N. Heintz, D. I. Hughes, and D. D. Ginty, The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn, Cell, vol.168, p.219, 2017.

A. Zeisel, A. B. Munoz-manchado, S. Codeluppi, P. Lonnerberg, L. Manno et al., Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq, Science, vol.347, pp.1138-1142, 2015.

K. Haenraets, G. W. Albisetti, E. Foster, and H. Wildner, Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord, J Vis Exp, 2018.

K. Haenraets, E. Foster, H. Johannssen, V. Kandra, N. Frezel et al., Spinal nociceptive circuit analysis with recombinant adeno-associated viruses: the impact of serotypes and promoters, J Neurochem, vol.142, pp.721-733, 2017.

D. Atasoy, Y. Aponte, H. H. Su, and S. M. Sternson, A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping, J Neurosci, vol.28, pp.7025-7030, 2008.

K. Anastassiadis, J. Fu, C. Patsch, S. Hu, S. Weidlich et al., Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice, Dis Model Mech, vol.2, pp.508-515, 2009.

D. G. Tervo, B. Y. Hwang, S. Viswanathan, T. Gaj, M. Lavzin et al., A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons, Neuron, vol.92, pp.372-382, 2016.

E. Foster, H. Wildner, L. Tudeau, S. Haueter, W. T. Ralvenius et al., Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch, Neuron, vol.85, pp.1289-1304, 2015.

F. F. Voigt, D. Kirschenbaum, E. Platonova, S. Pagès, R. A. Campbell et al., The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue, Biorxiv, 2019.

G. Corder, B. Ahanonu, B. F. Grewe, D. Wang, M. J. Schnitzer et al., An amygdalar neural ensemble that encodes the unpleasantness of pain, Science, vol.363, p.276, 2019.

B. F. Grewe, J. Grundemann, L. J. Kitch, J. A. Lecoq, J. G. Parker et al., Neural ensemble dynamics underlying a long-term associative memory, Nature, vol.543, pp.670-675, 2017.

D. S. Brenner, J. P. Golden, and R. W. Gereau, A novel behavioral assay for measuring cold sensation in mice, PLoS One, vol.7, p.39765, 2012.

G. J. Bennett and Y. K. Xie, A Peripheral Mononeuropathy in Rat That Produces Disorders of Pain Sensation Like Those Seen in Man, Pain, vol.33, pp.87-107, 1988.

N. Frezel, G. Kratzer, P. Verzar, J. Bürki, F. A. Weber et al., Does toe clipping for genotyping interfere with later-in-life nociception in mice?, PAIN Reports, vol.4, p.470, 2019.

D. Dubuisson and S. G. Dennis, The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats, Pain, vol.4, pp.161-174, 1977.

H. U. Zeilhofer, B. Studler, D. Arabadzisz, C. Schweizer, S. Ahmadi et al., Glycinergic neurons expressing enhanced green fluorescent protein in bacterial artificial chromosome transgenic mice, J Comp Neurol, vol.482, pp.123-141, 2005.

H. Taniguchi, M. He, P. Wu, S. Kim, R. Paik et al., A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex, Neuron, vol.71, pp.995-1013, 2011.

G. W. Albisetti, A. Ghanem, E. Foster, K. K. Conzelmann, H. U. Zeilhofer et al., Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus, J Neurosci, vol.37, pp.10358-10371, 2017.

T. Muller, H. Brohmann, A. Pierani, P. A. Heppenstall, G. R. Lewin et al., The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord, Neuron, vol.34, pp.551-562, 2002.

T. Kamiyama, H. Kameda, N. Murabe, S. Fukuda, N. Yoshioka et al., Corticospinal Tract Development and Spinal Cord Innervation Differ between Cervical and Lumbar Targets, Journal of Neuroscience, vol.35, pp.1181-1191, 2015.

X. Xu, K. D. Roby, and E. M. Callaway, Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells, J Comp Neurol, vol.518, pp.389-404, 2010.

E. M. Callaway and L. Luo, Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses, J Neurosci, vol.35, pp.8979-8985, 2015.

C. M. Constantinople and R. M. Bruno, Deep cortical layers are activated directly by thalamus, Science, vol.340, pp.1591-1594, 2013.

A. P. Tlamsa and J. C. Brumberg, Organization and morphology of thalamocortical neurons of mouse ventral lateral thalamus, Somatosens Mot Res, vol.27, pp.34-43, 2010.

S. Mcmahon, . M. Koltzenburg, D. Tracey, and D. Turk, Ascending projection systems, Wall & Melzack's Textbook of Pain, pp.187-192, 2013.

V. E. Abraira and D. D. Ginty, The sensory neurons of touch, Neuron, vol.79, pp.618-639, 2013.

X. Wang, Y. Liu, X. Li, Z. Zhang, H. Yang et al., Z. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell, vol.171, p.414, 2017.

G. W. Albisetti, M. Pagani, E. Platonova, L. Hosli, H. C. Johannssen et al., Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals, J Neurosci, vol.39, pp.2238-2250, 2019.

J. Hu, T. Huang, T. Li, Z. Guo, and L. Cheng, c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections, J Neurosci, vol.32, pp.5362-5373, 2012.

D. Barrio, M. G. Bourane, S. Grossmann, K. Schule, R. Britsch et al., A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord, PLoS One, vol.8, p.77928, 2013.

H. U. Zeilhofer, D. Benke, and G. E. Yevenes, Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control, Annu Rev Pharmacol Toxicol, vol.52, pp.111-133, 2012.

H. U. Zeilhofer, H. Wildner, and G. E. Yevenes, Fast synaptic inhibition in spinal sensory processing and pain control, Physiol Rev, vol.92, pp.193-235, 2012.

H. Petitjean, S. A. Pawlowski, S. L. Fraine, B. Sharif, D. Hamad et al., Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury, Cell Rep, vol.13, pp.1246-1257, 2015.

C. Torsney and A. B. Macdermott, Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord, J Neurosci, vol.26, pp.1833-1843, 2006.

K. K. Ghosh, L. D. Burns, E. D. Cocker, A. Nimmerjahn, Y. Ziv et al., Miniaturized integration of a fluorescence microscope, Nat Methods, vol.8, pp.871-147, 2011.

Z. Wang, B. Maunze, Y. Wang, P. Tsoulfas, and M. G. Blackmore, Global Connectivity and Function of Descending Spinal Input Revealed by 3D Microscopy and Retrograde Transduction, J Neurosci, vol.38, pp.10566-10581, 2018.

Y. Liu, A. Latremoliere, X. Li, Z. Zhang, M. Chen et al., Touch and tactile neuropathic pain sensitivity are set by corticospinal projections, Nature, vol.561, pp.547-550, 2018.

S. Lolignier, N. Eijkelkamp, and J. N. Wood, Mechanical allodynia, Pflugers Arch, vol.467, pp.133-139, 2015.

J. Braz, C. Solorzano, X. Wang, and A. I. Basbaum, Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control, Neuron, vol.82, pp.522-536, 2014.

H. U. Zeilhofer, H. Wildner, and G. E. Yevenes, Fast synaptic inhibition in spinal sensory processing and pain control, Physiol Rev, vol.92, pp.193-235, 2012.

C. Peirs, S. P. Williams, X. Zhao, C. E. Walsh, J. Y. Gedeon et al., Dorsal Horn Circuits for Persistent Mechanical Pain, Neuron, vol.87, pp.797-812, 2015.

Y. Liu, A. Latremoliere, X. Li, Z. Zhang, M. Chen et al., Touch and tactile neuropathic pain sensitivity are set by corticospinal projections, Nature, vol.561, pp.547-550, 2018.

B. Duan, L. Cheng, S. Bourane, O. Britz, C. Padilla et al., Identification of spinal circuits transmitting and gating mechanical pain, Cell, vol.159, pp.1417-1432, 2014.

M. Ueno, Y. Nakamura, J. Li, Z. Gu, J. Niehaus et al., Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons, Cell Rep, vol.23, p.1287, 2018.

V. E. Abraira, E. D. Kuehn, A. M. Chirila, M. W. Springel, A. A. Toliver et al., The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn, Cell, vol.168, p.219, 2017.

S. Bourane, K. S. Grossmann, O. Britz, A. Dalet, M. G. Del-barrio et al., Identification of a spinal circuit for light touch and fine motor control, Cell, vol.160, pp.503-515, 2015.

H. Wende, S. G. Lechner, C. Cheret, S. Bourane, M. E. Kolanczyk et al., The transcription factor c-Maf controls touch receptor development and function, Science, vol.335, pp.1373-1376, 2012.

D. S. Brenner, J. P. Golden, and R. Gereau, A novel behavioral assay for measuring cold sensation in mice, PLoS One, vol.7, p.39765, 2012.

G. J. Bennett and Y. K. Xie, A Peripheral Mononeuropathy in Rat That Produces Disorders of Pain Sensation Like Those Seen in Man, Pain, vol.33, pp.87-107, 1988.

N. Frezel, G. Kratzer, P. Verzar, J. Bürki, F. A. Weber et al., Does toe clipping for genotyping interfere with later-in-life nociception in mice?, PAIN Reports, vol.4, p.470, 2019.

M. Haring, A. Zeisel, H. Hochgerner, P. Rinwa, J. E. Jakobsson et al., Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types, Nat Neurosci, vol.21, pp.869-880, 2018.

W. D. Snider and S. B. Mcmahon, Tackling pain at the source: New ideas about nociceptors, Neuron, vol.20, pp.629-632, 1998.

A. J. Todd, D. I. Hughes, E. Polgar, G. G. Nagy, M. Mackie et al., The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn, Eur J Neurosci, vol.17, pp.13-27, 2003.

D. Usoskin, A. Furlan, S. Islam, H. Abdo, P. Lonnerberg et al., Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing, Nat Neurosci, vol.18, pp.145-153, 2015.

D. I. Hughes, S. Sikander, C. M. Kinnon, K. A. Boyle, M. Watanabe et al., A. Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn, Journal of Physiology-London, vol.590, pp.3927-3951, 2012.
URL : https://hal.archives-ouvertes.fr/in2p3-00010761

H. U. Zeilhofer, D. Benke, and G. E. Yévenes, Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control, Annu Rev Pharmacol Toxicol, vol.52, pp.111-133, 2012.

S. Haueter, PKC? and CCK expressing neurons in the spinal processing of somatosensory information. Dissertation. ETH-Zürich, p.23257, 2016.

L. Cheng, B. Duan, T. Huang, Y. Zhang, Y. Chen et al., Identification of spinal circuits involved in touch-evoked dynamic mechanical pain, Nat Neurosci, vol.20, pp.804-814, 2017.

L. Wang, S. R. Chen, H. Ma, H. Chen, W. N. Hittelman et al., Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons, J Neurochem, vol.147, pp.526-540, 2018.

K. Haenraets, G. W. Albisetti, E. Foster, and H. Wildner, Adeno-associated Virus-mediated Transgene Expression in Genetically Defined Neurons of the Spinal Cord, J Vis Exp, 2018.

D. G. Tervo, B. Y. Hwang, S. Viswanathan, T. Gaj, M. Lavzin et al., A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons, Neuron, vol.92, pp.372-382, 2016.

E. Klingler, A. De-la-rossa, S. Fievre, K. Devaraju, P. Abe et al., Genetic Logic for the Circuit Identity of Intracortically Projecting Neurons, Curr Biol, vol.29, p.335, 2019.

V. E. Abraira and D. D. Ginty, The sensory neurons of touch, Neuron, vol.79, pp.618-639, 2013.

S. Bourane, K. S. Grossmann, O. Britz, A. Dalet, M. G. Del-barrio et al., Identification of a spinal circuit for light touch and fine motor control, Cell, vol.160, pp.503-515, 2015.

L. Cheng, B. Duan, T. Huang, Y. Zhang, Y. Chen et al., Identification of spinal circuits involved in touch-evoked dynamic mechanical pain, Nat Neurosci, vol.20, pp.804-814, 2017.

C. Peirs, S. P. Williams, X. Zhao, C. E. Walsh, J. Y. Gedeon et al., Dorsal Horn Circuits for Persistent Mechanical Pain, Neuron, vol.87, pp.797-812, 2015.

V. E. Abraira, E. D. Kuehn, A. M. Chirila, M. W. Springel, A. A. Toliver et al., The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn, Cell, vol.168, p.219, 2017.

D. I. Hughes, S. Sikander, C. M. Kinnon, K. A. Boyle, M. Watanabe et al., A. Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn, J Physiol, vol.590, pp.3927-3951, 2012.
URL : https://hal.archives-ouvertes.fr/in2p3-00010761

X. Wang, Y. Liu, X. Li, Z. Zhang, H. Yang et al., Z. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell, vol.171, p.414, 2017.

E. Ciabatti, A. Gonzalez-rueda, L. Mariotti, F. Morgese, and M. Tripodi, Life-Long Genetic and Functional Access to Neural Circuits Using Self-Inactivating Rabies Virus, Cell, vol.170, p.314, 2017.

M. Matsuyama, L. Jin, T. K. Lavin, H. A. Sullivan, Y. Hou et al., Self-inactivating" rabies viruses are just first-generation, ?G rabies viruses. biorxiv, 2019.

L. Lo and D. J. Anderson, A Cre-dependent, anterograde transsynaptic viral tracer for mapping output pathways of genetically marked neurons, Neuron, vol.72, pp.938-950, 2011.

N. Frezel, G. Kratzer, P. Verzar, J. Bürki, F. A. Weber et al., Does toe clipping for genotyping interfere with later-in-life nociception in mice?, PAIN Reports, vol.4, p.740, 2019.

F. F. Voigt, D. Kirschenbaum, E. Platonova, S. Pagès, R. Campbell et al., The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue. Bioarxiv; under revision at Nat Methods. Contribution: prepared samples for clearing and imaging of whole mouse CNS

, Contribution: performed and analysed tracing experiments of corticospinal tract neurons

N. Frezel, S. Hauselmann, H. Wildner, J. M. Mateos, B. Ehret et al., Characterization of direct descending projections from the somatosensory cortex to the spinal dorsal horn

N. Frezel, S. Hauselmann, H. Wildner, C. Birchmeier, and H. U. Zeilhofer, Characterization of spinal c-maf expressing deep dorsal horn interneurons involved in the processing of mechanical stimuli, 2015.

. Phd, . Uzh, S. Zurich, and . Ibens, , 2014.

, Master's Degree Biologie intégrative, option Neurosciences Cellulaires et Intégrées at UPMC, 2012.

B. Agrégation-externe, Génie Biologique BGB, and Master 2 Formation des Enseignants du Supérieur, 2011.

, Bachelor's Degree in Biology (BGB), the ENS Cachan and University of Orsay PARIS XI, 2008.

C. Préparatoire-aux-grande-ecoles, . Bcpst, H. Lycée, and . Iv, High school graduation (Baccalaureat), Lycée HENRI IV, pp.2-2015, 2008.

, Title: Characterization of endocannabinoid expression and their role in glycine receptors diffusion in spinal cord neurons

, Title: Use of Viral retrograde and anterograde tracers to map neuronal circuitry involved in pain processing, Effect of antispastic medications baclofen and tizanidine on unloading and stretch reflexes in human soleus and tibialis anterior muscle

, Title: Role of voltage gated sodium channels in small fiber neuropathies and the generation of pain. 09/2010 Initiation to laboratory research, vol.757, 2013.

, Grant of the Zellidja Foundation, delivered by the Académie Française, CDSN: PhD grant from Ministry of Higher Education and Research, 2015.

N. Frezel, G. Kratzer, P. Verzar, J. Bürki, F. A. Weber et al., Does toe clipping for genotyping interfere with later-in-life nociception in mice?, PAIN Reports, vol.4, p.740, 2019.

F. F. Voigt, D. Kirschenbaum, E. Platonova, S. Pagès, R. Campbell et al., The mesoSPIM initiative: open-source light-sheet mesoscopes for imaging in cleared tissue, Nat Methods, 2019.

N. Frezel, F. Sohet, R. Daneman, and A. I. Basbaum, & Braz JM. Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE, Exp Neurol, vol.283, pp.224-234, 2016.

J. A. Black, N. Frezel, S. D. Dib-hajj, and S. G. Waxman, Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn, Mol Pain, vol.8, 2012.

, Conference posters and presentations 27.01.2017: SSN (Swiss society of Neurosciences), 2019.