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Theses

Deracemization of sodium chlorate with or without the influence of sodium dithionate

Abstract : In the field of pharmaceutical chemistry, crystallization based methods are used to obtain pure enantiomers. The advantage of deracemization is the conversion of the unwanted enantiomer into the desired enantiomer by means of racemization in liquid phase, giving rise to a theoretical yield of 100%. The mechanism of Temperature Cycling Induced Deracemization (TCID) process, still matter of debate, has been investigated in this thesis. Research was focused on the development of the TCID process for sodium chlorate (NaClO3). This model compound is achiral at the solvated state which enables to focus investigation on crystallization mechanisms involved during deracemization. After the full solid state characterization of sodium dithionate (Na2S2O6), this compound has been used as a nonchiral impurity in the TCID process of NaClO3 and highlighted the key role of secondary nucleation in the process. Thus, the success of the TCID process depends on the right balance between growth and secondary nucleation. From an industrial perspective, the Couette Taylor reactor has been considered as a promising device for the development of continuous deracemization process. Attempts to deracemize NaClO3 in this kind of reactor showed that symmetry breaking and deracemization of NaClO3 were successful. Nonetheless, crystal recycling, via either attrition or secondary nucleation, has to be improved to enhance deracemization process before considering the execution of continuous process.
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Submitted on : Friday, May 15, 2020 - 10:40:09 AM
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  • HAL Id : tel-02521046, version 2

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Manon Schindler. Deracemization of sodium chlorate with or without the influence of sodium dithionate. Cristallography. Normandie Université, 2020. English. ⟨NNT : 2020NORMR004⟩. ⟨tel-02521046v2⟩

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