol, vol.82, pp.9359-9368, 2008.

J. I. Young, E. P. Hong, J. C. Castle, J. Crespo-barreto, A. B. Bowman et al., Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2, Proc. Natl. Acad. Sci. U. S. A, vol.102, pp.17551-17558, 2005.

L. Zane, D. Sibon, C. Legras, J. Lachuer, A. Wierinckx et al., Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression, Virology, vol.407, pp.341-351, 2010.
URL : https://hal.archives-ouvertes.fr/pasteur-00530129

L. Zane, D. Sibon, V. Capraro, P. Galia, M. Karam et al., HTLV-1 positive and negative T cells cloned from infected individuals display telomerase and telomere genes deregulation that predominate in activated but untransformed CD4+ T cells, Int. J. Cancer, vol.131, pp.821-833, 2012.

H. Zhang, Z. Xing, S. K. Mani, B. Bancel, D. Durantel et al., RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis, Hepatol. Baltim. Md, vol.64, pp.1033-1048, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01796192

W. Zhang, J. W. Nisbet, B. Albrecht, W. Ding, F. Kashanchi et al., Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300, J. Virol, vol.75, pp.9885-9895, 2001.

Z. Zhang, A. Jones, H. Joo, D. Zhou, Y. Cao et al., USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing, Genes Dev, vol.27, pp.1581-1595, 2013.

B. Zhao, L. A. Barrera, I. Ersing, B. Willox, S. C. Schmidt et al., The NF-?B genomic landscape in lymphoblastoid B cells, Cell Rep, vol.8, pp.1595-1606, 2014.

T. Zhao, J. Yasunaga, Y. Satou, M. Nakao, M. Takahashi et al., Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB, Blood, vol.113, pp.2755-2764, 2009.

T. Zhao, Y. Satou, K. Sugata, P. Miyazato, P. L. Green et al., HTLV-1 bZIP factor enhances TGF-? signaling through p300 coactivator, Blood, vol.118, pp.1865-1876, 2011.

H. Zhi, L. Yang, Y. Kuo, Y. Ho, H. Shih et al., NF-?B hyperactivation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral antisense protein HBZ, PLoS Pathog, vol.7, p.1002025, 2011.

H. Zhong, M. J. May, E. Jimi, and S. Ghosh, The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1, Mol. Cell, vol.9, pp.625-636, 2002.

M. Zhou, H. Lu, H. Park, J. Wilson-chiru, R. Linton et al., Tax interacts with P-TEFb in a novel manner to stimulate human T-lymphotropic virus type 1 transcription, J. Virol, vol.80, pp.4781-4791, 2006.

L. J. Zhu, B. R. Holmes, N. Aronin, and M. H. Brodsky, CRISPRseek: A Bioconductor Package to Identify Target-Specific Guide RNAs for CRISPR-Cas9 Genome-Editing Systems, PLOS ONE, vol.9, 2014.

E. Zonta, D. Bittencourt, S. Samaan, S. Germann, M. Dutertre et al., , 2013.

, The RNA helicase DDX5/p68 is a key factor promoting c-fos expression at different levels from transcription to mRNA export, Nucleic Acids Res, vol.41, pp.554-564