, , 2012.
, Calcium Signaling and Gliotransmission in Normal vs, Reactive Astrocytes. Frontiers in Pharmacology, vol.3, p.139
, An ultrastructural study of the phagocytic activity of astrocytes in adult rat brain, Journal of Anatomy, vol.188, pp.257-262, 1996.
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability, Neurobiology of Disease, vol.100, pp.75-86, 2017. ,
,
Role of glia in developmental synapse formation, Current Opinion in Neurobiology, vol.23, issue.6, pp.1027-1033, 2013. ,
Neuroscience: Glia -more than just brain glue, Nature, vol.457, issue.7230, pp.675-677, 2009. ,
Novel intragenic deletion in OPHN1 in a family causing XLMR with cerebellar hypoplasia and distinctive facial appearance, Clinical Genetics, vol.79, issue.4, pp.363-370, 2011. ,
The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders, Frontiers in Bioengineering and Biotechnology, vol.6, 2018. ,
Dynamic signaling between astrocytes and neurons, Annual Review of Physiology, vol.63, pp.795-813, 2001. ,
,
Tripartite synapses: glia, the unacknowledged partner, Trends in Neurosciences, vol.22, issue.5, pp.208-215, 1999. ,
Gliotransmitters travel in time and space, Neuron, vol.81, issue.4, pp.728-739, 2014. ,
,
Down Syndrome iPSC-Derived Astrocytes Impair Neuronal Synaptogenesis and the mTOR Pathway In Vitro, Molecular Neurobiology, vol.55, issue.7, pp.5962-5975, 2018. ,
Rho GTPases as regulators of morphological neuroplasticity, Annals of Anatomy = Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft, vol.193, issue.4, pp.259-266, 2011. ,
,
Rho GTPase signaling at the synapse: implications for intellectual disability, Experimental Cell Research, vol.319, issue.15, pp.2368-2374, 2013. ,
Molecular diversity of astrocytes with implications for neurological disorders, Proceedings of the National Academy of Sciences of the United States of America, vol.101, issue.22, pp.8384-8389, 2004. ,
Astrocyte subtypes in the rat olfactory bulb: morphological heterogeneity and differential laminar distribution, The Journal of Comparative Neurology, vol.328, issue.4, pp.501-526, 1993. ,
Monitoring the prevalence of severe intellectual disability in children across Europe: feasibility of a common database, Developmental Medicine & Child Neurology, vol.56, issue.4, pp.361-369 ,
The Diagnostic Adaptive Behavior Scale: Evaluating its diagnostic sensitivity and specificity, vol.35, pp.2884-2893, 2014. ,
Mechanisms of synaptic plasticity and recognition memory in the perirhinal cortex, Progress in Molecular Biology and Translational Science, vol.122, pp.193-209, 2014. ,
,
Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario, Progress in Brain Research, vol.197, pp.29-51, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00724481
,
Developmental control of synaptic receptivity, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.28, issue.33, pp.8150-8160, 2008. ,
,
Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development, 2014. ,
, PloS One, vol.9, issue.3
The neurobiology of X-linked intellectual disability, The Neuroscientist: A Review Journal Bringing Neurobiology, vol.19, issue.5, pp.541-552, 2013. ,
,
Diagnostic evaluation of developmental delay/mental retardation: An overview, American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, vol.117, issue.1, pp.3-14, 2003. ,
Association of syndromic mental retardation with an Xq12q13.1 duplication encompassing the oligophrenin 1 gene, American Journal of Medical Genetics. Part A, vol.146, issue.13, pp.1718-1724, 2008. ,
Astrocyte-neuron communication: functional consequences, Neurochemical Research, vol.37, issue.11, pp.2464-2473, 2012. ,
,
Rho GTPases: role in dendrite and axonal growth, mental retardation, and axonal regeneration, Neurology, vol.68, issue.16, pp.1315-1318, 2007. ,
,
Oligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia, Brain: A Journal of Neurology, vol.126, pp.1537-1544, 2003. ,
,
Astrocyte-synapse structural plasticity, Neural Plasticity, p.232105, 2014. ,
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome, Nature Reviews. Drug Discovery, vol.17, issue.4, pp.280-299, 2018. ,
The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase, Journal of Cell Science, vol.120, pp.1859-1867, 2007. ,
Prenatal and perinatal factors associated with intellectual disability, American Journal on Intellectual and Developmental Disabilities, vol.118, issue.2, pp.156-176, 2013. ,
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation, Nature, vol.392, issue.6679, pp.923-926, 1998. ,
Determination of the gene structure of human oligophrenin-1 and identification of three novel polymorphisms by screening of DNA from 164 patients with non-specific X-linked mental retardation, Annales De Genetique, vol.43, issue.1, pp.5-9, 2000. ,
, Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation, 2013.
, , vol.33, pp.1538-1543
,
Signaling mechanisms regulating synapse formation and function in mental retardation, Current Opinion in Neurobiology, vol.20, issue.4, pp.519-527, 2010. ,
Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development, International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience, vol.42, pp.15-23, 2015. ,
,
Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology, Brain Research, vol.1399, pp.79-95, 2011. ,
,
The diverse actions of astrocytes during synaptic development, Current Opinion in Neurobiology, vol.47, pp.38-43, 2017. ,
,
, , 2016.
, Decoding astrocyte heterogeneity: New tools for clonal analysis, Neuroscience, vol.323, pp.10-19
Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains, Journal of Neuroscience, vol.22, issue.1, pp.183-192, 2002. ,
Small Rho-GTPases and cortical malformations: fine-tuning the cytoskeleton stability, Small GTPases, vol.4, issue.1, pp.51-56, 2013. ,
Intellectual developmental disorders: towards a new name, definition and framework for "mental retardation/intellectual disability" in ICD-11, World Psychiatry, vol.10, issue.3, pp.175-180 ,
Health checks for adults with intellectual and developmental disabilities in a family practice, 2018. ,
, Canadian Family Physician Medecin De Famille Canadien, vol.64, issue.2, pp.44-50
The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality? Frontiers in Synaptic Neuroscience, vol.9, 2017. ,
Developmental origins of astrocyte heterogeneity: the final frontier of CNS development, Developmental Neuroscience, vol.34, issue.5, pp.379-388, 2012. ,
,
Astrocyte form and function in the developing central nervous system, Seminars in Pediatric Neurology, vol.20, issue.4, pp.230-235, 2013. ,
,
Is mental retardation a defect of synapse structure and function, Pediatric Neurology, vol.29, issue.1, pp.11-17, 2003. ,
Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells, Nature Communications, vol.5, p.4430, 2014. ,
Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model, Molecular Brain, vol.9, issue.1, 2016. ,
Astrocytes and developmental plasticity in fragile X, Neural Plasticity, 2012. ,
Regulation of Small GTPases by GEFs, GAPs, and GDIs, Physiological Reviews, vol.93, issue.1, pp.269-309, 2013. ,
Advances in understanding -genetic basis of intellectual disability, 1000. ,
Exploring the complexity of intellectual disability in fetal alcohol spectrum disorders, Frontiers in Pediatrics, vol.2, p.90, 2014. ,
Neurons and glia: team players in axon guidance, Trends in Neurosciences, vol.27, issue.11, pp.655-661, 2004. ,
Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells, Transgenic Research, vol.17, issue.5, pp.919-928, 2008. ,
Astrocytes Control Synapse Formation, Function, and Elimination, Cold Spring Harbor Perspectives in Biology, vol.7, issue.9, 2015. ,
,
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways, Nature, vol.504, issue.7480, pp.394-400, 2013. ,
Do glia drive synaptic and cognitive impairment in disease?, Nature Neuroscience, vol.18, issue.11, pp.1539-1545, 2015. ,
,
Epithelial junctions and Rho family GTPases: the zonular signalosome, Small GTPases, vol.5, issue.4, pp.1-15, 2014. ,
,
Emerging roles of astrocytes in neural circuit development, Nature Reviews. Neuroscience, vol.14, issue.5, pp.311-321, 2013. ,
,
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function, Stem Cells Translational Medicine, vol.5, issue.7, pp.860-869, 2016. ,
A review of defining and measuring sociability in children with intellectual disabilities, vol.32, pp.11-24, 2011. ,
,
People with intellectual disability: what do we know about adulthood and life expectancy?, Developmental Disabilities Research Reviews, vol.18, issue.1, pp.6-16, 2013. ,
Evolutionary genomics of human intellectual disability, Evolutionary Applications, vol.3, issue.1, pp.52-63, 2010. ,
Modulation of RhoGTPases improves the behavioral phenotype and reverses astrocytic deficits in a mouse model of Rett syndrome, Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, vol.37, issue.5, pp.1152-1163, 2012. ,
Aberrant Rho GTPases signaling and cognitive dysfunction: in vivo evidence for a compelling molecular relationship, Neuroscience and Biobehavioral Reviews, vol.46, pp.285-301, 2014. ,
,
Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome, European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, vol.25, issue.6, pp.889-901, 2015. ,
,
Diagnostic exome sequencing in persons with severe intellectual disability, The New England Journal of Medicine, vol.367, issue.20, pp.1921-1929, 2012. ,
Single and collective cell migration: the mechanics of adhesions, Molecular Biology of the Cell, vol.28, issue.14, pp.1833-1846, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02058848
,
Astrocytes: Orchestrating synaptic plasticity?, Neuroscience, vol.323, pp.43-61, 2016. ,
Astrocyte Transcriptome from the Mecp2(308)-Truncated Mouse Model of Rett Syndrome, Neuromolecular Medicine, vol.17, issue.4, pp.353-363, 2015. ,
,
Glial heterogeneity may define the three-dimensional shape of mouse mesencephalic dopaminergic neurones, Nature, vol.307, issue.5952, pp.641-643, 1984. ,
Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes, The European Journal of Neuroscience, vol.18, issue.3, pp.629-638, 2003. ,
The role of microglia in brain maintenance: implications for Rett syndrome, Trends in Immunology, vol.34, issue.3, pp.144-150, 2013. ,
,
Signaling networks that regulate cell migration, Cold Spring Harbor Perspectives in Biology, vol.7, issue.8, 2015. ,
Enhancement of learning and memory after activation of cerebral Rho GTPases, Proceedings of the National Academy of Sciences of the United States of America, vol.104, pp.636-641, 2007. ,
Molecular signals of plasticity at the tetrapartite synapse, Current Opinion in Neurobiology, vol.21, issue.2, pp.353-359, 2011. ,
,
Plasticity of nonneuronal brain tissue: roles in developmental disorders, Mental Retardation and Developmental Disabilities Research Reviews, vol.10, issue.2, pp.85-90, 2004. ,
Seeking axon guidance molecules in the adult rat CNS, Progress in Brain Research, vol.137, pp.453-465, 2002. ,
RhoGDI: multiple functions in the regulation of Rho family GTPase activities, The Biochemical Journal, vol.390, pp.1-9, 2005. ,
,
Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses, Neuroscience Letters, vol.601, pp.4-10, 2015. ,
Rho GTPases in embryonic development, Small GTPases, vol.5, issue.2, 2014. ,
Aging in rare intellectual disability syndromes, Developmental Disabilities Research Reviews, vol.18, issue.1, pp.75-83, 2013. ,
Genetic basis of intellectual disability, Annual Review of Medicine, vol.64, pp.441-450, 2013. ,
In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization, Methods in Enzymology, vol.406, pp.565-578, 2006. ,
, , pp.6044-6051
Rho GTPases in cell biology, Nature, vol.420, issue.6916, pp.629-635, 2002. ,
Contributions of astrocytes to synapse formation and maturation -Potential functions of the perisynaptic extracellular matrix, Brain Research Reviews, vol.63, issue.1-2, pp.26-38, 2010. ,
The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain, Molecular and Cellular Neurosciences, vol.23, issue.4, pp.574-586, 2003. ,
, ? Down Syndrome and Other Genetic Developmental Disorders ECNP Network, 2018.
, Translating molecular advances in Down syndrome and Fragile X syndrome into therapies, European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, vol.28, issue.6, pp.675-690
,
Glial biology in learning and cognition, The Neuroscientist: A Review Journal Bringing Neurobiology, vol.20, issue.5, pp.426-431, 2014. ,
,
Updates in the genetic evaluation of the child with global developmental delay or intellectual disability, Seminars in Pediatric Neurology, vol.19, issue.4, pp.173-180, 2012. ,
Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice, Journal of Thrombosis and Haemostasis, vol.13, issue.4, pp.619-630, 2015. ,
,
Specification and morphogenesis of astrocytes, Science, issue.6005, pp.774-778, 2010. ,
The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns, 1000. ,
An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells, 2004. ,
, The Biochemical Journal, vol.378, pp.409-419
A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down's syndrome, PloS One, vol.5, issue.12, 2010. ,
Regionally specific properties of midbrain glia: I. Interactions with midbrain neurons, Journal of Neuroscience Research, vol.40, issue.4, pp.471-477, 1995. ,
Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex, PLoS Biology, vol.4, issue.11, 2006. ,
Connexin 30 controls astroglial polarization during postnatal brain development, Development, issue.4, p.145, 2018. ,
,
Perisynaptic astroglial processes: dynamic processors of neuronal information, Brain Structure & Function, vol.221, issue.5, pp.2427-2442, 2016. ,
,
Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain, Brain Research, vol.1596, pp.22-30, 2015. ,
An activating mutant of Cdc42 that fails to interact with Rho GDP-dissociation inhibitor localizes to the plasma membrane and mediates actin reorganization, Experimental Cell Research, vol.301, issue.2, pp.211-222, 2004. ,
,
Perineuronal nets protect fear memories from erasure, Science, issue.5945, pp.1258-1261, 2009. ,
,
Disrupted circuits in mouse models of autism spectrum disorder and intellectual disability, Current Opinion in Neurobiology, vol.48, pp.106-112, 2018. ,
KDM5C mutational screening among males with intellectual disability suggestive of X-Linked inheritance and review of the literature, European Journal of Medical Genetics, vol.57, issue.4, pp.138-144, 2014. ,
,
, , 2014.
, Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer, Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology, vol.81, issue.4, pp.190-198
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome-wide expression analysis, Glia, vol.63, issue.8, pp.1452-1468, 2015. ,
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis, Nature Neuroscience, vol.7, issue.4, pp.364-372, 2004. ,
,
The role of the Rho GTPases in neuronal development, Genes & Development, vol.19, issue.1, pp.1-49, 2005. ,
,
Intellectual disability as a disorder of reasoning and judgement: the gradual move away from intelligence quotient-ceilings, Current Opinion in Psychiatry, vol.27, issue.2, pp.110-116, 2014. ,
,
Exocytosis in astrocytes: transmitter release and membrane signal regulation, Neurochemical Research, vol.37, issue.11, pp.2351-2363, 2012. ,
,
Prenatal treatment of Down syndrome: a reality?, Current Opinion in Obstetrics & Gynecology, vol.26, issue.2, pp.92-103, 2014. ,
,
, , 2017.
, Acta Physiologica Sinica, vol.69, issue.3, pp.241-251
, , 2006.
, Activity-dependent ATP-waves in the mouse neocortex are independent from astrocytic calcium waves, Cerebral Cortex, vol.16, issue.2, pp.237-246, 1991.
Astrocytes play a key role in Drosophila mushroom body axon pruning, PloS One, vol.9, issue.1, 2014. ,
Synaptic islands defined by the territory of a single astrocyte, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.27, issue.24, pp.6473-6477, 2007. ,
,
Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior, Annual Review of Physiology, vol.72, pp.335-355, 2010. ,
Rho GTPases and the Actin Cytoskeleton, Science, vol.279, issue.5350, pp.509-514, 1998. ,
Rho family GTPases, Biochemical Society Transactions, vol.40, issue.6, pp.1378-1382, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-02267489
, , 2013.
, Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice, Cell Stem Cell, vol.12, issue.3, pp.342-353
,
Serum-activated assembly and membrane translocation of an endogenous Rac1:effector complex, Current Biology: CB, vol.11, issue.5, pp.356-360, 2001. ,
Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain, Frontiers in Neuroscience, vol.9, p.499, 2015. ,
Morphological plasticity of astroglial/neuronal interactions: functional implications, Glial ? Neuronal Signaling, pp.99-124, 2004. ,
Challenges and opportunities in the investigation of unexplained intellectual disability using family-based whole-exome sequencing, Clinical Genetics, vol.88, issue.2, pp.140-148, 2015. ,
Fragile X syndrome: from gene discovery to therapy, Frontiers in Bioscience, vol.16, pp.1211-1232, 2011. ,
Neuron-glia interactions during axon guidance in Drosophila, Biochemical Society Transactions, pp.50-55, 2003. ,
Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse, Human Molecular Genetics, vol.22, issue.10, pp.2041-2054, 2013. ,
Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.36, issue.27, pp.7079-7094, 2016. ,
Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifeninducible DNA recombinase variant CreERT2, Glia, vol.54, issue.1, pp.11-20, 2006. ,
,
Regulating Rho GTPases and their regulators, Nature Reviews. Molecular Cell Biology, vol.17, issue.8, pp.496-510, 2016. ,
,
, , 2017.
, Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome, Biological Psychiatry, vol.82, issue.2, pp.139-149
,
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing: Astrocyte morphology during wound healing, Journal of Neurochemistry, vol.95, issue.5, pp.1237-1248, 2005. ,
Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth, American Journal of Human Genetics, vol.94, issue.3, pp.470-478, 2014. ,
The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases, Cells, vol.5, issue.2, 2016. ,
Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride, Neuroscience, pp.120-129, 0200. ,
Gap junction-mediated astrocytic networks in the mouse barrel cortex, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.28, issue.20, pp.5207-5217, 2008. ,
,
Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.35, issue.31, pp.11045-11055, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02323341
,
Prenatal, Perinatal and Neonatal Risk Factors for Intellectual Disability: A Systemic Review and Meta-Analysis, PloS One, vol.11, issue.4, 2016. ,
Peripheral delivery of a ROCK inhibitor improves learning and working memory, Behavioral Neuroscience, vol.123, issue.1, pp.218-223, 2009. ,
,
Caring for older people with an intellectual disability: a systematic review, Maturitas, vol.72, issue.4, pp.286-295, 2012. ,
,
Identifying genes responsible for intellectual disability in consanguineous families, Human Heredity, vol.77, issue.1-4, pp.150-160, 2014. ,
,
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents, Glia, vol.44, issue.2, pp.102-110, 2003. ,
Roles of Rho small GTPases in the tangentially migrating neurons, Histology and Histopathology, vol.29, issue.7, pp.871-879, 2014. ,
,
Metabotropic glutamate receptor 5 in Down's syndrome hippocampus during development: increased expression in astrocytes, Current Alzheimer Research, vol.11, issue.7, pp.694-705, 2014. ,
The midline glia of Drosophila: a molecular genetic model for the developmental functions of glia, Progress in Neurobiology, vol.62, issue.5, pp.475-508, 2000. ,
Transition from school to adult services for young people with severe or profound intellectual disability: A systematic review utilizing framework synthesis, Journal of Applied Research in Intellectual Disabilities: JARID, 2018. ,
Hippocampal neuronal subtypes develop abnormal dendritic arbors in the presence of Fragile X astrocytes, Neuroscience, vol.324, pp.202-217, 2016. ,
Probing astrocyte function in fragile X syndrome. Results and Problems in Cell Differentiation, vol.54, pp.15-31, 2012. ,
,
Astrocytes prevent abnormal neuronal development in the fragile x mouse, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.30, issue.12, pp.4508-4514, 2010. ,
,
Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression, BMC Neuroscience, vol.11, 2010. ,
Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures, Molecular and Cellular Neurosciences, vol.31, issue.4, pp.774-784, 2006. ,
Ultrastructural evidence for increased contact between astrocytes and synapses in rats reared in a complex environment, Neurobiology of Learning and Memory, vol.65, issue.1, pp.48-56, 1996. ,
,
, , vol.5, 2018.
Nonneuronal cell responses differ between normal and Down syndrome developing brains, International Journal of Developmental Neuroscience: The Official Journal of the International Society for Developmental Neuroscience, issue.8, pp.796-803, 2013. ,
,
Genetic causes of intellectual disability in a birth cohort: a populationbased study, American Journal of Medical Genetics. Part A, vol.167, issue.6, pp.1204-1214, 2015. ,
,
Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis. Salud Pública de México, vol.50, pp.132-141, 2008. ,
Defective body-weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice, Human Molecular Genetics, vol.17, issue.12, pp.1707-1717, 2008. ,
,
Diversity of astrocyte functions and phenotypes in neural circuits, Nature Neuroscience, vol.18, issue.7, pp.942-952, 2015. ,
Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00165072
, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.27, issue.35, pp.9439-9450
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol.369, 1633. ,
URL : https://hal.archives-ouvertes.fr/hal-02392406
Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation, Human Molecular Genetics, vol.18, issue.14, pp.2575-2583, 2009. ,
URL : https://hal.archives-ouvertes.fr/inserm-00424014
The problem of astrocyte identity, Neurochemistry International, vol.45, issue.2-3, pp.191-202, 2004. ,
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans, Nature, vol.434, issue.7029, pp.93-99, 2005. ,
,
Array-based DNA methylation analysis in individuals with developmental delay/intellectual disability and normal molecular karyotype, European Journal of Medical Genetics, vol.58, issue.8, pp.419-425, 2015. ,
,
DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model, EMBO Reports, vol.16, issue.11, pp.1548-1562, 2015. ,
Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation, Nature Genetics, vol.26, issue.2, pp.247-250, 2000. ,
Intellectual Disability & Rare Disorders: A Diagnostic Challenge, Advances in Experimental Medicine and Biology, vol.1031, pp.39-54, 2017. ,
,
A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis, Development, issue.20, pp.4599-4610, 2005. ,
Epithelium-mesenchyme: a balancing act of RhoGAP and RhoGEF, Current Biology: CB, vol.14, issue.13, pp.508-510, 2004. ,
Developmental disorders with intellectual disability driven by chromatin dysregulation: Clinical overlaps and molecular mechanisms, Clinical Genetics, 2018. ,
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration, Small GTPases, vol.5, 2014. ,
Rho GTPase signaling complexes in cell migration and invasion, The Journal of Cell Biology, vol.217, issue.2, pp.447-457, 2018. ,
,
The role of glial cells in axon guidance, fasciculation and targeting, Advances in Experimental Medicine and Biology, vol.621, pp.156-166, 2007. ,
,
Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability, Nature Neuroscience, vol.19, issue.9, pp.1194-1196, 2016. ,
,
Potential therapeutic interventions for fragile X syndrome, Trends in Molecular Medicine, vol.16, issue.11, pp.516-527, 2010. ,
,
MEK Is a Key Regulator of Gliogenesis in the Developing Brain, Neuron, vol.75, issue.6, pp.1035-1050, 2012. ,
Reactive Astrocytes: Production, Function, and Therapeutic Potential, Immunity, vol.46, issue.6, pp.957-967, 2017. ,
,
RhoGDI Is Required for Cdc42-Mediated Cellular Transformation, Current Biology, vol.13, issue.17, pp.1469-1479, 2003. ,
,
Synaptic signaling between neurons and glia, Glia, vol.47, issue.3, pp.290-298, 2004. ,
Approaches of targeting Rho GTPases in cancer drug discovery, Expert Opinion on Drug Discovery, vol.10, issue.9, pp.991-1010, 2015. ,
,
Diverse roles of Rho family GTPases in neuronal development, survival, and death, Frontiers in Bioscience: A Journal and Virtual Library, vol.13, pp.657-676, 2008. ,
A role for glia in the progression of Rett's syndrome, Nature, vol.475, issue.7357, pp.497-500, 2011. ,
Epigenetic factors in intellectual disability: the Rubinstein-Taybi syndrome as a paradigm of neurodevelopmental disorder with epigenetic origin, Progress in Molecular Biology and Translational Science, vol.128, pp.139-176, 2014. ,
Fragile X and X-linked intellectual disability: four decades of discovery, American Journal of Human Genetics, vol.90, issue.4, pp.579-590, 2012. ,
Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations, Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol.84, pp.424-439, 2018. ,
,
Synaptic potentiation induces increased glial coverage of excitatory synapses in CA1 hippocampus, Hippocampus, vol.19, issue.8, pp.753-762, 2009. ,
, , 2009.
, DELETION OF ASTROCYTE CONNEXIN 43 AND 30 LEADS TO A DYSMYELINATING PHENOTYPE AND HIPPOCAMPAL CA1 VACUOLATION
, The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol.29, issue.24, pp.7743-7752
Deletion of the OPHN1 gene detected by aCGH, Journal of Intellectual Disability Research, vol.52, pp.190-194, 2008. ,
Analyse chromosomique sur puce à ADN (CGH array) : principe et application en diagnostic prénatal, vol.4, pp.67-73, 2012. ,
CNF1 Improves Astrocytic Ability to Support Neuronal Growth and Differentiation In vitro, PLoS ONE, vol.7, issue.4, 2012. ,
,
Familial mental retardation: a review and practical classification, Ciencia & Saude Coletiva, vol.18, issue.6, pp.1717-1729, 2013. ,
Regulation of RhoA activity by adhesion molecules and mechanotransduction, Current Molecular Medicine, vol.14, issue.2, pp.199-208, 2014. ,
Pharmacological Rescue of Hippocampal Fear Learning Deficits in Fragile X Syndrome, Molecular Neurobiology, vol.55, issue.7, pp.5951-5961, 2018. ,
RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development, PloS One, vol.12, issue.1, 2017. ,
Heterogeneity in astrocyte morphology and physiology, Brain Research Reviews, vol.63, issue.1-2, pp.2-10, 2010. ,
,
Cycling around cell-cell adhesion with Rho GTPase regulators, Journal of Cell Science, vol.126, pp.379-391, 2013. ,
,
Astrocytes conspire with neurons during progression of neurological disease, Current Opinion in Neurobiology, vol.22, issue.5, pp.850-858, 2012. ,
, Genomics, intellectual disability, and autism, vol.366, pp.733-743, 2012.
,
, , 2003.
, Medecine Sciences: M/S, vol.19, issue.3, pp.358-363
Regulation of adherens junctions by Rho GTPases and p120-catenin, Archives of Biochemistry and Biophysics, vol.524, issue.1, pp.48-55, 2012. ,
,
Report of a female patient with mental retardation and tall stature due to a chromosomal rearrangement disrupting the OPHN1 gene on Xq12, 2007. ,
, European Journal of Medical Genetics, vol.50, issue.6, pp.446-454
,
Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability, Human Molecular Genetics, vol.25, issue.11, pp.2314-2323, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02404671
Genetic testing in patients with global developmental delay / intellectual disabilities. A review, Clujul Medical, vol.88, issue.3, pp.288-292, 1957. ,
Comprehensive evaluation of the child with intellectual disability or global developmental delays, & Committee on Genetics, vol.134, issue.3, pp.903-918, 2014. ,
Astrocytes and disease: a neurodevelopmental perspective, Genes & Development, vol.26, issue.9, pp.891-907, 2012. ,
How important are Rho GTPases in neurosecretion, Journal of Neurochemistry, vol.117, issue.4, pp.623-631, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-02323434
HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients, European Journal of Human Genetics: EJHG, vol.26, issue.1, pp.64-74, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01746121
Quality of Life in Persons with Intellectual Disabilities and Mental Health Problems: An Explorative Study, 2013. ,
X-linked intellectual disability related genes disrupted by balanced X-autosome translocations, American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, vol.168, issue.8, pp.669-677, 2015. ,
,
Calcium entry through kainate receptors and resulting potassium-channel blockade in Bergmann glial cells, Science, issue.5063, pp.1563-1566, 1992. ,
The co-occurrence of mental disorders in children and adolescents with intellectual disability/intellectual developmental disorder, Current Opinion in Psychiatry, vol.29, issue.2, pp.95-102, 2016. ,
Small Rho GTPases in the control of cell shape and mobility, Cellular and Molecular Life Sciences: CMLS, vol.71, issue.9, pp.1703-1721, 2014. ,
,
A global doublefluorescent Cre reporter mouse, Genesis, vol.45, issue.9, pp.593-605, 2000. ,
,
Dual observation of the ATP-evoked small GTPase activation and Ca2+ transient in astrocytes using a dark red fluorescent protein, Scientific Reports, vol.6, 2016. ,
The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1, Current Biology: CB, vol.19, issue.13, pp.1133-1139, 2009. ,
,
The X-linked mental retardation protein OPHN1 interacts with Homer1b/c to control spine endocytic zone positioning and expression of synaptic potentiation, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.34, issue.26, pp.8665-8671, 2014. ,
Rho signaling research: history, current status and future directions, FEBS Letters, vol.592, issue.11, pp.1763-1776, 2018. ,
, Mental Retardation: Determining Eligibility for Social Security Benefits, 2002.
The Cajal school and the physiological role of astrocytes: a way of thinking, Frontiers in Neuroanatomy, vol.8, p.33, 2014. ,
Astrocytes mediate in vivo cholinergic-induced synaptic plasticity, PLoS Biology, vol.10, issue.2, 2012. ,
Rho GTPases, dendritic structure, and mental retardation, Journal of Neurobiology, vol.64, issue.1, pp.58-74, 2005. ,
,
Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.33, issue.48, pp.18764-18774, 2013. ,
Gap junctions and connexins in the inner ear: their roles in homeostasis and deafness. Current Opinion in Otolaryngology & Head and Neck Surgery, vol.16, pp.452-457, 2008. ,
Large-scale recording of astrocyte activity, Current Opinion in Neurobiology, vol.32, pp.95-106, 2015. ,
Affected kindred analysis of human X chromosome exomes to identify novel X-linked intellectual disability genes, PloS One, vol.10, issue.2, 2015. ,
Direct astrocytic contacts regulate local maturation of dendritic spines, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.27, issue.2, pp.331-340, 2007. ,
Developmental changes in the number, size, and orientation of GFAP-positive cells in the CA1 region of rat hippocampus, Glia, vol.12, issue.3, pp.180-195, 1994. ,
Do Evolutionary Changes in Astrocytes Contribute to the Computational Power of the Hominid Brain?, Neurochemical Research, vol.42, issue.9, pp.2577-2587, 2017. ,
Heterogeneity of astrocytic form and function, Methods in Molecular Biology, vol.814, pp.23-45, 2012. ,
,
, , 2012.
, Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome, PloS One, vol.7, issue.4
Differential distribution of Kir4.1 in spinal cord astrocytes suggests regional differences in K+ homeostasis, Journal of Neurophysiology, vol.98, issue.2, pp.786-793, 2007. ,
New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.35, issue.41, pp.13827-13835, 2015. ,
,
Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors, Small GTPases, vol.9, issue.3, pp.203-215, 2018. ,
,
Cdc42 localization and cell polarity depend on membrane traffic, The Journal of Cell Biology, vol.191, issue.7, pp.1261-1269, 2010. ,
, , 2015.
, Persistent astrocyte activation in the fragile X mouse cerebellum, Brain and Behavior, vol.5, issue.10
Recent discoveries on the functions of astrocytes in the copper homeostasis of the brain: a brief update, Neurotoxicity Research, vol.26, issue.1, pp.78-84, 2014. ,
,
Activation of Rho Family GTPases by Small Molecules, ACS Chemical Biology, vol.13, issue.6, pp.1514-1524, 2018. ,
Molecular basis of X-linked non-specific mental retardation, Indian Journal of Experimental Biology, vol.42, issue.6, pp.549-557, 2004. ,
Connexin 30 sets synaptic strength by controlling astroglial synapse invasion, Nature Neuroscience, vol.17, issue.4, pp.549-558, 2014. ,
URL : https://hal.archives-ouvertes.fr/cea-02290543
Emerging role for astroglial networks in information processing: from synapse to behavior, Trends in Neurosciences, vol.36, issue.7, pp.405-417, 2013. ,
,
Astrocytic control of synaptic function, Philosophical Transactions of the Royal Society of London, 2017. ,
, Biological Sciences, p.372, 1715.
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module, Nature, vol.450, issue.7168, pp.430-434, 2007. ,
,
Signaling in glial development: differentiation migration and axon guidance, Biochimie Et Biologie Cellulaire, vol.82, issue.6, pp.694-707, 2004. ,
Astrocytes revisited: concise historic outlook on glutamate homeostasis and signaling, Croatian Medical Journal, vol.53, issue.6, pp.518-528, 2012. ,
Gliotransmission: Exocytotic release from astrocytes, Brain Research Reviews, vol.63, issue.1-2, pp.83-92, 2010. ,
Astrocytic purinergic signaling coordinates synaptic networks, Science, issue.5745, pp.113-116, 2005. ,
Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle, Proceedings of the National Academy of Sciences of the United States of America, vol.111, pp.5385-5390, 2014. ,
Human RhoGAP domaincontaining proteins: structure, function and evolutionary relationships, FEBS Letters, vol.528, issue.1-3, pp.27-34, 2002. ,
The pathogenicity of genomic/genetic variant of X-chromosomal genes in males with intellectual disability, Yi Chuan = Hereditas, vol.39, issue.6, pp.455-468, 2017. ,
Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly, Journal of Medical Genetics, vol.53, issue.11, pp.735-742, 2016. ,
Synaptic regulation of the astrocyte calcium signal, Journal of Neural Transmission, vol.112, issue.1, pp.127-135, 1996. ,
,
Communication between astrocytes and neurons: a complex language, Journal of Physiology, vol.96, issue.3-4, pp.199-207, 2002. ,
Tripartite synapses: astrocytes process and control synaptic information, Trends in Neurosciences, vol.32, issue.8, pp.421-431, 2009. ,
,
Neuron-glia networks: integral gear of brain function, Frontiers in Cellular Neuroscience, vol.8, p.378, 2014. ,
Astrocytes and human cognition: modeling information integration and modulation of neuronal activity, Progress in Neurobiology, vol.92, issue.3, pp.405-420, 2010. ,
Structural and functional plasticity of astrocyte processes and dendritic spine interactions, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.34, issue.38, pp.12738-12744, 2014. ,
New innovations: therapeutic opportunities for intellectual disabilities, Annals of Neurology, vol.74, issue.3, pp.382-390, 2013. ,
,
Insertion of 16 amino acids in the BAR domain of the oligophrenin 1 protein causes mental retardation and cerebellar hypoplasia in an Italian family, Human Mutation, vol.32, issue.11, pp.2294-2307, 2011. ,
XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing, American Journal of Human Genetics, vol.93, issue.2, pp.368-383, 2013. ,
,
, , 2002.
, Reactivation of ocular dominance plasticity in the adult visual cortex, Science, issue.5596, pp.1248-1251
P-cadherin-mediated Rho GTPase regulation during collective cell migration, Small GTPases, vol.7, issue.3, pp.156-163, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01878043
,
Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development, Psychopharmacology, vol.231, issue.6, pp.1217-1226, 2014. ,
,
Astrocytic vesicle mobility in health and disease, International Journal of Molecular Sciences, vol.14, issue.6, pp.11238-11258, 2013. ,
Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation, The Journal of Physiology, vol.590, issue.4, pp.763-776, 2012. ,
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI, Nature Cell Biology, vol.4, issue.3, pp.232-239, 2002. ,
Genetic Approach to Diagnosis of Intellectual Disability, Indian Journal of Pediatrics, vol.83, issue.10, pp.1141-1149, 2016. ,
,
The role of the cytoskeleton in the formation of gap junctions by Connexin 30, Experimental Cell Research, vol.315, issue.10, pp.1683-1692, 2009. ,
,
Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes, Glia, vol.60, issue.3, pp.465-475, 2012. ,
Two types of astrocytes in cultures of developing rat white matter: differences in morphology, surface gangliosides, and growth characteristics, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.3, issue.6, pp.1289-1300, 1983. ,
Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome, 2018. ,
Rho proteins, mental retardation and the cellular basis of cognition, Trends in Neurosciences, vol.25, issue.4, pp.191-199, 2002. ,
The neurophysiology of glial cells, Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society, vol.9, issue.2, pp.224-251, 1992. ,
Coordinating Rho and Rac: the regulation of Rho GTPase signaling and cadherin junctions, Progress in Molecular Biology and Translational Science, vol.116, pp.49-68, 2013. ,
, , 2016.
, Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb, Human Molecular Genetics, vol.25, issue.23, pp.5198-5211
The Indispensable Roles of Microglia and Astrocytes during Brain Development, Frontiers in Human Neuroscience, vol.10, 2016. ,
Discontinuity in the genetic and environmental causes of the intellectual disability spectrum, Proceedings of the National Academy of Sciences of the United States of America, vol.113, issue.4, pp.1098-1103, 2016. ,
,
Regulation of RhoA by STAT3 coordinates glial scar formation, The Journal of Cell Biology, vol.216, issue.8, pp.2533-2550, 2017. ,
,
Non-syndromic X-linked mental retardation: from a molecular to a clinical point of view, Journal of Cellular Physiology, vol.204, issue.1, pp.8-20, 2005. ,
Successful ageing for people with an intellectual disability, Current Opinion in Psychiatry, vol.29, issue.2, pp.149-154, 2016. ,
,
Historical overview of Rho GTPases, Methods in Molecular Biology, vol.827, pp.3-12, 2012. ,
Neuropathological features in a female fetus with OPHN1 deletion and cerebellar hypoplasia, European Journal of Medical Genetics, vol.56, issue.5, pp.270-273, 2013. ,
,
Astrocyte glutamine synthetase: pivotal in health and disease, Biochemical Society Transactions, issue.6, pp.1518-1524, 2013. ,
,
Two sides of the same coin: sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions, Glia, issue.8, pp.1191-1205, 2013. ,
Phenotype profiling of patients with intellectual disability and copy number variations, European Journal of Paediatric Neurology: EJPN: Official Journal of the European Paediatric Neurology Society, vol.18, issue.5, pp.558-566, 2014. ,
Implications of gliotransmission for the pharmacotherapy of CNS disorders, CNS Drugs, vol.25, issue.8, pp.641-658, 2011. ,
,
What do we know about gliotransmitter release from astrocytes?, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol.369, 1654. ,
Aberrant epigenetic landscape in intellectual disability, Progress in Brain Research, vol.197, pp.53-71, 2012. ,
,
TNF? controls glutamatergic gliotransmission in the hippocampal dentate gyrus, Neuron, vol.69, issue.5, pp.988-1001, 2011. ,
,
Gliotransmission and the tripartite synapse, Advances in Experimental Medicine and Biology, vol.970, pp.307-331, 2012. ,
,
Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1?-induced attenuation of Rho signaling pathways in rat astrocytes, Journal of Neurochemistry, vol.117, issue.1, pp.164-174, 2011. ,
,
Rho GTPases: signaling, migration, and invasion, Experimental Cell Research, vol.261, issue.1, pp.1-12, 2000. ,
,
Expanding the phenotypic spectrum associated with OPHN1 variants, European Journal of Medical Genetics, 2018. ,
,
Connexins in epidermal homeostasis and skin disease, Biochimica Et Biophysica Acta, vol.1818, issue.8, pp.1952-1961, 2012. ,
,
GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.26, issue.20, pp.5370-5382, 2006. ,
Rho GTPases and their role in organizing the actin cytoskeleton, Journal of Cell Science, vol.124, issue.5, pp.679-683, 2011. ,
,
Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders, Current Opinion in Neurobiology, vol.27, pp.75-81, 2014. ,
Viewing the brain through the master hand of Ramon y Cajal, Nature Reviews Neuroscience, vol.4, issue.1, pp.71-77, 2003. ,
Three-dimensional organization of cell adhesion junctions at synapses and dendritic spines in area CA1 of the rat hippocampus, The Journal of Comparative Neurology, vol.393, issue.1, pp.58-68, 1998. ,
Dynamics of the Rho-family small GTPases in actin regulation and motility, Cell Adhesion & Migration, vol.5, issue.2, pp.170-180, 2011. ,
Involvement of Rho-family GTPases in axon branching, Small GTPases, vol.5, 2014. ,
Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms, Neuroscience and Biobehavioral Reviews, vol.46, pp.161-174, 2014. ,
Genetics and the investigation of developmental delay/intellectual disability, Archives of Disease in Childhood, vol.99, issue.4, pp.386-389, 2014. ,
,
Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration, Frontiers in Cellular Neuroscience, vol.8, p.314, 2014. ,
The complement system: an unexpected role in synaptic pruning during development and disease, Annual Review of Neuroscience, vol.35, pp.369-389, 2012. ,
X-linked intellectual disability: unique vulnerability of the male genome, Developmental Disabilities Research Reviews, vol.15, issue.4, pp.361-368, 2009. ,
Neuronastroglial interactions in cell-fate commitment and maturation in the central nervous system, Neurochemical Research, vol.37, issue.11, pp.2402-2418, 2012. ,
Structural remodeling of astrocytes in the injured CNS, The Neuroscientist: A Review Journal Bringing Neurobiology, vol.18, issue.6, pp.567-588, 2012. ,
Astrocyte-neuron lactate transport is required for long-term memory formation, Cell, vol.144, issue.5, pp.810-823, 2011. ,
Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo, PloS One, vol.3, issue.6, 2008. ,
Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.31, issue.49, pp.18155-18165, 2011. ,
The synaptic plasticity and memory hypothesis: encoding, storage and persistence, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol.369, 1633. ,
Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurogenesis and cognitive defects in intellectual disability and neuropsychiatric disorder models, BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology, vol.36, issue.9, pp.872-883, 2014. ,
Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons, Genes & Development, vol.28, issue.1, pp.20-33, 2014. ,
Current knowledge of the large RhoGAP family of proteins, Biology of the Cell, vol.99, issue.2, pp.67-86, 2007. ,
,
Modulation of actin dynamics by Rac1 to target cognitive function, Journal of Neurochemistry, vol.133, issue.6, pp.767-779, 2015. ,
,
Deletion including the oligophrenin-1 gene associated with enlarged cerebral ventricles, cerebellar hypoplasia, seizures and ataxia, European Journal of Human Genetics: EJHG, vol.7, issue.5, pp.541-548, 1999. ,
Activity-dependent structural and functional plasticity of astrocyte-neuron interactions, Physiological Reviews, vol.88, issue.3, pp.983-1008, 2008. ,
Physiological roles of Rho and Rho effectors in mammals, European Journal of Cell Biology, vol.92, pp.303-315, 2013. ,
,
Control of synapse development and plasticity by Rho GTPase regulatory proteins, Progress in Neurobiology, vol.94, issue.2, pp.133-148, 2011. ,
,
Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders, Neural Plasticity, 2016. ,
Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome, Free Radical Biology & Medicine, vol.114, pp.10-14, 2018. ,
Repurposing available drugs for neurodevelopmental disorders: The fragile X experience, 2018. ,
Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair, Science, issue.6092, pp.358-362, 2012. ,
,
Ageing in individuals with intellectual disability: issues and concerns in Hong Kong, Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, vol.24, issue.1, pp.68-72, 2018. ,
Next-generation sequencing in X-linked intellectual disability, European Journal of Human Genetics: EJHG, vol.23, issue.11, pp.1513-1518, 2015. ,
,
Genes, plasticity and mental retardation, Behavioural Brain Research, vol.192, issue.1, pp.88-105, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00320613
,
Synaptic dysfunction and intellectual disability, Advances in Experimental Medicine and Biology, vol.970, pp.433-449, 2012. ,
,
Genetic and epigenetic networks in intellectual disabilities, Annual Review of Genetics, vol.45, pp.81-104, 2011. ,
Rho proteins, mental retardation and the neurobiological basis of intelligence, Progress in Brain Research, vol.147, pp.295-317, 2005. ,
, , pp.47022-47030
Molecular basis for prospective pharmacological treatment strategies in intellectual disability syndromes, Developmental Neurobiology, vol.74, issue.2, pp.197-206, 2014. ,
Molecular and synaptic defects in intellectual disability syndromes, Current Opinion in Neurobiology, vol.22, issue.3, pp.530-536, 2012. ,
,
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?, Nature Reviews. Cancer, vol.10, issue.12, pp.842-857, 2010. ,
Genetic studies in intellectual disability and related disorders, Nature Reviews. Genetics, vol.17, issue.1, pp.9-18, 2016. ,
,
Dendritic spine abnormalities in mental retardation, Cell and Tissue Research, vol.342, issue.3, pp.317-323, 2010. ,
Contiguous gene deletions involving EFNB1, OPHN1, PJA1 and EDA in patients with craniofrontonasal syndrome, Clinical Genetics, vol.72, issue.6, pp.506-516, 2007. ,
,
, , 2014.
, Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons, Human Molecular Genetics, vol.23, issue.11, pp.2968-2980
Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus, Glia, vol.55, issue.1, pp.13-23, 2007. ,
,
Excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome, PLoS Genetics, vol.8, issue.12, 2012. ,
Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation, Glia, vol.57, issue.11, pp.1239-1249, 2009. ,
,
Morphologic heterogeneity of human adult astrocytes in culture: correlation with HLA-DR expression, Journal of Neuroscience Research, vol.27, issue.4, pp.678-688, 1990. ,
,
Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities, International Journal of Molecular Sciences, issue.6, p.19, 2018. ,
,
Oligophrenin 1 mutations frequently cause X-linked mental retardation with cerebellar hypoplasia, Neurology, vol.65, issue.9, pp.1364-1369, 2005. ,
,
Astroglia disturbances during development of the central nervous system in fetuses with Down's syndrome, Folia Neuropathologica, vol.49, issue.2, pp.109-114, 2011. ,
Rho GTPases in collective cell migration. Small GTPases, 5, e28997, 2014. ,
Control of astrocyte morphology by Rho GTPases, Brain Research Bulletin, vol.136, pp.44-53, 2018. ,
Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.37, issue.46, pp.11114-11126, 2017. ,
Filamin A Regulates Neuronal Migration through Brefeldin A-Inhibited Guanine Exchange Factor 2-Dependent Arf1, 2013. ,
, Activation. The Journal of Neuroscience, vol.33, issue.40, pp.15735-15746
,
Roles for gliotransmission in the nervous system, Journal of Neural Transmission, vol.112, issue.1, pp.121-125, 1996. ,
,
Astrocyte heterogeneity: an underappreciated topic in neurobiology, Current Opinion in Neurobiology, vol.20, issue.5, pp.588-594, 2010. ,
,
A smarter mouse with human astrocytes, Prospects & Overviews. BioEssays, 2013. ,
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex, The Journal of Neuroscience, vol.34, issue.36, pp.11929-11947, 2014. ,
Freshly isolated hippocampal CA1 astrocytes comprise two populations differing in glutamate transporter and AMPA receptor expression, 2001. ,
, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, vol.21, issue.20, pp.7901-7908
Mosaic analysis with double markers in mice, Cell, vol.121, issue.3, pp.479-492, 2005. ,
,
Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route, ASN Neuro, issue.2, p.4, 2012. ,